Reishi Polysaccrides uye Colitis

Dai pasina kuziviswa kwekusiya basa kweMutungamiriri weJapan Shinzo Abe musi wa28 Nyamavhuvhu, vanhu vazhinji vangadai vasina kuona chirwere ichi che autoimmune chinoda kurapwa kwehupenyu hwese-ulcerative colitis.

Vanhu vazhinji havagoni kushivirira mazuva akawanda ekurwadziwa kwemudumbu uye manyoka anokonzerwa nehutachiona hwehutachiona, rega ulcerative colitis ine zviratidzo zvakadai sehemafecia, fivha, kurutsa, kupera simba, uye kuora muviri.Iyo yekutanga inogona kurapwa nemishonga nepo yekupedzisira iri kuzvimba uye kukuvadzwa kwemukati mucosa kunokonzerwa nezvikonzero zvisingazivikanwi.Mishonga haigone kubvisa chirwere ichi uye inogona chete kudzvanya kuzvimba uye kubvisa zviratidzo zvine hukama.

Kutaura zvazviri, dambudziko reulcerative colitis riri mu“kuzvimba kusingafaniri kuitika hakumbomira.”Kana immune system inotanga mhinduro yekuzvimba ikatadza, mhinduro yekuzvimba inova mhondi yehutano uye inogona kutokonzera kenza yesero.

Zhang Yongping (pakati), maneja mukuru weGeneral Manager Hofisi yeXinhua News Agency nevamwe vanhu vanotungamira vakatora mufananidzo weboka nechikwata cheGANOHERB.

Iyo National Brand Project ipurojekiti yenyika-yepamusoro yekutaurirana yakagadzirwa neXinhua News Agency kuti ishandise zano reKumutsidzira China Kuburikidza neNational Brands chirongwa.Makambani akasarudzwa anofanirwa kusangana nemamiriro akaomesesa akadai sekugara achiomerera ku "kutarisisa basa repakati uye kushandira zvishuwo zvese", kutora chikamu mukuita uye kushandira chirongwa chebudiriro yenyika, kuve nepfungwa yakasimba yekutarisira magariro, indasitiri inotungamira yakazvimirira hunyanzvi hwekuvandudza. , kuoneka kwepamusoro munharaunda uye mukurumbira wemhando uye tsika dzakanaka dzekambani, kusimudzira mweya wehunyanzvi, kusimudzira Kutendeseka manejimendi uye kutevedzera mutemo, kuve nemhando yepamusoro inomiririra kugadzirwa kweChina uye hunhu hweChina, uye kuve nechido nezvekugara zvakanaka kwevanhu, nekushingaira kuita National. Targeted Poverty Alleviation Plan, uye chinzvimbo pamberi peindastiri maererano nehuwandu hwemasimba masimba.

Brand inzira yakakosha yekuti mabhizinesi avandudze kukwikwidza kwavo kwakazara.Kusarudzwa mu "National Brand Project yeXinhua News Agency" panguva ino inosimbisa chinzvimbo chinotungamira cheGANOHERB brand muChinese Reishi indasitiri.Kudyidzana kwakasimba neXinhua News Agency kuchawedzera kukosha kwemhando uye kusimba kwechiratidzo che "GANOHERB" uye kuratidza zvirinani runako rweChinese Lingzhi.

Mufananidzo 1 Schematic dhayagiramu yedumbu rakakura uye endoscopic mifananidzo yeulcerative colitis.

Ura hukuru hunosanganisira cecum, colon, uye rectum (mufananidzo wekuruboshwe): iyo cecum yakabatana nemukati maduku kudzivirira reflux yezvokudya kupinda mumatumbo makuru;iyo colon inodzora kugayiwa uye kunyudza basa remukati muhombe uye inoumba zvakasara kuita tsvina, iyo inochengetwa kwenguva pfupi murectum kuti ibude.Ulcerative colitis inowanzoitika mucosal tissues yecolon uye rectum.Endoscopy icharatidza kuzvimba uye maronda mucolonic mucosa.(Mufananidzo/Wikimedia Commons)

Kuderedza kuzvimba kunongo nyoro asi kudzora kusadzivirirwa kwemuviri kunogona kurapa zvachose.

Nezve dambudziko rezvirwere zvekudzivirira zvirwere, mishonga iripo inogona kungogadzirisa "zviratidzo" zvinokonzerwa nehutachiona hwehutachiona.

"Kudzora kusadzivirirwa uye kusimbisa uye kubatanidza kuramba kwemuviri" ndiyo yekutanga-yegoridhe-mavara signboard yeReishi mushroom.Zvinoenderana nezvinyorwa zvesainzi zvakaburitswa kusvika parizvino, zvinozivikanwa kuti ingave polysaccharides kana triterpenes kubva kuReishi mushroom, vanogona kudzora kusadzivirirwa uye kuita basa rakakosha mukuvandudzika kweulcerative colitis.

Reishi mushroom polysaccharides inoderedza kuoma kwecolitis.

