Ngo-Epreli 12, i-2017 / iYunivesithi yaseBrawijaya / Heart International

Umbhalo/ Wu Tingyao

Ukutya kwexesha elide le-cholesterol ephezulu kunokukhokelela ngokulula kwi-lipids yegazi engaqhelekanga, kwaye i-lipids yegazi engaqhelekanga yexesha elide inokukhokelela kwi-atherosclerosis.Nangona kunjalo, ukubaI-Ganoderma lucidumI-polysaccharides ingenelela, nangona i-lipids yegazi iseyinto engaqhelekanga, umngcipheko we-atherosclerosis unokunciphisa.

"I-Heart International" yapapasha ingxelo evela kwiYunivesithi yaseBrawijaya e-Indonesia kwi-2017, ebonisa ukubaI-Ganoderma lucidumi-polysaccharide peptides (i-protein-rich β-D-glucan ekhutshwe kuyoI-Ganoderma lucidum) babe nale mpembelelo yokukhusela.

Iziphumo ezininzi ngokuchasene ne-atherosclerosis

Abaphandi bondla iigundane kunye nokutya okuphezulu kwe-cholesterol kwiiveki ze-12.Amaqela amathathu eempuku asondliwa ngaxeshanye kunye namanani aphantsi, aphakathi kunye aphezulu (50, 150, 300 mg / kg)I-Ganoderma lucidumUkulungiswa kwe-polysaccharide peptides (PsP), equlethe i-20%I-Ganoderma lucidumi-polysaccharide peptides, kwiiveki ezi-4 zokugqibela zovavanyo.

Emva kovavanyo, impilo yemithambo yegazi yeempuku yahlaziywa kusetyenziswa izikhombisi ezine, kwaye iziphumo ezilandelayo zafunyanwa malunga neempuku ezityileyo.I-Ganoderma lucidumiipolysaccharide peptides:

1. I-concentration of free radicals i-H2O2 kwi-serum iphantsi kakhulu - i-cholesterol ephantsi ye-lipoprotein (i-LDL-C) eqokelelwe kwindonga yegazi i-oxidized yi-radicals yamahhala, eyona nyathelo lokuqala ekubunjweni kwe-atherosclerosis.Xa i-radicals yamahhala iyancipha, ithuba le-atherosclerosis liyancipha ngokwemvelo.

2. Imfihlo ye-IL-10, i-cytokine echasayo, iyancitshiswa - ithetha ukuba iqondo lokuvuvukala lincinci, ngoko akukho mfuneko ye-IL-10 eninzi ukulwa nokuvuvukala.

3. Inani "leeseli ze-endothelial progenitor" ezingasetyenziselwa ukulungisa iindonga zegazi ezonakalisiweyo ziye zanda - iiseli ze-endothelial progenitor ezijikeleza kuwo wonke umzimba ngegazi zinokulungisa iindonga zemithambo yegazi ezonakaliswe yi-oxidation kunye nokuvuvukala.Ke ngoko, ukwanda kweeseli ze-endothelial progenitor kubonisa ukuba amathuba okulungisa udonga lwemithambo yegazi eyonakalisiweyo anyuswe, kwaye ithuba lokuqhubekela phambili kwi-atherosclerosis liyancipha.

4. Ubunzima bodonga lwangaphakathi lwe-aorta (i-intima kunye nemidiya) isondele kwisiqhelo - i-cross-section of the arterial isitya sinokwahlulwa sibe ngamanqwanqwa amathathu ukusuka ngaphakathi ukuya ngaphandle: udonga lomtya wegazi ekunxibelelaneni. kunye nokuhamba kwegazi kubizwa ngokuba yi-intima, eyakhiwe ngeeseli ze-endothelial;umaleko ophakathi oqulunqwe sisihlunu esigudileyo ubizwa ngokuba yimidiya.Ezi zimbini zezicubu ze-vascular zezona ndawo zibalulekileyo ze-atherosclerosis.Ngoko ke, xa ubukhulu bemigangatho emibini busondele kwisiqhelo, kuthetha ukuba i-artery ikwimeko ephilileyo.

Ugxininiso olukhululekileyo lwasimahla kwiserum yeempuku

[Qaphela] i-H2O2 luhlobo lweradical yasimahla.Ukunciphisa ukugxininiswa kwayo, kuya kuba nzima ukuba yenze i-atherosclerosis.(Umzobo/Wu Tingyao, umthombo wedatha/Heart Int. 2017; 12(1): e1-e7.)

