Nyamavhuvhu 2017 / Yunivhesiti yePunjab / Biomedicine & Pharmacotherapy

Chinyorwa/ Wu Tingyao

Tisati tasuma zvitsva zvakawanikwa nemasayendisiti pamusoro pekuti reishi inodzivirira sei amnesia, ngatitarisei mashoma mashoma uye mazwi.

Chikonzero nei uropi huchigona kuziva uye kuyeuka zvinoreva munhu, chiitiko, kana chinhu ndechekuti inotsamira pamakemikari akadai seacetylcholine kuendesa mameseji pakati pemasero etsinga anodzora cognition uye ndangariro.Kana acetylcholine yapedza basa rayo, inozoitwa hydrolyzed ne "acetylcholinesterase (AChE)" uye yozoshandiswazve nemasero etsinga.

Nokudaro, kuvapo kweacetylcholinesterase kwakajairika.Inogona kupa nzvimbo yekufema kumasero etsinga kuitira kuti masero etsinga arege kugara ari mushishi yekugamuchira nekutumira mameseji.

Dambudziko nderekuti kana acetylcholinesterase ikaitwa zvisina kujairika kana kutariswa kwayo kwakanyanya, zvinokonzeresa kuderera kwakanyanya kweacetylcholine, zvichikanganisa kubatana pakati pemaseru etsinga uye zvichikonzera kutadza kwekuziva uye ndangariro.

Panguva ino, kana iyo oxidative pressure muuropi yakanyanya kukwira, zvichikonzera kufa kwenhamba huru yemasero etsinga anotungamira cognition uye ndangariro, mamiriro acho achatonyanya kuipa.

Yakawandisa kana yakawandisa acetylcholinesterase uye yakawandisa oxidative kusagadzikana zvakaonekwa sezvinhu zvakakosha zvinokonzeresa Alzheimer's uye amnesia.Clinical therapeutic drugs like donepezil (Aricept film-coated tablets) inowanzoshandiswa kunonoka kuparara kweamnesia nekudzivisa acetylcholinesterase.

Ganoderma zvakare ine mhedzisiro yekurapa amnesia

Chidzidzo chakabudiswa mune yazvino chinyorwa che "Biomedicine & Pharmacotherapy" neDhipatimendi rePharmaceutical Science uye Pharmaceutical Research, iyo University yePunjab, India, yakaratidza kuti Ganoderma doro rinobvisa rinogona kuderedza basa reacetylcholinesterase, kuderedza oxidative kusagadzikana kweiyo. uropi, uye kudzivirira kudzikira kwekugona kwekuziva nekurangarira.

Munyori webepa akataura kuti zvidzidzo zvekare zvakasimbisa kuti mamwe maGanoderma strains (sengeGanoderma lucidumuyeG. boninense) inogona kuchengetedza hurongwa hwemagetsi kuburikidza ne-anti-oxidation uye inhibition yeacetylcholinesterase.Nokudaro, vakasarudzaG. mediosinenseuyeG. ramosissimum, iyo isati yadzidzwa munyaya iyi asi inobudiswawo muIndia, nokuda kwekutsvakurudza mune tariro yekuwedzera simba idzva kune pre-kurapwa kweamnesia.

Sezvo in vitro cell kuyedza yakaratidza kuti kune imwechete kudhirowa ne70% methanol,G. mediosinensekubvisa (GME) zvaive pachena kuti zviri nani pane imwe mhando yeGanoderma mu antioxidation uye acetylcholinesterase inhibition, saka vakashandisa GME pakuedza mhuka.

Mbeva dzinodya Ganoderma hadzina kunyanya kuita amnesia.

(1) Ziva nzira yokunzvenga nayo magetsi

Vatsvakurudzi vakatanga kupa mbeva GME kana donepezil, iyo inowanzoshandiswa kurapa amnesia, uye jekiseni scopolamine (mushonga unodzivisa kushanda kweacetylcholine) maminitsi makumi matatu gare gare kuti iite anmesia.Maminitsi makumi matatu mushure mejekiseni uye zuva rakatevera, mbeva dzakaongororwa kugona kwavo kugona uye ndangariro kuburikidza ne "Passive Shock Avoidance Experiment" uye "Novel Object Recognition Experiment".

The passive shock avoidance experiment (PSA) inonyanya kuona kana mbeva dzichigona kudzidza kubva pane zvakaitika "kugara panzvimbo inopenya uye kusabuda mukamuri ine rima kudzivirira kuvhundutswa nemagetsi."Sezvo mbeva dzichingofanana nekuhwanda murima, dzinofanira kuvimba nendangariro kuti “dzizvimanikidzire kurega.”Naizvozvo, kureba kwenguva yavanogara muimba inopenya inogona kushandiswa sechiratidzo chekuongorora chendangariro.

Mhedzisiro inoratidzwa mu [Mufananidzo 1].Mbeva dzaive dzakadyiswa neDonepezil neGME pachine nguva dzakakwanisa kuchengetedza ndangariro dziri nani padzakatarisana nekukuvara kwe scopolamine.

