Phato 2017 / Univesithi ea Punjab / Biomedicine & Pharmacotherapy

Mongolo/ Wu Tingyao

Pele re hlahisa liphuputso tse ncha tsa bo-ramahlale mabapi le hore na reishi e thibela amnesia joang, ha re shebeng mehopolo le mantsoe a 'maloa.

Lebaka leo boko bo khonang ho lemoha le ho hopola moelelo oa motho, ketsahalo, kapa ntho ke hore bo itšetlehile ka lik'hemik'hale tse kang acetylcholine ho fetisa melaetsa pakeng tsa lisele tsa methapo tse laolang ho tseba le ho hopola.Ha acetylcholine e qeta mosebetsi oa eona, e tla kenngoa ka hydrolyzed ka "acetylcholinesterase (AChE)" ebe e sebelisoa hape ke lisele tsa methapo.

Ka hona, ho ba teng ha acetylcholinesterase ho tloaelehile.E ka fana ka sebaka sa ho hema liseleng tsa methapo e le hore lisele tsa methapo li se ke tsa lula li le boemong bo thata ba ho amohela le ho romela melaetsa.

Bothata ke hore ha acetylcholinesterase e sebelisoa ka tsela e sa tloaelehang kapa mahloriso a eona a phahame haholo, e tla baka ho fokotseha ho hoholo ha acetylcholine, ho ama likamano pakeng tsa lisele tsa methapo le ho baka ho senyeha ha kelello le mohopolo.

Ka nako ena, haeba khatello ea oxidative bokong e phahame haholo, e bakang palo e kholo ea lefu la lisele tsa methapo tse ikarabellang bakeng sa ho tseba le ho hopola, boemo bo tla mpefala le ho feta.

Acetylcholinesterase e ngata haholo kapa e feteletseng le khatello e feteletseng ea oxidative e 'nile ea nkoa e le lintlha tsa bohlokoa tse bakang Alzheimer's le amnesia.Lithethefatsi tsa phekolo ea meriana tse kang donepezil (Aricept filimi-coated tablets) li atisa ho sebelisoa ho liehisa ho senyeha ha amnesia ka ho thibela acetylcholinesterase.

Ganoderma e boetse e na le phello ea ho phekola amnesia

Phuputso e phatlalalitsoeng khatisong ea morao-rao ea "Biomedicine & Pharmacotherapy" ke Lefapha la Pharmaceutical Science le Pharmaceutical Research, Univesithi ea Punjab, India, e bontšitse hore motsoako oa joala oa Ganoderma o ka fokotsa mosebetsi oa acetylcholinesterase, oa fokotsa khatello ea kelello ea oxidative. boko, le ho thibela ho senyeha ha bokhoni ba kelello le mohopolo.

Sengoli sa pampiri se boletse hore lithuto tsa nakong e fetileng li netefalitse hore mefuta e meng ea Ganoderma (joalo kaGanoderma lucidumleG. boninense) e ka sireletsa tsamaiso ea methapo ka ho thibela oxidation le ho thibela acetylcholinesterase.Ka hona, ba ile ba khethaG. mediosinenseleG. ramosissimum, tse sa ithutoang karolong ena empa hape li hlahisoa India, bakeng sa lipatlisiso ka tšepo ea ho eketsa tšusumetso e ncha ho phekolo ea pele ea amnesia.

Kaha liteko tsa in vitro cell li bonts'itse hore bakeng sa ho ntšoa ho tšoanang le 70% methanol,G. mediosinenseextract (GME) ho hlakile hore e ne e le betere ho feta mofuta o mong oa Ganoderma ho antioxidation le acetylcholinesterase inhibition, kahoo ba sebelisitse GME bakeng sa liteko tsa liphoofolo.

Litoeba tse jang Ganoderma ha li na monyetla oa ho ba le amnesia.

(1) Tseba mokhoa oa ho qoba ho tsosoa ke motlakase

Bafuputsi ba ile ba qala ho fa litoeba GME kapa donepezil, e atisang ho sebelisoa ho phekola amnesia, le ente ea scopolamine (sethethefatsi se thibelang phello ea acetylcholine) metsotso ea 30 hamorao ho etsa hore anmesia e be teng.Metsotso e mashome a mararo ka mor'a ente le letsatsing le hlahlamang, litoeba li ile tsa lekoa bakeng sa bokhoni ba tsona ba kelello le mohopolo ka "Passive Shock Avoidance Experiment" le "Novel Object Recognition Experiment".

Teko ea ho qoba ts'oenyeho (PSA) haholo-holo ke ho bona hore na litoeba li ka ithuta ho tsoa boiphihlelo "ho lula sebakeng se khanyang le ho tsoa phaposing e lefifi ho qoba ho ts'oha motlakase."Kaha ka tlhaho litoeba li tšoana le ho ipata lefifing, li tlameha ho itšetleha ka mohopolo ho “iqobella ho ithiba.”Ka hona, bolelele ba nako eo ba e lutseng ka phapusing e khanyang e ka sebelisoa e le sesupo sa tlhahlobo ea mohopolo.

Liphetho li bontšoa ho [Setšoantšo sa 1].Litoeba tse neng li feptjoa ka Donepezil le GME esale pele li ile tsa khona ho boloka mohopolo o betere ha li tobane le tšenyo ea scopolamine.

Hoa thahasellisa hore phello ea litekanyetso tse tlaase le tse mahareng (200 le 400 mg / kg) ea GME e ne e se ea bohlokoa, empa phello ea litekanyetso tse phahameng (800 mg / kg) ea GME e ne e le ea bohlokoa ebile e bapisoa le ea Donepezil.

