Plaub Hlis 12, 2017 / University of Brawijaya / Heart International

Text/Wu Tingyao

Kev noj haus cov roj cholesterol ntev ntev tuaj yeem ua rau cov ntshav lipids txawv txav, thiab cov ntshav lipids ntev ntev tuaj yeem ua rau atherosclerosis.Txawm li cas los xij, yog tiasGanoderma lucidumpolysaccharides cuam tshuam, txawm tias cov ntshav lipids tseem txawv txav, qhov kev pheej hmoo ntawm atherosclerosis yuav raug txo.

"Lub Plawv International" tau tshaj tawm tsab ntawv ceeb toom los ntawm University of Brawijaya hauv Indonesia hauv 2017, ua pov thawj tiasGanoderma lucidumpolysaccharide peptides (protein-nplua nuj β-D-glucan muab rho tawm los ntawmGanoderma lucidum) muaj qhov kev tiv thaiv no.

Muaj ntau yam cuam tshuam rau atherosclerosis

Cov kws tshawb fawb tau pub cov nas nrog cov khoom noj muaj roj (cholesterol) siab rau 12 lub lis piam.Peb pawg nas tau noj ib txhij nrog cov koob tshuaj qis, nruab nrab thiab siab (50, 150, 300 mg / kg) ntawmGanoderma lucidumpolysaccharide peptides (PsP) kev npaj, uas muaj 20%Ganoderma lucidumpolysaccharide peptides, hauv 4 lub lis piam dhau los ntawm kev sim.

Tom qab kev sim, kev noj qab haus huv ntawm cov hlab ntsha ntawm nas tau txheeb xyuas los ntawm plaub qhov ntsuas, thiab cov txiaj ntsig hauv qab no tau pom txog cov nas uas tau noj.Ganoderma lucidumpolysaccharide peptides:

1. Cov concentration ntawm cov dawb radicals H2O2 hauv cov ntshav yog qis dua - cov roj lipoproteins tsawg ntom ntom (LDL-C) hauv cov hlab ntsha phab ntsa yog oxidized los ntawm cov dawb radicals, uas yog thawj kauj ruam hauv kev tsim cov atherosclerosis.Thaum cov dawb radicals txo qis, txoj hauv kev ntawm atherosclerosis ib txwm txo qis.

2. Kev tso tawm ntawm IL-10, ib qho tshuaj tiv thaiv kab mob cytokine txo qis - nws txhais tau hais tias qhov kev mob ntawm qhov mob me me, yog li tsis tas yuav muaj ntau npaum li IL-10 los tiv thaiv kev mob.

3. Tus naj npawb ntawm "endothelial progenitor cells" uas tuaj yeem siv los kho cov hlab ntsha puas ntsoog tau nce ntxiv - endothelial progenitor cells uas ncig thoob plaws lub cev nrog cov ntshav tuaj yeem kho cov hlab ntsha puas tsuaj los ntawm oxidation thiab o.Yog li, qhov nce ntawm endothelial progenitor hlwb qhia tau hais tias muaj peev xwm kho cov hlab ntsha puas ntsoog yog nce, thiab txoj hauv kev ntawm kev hloov mus rau atherosclerosis yog txo qis.

4. Lub thickness ntawm lub puab phab ntsa ntawm lub aorta (intima thiab media) yog nyob ze rau qhov qub - qhov hla ntawm cov hlab ntsha tuaj yeem muab faib ua peb txheej ntawm sab hauv mus rau sab nraud: phab ntsa ntawm cov hlab ntsha hauv kev sib cuag. nrog rau cov ntshav khiav yog hu ua intima, uas yog tsim los ntawm endothelial hlwb;nruab nrab txheej uas muaj cov leeg nqaij yog hu ua xov xwm.Ob txheej ntawm cov ntaub so ntswg vascular yog qhov chaw tseem ceeb tshaj plaws ntawm atherosclerosis.Yog li ntawd, thaum lub thickness ntawm ob txheej yog los ze zog mus rau ib txwm, nws txhais tau hais tias cov hlab ntsha nyob rau hauv ib tug kuj noj qab nyob zoo lub xeev.

