Kanama 2017 / Kaminuza ya Punjab / Biomedicine & Pharmacotherapy

Inyandiko / Wu Tingyao

Mbere yo kumenyekanisha ubushakashatsi bushya bwabahanga muburyo reishi irinda amnesia, reka turebe ibitekerezo bike.

Impamvu ubwonko bushobora kumenya no kwibuka ibisobanuro byumuntu, ibyabaye, cyangwa ikintu nuko yishingikiriza kumiti nka acetylcholine kugirango yohereze ubutumwa hagati yingirabuzimafatizo zigenzura ubwenge no kwibuka.Iyo acetylcholine irangije inshingano zayo, izaba hydrolyz na “acetylcholinesterase (AChE)” hanyuma igakoreshwa na selile nervice.

Kubwibyo, kubaho kwa acetylcholinesterase nibisanzwe.Irashobora gutanga umwanya uhumeka utugingo ngengabuzima kugirango ingirabuzimafatizo zitajya zihora mubihe bikomeye byo kwakira no kohereza ubutumwa.

Ikibazo nuko iyo acetylcholinesterase ikozwe muburyo budasanzwe cyangwa ubunini bwayo bukaba bwinshi, bizatera kugabanuka gukabije kwa acetyloline, bigira ingaruka kumasano hagati yingirabuzimafatizo no gutera ubwenge no kwibuka.

Muri iki gihe, niba umuvuduko wa okiside mu bwonko uba mwinshi cyane, bigatuma umubare munini wimpfu zingirabuzimafatizo zishinzwe kumenya no kwibuka, ibintu bizaba bibi kurushaho.

Byinshi cyangwa birenze urugero acetylcholinesterase hamwe na stress ya okiside ikabije byafashwe nkibintu byingenzi bitera Alzheimer na amnesia.Imiti ivura ivura nka donepezil (ibinini byanditseho firime ya Aricept) ikoreshwa mugutinda kwangirika kwa amnesia mukubuza acetylcholinesterase.

Ganoderma nayo ifite ingaruka zo kuvura amnesia

Ubushakashatsi bwasohotse mu nomero iheruka ya “Biomedicine & Pharmacotherapy” n’ishami ry’ubumenyi bw’imiti n’ubushakashatsi mu bya farumasi, kaminuza ya Punjab, mu Buhinde, bwerekanye ko ibinyobwa bisindisha bya Ganoderma bishobora kugabanya ibikorwa bya acetylcholinesterase, bikagabanya imbaraga za oxydeide ya ubwonko, kandi wirinde kwangirika kwubushobozi bwo kumenya no kwibuka.

Umwanditsi w'uru rupapuro yavuze ko ubushakashatsi bwahise bwemeza ko imiterere ya Ganoderma (nkaGanoderma lucidumnaG. boninense) irashobora kurinda sisitemu yimitsi ikoresheje anti-okiside no kubuza acetylcholinesterase.Ni yo mpamvu bahisemoG. mediosinensenaG. ramosissimum, zitarigeze zigwa muri iyi ngingo ariko kandi zikorerwa mu Buhinde, kugira ngo zikore ubushakashatsi twizeye ko zizongerera imbaraga nshya mbere yo kuvura amnesia.

Kuva muri vitro selile ubushakashatsi bwerekanye ko kubikuramo kimwe na 70% methanol,G. mediosinenseibiyikuramo (GME) biragaragara ko byari byiza kuruta ubundi bwoko bwa Ganoderma muri antioxyde na acetylcholinesterase yabujije, bityo bakoresheje GME mubushakashatsi bwinyamaswa.

Imbeba zirya Ganoderma ntizishobora guhura na amnesia.

(1) Menya kwirinda guhungabana amashanyarazi

Abashakashatsi babanje guha imbeba GME cyangwa donepezil, ikunze gukoreshwa mu kuvura amnesia, hanyuma batera scopolamine (imiti ibuza ingaruka za acetyloline) nyuma yiminota 30 kugirango itere anmesia.Nyuma yiminota 30 nyuma yo guterwa no bukeye bwaho, imbeba zasuzumwe ubushobozi bwazo bwo kumenya no kwibuka binyuze muri "Passive Shock Avoidance Experiment" na "Ubushakashatsi bwa Novel Object Recognition Experiment".

Ikigeragezo cyo kwirinda guhungabana (PSA) ni ukureba niba imbeba zishobora kwigira kuburambe "kuguma ahantu heza kandi ntugume mucyumba cyijimye kugirango wirinde gutungurwa n'amashanyarazi."Kubera ko imbeba zisanzwe zimeze nko kwihisha mu mwijima, zigomba kwishingikiriza ku kwibuka kugira ngo “zihatire kwifata.”Kubwibyo, uburebure bwigihe bamara mucyumba cyaka burashobora gukoreshwa nkigipimo cyo gusuzuma cyo kwibuka.

Ibisubizo byerekanwe muri [Ishusho 1].Imbeba zari zagaburiwe na Donepezil na GME mbere zashoboye gukomeza kwibuka neza mugihe zihuye na scopolamine.

