Ephreli 12, 2017 / University of Brawijaya / Heart International

Umbhalo/ Wu Tingyao

Ukudla isikhathi eside kwe-cholesterol ephezulu kungaholela kalula ku-lipids yegazi engavamile, futhi i-lipids yegazi engavamile yesikhathi eside ingaholela ku-atherosclerosis.Nokho, umaI-Ganoderma lucidumi-polysaccharides iyangenelela, noma ngabe i-lipids yegazi isengajwayelekile, ingozi ye-atherosclerosis cishe izoncishiswa.

I-"Heart International" ishicilele umbiko ovela eNyuvesi yaseBrawijaya e-Indonesia ngo-2017, okufakazela lokhoI-Ganoderma lucidumi-polysaccharide peptides (i-β-D-glucan ecebile ngamaprotheni ekhishwe kuyoI-Ganoderma lucidum) babe nalo mphumela wokuvikela.

Imiphumela eminingi ngokumelene ne-atherosclerosis

Abacwaningi bondle amagundane ngokudla okune-cholesterol ephezulu amasonto angu-12.Amaqembu amathathu amagundane anikezwa ngesikhathi esisodwa ngemithamo ephansi, ephakathi nendawo ephezulu (50, 150, 300 mg / kg)I-Ganoderma lucidumukulungiswa kwe-polysaccharide peptides (PsP), equkethe ama-20%I-Ganoderma lucidumama-polysaccharide peptides, emasontweni angu-4 okugcina okuhlolwa.

Ngemva kokuhlolwa, impilo yemithambo yegazi yamagundane yahlaziywa kusetshenziswa izinkomba ezine, kwatholakala imiphumela elandelayo mayelana namagundane adlayo.I-Ganoderma lucidumi-polysaccharide peptides:

1. Ukuhlushwa kwama-radicals mahhala i-H2O2 ku-serum iphansi kakhulu - i-low-density lipoprotein cholesterol (LDL-C) eqoqwe odongeni lwemithambo yegazi i-oxidized ngama-radicals mahhala, okuyisinyathelo sokuqala ekwakhekeni kwe-atherosclerosis.Lapho ama-radicals wamahhala ehla, amathuba okuba ne-atherosclerosis ayancipha ngokwemvelo.

2. Imfihlo ye-IL-10, i-cytokine ephikisana nokuvuvukala, iyancipha - kusho ukuthi izinga lokuvuvukala lincane, ngakho-ke asikho isidingo se-IL-10 eningi ukulwa nokuvuvukala.

3. Inani “lamangqamuzana ozala we-endothelial” angasetshenziswa ukulungisa izindonga zemithambo yegazi eyonakele liye landa - amangqamuzana e-endothelial progenitor ajikeleza umzimba wonke ngegazi angalungisa izindonga zemithambo yegazi ezilinyazwe i-oxidation nokuvuvukala.Ngakho-ke, ukwanda kwamaseli e-endothelial progenitor kukhombisa ukuthi amathuba okulungisa udonga lwemithambo yegazi eyonakele ayakhula, futhi ithuba lokuqhubekela phambili ku-atherosclerosis liyancipha.

4. Ubukhulu bodonga lwangaphakathi lwe-aorta (i-intima kanye nemidiya) iseduze nokujwayelekile - ingxenye yesiphambano somkhumbi we-arterial ingahlukaniswa ibe yizingqimba ezintathu ukusuka ngaphakathi kuya ngaphandle: udonga lomkhumbi wegazi othintana naye. ngokugeleza kwegazi kubizwa ngokuthi i-intima, eyakhiwe ngamaseli endothelial;ungqimba oluphakathi olwakhiwe imisipha ebushelelezi lubizwa ngokuthi imidiya.Lezi zingqimba ezimbili zezicubu zemithambo ziyizindawo eziyingozi kakhulu ze-atherosclerosis.Ngakho-ke, lapho ukujiya kwezingqimba ezimbili kusondele kokujwayelekile, kusho ukuthi imithambo isesimweni esinempilo.

Ukugxiliswa kwe-radical yamahhala ku-serum yamagundane

[Qaphela] I-H2O2 iwuhlobo lwe-radical yamahhala.Lapho igxila ephansi, mancane amathuba okuba yenze i-atherosclerosis.(Umdwebo/Wu Tingyao, umthombo wedatha/I-Heart Int. 2017; 12(1): e1-e7.)

