Eprel 12, 2017 / Mahadum Brawijaya / Heart International

Ederede/ Wu Tingyao

Nri cholesterol dị elu ogologo oge nwere ike iduga n'ụzọ dị mfe na lipids ọbara adịghị mma, lipids ọbara na-adịte aka nwere ike ibute atherosclerosis.Agbanyeghị, ọ bụrụGanoderma lucidumA na-etinye aka na polysaccharides, ọ bụrụgodị na lipids ọbara ka na-adịghị mma, ihe ize ndụ nke atherosclerosis nwere ike ibelata.

"Heart International" bipụtara akụkọ sitere na Mahadum Brawijaya dị na Indonesia na 2017, na-egosi naGanoderma lucidumpeptides polysaccharide (protein bara ụba β-D-glucan ewepụtara naGanoderma lucidum) nwee mmetụta nchebe a.

Ọtụtụ mmetụta megide atherosclerosis

Ndị ọrụ nyocha ahụ jiri nri cholesterol dị elu nye ụmụ oke nri maka izu iri na abụọ.A na-enye otu oke atọ nri n'otu oge na obere obere, ọkara na nnukwu doses (50, 150, 300 mg / kg) nkeGanoderma lucidumNkwadebe nke peptides polysaccharide (PsP), nke nwere 20%Ganoderma lucidumpeptides polysaccharide, n'ime izu anọ ikpeazụ nke nnwale ahụ.

Mgbe nnwale ahụ gasịrị, a nyochara ahụike nke arịa ọbara nke oke site na ihe ngosi anọ, wee chọpụta nsonaazụ ndị a gbasara oke ndị riri.Ganoderma lucidumpeptides nke polysaccharides:

1. The ịta nke free radicals H2O2 ke ọbara bụ budata ala - ala-njupụta lipoprotein cholesterol (LDL-C) chịkọbara na ọbara arịa mgbidi na-oxidized site free radicals, nke bụ nzọụkwụ mbụ na e guzobere atherosclerosis.Mgbe free radicals ibelata, ohere nke atherosclerosis na-ebelata ndammana.

2. Ihe nzuzo nke IL-10, cytokine na-egbochi mkpali, na-ebelata - ọ pụtara na ogo nke mbufụt dị nro, n'ihi ya, ọ dịghị mkpa ka IL-10 dị ukwuu na-alụ ọgụ.

3. Ọnụ ọgụgụ nke "endothelial progenitor cell" nke a pụrụ iji na-arụzi mgbidi arịa ọbara mebiri emebi abawanyela - endothelial progenitor cell na-ekesa n'ime ahụ na ọbara nwere ike ịrụkwa mgbidi arịa ọbara mebiri site na oxidation na mbufụt.Ya mere, mmụba nke mkpụrụ ndụ endothelial progenitor na-egosi na ohere nke ịrụzi mgbidi arịa ọbara mebiri emebi na-abawanye, na ohere nke ịmalite ịmalite n'ihu na atherosclerosis na-ebelata.

4. Ọkpụrụkpụ nke mgbidi dị n'ime nke aorta (intima na mgbasa ozi) dị nso na nkịtị - akụkụ obe nke arịa akwara nwere ike kewaa atọ n'ígwé site n'ime ruo n'èzí: mgbidi nke arịa ọbara na kọntaktị. na-erugharị ọbara ka a na-akpọ intima, nke mejupụtara mkpụrụ ndụ endothelial;A na-akpọ oyi akwa etiti nke mejupụtara akwara dị nro bụ mgbasa ozi.Akụkụ abụọ a nke anụ ahụ vaskụla bụ akụkụ ọnya kachasị mkpa nke atherosclerosis.Ya mere, mgbe ọkpụrụkpụ nke okpukpu abụọ dị nso na nkịtị, ọ pụtara na akwara dị n'ọnọdụ dị mma.

Ntinye uche nke radical efu na serum oke

[Cheta] H2O2 bụ ụdị radical efu.Ka itinye uche ya dị ala, ọ ga-abụrịrị na ọ na-etolite atherosclerosis.(Drawing/Wu Tingyao, isi iyi data/Heart Int. 2017; 12(1): e1-e7.)