Igishimishije, ingaruka za dosiye nkeya kandi ziciriritse (200 na 400 mg / kg) za GME ntabwo zari zikomeye, ariko ingaruka za dosiye nyinshi (800 mg / kg) za GME zari zikomeye kandi ugereranije niza Donepezil.

(2) Irashobora kumenya ibintu bishya

"Ikigeragezo cyo kumenyekanisha ibintu bishya (NOR)" gikoresha ubushake bwimbeba kugirango ugire amatsiko kandi ukunda kugerageza shyashya kugirango ugerageze niba ushobora gutandukanya ikimenyane nicyashya mubintu bibiri.

Ikigereranyo cyabonetse mugabanye umwanya imbeba ifata kugirango ishakishe (guhumeka cyangwa gukoraho numubiri) ikintu gishya mugihe bifata kugirango tumenye ibintu byombi ni "indangagaciro yo kumenyekanisha (RI)".Kurenza agaciro, nibyiza byo kumenya no kwibuka ubushobozi bwimbeba.

Ibisubizo byerekanwe muri [Ishusho 2], byari bihuye neza neza nubwa mbere ubushakashatsi bwimbitse bwo kwirinda impanuka-imbeba zari zariye mbere Donepezil na GME zakoze neza, n'ingaruka zaG. mediosinenseyari ihwanye na dose.

Uburyo bwo kurwanya amnesic ya Ganoderma

(1) Kubuza Acetylcholinesterase + antioxyde

Ubundi isesengura ryibice byubwonko bwimbeba byerekanaga ko scopolamine yongereye cyane ibikorwa bya acetylcholinesterase hamwe nigitutu cya okiside.Nyamara, urugero rwinshi rwa GME ntirwagabanije gusa ibikorwa bya acetylcholinesterase mu mbeba kurwego rusanzwe (Ishusho 3) ariko kandi byagabanije cyane kwangiza okiside yatewe nimbeba (Ishusho 4).

(1) Kurinda ubusugire bwingirabuzimafatizo zubwonko

Byongeye kandi, abashakashatsi bifashishije kandi ibice bisize irangi kugira ngo barebe imvubu ya hippocampal na cortre cerebral cortex yimbeba.

Ibi bice byombi byubwonko nibice byingenzi bishinzwe kumenya no kwibuka.Ingirabuzimafatizo muri zo ahanini ziri muburyo bwa piramide, zishobora kohereza no kwakira amakuru neza.Kubaho kwa cytoplasmeque vacuolation muri selile byerekana ibimenyetso bya patologique ya amnesia.

Birashobora kugaragara hifashishijwe igice cyerekana ko scopolamine izagabanya selile piramide kandi ikongerera ingirabuzimafatizo muri utwo turere twombi twubwonko.Ariko, niba uturere turinzwe hamwe na GME hakiri kare, ibintu birashobora guhinduka: selile piramide iziyongera mugihe ingirabuzimafatizo zizagabanuka (reba urupapuro rwa 6 rwimpapuro zumwimerere kugirango ubone ibisobanuro).

"Fenol" nisoko ikora ya Ganoderma irwanya amnesia.

Mu gusoza, imbere yimpanuka ziterwa na amnesia, kwibanda cyane kuri GME birashobora gukomeza imirimo isanzwe yo kumenya no kwibuka muguhagarika acetylcholinesterase, kugabanya imihangayiko ya okiside, no kurinda ingirabuzimafatizo muri girusi ya hippocampal na cortex.

Kubera ko buri garama 1 ya GME irimo mg zigera kuri 67.5 za fenolike, byagaragaye ko ibuza acetylcholinesterase kandi ikaba ari antioxydeid mu bihe byashize, abashakashatsi bemeza ko izo fenolole zigomba kuba intandaro y’ibikorwa bya Ganoderma byo kurwanya amnestic.

Kubera ko imiti ikoreshwa mubuvuzi ivura amnesia ishobora gutera peristalisite yo mu gifu kandi ikagira ingaruka mbi nko kugira isesemi, kuruka, ubushake buke, impiswi cyangwa impatwe, imiti karemano nka Ganoderma ikuramo ishobora gukumira no kuvura gutakaza kwibuka birakwiriye ko tubyitega.

Kurya Ganoderma hakiri kare kugirango wirindeAlzheimer Indwara

Indwara yo guta umutwe nikibazo cyisi yose.Ukurikije icyerekezo kigezweho, bizarushaho kuba bibi.

Mugihe abantu bishimira kwiyongera kwumwaka mubyizere byo kubaho, guta umutwe byabaye impungenge zikomeye kubasaza.Niba ubusaza bushobora gukoreshwa gusa no guta umutwe, kuramba bisobanura iki?

Kurya rero Ganoderma hakiri kare!Kandi nibyiza kurya Ganoderma irimo "alcool" ikuramo umubiri wera.N'ubundi kandi, ubusaza bwonyine bushobora gutanga umunezero kuriwe no ku bana.

[Inkomoko] Kaur R, n'abandi.Ingaruka zo kurwanya amnesic yubwoko bwa Ganoderma: Uburyo bushoboka bwa cholinergique na antioxydeant.Imiti ya Biomed.2017 Kanama;92: 1055-1061.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao
Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).
 
★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.