Ukuxinwa kwe-cytokine echasayo kwi-serum yegundane

[Qaphela] Xa i-IL-10 i-anti-inflammatory concentration kwi-serum ingekho phezulu kakhulu, oko kuthetha ukuba ukudumba kodonga lwemithambo yegazi kunokuba nzima kakhulu, kwaye umngcipheko we-atherosclerosis nawo uyancipha.(Umzobo/Wu Tingyao, umthombo wedatha/Heart Int. 2017; 12(1): e1-e7.)

Inani leeseli ze-endothelial progenitor kwigazi lempuku

[Qaphela] Iiseli ze-Endothelial progenitor zinokulungisa iindonga zemithambo yegazi ezonakeleyo.Xa inani labo linyuka, kuthetha ukuba umngcipheko we-atherosclerosis uyancitshiswa okanye unokulibaziseka.(Umzobo/Wu Tingyao, umthombo wedatha/Heart Int. 2017; 12(1): e1-e7.)

Ubukhulu bodonga lwe-arterial ye-rat

[Qaphela] I-vascular "intima" kunye ne "media" zezona ndawo zibalulekileyo ze-atherosclerosis.Ukusondela kobunzima babo kuleyo yemithambo ephantsi kokutya okuqhelekileyo, imithambo yegazi iya kuba sempilweni.(Umzobo/Wu Tingyao, umthombo wedatha/Heart Int. 2017; 12(1): e1-e7.)

Ukhuseleko lweI-Ganoderma lucidumI-polysaccharide peptides kwi-cardiovascular system ayinakubonakaliswa ngokupheleleyo kwiimpawu ezibonakalayo.

Olu vavanyo lungasentla lubonisa ukuba nangona unobangela we-atherosclerosis (ukutya okunamafutha amaninzi) usekho, kwaye iilipids zegazi aziqhelekanga,I-Ganoderma lucidumI-polysaccharide peptides inokugcina imithambo yegazi ikwimeko esempilweni ngokweziphumo ezithathu ze-anti-oxidation, i-anti-inflammation kunye nokuphucula ithuba lokulungisa iindonga zemithambo yegazi ezonakalisiweyo.Kwaye umphumo weI-Ganoderma lucidumi-polysaccharide peptides ihambelana nedosi yayo.

Ngenxa yokuba iqela lophando liye laqinisekisa ngaphambili ngezifundo zeklinikhi ukuba ukusetyenziswa kokuI-Ganoderma lucidumi-polysaccharide peptides ukulungiselela unyango lwe-adjuvant yezigulane ezine-angina pectoris inokuphucula kakhulu ukudumba, umonakalo owenziwe nge-oxidative, iswekile yegazi, kunye ne-lipids yegazi emzimbeni, ngaloo ndlela kuncitshiswa ukuphindaphinda kunye nobukhulu be-angina pectoris.Ke ngoko, amandla esicelo seklinikhiI-Ganoderma lucidumiipolysaccharide peptides eneneni ilufanele ulindelo lwethu.

Izifundo ezininzi kwixesha elidlulileyo zisebenzise "ukunciphisa i-lipids yegazi ukuya kwisiqhelo" njengesalathisi esithile sokusebenza kweI-Ganoderma lucidumekukhuseleni inkqubo ye-cardiovascular system.Nangona kunjalo, uphando oluvela e-Indonesia lusixelela ukuba nokuba i-lipids yegazi ayibuyelanga kwisiqhelo, okanye nokuba i-angina pectoris isenzeka, asifanele siphoxeke.I-Ganoderma lucidumngenxa yokuba iyasebenza, kodwa aninako ukuyibona imiphumo yayo ngamehlo enu.Logama nje ityiwa rhoqo kwaye ixesha elide, ukukhuselwaI-Ganoderma lucidumkwi-cardiovascular system iya kuqhubeka.

[Umthombo weDatha] Wihastuti TA, et al.Iziphumo zokuthintela i-polysaccharide peptides (PsP) yeGanoderma lucidum ngokuchasene ne-atherosclerosis kwiigundane ezine-dyslipidemia.Intliziyo Int.2017;12(1): e1-e7.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.