Lub Yim Hli 2017 / University of the Punjab / Biomedicine & Pharmacotherapy

Text/Wu Tingyao

Ua ntej tshaj tawm cov kev tshawb fawb tshiab ntawm reishi tiv thaiv amnesia, cia peb saib ob peb lub ntsiab lus thiab cov ntsiab lus.

Qhov laj thawj yog vim li cas lub hlwb thiaj paub thiab nco ntsoov lub ntsiab lus ntawm ib tug neeg, kev tshwm sim, los yog tej yam yog vim hais tias nws tso siab rau cov tshuaj xws li acetylcholine xa xov ntawm paj hlwb uas tswj kev paub thiab nco.Thaum acetylcholine ua tiav nws txoj haujlwm, nws yuav raug hydrolyzed los ntawm "acetylcholinesterase (AChE)" thiab rov ua dua los ntawm cov paj hlwb.

Yog li ntawd, lub xub ntiag ntawm acetylcholinesterase yog qhov qub.Nws tuaj yeem muab qhov chaw ua pa rau cov paj hlwb kom cov paj hlwb tsis tas yuav nyob hauv lub xeev nruj ntawm kev txais thiab xa xov.

Qhov teeb meem yog tias thaum acetylcholinesterase ua haujlwm txawv txav lossis nws cov concentration siab dhau lawm, nws yuav ua rau muaj kev txo qis hauv acetylcholine, cuam tshuam rau kev sib txuas ntawm cov paj hlwb thiab ua rau kev txawj ntse thiab kev nco degeneration.

Nyob rau lub sijhawm no, yog tias oxidative siab nyob rau hauv lub hlwb siab dhau lawm, ua rau muaj coob tus neeg tuag ntawm cov hlab ntsha hauv lub cev ntawm kev paub thiab kev nco, qhov xwm txheej yuav hnyav dua.

Ntau dhau los yog overactive acetylcholinesterase thiab ntau dhau oxidative kev nyuaj siab tau raug suav hais tias yog qhov tseem ceeb uas ua rau Alzheimer's thiab amnesia.Cov tshuaj kho mob xws li donepezil (Aricept film-coated tablets) feem ntau yog siv los ncua kev tsis zoo ntawm amnesia los ntawm inhibiting acetylcholinesterase.

Ganoderma tseem muaj cov txiaj ntsig ntawm kev kho mob amnesia

Ib txoj kev tshawb fawb luam tawm nyob rau hauv qhov tseeb qhov teeb meem ntawm "Biomedicine & Pharmacotherapy" los ntawm Department of Pharmaceutical Science thiab Pharmaceutical Research, University of Punjab, India, tau taw qhia tias Ganoderma cawv extract tuaj yeem txo cov kev ua ntawm acetylcholinesterase, txo cov oxidative kev nyuaj siab ntawm cov tshuaj. lub paj hlwb, thiab tiv thaiv kev puas tsuaj ntawm kev txawj ntse thiab kev nco muaj peev xwm.

Tus kws sau ntawv tau hais tias cov kev tshawb fawb yav dhau los tau lees paub tias qee yam kab mob Ganoderma (xws liGanoderma lucidumthiabG. zoo) tuaj yeem tiv thaiv lub paj hlwb los ntawm kev tiv thaiv oxidation thiab inhibition ntawm acetylcholinesterase.Yog li ntawd, lawv xaivG. mediosinensethiabG. ramosissimum, uas tsis tau kawm nyob rau hauv no nam tab sis kuj yog tsim nyob rau hauv Is Nrias teb, rau kev tshawb fawb nyob rau hauv kev cia siab ntawm ntxiv dag zog rau lub pre-kev kho mob ntawm amnesia.

Txij li cov kev sim hauv vitro cell tau pom tias rau tib qhov kev rho tawm nrog 70% methanol,G. mediosinenseExtract (GME) tau pom tseeb zoo dua li lwm hom Ganoderma hauv kev tiv thaiv oxidation thiab acetylcholinesterase inhibition, yog li lawv siv GME rau kev sim tsiaj.

