Chivabvu 22, 2015 / Tianjin University yeScience uye Technology / Lipids muHutano neChirwere
Chinyorwa/Wu Tingyao
Pave nehurukuro dzakawanda dzesainzi pamusoro pekuti seiGanoderma lucidumMitumbi inobereka michero inogona kuvandudza chirwere cheshuga, asi pane zvishoma zvidzidzo zvine hukama pamusoro pebasa reGanoderma lucidumspores panyaya iyi.Chirevo ichi, chakabudiswa mu "Lipids in Health and Disease" neTianjin University of Science and Technology, China, inoongorora mhedzisiro yegoko rakaputsika.Ganoderma lucidumspore powder (GLSP) ine shell-broken rate> 99.9% paglucose yeropa, ropa lipids uye oxidative stress mumhando ye2 diabetic rats.
Mapoka matatu emakonzo echirume ari kutora chikamu mukuyedza vese vanhu vakuru, vane 8 makonzo muboka rega rega.Boka 1: Kudzora kwakajairika, makonzo akajairwa ane chikafu chakajairwa;Boka 2: Kudzora kwemuenzaniso, makonzo ane chirwere cheshuga ane akajairwa chikafu pasina kupindira;Boka rechitatu: GLSP, makonzo ane chirwere cheshuga ane chikafu chakajairwa, boka rekupindira rinoshandisa GLSP ye1 g pazuva nemuromo gavages kwemavhiki mana akateedzana.Mumakonzo, rudzi rwechipiri chirwere cheshuga chinokonzerwa nekuparadzwa kweislet masero nejekiseni reStreptozocin.
Zvakaonekwa kuti glucose yeropa yemakonzo ane chirwere cheshuga aidya shell-brokenGanoderma lucidumSpore poda yakatanga kudonha kubva muvhiki yechipiri uye yaive 21% yakaderera pane iyo yemakonzo ane chirwere cheshuga asina kutora Ganoderma lucidum pakupera kwevhiki yechina, asi yakanga ichiri yakapetwa kana yeropa glucose yemakonzo akajairika.
Panyaya yeropa lipid zvinyorwa, zvichienzaniswa nemakonzo ane chirwere cheshuga asina kudya goko rakatsemukaGanoderma lucidumspore poda, iyo yakazara cholesterol yemakonzo ane chirwere cheshuga muGanoderma lucidumboka rakaderedzwa ne49%, uye triglycerides yavo yakaderedzwa ne17.8%.Zvisinei, indekisi dzadzo dzose dziri mbiri dzakanga dziri kure neayo emakonzo enguva dzose (cholesterol yawo yose inopeta kanenge kashanu pamakonzo enguva dzose, uye matriglycerides awo anowedzera nekamwe nehafu.) HDL-C chete, inowanzozivikanwa seHDL-C. "yakanaka cholesterol," inokwira kusvika kumazinga ari pedyo neaya emakonzo akajairwa.
Chirwere cheshuga chinogona kuwedzera zvakanyanya iyo oxidative kusagadzikana mumuviri, asi kudya shell-yakatsemukaGanoderma lucidumspores kwemavhiki mana anogona kuderedza zvakanyanya kuwanda kweMDA (malondialdehyde) uye ROS (reactive oxygen marudzi) muropa remakonzo ane chirwere cheshuga.Aya maitiro maviri achiri akakwira kupfuura emakonzo akajairwa, asi maviri akakosha maantioxidant enzymes, GSH-Px (glutathione peroxidase) uye SOD (superoxide dismutase) zvakare akakwira kupfuura ayo emakonzo akajairwa, achiratidza kuti shell-yakatsemuka.Ganoderma lucidumspores inogona kunyatso kusimudzira iyo antioxidant kugona kwemakonzo ane chirwere cheshuga, nekudaro kuderedza yakawandisa oxidative kusagadzikana.
Kumwe kuongorora kwakaratidza kuti majini akati wandei ane chekuita nelipid metabolism (Acox1, ACC, Insig-1 uye Insig-2), pamwe nemajini ane hukama neglycogen synthesis (GS2 neGYG1), ane mazinga ekutaura kupfuura aya makonzo ane chirwere cheshuga asina kudya. shell-brokenGanoderma lucidumspores.Zvisinei, mamwe majini haana kuratidza kusiyana kwakakosha, kusanganisira SREBP-1, Acly, Fas, Fads1, Gpam uye Dgat1 inobatanidzwa mu lipid metabolism, uye PEPCK uye G6PC1 inobatanidzwa mu carbohydrate metabolism.
Zvose mune zvose, kunyange zvazvo kuchine imwe nzvimbo kubva "kudzokera kune zvakajairika", shell-yakaputsikaGanoderma lucidumspore poda yakaratidza mabhenefiti ayo erudzi rwechipiri chirwere cheshuga mukati memwedzi, kusanganisira kudzikisa shuga yeropa uye lipids yeropa.Kubva pakuona kwekutaura kwemajini, maitiro ayo ekuita angave ane chokuita nekusimudzira glycogen synthesis, inhibiting gluconeogenesis (kudzivisa kutendeuka kweasiri-carbohydrates muglucose), nekugadzirisa chikamu cheHDL mucholesterol.Kana zviri izvo zvinoshanda zvinogadzira iyo shell-yakaputsikaGanoderma lucidumspore poda inoshanda, bepa iri harina kutsanangura..
[Kwakabva] Wang F, et al.Mhedzisiro yeGanoderma lucidumspores kupindira paglucose uye lipid metabolism gene expression profiles mumhando ye2 diabetic rats.Lipids Health Dis.2015 Chivabvu 22;14:49.doi: 10.1186/s12944-015-0045-y.
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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).
★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.
Nguva yekutumira: Sep-15-2021