Agusta 2017 / Jami'ar Punjab / Biomedicine & Pharmacotherapy

Rubutu/ Wu Tingyao

Kafin gabatar da sabon binciken masana kimiyya kan yadda reishi ke hana amnesia, bari mu kalli wasu ‘yan dabaru da sharuddan.

Dalilin da ya sa kwakwalwa za ta iya ganewa da tunawa da ma'anar mutum, abu, ko abu shine cewa ta dogara da sinadarai irin su acetylcholine don aikawa da sakonni tsakanin kwayoyin jijiyoyi masu sarrafa fahimta da ƙwaƙwalwa.Lokacin da acetylcholine ya kammala aikinsa, za a yi amfani da shi ta hanyar "acetylcholinesterase (AChE)" sannan kuma a sake sarrafa shi ta ƙwayoyin jijiya.

Saboda haka, kasancewar acetylcholinesterase al'ada ne.Yana iya ba da sararin numfashi ga ƙwayoyin jijiya ta yadda ƙwayoyin jijiya ba za su kasance koyaushe cikin yanayin tashin hankali na karɓa da aika saƙonni ba.

Matsalar ita ce lokacin da aka kunna acetylcholinesterase ba daidai ba ko kuma maida hankalinsa ya yi yawa, zai haifar da raguwa mai yawa a cikin acetylcholine, yana shafar haɗin kai tsakanin ƙwayoyin jijiya da haifar da fahimi da ƙwaƙwalwar ajiya.

A wannan lokacin, idan matsa lamba na oxidative a cikin kwakwalwa ya yi yawa, yana haifar da adadi mai yawa na mutuwar kwayoyin jijiyoyi masu kula da hankali da ƙwaƙwalwar ajiya, lamarin zai fi muni.

An yi la'akari da yawa ko yawan aiki acetylcholinesterase da matsanancin damuwa na oxidative a matsayin mahimman abubuwan da ke haifar da Alzheimer da amnesia.Magungunan warkewa na asibiti kamar dondonpezil (Aricept allunan masu rufin fim) ana amfani da su don jinkirta lalacewar amnesia ta hana acetylcholinesterase.

Ganoderma kuma yana da tasirin maganin amnesia

Wani binciken da aka buga a cikin sabon fitowar "Biomedicine & Pharmacotherapy" ta Ma'aikatar Kimiyyar Magunguna da Nazarin Magunguna, Jami'ar Punjab, Indiya, ya nuna cewa ruwan Ganoderma na barasa zai iya rage yawan aikin acetylcholinesterase, rage yawan damuwa na oxidative. kwakwalwa, da kuma hana tabarbarewar iyawar fahimta da ƙwaƙwalwar ajiya.

Marubucin takardar ya bayyana cewa binciken da aka yi a baya ya tabbatar da cewa wasu nau'in Ganoderma (kamarGanoderma lucidumkumaG. bonin) zai iya kare tsarin mai juyayi ta hanyar anti-oxidation da hanawa na acetylcholinesterase.Saboda haka, sun zaɓiG. mediosinensekumaG. ramosissimum, wanda ba a yi nazari a wannan fanni ba amma kuma an samar da shi a Indiya, don bincike da bege na ƙara sabon kuzari ga riga-kafin maganin amnesia.

Tun da gwaje-gwajen ƙwayoyin in vitro sun nuna cewa don hakar guda ɗaya tare da 70% methanol.G. mediosinensecire (GME) ya fi kyau fiye da wani nau'in Ganoderma a cikin maganin antioxidation da hanawar acetylcholinesterase, don haka sun yi amfani da GME don gwaje-gwajen dabba.

Mice da ke cin Ganoderma ba su da saurin kamuwa da amnesia.

(1) Sanin yadda ake gujewa girgiza wutar lantarki

Masu binciken sun fara ba wa mice GME ko donedpezil, wanda aka fi amfani da shi don magance amnesia, kuma an yi musu allurar scopolamine (maganin da ke hana tasirin acetylcholine) mintuna 30 daga baya don haifar da anmesia.Minti 30 bayan allurar da washegari, an kimanta berayen don fahimi da iya ƙwaƙwalwar ajiya ta hanyar "Gwajin Kaucewa Shock Shock" da "Gwajin Gane Abun Novel".

Gwajin guje wa girgiza kai (PSA) galibi shine don ganin ko beraye za su iya koyo daga gogewa "don zama a wuri mai haske kuma su nisanta daga daki mai duhu don guje wa girgiza ta lantarki."Tun da beraye a zahiri suna kama da ɓoye a cikin duhu, dole ne su dogara ga ƙwaƙwalwar ajiya don "tilasta kansu su ja da baya."Sabili da haka, ana iya amfani da tsawon lokacin da suke zama a cikin ɗakin haske a matsayin alamar ƙima na ƙwaƙwalwar ajiya.

Ana nuna sakamakon a [Hoto 1].Berayen da aka ciyar da Donepezil da GME a gaba sun sami damar kiyaye mafi kyawun ƙwaƙwalwar ajiya lokacin da suka fuskanci lalacewar scopolamine.