Cov nas uas noj Ganoderma tsawg dua rau amnesia.

(1) Paub txog kev tiv thaiv hluav taws xob

Cov kws tshawb nrhiav thawj zaug tau muab cov nas GME los yog donepezil, uas feem ntau yog siv los kho amnesia, thiab txhaj tshuaj scopolamine (ib yam tshuaj uas cuam tshuam cov nyhuv ntawm acetylcholine) 30 feeb tom qab los ua kom anmesia.Peb caug feeb tom qab txhaj tshuaj thiab hnub tom qab, cov nas raug soj ntsuam rau lawv lub peev xwm kev txawj ntse thiab kev nco los ntawm "Passive Shock Avoidance Experiment" thiab "Novel Object Recognition Experiment".

Qhov kev sim ua kom tsis txhob poob siab (PSA) feem ntau yog saib seb cov nas tuaj yeem kawm los ntawm kev paub "kom nyob hauv qhov chaw kaj thiab tawm hauv chav tsaus kom tsis txhob raug hluav taws xob poob."Txij li cov nas yog ib txwm zoo li nkaum hauv qhov tsaus ntuj, lawv yuav tsum cia siab rau lub cim xeeb "yuav tsum tuav lawv rov qab."Yog li ntawd, ntev npaum li cas lawv nyob hauv chav ci ntsa iab tuaj yeem siv los ua qhov ntsuas ntsuas ntawm kev nco.

Cov txiaj ntsig tau pom hauv [Daim duab 1].Cov nas uas tau noj nrog Donepezil thiab GME ua ntej tuaj yeem khaws cia zoo dua thaum ntsib kev puas tsuaj scopolamine.

Interestingly, cov nyhuv ntawm cov koob tshuaj qis thiab nruab nrab (200 thiab 400 mg / kg) ntawm GME tsis tseem ceeb, tab sis cov nyhuv ntawm cov koob tshuaj siab (800 mg / kg) ntawm GME yog qhov tseem ceeb thiab piv rau Donepezil.

(2) tuaj yeem paub cov khoom tshiab

Qhov "novel object recognition trial (NOR)" siv qhov kev xav ntawm tus nas kom xav paub thiab nyiam sim tshiab los sim seb nws puas tuaj yeem paub qhov txawv ntawm qhov paub thiab tus tshiab ntawm ob yam khoom.

Qhov piv tau los ntawm kev faib lub sijhawm tus nas siv los tshawb nrhiav (sniff lossis kov nrog lub cev) ib yam khoom tshiab los ntawm lub sijhawm nws yuav siv sijhawm los tshawb txog ob yam khoom yog "kev lees paub qhov ntsuas (RI)".Tus nqi siab dua, qhov zoo ntawm kev paub thiab kev nco muaj peev xwm ntawm tus nas.

Qhov tshwm sim tau pom nyob rau hauv [Daim duab 2], uas yog ib yam nkaus li ntawm qhov kev sim siab dhau los ntawm kev zam dhau los-cov nas uas yav tas los noj Donepezil thiab GME ua tau zoo dua, thiab cov txiaj ntsig ntawmG. mediosinenseyog proportional rau koob tshuaj.

Anti-amnesic mechanism ntawm Ganoderma

(1) Acetylcholinesterase inhibition + antioxidation

Kev soj ntsuam ntxiv ntawm cov hlwb ntawm cov nas pom tau tias scopolamine ua rau muaj kev ua haujlwm ntawm acetylcholinesterase thiab oxidative siab.Txawm li cas los xij, koob tshuaj GME tsis tsuas yog txo cov kev ua ntawm acetylcholinesterase hauv cov nas mus rau qhov qub (Daim duab 3) tab sis kuj txo qis cov oxidative puas tsuaj los ntawm nas (Daim duab 4).

(1) Tiv thaiv kev ncaj ncees ntawm lub hlwb paj hlwb

Tsis tas li ntawd, cov kws tshawb fawb kuj tau siv cov ntaub so ntswg los soj ntsuam cov hippocampal gyrus thiab cerebral cortex ntawm nas.

