May 22, 2015 / Tianjin University of Science and Technology / Lipids in Health and Disease

Umbhalo/Wu Tingyao

Kube nezingxoxo eziningi zesayensi zokuthi kanjaniI-Ganoderma lucidumimizimba yezithelo ingathuthukisa isifo sikashukela, kodwa kunezifundo ezimbalwa ezihlobene ngendima yeI-Ganoderma lucidumama-spores kulokhu.Lo mbiko, oshicilelwe ku- "Lipids in Health and Disease" yi-Tianjin University of Science and Technology, eChina, uhlola umphumela wokuphulwa kwegobolondo.I-Ganoderma lucidumI-spore powder (GLSP) enezinga eliphukile igobolondo>99.9% kushukela wegazi, i-lipids yegazi kanye nokucindezeleka okwenziwe nge-oxidative ohlotsheni lwe-2 lwamagundane esifo sikashukela.

Amaqembu amathathu amagundane abesilisa abambe iqhaza ekuhloleni wonke angabantu abadala, anamagundane angu-8 eqenjini ngalinye.Iqembu 1: Ukulawula okujwayelekile, amagundane avamile anokudla okujwayelekile;Iqembu lesi-2: Ukulawulwa kwemodeli, amagundane anesifo sikashukela anokudla okuvamile ngaphandle kokungenelela;Iqembu 3: I-GLSP, amagundane anesifo sikashukela anokudla okuvamile, iqembu lokungenelela elisebenzisa i-GLSP ye-1 g ngosuku ngama-gavages omlomo amaviki angu-4 alandelanayo.Emagundaneni, uhlobo lwesifo sikashukela sohlobo 2 lubangelwa ukubhujiswa kwamaseli e-islet ngomjovo we-Streptozocin.

Kwatholakala ukuthi i-glucose yegazi lamagundane esifo sikashukela ayedla igobolondo eliphukileI-Ganoderma lucidumI-spore powder yaqala ukwehla kusukela ngesonto lesibili futhi yayiphansi ngo-21% kunaleyo yamagundane esifo sikashukela engazange ithathe i-Ganoderma lucidum ekupheleni kwesonto lesine, kodwa yayisephindwe kane i-glucose yegazi lamagundane avamile.

Ngokuphathelene nokuqanjwa kwe-lipid yegazi, uma kuqhathaniswa namagundane esifo sikashukela angazange adle igobolondo eliphukileI-Ganoderma lucidumI-spore powder, i-cholesterol ephelele yamagundane anesifo sikashukelaI-Ganoderma lucidumiqembu lehliswe ngo-49%, futhi i-triglycerides yabo yehla ngo-17.8%.Nokho, lezi zikhombo zawo womabili zaziqhelelene nalezo zamagundane avamile (ingqikithi ye-cholesterol yawo icishe iphindwe kahlanu kunamagundane avamile, futhi ama-triglyceride awo aphindwe kanye nengxenye kunaleyo.) I-HDL-C kuphela, eyaziwa ngokuthi amagundane avamile. I-cholesterol “enhle,” ikhuphukela kumazinga asondelene namagundane avamile.

Isifo sikashukela singakhuphula kakhulu ukucindezeleka kwe-oxidative emzimbeni, kodwa ukudla okuphukile kwegobolondoI-Ganoderma lucidumama-spores amasonto amane anganciphisa kakhulu ukugcwala kwe-MDA (malondialdehyde) kanye ne-ROS (uhlobo lwe-oxygen esebenzayo) egazini lamagundane anesifo sikashukela.Lawa manani amabili asephakeme kunalawo amagundane avamile, kodwa ama-enzyme amabili abalulekile e-antioxidant, i-GSH-Px (glutathione peroxidase) ne-SOD (superoxide dismutase) nawo aphakeme kunalawo amagundane avamile, okubonisa ukuthi igobolondo eliphukile.I-Ganoderma lucidumama-spores angakhuphula ngempumelelo amandla e-antioxidant wamagundane anesifo sikashukela, ngaleyo ndlela anciphise ukucindezeleka okweqile kwe-oxidative.

Ukuhlaziywa okwengeziwe kwembula ukuthi izakhi zofuzo ezimbalwa ezihlobene ne-lipid metabolism (i-Acox1, ACC, Insig-1 ne-Insig-2), kanye nezakhi zofuzo ezihlobene ne-glycogen synthesis (GS2 ne-GYG1), zinamazinga okukhuluma amaningi kunalawo magundane anesifo sikashukela angadli. igobolondo eliphukileI-Ganoderma lucidumizinhlamvu.Kodwa-ke, ezinye izakhi zofuzo azizange zibonise umehluko ophawulekayo, okuhlanganisa i-SREBP-1, i-Acly, i-Fas, i-Fads1, i-Gpam ne-Dgat1 ehilelekile ku-lipid metabolism, kanye ne-PEPCK ne-G6PC1 ehilelekile ku-carbohydrate metabolism.

Sekukonke, nakuba kusekhona ibanga elithile ukusuka "ekubuyeleni evamile", igobolondo-ephukileI-Ganoderma lucidumi-spore powder ibonise izinzuzo zayo zohlobo lwe-2 yesifo sikashukela phakathi nenyanga, okuhlanganisa ukwehlisa ushukela wegazi kanye nama-lipids egazi.Ngokombono wokuvezwa kwezakhi zofuzo, indlela yokusebenza kwayo ingase ihlobane nokukhuthaza ukuhlanganiswa kwe-glycogen, ukuvimbela i-gluconeogenesis (ukuvimbela ukuguqulwa kwama-non-carbohydrate abe yi-glucose), nokulawula ingxenye ye-HDL ku-cholesterol.Ngokuqondene nokuthi yiziphi izithako ezisebenzayo ezenza igobolondo liphukeI-Ganoderma lucidumI-spore powder isebenza kahle, leli phepha alinaki ngokuqondile.

[Umthombo] Wang F, et al.Umthelela weI-Ganoderma lucidumukungenelela kwe-spores kumaphrofayili we-glucose kanye ne-lipid metabolism gene expression kumagundane esifo sikashukela sohlobo 2.I-Lipids Health Dis.2015 Meyi 22;14:49.doi: 10.1186/s12944-015-0045-y.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.