Epulo 12, 2017 / University of Brawijaya / Heart International

Zolemba / Wu Tingyao

Zakudya zokhala ndi cholesterol yayikulu nthawi yayitali zimatha kuyambitsa matenda a lipids osakhazikika m'magazi, ndipo lipids yanthawi yayitali yamagazi imatha kuyambitsa atherosulinosis.Komabe, ngatiGanoderma lucidumma polysaccharides amalowetsedwa, ngakhale kuti lipids m'magazi akadali achilendo, chiopsezo cha atherosulinosis chikhoza kuchepetsedwa.

"Heart International" idasindikiza lipoti lochokera ku University of Brawijaya ku Indonesia ku 2017, kutsimikizira iziGanoderma lucidumma polysaccharide peptides (olemera ma protein β-D-glucan otengedwa kuchokeraGanoderma lucidum) kukhala ndi chitetezo ichi.

Zambiri zolimbana ndi atherosulinosis

Ofufuzawo adadyetsa makoswe ndi zakudya zokhala ndi cholesterol yambiri kwa milungu 12.Magulu atatu a makoswe amadyetsedwa nthawi imodzi ndi mlingo wochepa, wapakati komanso wapamwamba (50, 150, 300 mg / kg) waGanoderma lucidumKukonzekera kwa polysaccharide peptides (PsP), komwe kuli 20%Ganoderma lucidumma polysaccharide peptides, m'masabata a 4 omaliza a kuyesa.

Pambuyo poyesera, thanzi la mitsempha ya magazi a makoswe linawunikidwa kupyolera mu zizindikiro zinayi, ndipo zotsatira zotsatirazi zinapezeka zokhudzana ndi makoswe omwe amadya.Ganoderma lucidumpolysaccharides peptides:

1. Kuchuluka kwa ma free radicals H2O2 mu seramu kumakhala kotsika kwambiri - mafuta otsika kwambiri a lipoprotein cholesterol (LDL-C) omwe amasonkhanitsidwa mu khoma la mitsempha ya magazi amapangidwa ndi oxidized ndi ma free radicals, omwe ndi sitepe yoyamba yopanga atherosclerosis.Pamene ma free radicals achepa, mwayi wa atherosulinosis mwachilengedwe umachepa.

2. Kutsekemera kwa IL-10, anti-inflammatory cytokine, kumachepetsedwa - kumatanthauza kuti mlingo wa kutupa ndi wochepa, kotero palibe chifukwa cha IL-10 yochuluka yolimbana ndi kutupa.

3. Chiwerengero cha "maselo a endothelial progenitor" omwe angagwiritsidwe ntchito kukonzanso makoma a mitsempha yamagazi owonongeka awonjezeka - maselo a endothelial progenitor omwe amazungulira thupi lonse ndi magazi amatha kukonza makoma a mitsempha ya magazi omwe awonongeka ndi okosijeni ndi kutupa.Chifukwa chake, kuchuluka kwa ma endothelial progenitor cell kukuwonetsa kuti kuthekera kokonzanso khoma lowonongeka la mitsempha yamagazi kumawonjezeka, ndipo mwayi wopitilira kufalikira kwa atherosulinosis wachepa.

4. Makulidwe a khoma lamkati la aorta (intima ndi media) ali pafupi ndi zachilendo - gawo lodutsana la chotengera chamagazi likhoza kugawidwa m'magulu atatu kuchokera mkati kupita kunja: khoma la mitsempha yamagazi yokhudzana. ndi kutuluka kwa magazi kumatchedwa intima, yomwe imapangidwa ndi maselo a endothelial;wosanjikiza wapakati wopangidwa ndi minofu yosalala amatchedwa media.Magawo awiriwa a mitsempha yam'mitsempha ndi gawo lofunikira kwambiri la atherosulinosis.Choncho, pamene makulidwe a zigawo ziwirizo ndi pafupi ndi zachilendo, zikutanthauza kuti mitsempha ili ndi thanzi labwino.