Sezvineiwo, mhedzisiro yakaderera uye yepakati doses (200 uye 400 mg / kg) yeGME yakanga isiri yakakosha, asi iyo yakakwira madhisi (800 mg / kg) yeGME yaive yakakosha uye yakaenzana neyeDonepezil.

(2) Inogona kuziva zvinhu zvitsva

Iyo "novel object recognition experiment (NOR)" inoshandisa masikirwo embeva kuda kuziva uye kuda kuyedza kutsva kuona kana ichigona kusiyanisa pakati pechajaira neichi chitsva muzvinhu zviviri.

Chiyero chinowanikwa nekupatsanura nguva inotora mbeva kuongorora (kufembedza kana kubata nemuviri) chinhu chitsva nenguva yazvinoda kuongorora zvinhu zviviri izvi ndiyo “recognition index (RI)”.Iyo yakakwirira kukosha, zviri nani kugona kwekuziva nekurangarira kwembeva.

Mhedzisiro yakaratidzwa mu[Mufananidzo 2], iyo yakanga yakangofanana neyeye yapfuura passive kuvhunduka kudzivirira kuedza-mbeva dzakambodya Donepezil neGME dzakaita zvirinani, uye mhedzisiro yeG. mediosinenseyakanga yakaenzana nedosi.

Iyo anti-amnesic mechanism yeGanoderma

(1) Acetylcholinesterase inhibition + antioxidation

Kumwe kuongorora kwehuropi hwemakonzo kwakaratidza kuti scopolamine yakawedzera zvakanyanya basa reacetylcholinesterase uye oxidative pressure.Zvisinei, high-dose GME haina kungoderedza basa reacetylcholinesterase mumakonzo kusvika kumatanho akajairwa (Mufananidzo 3) asi zvakare yakaderedza zvakanyanya kukuvadzwa kweoxidative kwakatambura nemakonzo (Mufananidzo 4).

(1) Chengetedza kuvimbika kwemasero etsinga dzeuropi

Pamusoro pezvo, vatsvakurudzi vakashandisawo zvikamu zvinosvibisa nyama kuti vaone hippocampal gyrus uye cerebral cortex yemakonzo.

Idzi mativi maviri ehuropi ndidzo nzvimbo dzakanyanya kukosha mukutarisira cognition uye ndangariro.Masero etsinga ari mavari anowanzo mu pyramidal mafomu, anogona kufambisa uye kugamuchira ruzivo.Kuvapo kwe cytoplasmic vacuolation mumasero kunoratidza maitiro epathologic eamnesia.

Inogona kucherechedzwa kuburikidza nechikamu chetish staining kuti scopolamine inoderedza pyramidal masero uye kuwedzera vacuolated masero munzvimbo idzi mbiri dzehuropi.Zvisinei, kana nzvimbo dzakachengetedzwa neGME pachine nguva, mamiriro acho anogona kuchinjwa: masero epiramidi achawedzera apo masero ekutsvaira achaderera (ona peji 6 yebepa rekutanga kuti uwane ruzivo).

"Phenols" ndiyo inoshanda sosi yeGanoderma kurwisa amnesia.

Mukupedzisa, pakatarisana nenjodzi dzeamnesia, huwandu hwepamusoro hweGME hunogona kuchengetedza zvakajairwa kuziva uye ndangariro mabasa nekudzivisa acetylcholinesterase, kuderedza oxidative kusagadzikana, uye kudzivirira masero etsinga muhippocampal gyrus uye cerebral cortex.

Sezvo yega yega 1 gramu yeGME ine inenge 67.5 mg ye phenols, iyo yakaratidza kuti inhibit acetylcholinesterase uye kuva antioxidative munguva yakapfuura, vatsvakurudzi vanotenda kuti izvi phenols zvinofanira kuva tsime reGanoderma's anti-amnestic activity.

Sezvo zvinodhaka zvinoshandiswa nekliniki kurapa amnesia zvinogona kukurudzira gastric peristalsis uye kuva nemigumisiro yakaipa yakadai sekusvotwa, kurutsa, kusada kudya, manyoka kana kuvhara, mishonga yechisikigo yakadai seGanoderma extract inogona kudzivirira nekurapa kurasikirwa kwekuyeuka ndiyo inonyanya kukodzera kutarisira kwedu.

Idya Ganoderma mangwanani kuti udziviseAlzheimer's Chirwere

Dementia idambudziko repasi rose.Uye tichitarisa kubva pane zvazvino, zvichatowedzera.

Kunyange zvazvo vanhu vari kupemberera kuwedzera kwegore negore kwehupenyu hunotarisirwa, dementia ndiyo inonyanya kunetseka kune vakwegura.Kana kuchembera kuchingoshandiswa mukuora mwoyo, chii chinorehwa nehupenyu hurefu?

Saka idya Ganoderma kare!Uye zviri nani kudya Ganoderma iyo ine "doro" inotorwa yemuviri wechibereko.Mushure mezvose, kuchembera chete kunogona kupa mufaro kune iwe uye kuvana.

[Kwakabva] Kaur R, et al.Anti-amnesic mhedzisiro yeGanoderma marudzi: A inogoneka cholinergic uye antioxidant mechanism.Biomed Pharmacother.2017 Aug;92: 1055-1061.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
 
★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.