Ukuhlushwa kwe-cytokine elwa nokuvuvukala ku-serum yamagundane

[Qaphela] Uma ukugxila kwe-IL-10 eqeda ukuvuvukala ku-serum kungaphakeme kangako, kusho ukuthi ukuvuvukala kodonga lomkhumbi wegazi kungase kungabi kubi kangako, futhi ingozi ye-atherosclerosis nayo iyancipha.(Umdwebo/Wu Tingyao, umthombo wedatha/I-Heart Int. 2017; 12(1): e1-e7.)

Inani lamaseli e-endothelial progenitor egazini legundane

[Qaphela] Amaseli e-Endothelial progenitor angalungisa izindonga zemithambo yegazi ezilimele.Lapho inani labo likhula, kusho ukuthi ingozi ye-atherosclerosis iyancipha noma ingabambezeleka.(Umdwebo/Wu Tingyao, umthombo wedatha/I-Heart Int. 2017; 12(1): e1-e7.)

Ubukhulu bodonga lwe-arterial yegundane

[Qaphela] I-vascular "intima" kanye "nemidiya" yizindawo zezilonda ezibaluleke kakhulu ze-atherosclerosis.Uma ugqinsi lwabo lusondelana nolwemithambo engaphansi kokudla okujwayelekile, imithambo yegazi izoba nempilo.(Umdwebo/Wu Tingyao, umthombo wedatha/I-Heart Int. 2017; 12(1): e1-e7.)

Ukuvikelwa kweI-Ganoderma lucidumI-polysaccharide peptides ohlelweni lwenhliziyo nemithambo yegazi kungenzeka ingabonakali ngokuphelele ezinkomba ezibonakalayo.

Ukuhlola okungenhla kubonisa ukuthi nakuba imbangela ye-atherosclerosis (ukudla okunamafutha amaningi) isekhona, futhi i-lipids yegazi isengajwayelekile,I-Ganoderma lucidumama-polysaccharide peptides angagcina imithambo yegazi isesimweni esinempilo ngokuqhathaniswa nemiphumela emithathu ye-anti-oxidation, anti-inflammation kanye nokwenza ngcono ithuba lokulungisa izindonga zemithambo yegazi ezilimele.Nomphumela weI-Ganoderma lucidumi-polysaccharide peptides ilingana nomthamo wayo.

Ngoba ithimba labacwaningi liye laqinisekisa ngaphambilini ngezifundo zomtholampilo ukuthi ukusetshenziswa kwalokhuI-Ganoderma lucidumUkulungiselela ama-polysaccharide peptides ukwelashwa kwe-adjuvant yeziguli ezine-angina pectoris kungathuthukisa kakhulu ukuvuvukala, ukulimala kwe-oxidative, ushukela wegazi, nama-lipids egazi emzimbeni, ngaleyo ndlela kunciphise imvamisa nokuqina kwe-angina pectoris.Ngakho-ke, amandla okusebenza emtholampilo weI-Ganoderma lucidumi-polysaccharide peptides ikufanele ngempela lokho esikulindele.

Ucwaningo oluningi esikhathini esidlule lusebenzise "ukwehlisa i-lipids yegazi kuya kwejwayelekile" njengenkomba ethile yokusebenza ngempumeleloI-Ganoderma lucidumekuvikeleni isimiso senhliziyo nemithambo yegazi.Kodwa-ke, ucwaningo oluvela e-Indonesia lusitshela ukuthi ngisho noma i-lipids yegazi ingakabuyeli esimeni esijwayelekile, noma ngisho noma i-angina pectoris isenzeka, akufanele sidumale.I-Ganoderma lucidumngoba ibisebenza, kodwa anikwazi ukubona umphumela wayo ngamehlo enu.Uma nje idliwa njalo futhi isikhathi eside, ukuvikelwa kweI-Ganoderma lucidumohlelweni lwenhliziyo nemithambo yegazi izoqhubeka.

[Umthombo Wedatha] Wihastuti TA, et al.Imiphumela evimbelayo ye-polysaccharide peptides (PsP) ye-Ganoderma lucidum ngokumelene ne-atherosclerosis kumagundane ane-dyslipidemia.Inhliziyo Int.2017;12(1): e1-e7.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.