Mee 22, 2015 / Mahadum Sayensị na Teknụzụ Tianjin / Lipids na Ahụike na Ọrịa

Ederede/Wu Tingyao

Enweela ọtụtụ mkparịta ụka sayensị banyere otúGanoderma lucidumahụ mkpụrụ osisi nwere ike melite ọrịa shuga, mana enwere ọmụmụ ole na ole metụtara ọrụ nkeGanoderma lucidumspores na nke a.Akụkọ a, nke e bipụtara na "Lipids in Health and Disease" nke Mahadum Sayensị na Nkà na ụzụ Tianjin, China, na-enyocha mmetụta nke agbajiri agbaji.Ganoderma lucidumspore ntụ ntụ (GLSP) nwere ọnụego agbajiri shei>99.9% na glucose ọbara, lipids ọbara na nrụgide oxidative na ụdị oke ọrịa shuga 2.

Otu atọ nke oke oke na-esonye na nnwale ahụ bụ ndị okenye niile, nwere oke 8 n'ime otu ọ bụla.Otu 1: njikwa nkịtị, oke nkịtị nwere nri nkịtị;Otu 2: njikwa ụdị, oke ọrịa shuga nwere nri nkịtị na-enweghị enyemaka;Otu 3: GLSP, oke na-arịa ọrịa shuga nwere nri nkịtị, otu ntinye aka na-eji GLSP nke 1 g kwa ụbọchị site na ọnụ ọnụ maka izu anọ sochiri.N'ime oke, ụdị ọrịa shuga 2 na-esite na mbibi nke mkpụrụ ndụ agwaetiti site na ịgba ọgwụ Streptozocin.

Achọpụtara na glucose ọbara nke oke ndị na-arịa ọrịa shuga riri shei gbajiri agbajiGanoderma lucidumspore ntụ ntụ malitere ịda site n'izu nke abụọ ma dị 21% dị ala karịa nke oke ndị na-arịa ọrịa shuga na-adịghị ewere Ganoderma lucidum na njedebe nke izu nke anọ, ma ọ ka dị okpukpu anọ karịa glucose ọbara nke oke nkịtị.

N'ihe gbasara mkpokọta lipid ọbara, ma e jiri ya tụnyere oke ndị na-arịa ọrịa shuga na-erighị shei agbajiri agbajiGanoderma lucidumspore ntụ ntụ, mkpokọta cholesterol nke oke ndị ọrịa mamịrị n'imeGanoderma lucidumE belatara otu ahụ site na 49%, yana triglycerides belatara site na 17.8%.Otú ọ dị, ndepụta ndị a nke ha abụọ dị anya na nke oke nkịtị (ngụkọta cholesterol ha dị ihe dị ka okpukpu ise karịa nke oke nkịtị, na triglycerides ha dị otu ugboro na ọkara.) Naanị HDL-C, nke a na-akpọkarị dị ka. "ezigbo cholesterol," na-ebili na ọkwa dị nso nke oke oke.

Ọrịa shuga mellitus nwere ike ịbawanye nrụgide oxidative n'ime ahụ, mana iri agbajiri agbajiGanoderma lucidumspores maka izu anọ nwere ike ibelata mkpokọta MDA (malondialdehyde) na ROS (ụdị oxygen na-emeghachi omume) n'ọbara nke oke ndị na-arịa ọrịa shuga.Ụkpụrụ abụọ a ka dị elu karịa nke oke oke nkịtị, mana enzymes antioxidant abụọ dị mkpa, GSH-Px (glutathione peroxidase) na SOD (superoxide dismutase) dịkwa elu karịa nke oke nkịtị, na-egosi na agbajiri shei.Ganoderma lucidumspores nwere ike ịkwalite ikike antioxidant nke oke ndị na-arịa ọrịa shuga, si otú a na-ebelata oke nrụgide oxidative.

Nnyocha ọzọ gosipụtara na ọtụtụ mkpụrụ ndụ ihe nketa metụtara metabolism lipid (Acox1, ACC, Insig-1 na Insig-2), yana mkpụrụ ndụ ihe nketa metụtara njikọ glycogen (GS2 na GYG1), nwere ọkwa nkwupụta karịa oke oke ndị ahụ na-arịa ọrịa shuga na-erighị nri. shei gbajiri agbajiGanoderma lucidumspores.Otú ọ dị, ụfọdụ mkpụrụ ndụ ihe nketa egosighị ọdịiche dị ịrịba ama, gụnyere SREBP-1, Acly, Fas, Fads1, Gpam na Dgat1 na-etinye aka na metabolism lipid, na PEPCK na G6PC1 na-etinye aka na carbohydrate metabolism.

N'ihe niile, ọ bụ ezie na a ka nwere ebe dị anya site na "ịlaghachi na nkịtị", shei ahụ gbajiriGanoderma lucidumspore ntụ ntụ egosila uru ya maka ụdị ọrịa shuga 2 n'ime otu ọnwa, gụnyere ibelata glucose ọbara na lipids ọbara.Site n'echiche nke mkpụrụ ndụ ihe nketa, usoro ya nwere ike jikọta ya na ịkwalite njikọ glycogen, igbochi gluconeogenesis (na-egbochi ntụgharị nke ndị na-abụghị carbohydrate n'ime glucose), na ịhazi oke HDL na cholesterol.Dị ka ihe na-arụsi ọrụ ike na-eme ka shei-agbajikwaGanoderma lucidumspore ntụ ntụ dị irè, akwụkwọ a anaghị akọwapụta nke ọma.

[Isi iyi] Wang F, et al.Mmetụta nkeGanoderma lucidumspores itinye aka na glucose na profaịlụ mkpụrụ ndụ ihe nketa lipid metabolism na ụdị oke ọrịa shuga 2.Lipids Health Dis.2015 Mee 22;14:49 .doi: 10.1186/s12944-015-0045-y.

N'ikpeazụ

Banyere onye odee/ Oriakụ Wu Tingyao

Wu Tingyao na-akọ akụkọ gbasara Ganoderma nke mbụ kemgbe 1999. Ọ bụ ya bụ onye dere akwụkwọ akụkọ.Ọgwụgwọ na Ganoderma(nke e bipụtara na The People's Medical Publishing House na Eprel 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede.★ Enweghị ike imepụtagharị ọrụ ndị a dị n'elu, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede.★ Maka mmebi nke nkwupụta a dị n'elu, onye edemede ga-agbaso ọrụ iwu dị mkpa.★ Wu Tingyao dere ederede izizi nke akụkọ a n'asụsụ Chinese wee sụgharịa ya n'asụsụ Bekee site n'aka Alfred Liu.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.