Zvese zviri zviviri chirevo chakaburitswa neDhipatimendi reImmunology yeChina Medical University muJournal yeImmunology Research muna 2018 uye mushumo wakaburitswa muChikafu & Nutrition Tsvagiridzo neDhipatimendi reChikafu Sayenzi neUinjiniya reJinan University muna 2019 zvakangoratidza kuti kutonga kwemuromo. yeGanoderma lucidum polysaccharides pachiyero chekudzivirira mumavhiki maviri kusvika ku3 inogona kuderedza zvakanyanya kuoma kweulcerative colitis kurwisa (Mufananidzo 2).

Mufananidzo 2 Ganoderma lucidum polysaccharides inoderedza zviratidzo zve ulcerative colitis.

Mbeva dzakawedzerwa neGanoderma lucidum polysaccharides (100 mg/kg pazuva) kwemavhiki maviri pachine nguva isati yasvika yakanga ine uremu hushoma uye basa rechirwere chepasi (kureruka kwehuremu, manyoka uye hemafecia) nehurefu hurefu hwekoloni (inoratidza kushoma kuzvimba uye kukuvara) uye kuderera kwakanyanya kwematishu (kusanganisira dhigirii yekukuvadzwa kwemucosal tissue uye leukocyte infiltration) apo kurwiswa kwakanyanya kweulcerative colitis kwakakonzerwa.(Kwakabva/Chiratidzo 1).

Sei Ganoderma lucidum polysaccharides inogona kuvandudza ulcerative colitis?Mishumo miviri yekutsvagisa yakaongororwa kubva pamaonero maviri akasiyana: "kutonga immune immune" uye "kudzora intestinal ecology":

Mechanism 1: Ganoderma lucidum polysaccharides inodzora kuzvimba uye inhibit Th17 masero.

Ongororo yakaitwa neChina Medical University yakawana kuti mbeva dzainge dzawedzerwa neGanoderma lucidum polysaccharides pachine nguva dzaive nemacytokines mashoma ane chekuita nekuzvimba mu colorectal mucosal tissue panguva yekurwiswa kwakanyanya kweulcerative colitis (Mufananidzo 3).Pakanga pasina akawanda masero emhondi echisikigo uye masero eT17 aikurudzira kuzvimba, asi B masero anogona kuburitsa IgA, iyo huru antibody yemucosal tissue, yakakura ichipokana nemaitiro.

Izvi zvinoshanduka zvekudzivirira zvirwere hazvibatsiri chete kuderedza mhinduro yekuputika uye kubatsira matumbo kuti arambe zvirwere zvinogona kuitika asiwo ane mukana wekugadzirisa kusaenzana kweTh17 masero uye masero ekugadzirisa T (Treg) uye kuvandudza dambudziko rekudzivirira kwechirwere che ulcerative colitis kubva panzvimbo.

Chirwere chega chega che autoimmune chine chinhu chakakosha chinokurudzira kutanga kwayo uye kunowedzera kuderera kwayo.Kune ulcerative colitis, imwe yeT-cell subtypes inonzi Th17 masero.Iyo yakavanzika cytokine IL-17 (IL-17A ndiyo inonyanya kukosha) inogona kurwisa akasiyana mabhakitiriya uye fungal utachiona kuburikidza nekuzvimba uye ibasa rakakosha remukati mekudzivirira immune barriers.

Kuwandisa kwakangoipa sekuperevedza.Th17 masero uye "masero ekugadzirisa T" achaongorora uye akaenzana, ane zvakawanda kune rumwe rutivi uye zvishoma kune imwe.Basa rekutonga T masero nderekuchengetedza autoimmune kushivirira (kwete kutanga mhinduro yekudzivirira kumhuri yako) uye kuisa mabhureki pamhinduro yekuzvimba panguva yakakodzera.Naizvozvo, kana masero eTh17 akanyanya kushanda, masero eT anodzora anopera simba uye kuzvimba kwakawanda kuchaitika.

Kusaenzana kwemapoka maviri aya emasero kunoonekwa sekiyi yekubvisa ulcerative colitis.Muchidzidzo chambotaurwa cheChina Medical University, kunyange zvazvo masero eT anodzora mumakumbo emucosal emukoko mukuru wematumbo haana kuwedzerwa nekupindira kweGanoderma lucidum polysaccharides, kubudiswa kwemasero eT17 uye IL-17A kwakaderedzwa zvakanyanya ( Mufananidzo 3), iyo inofanirwa kunge iri kutanga kwakanaka kwechiyero pakati peTh17 masero uye anotonga T masero.

Mufananidzo 3 Ganoderma lucidum polysaccharides inodzora hutachiona uye inovandudza colitis.

