Mei 22, 2015 / Tianjin University of Science and Technology / Lipid in Health and Disease

Text/Wu Tingyao

Ua nui nā kūkākūkā ʻepekema e pili ana i ke ʻanoʻO Ganoderma lucidumHiki i nā kino hua ke hoʻomaikaʻi i ka maʻi diabetes, akā he kakaikahi nā haʻawina e pili ana i ka hana oʻO Ganoderma lucidumspores ma keia mea.ʻO kēia hōʻike, i paʻi ʻia ma "Lipids in Health and Disease" e Tianjin University of Science and Technology, Kina, e ʻimi ana i ka hopena o nā pūpū i haki ʻia.ʻO Ganoderma lucidumʻO ka pauka spore (GLSP) me ka helu haʻihaʻi shell> 99.9% ma ke koko glucose, lipids koko a me ke koʻikoʻi oxidative i nā ʻiole diabetic type 2.

ʻO nā hui ʻekolu o nā ʻiole kāne e komo ana i ka hoʻokolohua he poʻe mākua a pau, me 8 mau ʻiole i kēlā me kēia hui.Pūʻulu 1: Mana maʻamau, nā ʻiole maʻamau me ka hānai maʻamau;Pūʻulu 2: Ka hoʻoponopono hoʻohālike, nā ʻiole diabetic me ka hānai maʻamau me ka ʻole o ka hana ʻana;Pūʻulu 3: GLSP, nā ʻiole maʻi diabetic me ka hānai maʻamau, kahi pūʻulu hana e hoʻohana ana i ka GLSP o 1 g i kēlā me kēia lā ma nā haʻi waha no 4 mau pule.I nā ʻiole, loaʻa ka maʻi maʻi type 2 ma muli o ka luku ʻia ʻana o nā pūnaewele mokupuni ma o ka hoʻokomo ʻana iā Streptozocin.

Ua ʻike ʻia ʻo ka glucose koko o nā ʻiole maʻi maʻi i ʻai ʻia i ka ʻāʻīʻO Ganoderma lucidumUa hoʻomaka ka hāʻule ʻana o ka pauka spore mai ka pule ʻelua a he 21% ka haʻahaʻa ma mua o ka ʻiole maʻi maʻi i lawe ʻole i ka Ganoderma lucidum ma ka hopena o ka pule ʻehā, akā ʻehā mau manawa o ka glucose koko o nā ʻiole maʻamau.

Ma ke ʻano o nā haku lipid koko, i hoʻohālikelike ʻia me nā ʻiole maʻi diabetes ʻaʻole i ʻai i ka pūpū i hakiʻO Ganoderma lucidumka pauda spore, ka huina cholesterol o na iole ma'i ma'i ma'iʻO Ganoderma lucidumUa hōʻemi ʻia ka hui e 49%, a ua hoʻemi ʻia kā lākou triglycerides e 17.8%.Akā naʻe, ua mamao loa kēia mau papa kuhikuhi o lāua ʻelua mai nā ʻiole maʻamau (ʻo ka nui o ka cholesterol ma kahi o ʻelima mau manawa ma mua o nā ʻiole maʻamau, a ʻo kā lākou triglycerides he hoʻokahi a me ka hapa ka nui.) ʻO HDL-C wale nō, i ʻike nui ʻia. ʻO ka "cholesterol maikaʻi," piʻi i nā pae kokoke i nā ʻiole maʻamau.

Hiki i ka maʻi maʻi ke hoʻonui nui i ke koʻikoʻi oxidative i loko o ke kino, akā ʻo ka ʻai ʻana i ka pūpūʻO Ganoderma lucidumHiki i nā spores no nā pule ʻehā ke hoʻemi nui i ka neʻe ʻana o MDA (malondialdehyde) a me ROS (reactive oxygen species) i loko o ke koko o nā ʻiole diabetic.ʻOi aku ka kiʻekiʻe o kēia mau waiwai ʻelua ma mua o nā ʻiole maʻamau, akā ʻoi aku ka kiʻekiʻe o nā enzyme antioxidant koʻikoʻi ʻelua, GSH-Px (glutathione peroxidase) a me SOD (superoxide dismutase) ma mua o nā ʻiole maʻamau, e hōʻike ana i ka haki ʻana o ka pūpū.ʻO Ganoderma lucidumHiki i nā spores ke hoʻoikaika maikaʻi i ka mana antioxidant o nā ʻiole maʻi maʻi, a laila e hoʻēmi i ke kaumaha oxidative.

Ua hōʻike hou ʻia ka nānā ʻana he nui nā genes e pili ana i ka lipid metabolism (Acox1, ACC, Insig-1 a me Insig-2), a me nā genes e pili ana i ka glycogen synthesis (GS2 a me GYG1), ʻoi aku ka nui o nā pae hōʻike ma mua o kēlā mau ʻiole maʻi maʻi i ʻai ʻole. ʻāhaʻi ʻiaʻO Ganoderma lucidumspores.Eia naʻe, ʻaʻole i hōʻike ʻia kekahi mau genes i nā ʻokoʻa koʻikoʻi, me SREBP-1, Acly, Fas, Fads1, Gpam a me Dgat1 i komo i ka lipid metabolism, a me PEPCK a me G6PC1 i komo i ka metabolism carbohydrate.

ʻO nā mea a pau, ʻoiai aia kahi mamao mai ka "hoʻi i ka maʻamau", ʻo ka ʻāʻī o ka pūpūʻO Ganoderma lucidumUa hōʻike ka pauka spore i kāna mau pono no ka maʻi diabetes type 2 i loko o hoʻokahi mahina, me ka hoʻohaʻahaʻa ʻana i ka glucose koko a me nā lipids koko.Mai ka hiʻohiʻona o ka hōʻike gene, pili paha kāna hana o ka hana i ka hoʻoulu ʻana i ka glycogen synthesis, ke kāohi ʻana i ka gluconeogenesis (kaohi ʻana i ka hoʻololi ʻana o nā mea ʻole i loko o ka glucose), a me ka hoʻoponopono ʻana i ka māhele o HDL i loko o ka cholesterol.He aha nā mea hana e hana ai i ka iwi-haʻihaʻiʻO Ganoderma lucidumPono ka pauka spore, ʻaʻole wehewehe kikoʻī kēia pepa.

[Puna] Wang F, et al.Ka hopena oʻO Ganoderma lucidumspores interventions on glucose and lipid metabolism gene expression profiles in type 2 diabetes iole.Lipid Health Dis.2015 Mei 22;14:49.doi: 10.1186/s12944-015-0045-y.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau.★ ʻAʻole hiki ke paʻi hou ʻia nā hana i luna, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e ka mea kākau.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ka mea kākau i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.