Kukhazikika kwaulere kwamphamvu mu seramu ya makoswe

[Zindikirani] H2O2 ndi mtundu wa free radical.Kutsika kwake, m'pamenenso kumakhala kosavuta kupanga atherosulinosis.(Kujambula/Wu Tingyao, gwero la data/Heart Int. 2017; 12(1): e1-e7.)

Kuchuluka kwa anti-inflammatory cytokine mu seramu ya makoswe

[Zindikirani] Pamene anti-inflammatory IL-10 ndende mu seramu siikwera kwambiri, zikutanthauza kuti kutupa kwa khoma la mitsempha ya magazi sikungakhale koopsa kwambiri, ndipo chiopsezo cha atherosclerosis chimachepa.(Kujambula/Wu Tingyao, gwero la data/Heart Int. 2017; 12(1): e1-e7.)

Chiwerengero cha maselo a endothelial progenitor mu magazi a makoswe

[Zindikirani] Endothelial progenitor cell amatha kukonza makoma a mitsempha yamagazi owonongeka.Pamene chiwerengero chawo chikuwonjezeka, zikutanthauza kuti chiopsezo cha atherosulinosis chimachepetsedwa kapena chikhoza kuchedwa.(Kujambula/Wu Tingyao, gwero la data/Heart Int. 2017; 12(1): e1-e7.)

Kuchuluka kwa khoma lapakati la makoswe

[Zindikirani] Mitsempha ya "intima" ndi "media" ndiye madera ofunikira kwambiri a atherosulinosis.Kuyandikira kwa makulidwe awo ndi a mitsempha pansi pa zakudya zachibadwa, mitsempha yamagazi idzakhala yathanzi.(Kujambula/Wu Tingyao, gwero la data/Heart Int. 2017; 12(1): e1-e7.)

Chitetezo chaGanoderma lucidumma polysaccharide peptides pamtima pamtima sangawonekere mokwanira muzowonetsa zowoneka.

Zofufuza zomwe zili pamwambazi zikuwonetsa kuti ngakhale chomwe chimayambitsa atherosulinosis (zakudya zonenepa kwambiri) zikadalipo, komanso lipids m'magazi akadali achilendo,Ganoderma lucidumma polysaccharide peptides amatha kusunga mitsempha yamagazi kukhala yathanzi labwino kudzera muzotsatira zitatu za anti-oxidation, anti-inflammation komanso kupititsa patsogolo mwayi wokonza makoma owonongeka a mitsempha yamagazi.Ndipo zotsatira zaGanoderma lucidumma polysaccharide peptides ndi ofanana ndi mlingo wake.

Chifukwa gulu lofufuza latsimikizira kale kudzera m'maphunziro azachipatala kuti kugwiritsa ntchito iziGanoderma lucidumpolysaccharide peptides pokonzekera adjuvant mankhwala a odwala angina pectoris akhoza kwambiri kusintha kutupa, makutidwe ndi okosijeni kuwonongeka, shuga magazi, ndi magazi lipids mu thupi, potero kuchepetsa pafupipafupi ndi kuopsa kwa angina pectoris.Choncho, matenda ntchito kuthekera kwaGanoderma lucidumma polysaccharide peptides ndiwoyeneradi zomwe tikuyembekezera.

Kafukufuku wambiri m'mbuyomu adagwiritsa ntchito "kutsitsa lipids m'magazi kukhala abwinobwino" ngati chizindikiritso champhamvu yaGanoderma lucidumpoteteza dongosolo la mtima.Komabe, kafukufuku wochokera ku Indonesia akutiuza kuti ngakhale magazi a lipids sanabwerere mwakale, kapena ngakhale angina pectoris ikuchitikabe, sitiyenera kukhumudwa.Ganoderma lucidumchifukwa zikugwira ntchito, koma simungathe kuziwona ndi maso anu.Malingana ngati imadyedwa nthawi zambiri komanso kwa nthawi yayitali, chitetezo chaGanoderma lucidumpa mtima dongosolo adzapitiriza.

[Data Source] Wihastuti TA, et al.Zotsatira zoletsa za polysaccharide peptides (PsP) ya Ganoderma lucidum motsutsana ndi atherosclerosis mu makoswe okhala ndi dyslipidemia.Moyo Int.2017;12(1): e1-e7.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).
 
★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.