Ntinye nke cytokine mgbochi mkpali na serum oke

[Rịba ama] Mgbe mgbochi IL-10 mgbochi mkpali na ọbara adịghị elu, ọ na-egosi na mbufụt nke mgbidi arịa ọbara nwere ike ọ gaghị adị oke njọ, na ihe ize ndụ nke atherosclerosis na-ebelatakwa.(Drawing/Wu Tingyao, isi iyi data/Heart Int. 2017; 12(1): e1-e7.)

Ọnụọgụ mkpụrụ ndụ endothelial progenitor dị n'ọbara oke

[Cheta] Selụ progenitor endothelial nwere ike ịrụkwa mgbidi arịa ọbara mebiri emebi.Mgbe ọnụọgụ ha na-abawanye, ọ pụtara na ihe ize ndụ nke atherosclerosis na-ebelata ma ọ bụ nwee ike igbu oge.(Drawing/Wu Tingyao, isi iyi data/Heart Int. 2017; 12(1): e1-e7.)

Ọkpụrụkpụ nke mgbidi akwara nke oke

[Cheta] vaskụla “intima” na “mgbasa ozi” bụ mpaghara ọnya kachasị mkpa nke atherosclerosis.Ka ọkpụrụkpụ ha na-eru nso na akwara akwara n'okpuru nri nkịtị, ka arịa ọbara ga-adịwanye mma.(Drawing/Wu Tingyao, isi iyi data/Heart Int. 2017; 12(1): e1-e7.)

Nchedo nkeGanoderma lucidumpeptides polysaccharide na sistemu obi nwere ike ọ gaghị egosipụta nke ọma na ihe ngosi a na-ahụ anya.

Nnwale ndị a dị n'elu na-egosi na ọ bụ ezie na ihe kpatara atherosclerosis (nri dị oke abụba) ka dị, na lipids ọbara ka na-adịghị mma.Ganoderma lucidumpeptides polysaccharide nwere ike idowe arịa ọbara akwara na ọnọdụ ahụike dịtụ mma site na mmetụta atọ nke mgbochi oxidation, mgbochi mbufụt na ime ka ohere nke ịrụzi mgbidi arịa ọbara mebiri emebi.Na mmetụta nkeGanoderma lucidumpeptides polysaccharide dabara na usoro onunu ogwu.

N'ihi na ndị nnyocha otu na mbụ kwadoro site na-adakarị ọmụmụ na ojiji nke aGanoderma lucidumNkwadebe nke peptides polysaccharide maka ọgwụgwọ adjuvant nke ndị ọrịa nwere angina pectoris nwere ike imeziwanye mbufụt, mmebi oxidative, shuga ọbara, na lipids ọbara n'ime ahụ, si otú ahụ belata ugboro na ịdị njọ nke angina pectoris.Ya mere, na-adakarị ngwa ike nkeGanoderma lucidumpeptides polysaccharide kwesịrị n'ezie ihe anyị tụrụ anya ya.

Ọtụtụ ọmụmụ n'oge gara aga ejirila "iweda lipids ọbara ka ọ dị mma" dị ka ihe ngosi akọwapụtara nke ọmaGanoderma lucidumn'ichekwa usoro obi.Otú ọ dị, nnyocha e mere na Indonesia na-agwa anyị na ọ bụrụgodị na lipids ọbara alaghachibeghị n'ọnọdụ nkịtị, ma ọ bụ ọ bụrụgodị na angina pectoris ka na-eme, anyị ekwesịghị inwe ndakpọ olileanya.Ganoderma lucidumn'ihi na ọ na-arụ ọrụ, ma ị nwere ike ghara iji anya gị onwe gị hụ mmetụta ya.Dị ka ogologo dị ka ọ na-eri mgbe na ruo ogologo oge, nchebe nkeGanoderma lucidumna usoro obi ga-aga n'ihu.

[Ebe data] Wihastuti TA, et al.Mmetụta mgbochi nke polysaccharide peptides (PsP) nke Ganoderma lucidum megide atherosclerosis na oke nwere dyslipidemia.Obi Int.2017;12 (1): e1-e7.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao
Wu Tingyao na-akọ akụkọ gbasara Ganoderma nke mbụ kemgbe 1999. Ọ bụ ya bụ onye dere akwụkwọ akụkọ.Ọgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).
 
★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede.★ Enweghị ike imepụtagharị ọrụ ndị a dị n'elu, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede.★ Maka mmebi nke nkwupụta a dị n'elu, onye edemede ga-agbaso ọrụ iwu dị mkpa.★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.