Dawb radical concentration nyob rau hauv nas cov ntshav

[Ceeb Toom] H2O2 yog ib hom dawb radical.Qhov qis dua nws cov concentration, qhov tsawg dua nws yuav tsim atherosclerosis.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

Qhov concentration ntawm anti-inflammatory cytokine nyob rau hauv nas cov ntshav

[Ceeb Toom] Thaum cov tshuaj tiv thaiv IL-10 concentration hauv cov ntshav tsis siab, nws txhais tau hais tias qhov mob ntawm cov hlab ntsha phab ntsa yuav tsis hnyav heev, thiab kev pheej hmoo ntawm atherosclerosis kuj txo.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

Tus naj npawb ntawm endothelial progenitor cells hauv cov ntshav nas

[Ceeb Toom] Endothelial progenitor cells tuaj yeem kho cov hlab ntsha puas.Thaum lawv cov lej nce ntxiv, nws txhais tau tias qhov kev pheej hmoo ntawm atherosclerosis raug txo qis lossis tuaj yeem ncua sijhawm.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

Lub thickness ntawm arterial phab ntsa ntawm nas

[Ceeb toom] Cov vascular "intima" thiab "media" yog qhov chaw kho mob tseem ceeb tshaj plaws ntawm atherosclerosis.Qhov ze ntawm lawv cov thickness yog rau cov hlab ntsha nyob rau hauv ib txwm noj, cov hlab ntsha yuav noj qab haus huv.(Drawing/Wu Tingyao, data source/Heart Int. 2017; 12(1): e1-e7.)

Kev tiv thaiv ntawmGanoderma lucidumpolysaccharide peptides nyob rau hauv lub plawv system tej zaum yuav tsis muaj kev cuam tshuam tag nrho nyob rau hauv cov kev taw qhia pom.

Cov kev sim saum toj no qhia tau hais tias txawm tias qhov ua rau atherosclerosis (kev noj zaub mov muaj rog) tseem muaj, thiab cov ntshav lipids tseem txawv txav,Ganoderma lucidumpolysaccharide peptides tuaj yeem khaws cov hlab ntsha hauv cov hlab ntsha hauv lub xeev uas muaj kev noj qab haus huv los ntawm kev cuam tshuam triple ntawm kev tiv thaiv oxidation, tiv thaiv kab mob thiab txhim kho txoj hauv kev kho cov hlab ntsha puas.Thiab cov nyhuv ntawmGanoderma lucidumpolysaccharide peptides yog proportional rau nws npaum li cas.

Vim tias pab pawg tshawb fawb yav dhau los tau lees paub los ntawm kev tshawb fawb soj ntsuam uas siv qhov noGanoderma lucidumpolysaccharide peptides npaj rau adjuvant kev kho mob ntawm cov neeg mob angina pectoris tuaj yeem txhim kho o, oxidative puas, ntshav qab zib, thiab ntshav lipids hauv lub cev, yog li txo qhov zaus thiab qhov hnyav ntawm angina pectoris.Yog li ntawd, kev kho mob daim ntawv thov muaj peev xwm ntawmGanoderma lucidumpolysaccharide peptides yog qhov tsim nyog ntawm peb cov kev cia siab.

Ntau qhov kev tshawb fawb yav dhau los tau siv "txo cov ntshav lipids kom zoo" raws li qhov qhia tshwj xeeb ntawm kev ua tau zoo ntawmGanoderma lucidumhauv kev tiv thaiv kab mob plawv.Txawm li cas los xij, kev tshawb fawb los ntawm Indonesia qhia peb tias txawm tias cov ntshav lipids tsis tau rov qab los zoo li qub, lossis txawm tias angina pectoris tseem tshwm sim, peb yuav tsum tsis txhob poob siab.Ganoderma lucidumvim nws tau ua hauj lwm, tab sis tej zaum koj yuav tsis pom nws cov nyhuv ntawm koj tus kheej ob lub qhov muag.Ntev npaum li nws tau noj ntau zaus thiab ntev, kev tiv thaiv ntawmGanoderma lucidumntawm cov hlab plawv system yuav txuas ntxiv mus.

[Data Source] Wihastuti TA, et al.Cov teebmeem inhibitory ntawm polysaccharide peptides (PsP) ntawm Ganoderma lucidum tiv thaiv atherosclerosis hauv nas nrog dyslipidemia.Lub Plawv Int.2017;12(1): e1-e7.

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.