NgoMeyi 22, 2015 / iYunivesithi yaseTianjin yeSayensi kunye neTekhnoloji / iLipids kwiMpilo kunye neZifo
Umbhalo/Wu Tingyao
Kukho iingxoxo ezininzi zenzululwazi malunga nokuba njaniI-Ganoderma lucidumimizimba yeziqhamo inokuphucula isifo seswekile, kodwa kukho izifundo ezimbalwa ezinxulumene nendimaI-Ganoderma lucidumiimbewu kulo mba.Le ngxelo, epapashwe kwi "Lipids kwiMpilo kunye neSifo" yiYunivesithi yaseTianjin yeSayensi kunye neTekhnoloji, eChina, iphonononga umphumo wegobolondo-ephukile.I-Ganoderma lucidumI-spore powder (i-GLSP) ene-shell-broken rate> 99.9% kwi-glucose yegazi, i-lipids yegazi kunye noxinzelelo lwe-oxidative kuhlobo lwe-2 yeegundane zesifo sikashukela.
Amaqela amathathu eempuku zamadoda athatha inxaxheba kuvavanyo ngabantu abadala bonke, kunye neempuku ezisi-8 kwiqela ngalinye.Iqela 1: Ulawulo oluqhelekileyo, iigundane eziqhelekileyo ezinokutya okuqhelekileyo;Iqela le-2: Ukulawula imodeli, iigundane zesifo sikashukela kunye nokutya okuqhelekileyo ngaphandle kokungenelela;Iqela lesi-3: I-GLSP, iimpuku zesifo seswekile ezinokutya okuqhelekileyo, iqela longenelelo elisebenzisa i-GLSP ye-1 g ngosuku ngamagava omlomo kwiiveki ezi-4 ezilandelelanayo.Kwiigundane, thayipha isifo seswekile se-2 ngenxa yokutshatyalaliswa kweeseli ze-islet ngesitofu seStreptozocin.
Kwafunyaniswa ukuba iswekile yegazi yeempuku zeswekile ezitye iqokobhe eliqhekeziweyoI-Ganoderma lucidumI-powder spore yaqala ukuhla ukusuka kwiveki yesibini kwaye yayingaphantsi kwe-21% kuneempuku zesifo seswekile engazange ithathe i-Ganoderma lucidum ekupheleni kweveki yesine, kodwa yayisele iphindwe kane i-glucose yegazi yeegundane eziqhelekileyo.
Ngokumalunga ne-blood lipid compositions, xa kuthelekiswa neempuku zesifo seswekile ezingazange zitye iqokobhe eliqhekeziweyoI-Ganoderma lucidumI-spore powder, iyonke i-cholesterol yeempuku zesifo seswekile kwiI-Ganoderma lucidumiqela lancitshiswa nge-49%, kwaye i-triglycerides yabo yancitshiswa nge-17.8%.Noko ke, ezi zalathisi zazo zombini zazikude kakhulu kwezo zeempuku eziqhelekileyo (icholesterol yazo iyonke imalunga nezihlandlo ezihlanu kuneempuku eziqhelekileyo, yaye itriglycerides yazo iliphinda-phinda elinesiqingatha kunalo.) Kuphela yiHDL-C, ngokuqhelekileyo eyaziwa ngokuba yi-HDL-C. “I-cholesterol elungileyo,” iyenyuka iye kumanqanaba akufutshane nalawo eempuku eziqhelekileyo.
Isifo seswekile sinokwandisa kakhulu uxinzelelo lwe-oxidative emzimbeni, kodwa ukutya igobolondo ephukileI-Ganoderma lucidumi-spores kwiiveki ezine zinokunciphisa kakhulu ukuxinwa kwe-MDA (malondialdehyde) kunye ne-ROS (iintlobo ze-oksijini ezisebenzayo) egazini leegundane zesifo sikashukela.Ezi xabiso zimbini zisephezulu kunezo iigundane eziqhelekileyo, kodwa i-enzymes ebaluleke kakhulu ye-antioxidant, i-GSH-Px (glutathione peroxidase) kunye ne-SOD (i-superoxide dismutase) nazo ziphezulu kunezo zeempuku eziqhelekileyo, ezibonisa ukuba i-shell-ephukile.I-Ganoderma lucidumI-spores inokuphucula ngokufanelekileyo amandla e-antioxidant yeempuku zeswekile, ngaloo ndlela inciphisa uxinzelelo olugqithisileyo lwe-oxidative.
Uhlalutyo olongezelelweyo lubonise ukuba iijini ezininzi ezinxulumene ne-lipid metabolism (i-Acox1, i-ACC, i-Insig-1 kunye ne-Insig-2), kunye nemfuza enxulumene ne-glycogen synthesis (GS2 kunye ne-GYG1), inamanqanaba okuthetha ngakumbi kuneempuku zeswekile ezingazange zitye. iqokobhe lophukileI-Ganoderma lucidumiimbewu.Nangona kunjalo, ezinye izakhi zofuzo azibonisi nantlukwano ebalulekileyo, kuquka i-SREBP-1, i-Acly, i-Fas, i-Fads1, i-Gpam kunye ne-Dgat1 ebandakanyekayo kwi-lipid metabolism, kunye ne-PEPCK kunye ne-G6PC1 ebandakanyekayo kwi-carbohydrate metabolism.
Konke kuzo zonke, nangona kusekho umgama ukusuka "ukubuyela kwisiqhelo", igobolondo-yaphukileI-Ganoderma lucidumI-powder spore ibonise izibonelelo zayo zohlobo lwe-2 yeswekile ngaphakathi kwenyanga, kubandakanywa ukunciphisa i-glucose yegazi kunye ne-lipids yegazi.Ukususela kumbono we-gene expression, indlela yokusebenza kwayo inokuhambelana nokukhuthaza i-glycogen synthesis, inhibiting gluconeogenesis (ukuvimbela ukuguqulwa kwe-non-carbohydrates kwi-glucose), kunye nokulawula umlinganiselo we-HDL kwi-cholesterol.Ngokumalunga nokuba zeziphi izithako ezisebenzayo ezenza igobolondo-yaphukileI-Ganoderma lucidumUmgubo we-spore uyasebenza, eli phepha alicacisi ngokuthe ngqo.
[Umthombo] Wang F, et al.Isiphumo seI-Ganoderma lucidumukungenelela kwe-spores kwi-glucose kunye ne-lipid metabolism yeeprofayili zegene yokubonisa uhlobo lwe-2 yesifo sikashukela.Lipids Health Dis.2015 Meyi 22;14:49.doi: 10.1186/s12944-015-0045-y.
ISIPHELO
Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.
Ixesha lokuposa: Sep-15-2021