Kune mbeva dzakanga dzawedzerwa neGanoderma lucidum polysaccharide kwemavhiki maviri (100 mg / kg pazuva), panguva yekurwisa kwakanyanya kweulcerative colitis, chirwere chinokonzerwa nekuputika kwechirwere necrosis factor (TNF-α) uye interleukins yakadai seIL-1β, IL-6, IL-4, IL-17A mucolonic mucosa tissue yakaderedzwa zvakanyanya, uye chiyero chemasero eT17 chakaderedzwawo zvakanyanya, asi chiyero chemasero eT chekutonga chakanga chisinganyanyi kukosha (mukuenzanisa nemakonzo ecolitis akanga asina. yakawedzerwa neGanoderma lucidum polysaccharides).(Kwakabva/Reference 1)

Mechanism 2: Ganoderma lucidum polysaccharides inodzora intestinal ecology uye kubatsira kugadzirisa kusaenzana kwekudzivirira.

Tsvagiridzo kubva kuJinan University yakawana kuti Ganoderma lucidum polysaccharides inogona kugadzirisa chiyero chemukati chemaruva emakonzo ekuyedza (sekuderedza maruva epathogenic, kuwedzera maruva anoramba kuzvimba uye kuvanzika mapfupi-ketani fatty acid), uye kukurudzira turakiti remukati kuti riburitse. mamwe mapfupi-chain chain fatty acids (Mufananidzo 4), iyo inogadzirisa maitiro ekudzivirira emudumbu mucosa uye inoderedza kuoma kwe ulcerative colitis.

Chikamu chikuru chezvinhu zvakabatwa nedumbu guru rinobudiswa nebhakitiriya inogara mumatumbo makuru.Kana iwo ma polysaccharides asingagone kugayiwa nemudumbu mudiki (senge dietary fiber, Ganoderma lucidum polysaccharides) ichipinda muura hombe, inoputswa kuita akasiyana-siyana mapfupi-chain fatty acids neboka remabhakitiriya anotsamira paari kuti ararame. .Aya maacetic acids, propionic acids uye butyric acids haangopa muviri masero emudumbu chete asiwo anodzivirira mucosal barrier uye kudzora maitiro ezvirwere zvemuviri.Kuenzaniswa nemhando iyi yemabhakitiriya ane hushamwari, mamwe mabhakitiriya emudumbu ndiwo anokurudzira kuzvimba.Kana chikamu cheumwe neumwe chinenge chisina kuenzana, kazhinji kacho kutanga kwechirwere.

Zvidzidzo zvakasimbisa kuti kusaenzana kweyero yemaruva emudumbu uye kusakwana kwekuvanzika kwepfupi-cheni fatty acids kunogona kukonzera kusagadzikana kwekudzivirira uye kukonzera ulcerative colitis.Ganoderma lucidum polysaccharides inogona kudzoreredza mamiriro acho ezvinhu, kugadzirisa kusadzivirirwa nekudzora intestinal ecology, uye kuwedzera kunatsiridza ulcerative colitis.Hazvina kunaka here?(Kuzoenderera mberi-Ganoderma triterpenes)

Mufananidzo 4 Ganoderma lucidum polysaccharides inodzora intestinal ecology uye inovandudza colitis.

Mbeva dzakadyiswa neGanoderma lucidum polysaccharides kwemavhiki e3 (393.75 mg / kg pazuva) uye yakabva yaitwa kurwisa kwakanyanya kweulcerative colitis.Matumbu avo anopisa kazhinji ane chiitiko chekuwedzera kweProteobacteria flora, yakaderera Firmicutes flora, uye yakaderera-pfupi-cheni fatty acid secretion.Zvisinei, mudumbu guru rinodzivirirwa neGanoderma lucidum polysaccharides, maruva maviri makuru akawana kukura kukuru uye kuderera, uye zviri mukati-mapfupi-cheni fatty acids zvakakwirawo zvakanyanya.(Kwakabva/Chinyorwa 2)

【Mareferensi】

Wei B, nevamwe.Kudzvinyirirwa kweTh17 Cell Response muKuderedza Dextran Sulfate Sodium-Induced Colitis neGanoderma lucidum Polysaccharides.JImmunolRes.2018 Chivabvu 20;2018:2906494.doi: 10.1155/2018/2906494.eCollection 2018.2.Xie J, nevamwe.Ganoderma lucidum polysaccharide inovandudza rat DSS-induced colitis nekushandura cecalmicrobiota uye gene expression ye colonic epithelial cells.Food Nutr Res.2019 Feb 12;63.doi: 10.29219/fnr.v63.1559.eCollection 2019.

Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achirondedzera nezvekutanga-ruoko Ganoderma lucidum ruzivo kubvira 1999. Ndiye munyori we "Ganoderma lucidum: Ingenious Beyond Description" (yakabudiswa muThe People's Medical Publishing House muna April 2017).

★ Chinyorwa ichi chakaburitswa pasi pemvumo yakasarudzika yemunyori, uye muridzi ndeweGANOHERB ★ Mabasa ari pamusoro haagone kudhindwa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yeGanoHerb ★ Kana mabasa acho akatenderwa kushandiswa, iwo inofanira kushandiswa mukati mechikamu chemvumo uye kuratidza kwainobva: GanoHerb ★ Kutyora chirevo chiri pamusoro, GanoHerb ichatevera mabasa ayo ane chekuita nemutemo.

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