(2) E khona ho lemoha lintho tse ncha

"Tlhahiso ea "novel object recognition test (NOR)" e sebelisa tlhaho ea toeba ho labalabela ho tseba le ho rata ho leka e ncha ho leka hore na e khona ho khetholla pakeng tsa e tloaelehileng le e ncha linthong tse peli.

Karo-karolelano e fumanoang ka ho arola nako eo mouse e e nkang ho hlahloba (ho tsuba kapa ho ama ka 'mele) ntho e ncha ka nako eo e e nkang ho hlahloba lintho tse peli ke "recognition index (RI)".Ha boleng bo phahame, bo ntlafatsa bokhoni ba kelello le mohopolo oa mouse.

Sephetho se bontšitsoe ho [Setšoantšo sa 2], se neng se ts'oana hantle le sa liteko tse fetileng tsa ho qoba ts'oenyeho-litoeba tse neng li jele Donepezil le GME li sebelitse hamolemo, mme phello eaG. mediosinensee ne e lekana le lethal dose.

Mokhoa oa anti-amnesic oa Ganoderma

(1) Acetylcholinesterase inhibition + antioxidation

Tlhahlobo e eketsehileng ea lisele tsa boko ba litoeba e bontšitse hore scopolamine e ekelitse haholo ts'ebetso ea acetylcholinesterase le khatello ea oxidative.Leha ho le joalo, tekanyo e phahameng ea GME ha ea ka ea fokotsa feela mosebetsi oa acetylcholinesterase ho litoeba ho ea ho maemo a tloaelehileng (Setšoantšo sa 3) empa hape e fokotsa haholo tšenyo ea oxidative e hlokofatsoang ke litoeba (Setšoantšo sa 4).

(1) Sireletsa botšepehi ba lisele tsa methapo ea boko

Ntle le moo, bafuputsi ba boetse ba sebelisitse likarolo tse silafatsang lisele ho bona hippocampal gyrus le cerebral cortex ea litoeba.

Likarolo tsena tse peli tsa boko ke libaka tsa bohlokoa ka ho fetisisa tse laolang ho tseba le ho hopola.Lisele tsa methapo ea kutlo tse ho tsona li na le mefuta e mengata ea pyramidal, e ka fetisang le ho amohela tlhahisoleseling.Ho ba teng ha cytoplasmic vacuolation liseleng ho bonahatsa likarolo tsa pathological tsa amnesia.

E ka bonoa ka karolo ea matheba a lisele hore scopolamine e tla fokotsa lisele tsa pyramidal le ho eketsa lisele tse hlakotsoeng libakeng tsena tse peli tsa boko.Leha ho le joalo, haeba libaka li sirelelitsoe ka GME esale pele, boemo bo ka fetoloa: lisele tsa pyramidal li tla eketseha ha lisele tsa vacuolating li tla fokotseha (sheba leqephe la 6 la pampiri ea pele bakeng sa lintlha).

"Phenols" ke mohloli o sebetsang oa Ganoderma khahlanong le amnesia.

Qetellong, ha ho tobane le maemo a kotsi a amnesia, khatello e phahameng ea GME e ka boloka mesebetsi e tloaelehileng ea ho tseba le ho hopola ka ho thibela acetylcholinesterase, ho fokotsa khatello ea oxidative, le ho sireletsa lisele tsa methapo ho hippocampal gyrus le cerebral cortex.

Kaha gram e 'ngoe le e' ngoe ea GME e na le hoo e ka bang 67.5 mg ea phenols, e 'nileng ea pakoa hore e thibela acetylcholinesterase le ho ba antioxidative nakong e fetileng, bafuputsi ba lumela hore li-phenols tsena e lokela ho ba mohloli oa mosebetsi oa Ganoderma oa anti-amnestic.

Kaha lithethefatsi tse sebelisoang ka tleliniking ho phekola amnesia li ka susumetsa gastric peristalsis 'me li na le litla-morao tse kang ho nyekeloa ke pelo, ho hlatsa, takatso e mpe ea lijo, letšollo kapa ho pipitlelana, meriana ea tlhaho e kang Ganoderma extract e ka thibelang le ho phekola tahlehelo ea mohopolo e tšoaneloa ke tebello ea rona.

Ja Ganoderma pele ho nako ho qobaLefu la Alzheimer Boloetse

'dementia' ke bothata ba lefatše lohle.'Me ho latela mokhoa oa hona joale, ho tla mpefala le ho feta.

Le hoja batho ba keteka keketseho ea selemo le selemo ea karolelano ea nako ea bophelo, 'dementia' e fetohile ntho e tšoenyang ka ho fetisisa ho batho ba hōlileng.Haeba botsofali bo ka sebelisoa feela ho 'dementia', moelelo oa bophelo bo bolelele ke ofe?

Kahoo ja Ganoderma pele ho nako!'Me ho molemo ho ja Ganoderma e nang le "joala" e ntšitsoeng 'meleng oa litholoana.Etsoe ke botsofali bo itekanetseng feela bo ka fang motho thabo le bana.

[Mohloli] Kaur R, et al.Liphello tsa Anti-amnesic tsa mefuta ea Ganoderma: Mokhoa o ka khonehang oa cholinergic le antioxidant.Biomed Pharmacother.2017 Aug;92: 1055-1061.

QETA

Mabapi le mongoli/ Mme Wu Tingyao
Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).
 
★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.