Ob qhov ntawm lub hlwb no yog qhov tseem ceeb tshaj plaws hauv kev saib xyuas kev paub thiab kev nco.Cov paj hlwb hauv lawv feem ntau yog cov ntawv pyramidal, uas tuaj yeem xa tawm thiab tau txais cov ntaub ntawv zoo.Lub xub ntiag ntawm cytoplasmic vacuolation nyob rau hauv cov hlwb qhia txog cov yam ntxwv ntawm cov kab mob amnesia.

Nws tuaj yeem pom los ntawm cov ntaub so ntswg staining seem uas scopolamine yuav txo cov pyramidal hlwb thiab ua kom cov hlwb vacuolated hauv ob lub hlwb.Txawm li cas los xij, yog tias thaj chaw muaj kev tiv thaiv nrog GME ua ntej, qhov xwm txheej tuaj yeem thim rov qab: cov hlwb pyramidal yuav nce ntxiv thaum lub tshuab nqus tsev vacuolating yuav txo qis (saib nplooj 6 ntawm daim ntawv tseem ceeb kom paub meej).

"Phenols" yog lub hauv paus tseem ceeb ntawm Ganoderma tawm tsam amnesia.

Hauv kev xaus, nyob rau hauv lub ntsej muag ntawm kev pheej hmoo ntawm amnesia, lub siab concentration ntawm GME tuaj yeem tswj cov kev txawj ntse thiab kev nco ua haujlwm los ntawm inhibiting acetylcholinesterase, txo oxidative kev nyuaj siab, thiab tiv thaiv cov paj hlwb hauv hippocampal gyrus thiab cerebral cortex.

Txij li txhua txhua 1 gram ntawm GME muaj kwv yees li 67.5 mg ntawm phenols, uas tau raug pov thawj los tiv thaiv acetylcholinesterase thiab ua cov tshuaj tiv thaiv kab mob yav dhau los, cov kws tshawb fawb ntseeg tias cov phenols yuav tsum yog lub hauv paus ntawm Ganoderma cov tshuaj tiv thaiv amnestic.

Txij li cov tshuaj siv kho mob los kho amnesia tuaj yeem ua rau lub plab peristalsis thiab muaj kev phiv xws li xeev siab, ntuav, tsis qab los noj mov, raws plab lossis cem quav, cov tshuaj ntuj xws li Ganoderma extract uas tuaj yeem tiv thaiv thiab kho qhov tsis nco qab yog qhov tsim nyog ntawm peb qhov kev cia siab.

Noj Ganoderma ntxov kom tsis txhobAlzheimer tus kab mob Kab mob

Dementia yog ib qho teeb meem thoob ntiaj teb.Thiab txiav txim los ntawm cov qauv tam sim no, nws tsuas yog zuj zus.

Thaum tib neeg tab tom ua kev zoo siab rau qhov nce txhua xyoo hauv qhov nruab nrab lub neej expectancy, dementia tau dhau los ua kev txhawj xeeb loj tshaj plaws rau cov neeg laus.Yog tias muaj hnub nyoog laus tsuas yog siv tau rau hauv kev dementia, lub ntsiab lus ntawm lub neej ntev yog dab tsi?

Yog li noj Ganoderma ntxov!Thiab nws yog qhov zoo tshaj plaws los noj Ganoderma uas muaj "cawv" extract ntawm lub cev txiv hmab txiv ntoo.Tom qab tag nrho, tsuas yog lub hnub nyoog laus laus tuaj yeem muab kev zoo siab rau nws tus kheej thiab cov menyuam yaus.

[Source] Kaur R, et al.Anti-amnesic teebmeem ntawm Ganoderma hom: Ib qho ua tau cholinergic thiab antioxidant mechanism.Biomed Pharmacother.Aug 2017;92: 1055-1061 .

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Hais txog tus sau/ Ms. Wu Tingyao
Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).
 
★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.