April 12, 2017 / Univesithi ea Brawijaya / Heart International

Mongolo/ Wu Tingyao

Lijo tsa nako e telele tse nang le k'holeseterole e ngata li ka lebisa ho lipids tse sa tloaelehang maling, 'me lipids tse sa tloaelehang tsa mali tsa nako e telele li ka lebisa ho atherosclerosis.Leha ho le joalo, haebaGanoderma lucidumli-polysaccharides lia kenella, le haeba lipids tsa mali li ntse li sa tloaeleha, kotsi ea ho ba le atherosclerosis e ka fokotseha.

"Heart International" e phatlalalitse tlaleho e tsoang Univesithing ea Brawijaya Indonesia ka 2017, e pakang seoGanoderma lucidumpolysaccharide peptides (e nang le protheine e ngata β-D-glucan e ntšitsoeng hoGanoderma lucidum) ba le phello ena e sireletsang.

Liphello tse ngata khahlanong le atherosclerosis

Bafuputsi ba ile ba fepa likhoto ka lijo tse nang le k'holeseterole e ngata bakeng sa libeke tse 12.Lihlopha tse tharo tsa likhoto li ne li feptjoa ka nako e le 'ngoe ka tekanyo e tlaase, e bohareng le e phahameng (50, 150, 300 mg / kg) eaGanoderma lucidumho hlophisoa ha polysaccharide peptides (PsP), e nang le 20%Ganoderma lucidumli-peptide tsa polysaccharide, libekeng tse 4 tse fetileng tsa teko.

Ka mor'a teko, bophelo ba methapo ea mali ea likhoto bo ile ba hlahlojoa ka matšoao a mane, 'me ho ile ha fumanoa liphello tse latelang mabapi le likhoto tse jang.Ganoderma lucidumli-peptide tsa polysaccharide:

1. Li-radicals tsa mahala tsa H2O2 ka serum li fokotsehile haholo - k'holeseterole e tlaase-density lipoprotein (LDL-C) e bokelletsoeng leboteng la methapo ea mali e oxidized ke li-radicals tsa mahala, e leng mohato oa pele oa ho thehoa ha atherosclerosis.Ha li-radicals tsa mahala li fokotseha, monyetla oa ho ba le atherosclerosis oa fokotseha ka tlhaho.

2. Sephiri sa IL-10, cytokine e khahlanong le ho ruruha, e fokotsehile - e bolela hore tekanyo ea ho ruruha e bonolo, kahoo ha ho hlokahale hore ho be le IL-10 e ngata ho loantša ho ruruha.

3. Palo ea "lisele tsa "endothelial progenitor" tse ka sebelisoang ho lokisa marako a methapo ea mali e senyehileng e eketsehile - lisele tsa endothelial progenitor tse potolohang 'meleng ka mali li ka lokisa marako a methapo ea mali a senyehileng ke oxidation le ho ruruha.Ka hona, ho eketseha ha lisele tsa endothelial progenitor ho bontša hore monyetla oa ho lokisa lerako la methapo ea mali e senyehileng oa eketseha, 'me monyetla oa ho tsoela pele ho fetoha atherosclerosis o fokotsehile.

4. Botenya ba lerako le ka hare la aorta (intima le mecha ea litaba) e haufi le e tloaelehileng - karolo ea sefapano sa sejana sa methapo e ka aroloa ka likarolo tse tharo ho tloha ka hare ho ea ka ntle: lerako la sejana sa mali se kopane. ka phallo ea mali e bitsoa intima, e entsoeng ka lisele tsa endothelial;karolo e bohareng e entsoeng ka mesifa e boreleli e bitsoa mecha ea litaba.Likarolo tsena tse peli tsa lisele tsa methapo ke libaka tsa bohlokoa ka ho fetesisa tsa atherosclerosis.Ka hona, ha botenya ba lihlopha tse peli bo le haufi le ho tloaelehile, ho bolela hore methapo ea mali e boemong bo batlang bo le boemong bo botle.

Free radical concentration ka har'a serum ea likhoto

[Hlokomela] H2O2 ke mofuta oa radical mahala.Ha e le tlase haholo, ho na le monyetla o fokolang oa ho theha atherosclerosis.(Moralo/Wu Tingyao, mohloli oa data/Heart Int. 2017; 12(1): e1-e7.)