Abin sha'awa shine, tasirin ƙananan ƙwayoyi da matsakaici (200 da 400 mg / kg) na GME ba su da mahimmanci, amma tasirin manyan allurai (800 mg / kg) na GME yana da mahimmanci kuma ya kwatanta da na Donepezil.

(2) Iya gane sabon abu

Gwajin sanin sabon abu (NOR) yana amfani da ilhami na linzamin kwamfuta don sha'awa da son gwada sabo don gwada ko zai iya bambanta tsakanin saba da sabo a cikin abubuwa biyu.

Matsakaicin da aka samu ta hanyar rarraba lokacin da linzamin kwamfuta ke ɗauka don ganowa (numfasa ko taɓa jiki) sabon abu ta lokacin da ake ɗaukar abubuwan biyu shine "ƙididdigar ganewa (RI)".Mafi girman ƙimar, mafi kyawun fahimi da ƙwarewar ƙwaƙwalwa na linzamin kwamfuta.

An nuna sakamakon a cikin [Hoto 2], wanda ya kasance daidai da na baya-bayan nan na gwajin gujewa girgizar da aka yi a baya-berayen da suka ci Donepezil da GME a baya sun yi aiki mafi kyau, da kuma tasirinG. mediosinenseya yi daidai da adadin.

Tsarin anti-amnesic na Ganoderma

(1) hanawa Acetylcholinesterase + antioxidation

Ƙarin bincike na ƙwayoyin kwakwalwa na mice ya nuna cewa scopolamine ya kara yawan aikin acetylcholinesterase da matsa lamba na oxidative.Duk da haka, babban adadin GME ba kawai ya rage yawan aikin acetylcholinesterase a cikin mice zuwa matakan al'ada ba (Figure 3) amma kuma ya rage yawan lalacewar oxidative da ke fama da mice (Figure 4).

(1) Kare mutuncin ƙwayoyin jijiya na kwakwalwa

Bugu da ƙari, masu binciken sun kuma yi amfani da sassan ɓawon nama don lura da gyrus hippocampal da ƙwayar ƙwayar ƙwayar cuta na mice.

Wadannan sassan biyu na kwakwalwa sune mafi mahimmancin wuraren da ke kula da hankali da ƙwaƙwalwa.Kwayoyin jijiya a cikinsu galibi suna cikin nau'ikan pyramidal, waɗanda ke iya watsawa da karɓar bayanai yadda yakamata.Kasancewar ɓarkewar cytoplasmic a cikin sel yana nuna alamun cututtukan amnesia.

Ana iya lura da shi ta hanyar sashin launi na nama cewa scopolamine zai rage sel pyramidal kuma ya kara ƙwayoyin da aka kwashe a cikin waɗannan yankuna biyu na kwakwalwa.Duk da haka, idan an kare yankunan da GME a gaba, za'a iya canza halin da ake ciki: ƙwayoyin pyramidal za su karu yayin da ƙwayoyin vacuoating za su ragu (duba shafi na 6 na ainihin takarda don cikakkun bayanai).

"Phenols" sune tushen aiki na Ganoderma akan amnesia.

A ƙarshe, a cikin fuskantar matsalolin haɗari na amnesia, babban taro na GME zai iya kula da al'ada na al'ada da ayyukan ƙwaƙwalwar ajiya ta hanyar hana acetylcholinesterase, rage damuwa na oxidative, da kuma kare kwayoyin jijiyoyi a cikin gyrus hippocampal da cerebral cortex.

Tun da kowane gram 1 na GME ya ƙunshi kusan 67.5 MG na phenols, waɗanda aka tabbatar sun hana acetylcholinesterase kuma sun zama antioxidative a baya, masu bincike sun yi imanin cewa waɗannan phenols ya kamata su zama tushen aikin Ganoderma na anti-amnestic.

Tun da magungunan da aka yi amfani da su a asibiti don magance amnesia na iya tayar da peristalsis na ciki kuma suna da sakamako masu illa kamar tashin zuciya, amai, rashin cin abinci mara kyau, zawo ko maƙarƙashiya, magungunan halitta irin su Ganoderma tsantsa wanda zai iya hanawa da kuma magance asarar ƙwaƙwalwar ajiya sun fi dacewa da tsammaninmu.

Ku ci Ganoderma da wuri don gujewaAlzheimer ta Cuta

Dementia matsala ce ta duniya.Kuma idan aka yi la'akari da halin da ake ciki yanzu, zai kara muni.

Yayin da 'yan adam ke bikin karuwar yawan shekarun rayuwa na shekara-shekara, ciwon hauka ya zama babban damuwa ga tsofaffi.Idan tsufa kawai za a iya kashe shi a cikin hauka, menene ma'anar dadewa?

Don haka ku ci Ganoderma da wuri!Kuma yana da kyau a ci Ganoderma wanda ke dauke da "giya" daga cikin 'ya'yan itace.Bayan haka, tsufa mai hankali ne kawai zai iya ba da farin ciki ga kansa da yara.

[Madogararsa] Kaur R, et al.Abubuwan anti-amnesic na nau'in Ganoderma: Mai yiwuwa cholinergic da tsarin antioxidant.Biomed Pharmacother.2017 Agusta;92: 1055-1061.

KARSHE

Game da marubucin / Ms. Wu Tingyao
Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).
 
★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.