Khokahano ea anti-inflammatory cytokine ho serum ea rat

[Tlhokomeliso] Ha khatello ea IL-10 e khahlanong le ho ruruha ka har'a serum e sa phahame hakaalo, ho bolela hore ho ruruha ha lebota la methapo ea mali ho ka 'na ha se ke ha e-ba matla hakaalo,' me kotsi ea atherosclerosis le eona e fokotsehile.(Moralo/Wu Tingyao, mohloli oa data/Heart Int. 2017; 12(1): e1-e7.)

Palo ea lisele tsa endothelial progenitor maling a likhoto

[Tlhokomeliso] Lisele tsa endothelial progenitor li ka lokisa mabota a senyehileng a methapo ea mali.Ha palo ea bona e eketseha, ho bolela hore kotsi ea atherosclerosis e fokotsehile kapa e ka lieha.(Moralo/Wu Tingyao, mohloli oa data/Heart Int. 2017; 12(1): e1-e7.)

Botenya ba lebota la arterial la rat

[Tlhokomeliso] "Intima" le "media" ea vascular ke libaka tsa bohlokoa ka ho fetisisa tsa lefu la atherosclerosis.Ha botenya ba bona bo le haufi le ba methapo e tlas'a lijo tse tloaelehileng, methapo ea mali e tla phela hantle.(Moralo/Wu Tingyao, mohloli oa data/Heart Int. 2017; 12(1): e1-e7.)

Tšireletso eaGanoderma lucidumli-peptide tsa polysaccharide tsamaisong ea pelo li ka 'na tsa se ke tsa bonahala ka ho feletseng ho matšoao a bonahalang.

Liteko tse ka holimo li bontša hore le hoja sesosa sa lefu la atherosclerosis (lijo tse nang le mafura a mangata) se ntse se le teng, 'me mafura a mali a ntse a sa tloaeleha,Ganoderma lucidumli-peptide tsa polysaccharide li ka boloka methapo ea mali e le boemong bo batlang bo le boemong bo botle ka liphello tse tharo tsa anti-oxidation, anti-inflammation le ho ntlafatsa monyetla oa ho lokisa marako a methapo ea mali a senyehileng.Le phello eaGanoderma lucidumli-peptide tsa polysaccharide li lekana le litekanyetso tsa tsona.

Hobane sehlopha sa bafuputsi se netefalitse ka lithuto tsa bongaka hore tšebeliso ea senaGanoderma lucidumLi-peptide tsa polysaccharide li itokisetsa kalafo ea adjuvant ea bakuli ba nang le angina pectoris li ka ntlafatsa haholo ho ruruha, tšenyo ea oxidative, tsoekere e maling le lipids tsa mali 'meleng, ka hona, ho fokotsa sekhahla le ho teba ha angina pectoris.Ka hona, bokhoni ba kopo ea kliniki eaGanoderma lucidumLi-peptide tsa polysaccharide ehlile li lokeloa ke litebello tsa rona.

Lithuto tse ngata nakong e fetileng li sebelisitse "ho theola lipids ea mali ho ea ho se tloaelehileng" e le sesupo se itseng sa katleho eaGanoderma lucidumka ho sireletsa tsamaiso ea pelo.Leha ho le joalo, lipatlisiso tse tsoang Indonesia li re bolella hore le haeba mali a lipids a sa khutlela ho tloaelehileng, kapa esita le haeba angina pectoris e ntse e etsahala, ha rea ​​​​lokela ho soetseha.Ganoderma lucidumhobane e ntse e sebetsa, empa le ke ke la khona ho bona phello ea eona ka mahlo a lōna.Hafeela e jeoa hangata le ka nako e telele, tšireletso eaGanoderma lucidumtsamaisong ea pelo le methapo e tla tsoela pele.

[Mohloli oa Boitsebiso] Wihastuti TA, et al.Litlamorao tsa inhibitory tsa polysaccharide peptides (PsP) ea Ganoderma lucidum khahlano le atherosclerosis ho likhoto tse nang le dyslipidemia.Heart Int.2017;12(1): e1-e7.

QETA

Mabapi le mongoli/ Mme Wu Tingyao
Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).
 
★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.