May 22, 2015 / Univesithi ea Tianjin ea Saense le Theknoloji / Lipids ho Bophelo bo Botle le Mafu

Mongolo/Wu Tingyao

Ho bile le lipuisano tse ngata tsa saense mabapi le hore na joangGanoderma lucidum'mele ea litholoana e ka ntlafatsa lefu la tsoekere, empa ho na le lithuto tse fokolang tse amanang le karolo eaGanoderma lucidumspores tabeng ena.Tlaleho ena, e hatisitsoeng ho "Lipids in Health and Disease" ke Tianjin University of Science and Technology, Chaena, e hlahloba phello ea likhetla tse robehileng.Ganoderma lucidumphofo ea spore (GLSP) e nang le sekhahla se robehileng sa khetla> 99.9% ho tsoekere ea mali, lipids ea mali le khatello ea oxidative ho likhoto tsa mofuta oa 2 oa lefu la tsoekere.

Lihlopha tse tharo tsa likhoto tse tona tse kenyang letsoho tekong kaofela ke batho ba baholo, ba nang le likhoto tsa 8 sehlopheng ka seng.Sehlopha sa 1: Taolo e tloaelehileng, likhoto tse tloaelehileng tse nang le phepo e tloaelehileng;Sehlopha sa 2: Taolo ea mohlala, likhoto tsa lefu la tsoekere tse nang le phepo e tloaelehileng ntle le ho kenella;Sehlopha sa 3: GLSP, likhoto tse nang le lefu la tsoekere tse nang le phepo e tloaelehileng, sehlopha sa ho kenella se sebelisang GLSP ea 1 g ka letsatsi ka li-gavages tsa molomo bakeng sa libeke tse 4 tse latellanang.Ho likhoto, lefu la tsoekere la mofuta oa 2 le bakoa ke timetso ea lisele tsa islet ka ente ea Streptozocin.

Ho ile ha fumanoa hore tsoekere ea mali ea likhoto tsa lefu la tsoekere tse jang likhetla tse robehilengGanoderma lucidumphofo ea spore e ile ea qala ho theoha ho tloha bekeng ea bobeli 'me e ne e le tlase ho 21% ho feta ea litoeba tsa lefu la tsoekere tse sa kang tsa nka Ganoderma lucidum qetellong ea beke ea bone, empa e ne e ntse e le makhetlo a mane a tsoekere ea mali ea likhoto tse tloaelehileng.

Mabapi le lipina tsa lipid tsa mali, ha li bapisoa le likhoto tsa lefu la tsoekere tse sa kang tsa ja khetla e robehilengGanoderma lucidumspore powder, k'holeseterole eohle ea likhoto tsa lefu la tsoekere ka har'aGanoderma lucidumsehlopha se fokotsehile ka 49%, 'me triglycerides ea bona e fokotsehile ka 17.8%.Leha ho le joalo, li-index tsena tsa tsona ka bobeli li ne li le hōle le tsa likhoto tse tloaelehileng (k’holeseterole eohle ea tsona e batla e imena ka makhetlo a mahlano ho feta ea likhoto tse tloaelehileng, ’me triglyceride ea tsona e imena ka makhetlo a le mong le halofo.) Ke HDL-C feela, eo ka tloaelo e tsejoang ka hore ke HDL-C. “Kholeseterole e ntle,” e nyolohela maemong a haufi le a likhoto tse tloaelehileng.

Lefu la tsoekere le ka eketsa haholo khatello ea oxidative 'meleng, empa ho ja khetla e robehilengGanoderma lucidumli-spores bakeng sa libeke tse 'nè li ka fokotsa haholo khatello ea MDA (malondialdehyde) le ROS (mofuta o sebetsang oa oksijene) maling a likhoto tsa lefu la tsoekere.Litekanyetso tsena tse peli li ntse li phahame ho feta tsa likhoto tse tloaelehileng, empa li-enzyme tse peli tsa bohlokoa tsa antioxidant, GSH-Px (glutathione peroxidase) le SOD (superoxide dismutase) le tsona li phahame ho feta tsa likhoto tse tloaelehileng, tse bontšang hore khetla e robehileng.Ganoderma lucidumli-spores li ka ntlafatsa bokhoni ba li-antioxidant tsa likhoto tsa lefu la tsoekere, ka hona li fokotsa khatello e feteletseng ea oxidative.

Litlhahlobo tse ling li senotse hore liphatsa tsa lefutso tse 'maloa tse amanang le metabolism ea lipid (Acox1, ACC, Insig-1 le Insig-2), hammoho le liphatsa tsa lefutso tse amanang le glycogen synthesis (GS2 le GYG1), li na le maemo a ho bua ho feta likhoto tsa lefu la tsoekere tse neng li sa je. kgetla e robehilengGanoderma lucidumspores.Leha ho le joalo, liphatsa tsa lefutso tse ling ha lia ka tsa bontša phapang e khōlō, ho akarelletsa le SREBP-1, Acly, Fas, Fads1, Gpam le Dgat1 e amehang ho metabolism ea lipid, le PEPCK le G6PC1 tse amehang ho metabolism ea carbohydrate.

Ka kakaretso, le hoja ho ntse ho e-na le sebaka se seng sa "ho khutlela ho tloaelehileng", khetla e robehilengGanoderma lucidumspore powder e bontšitse melemo ea eona bakeng sa lefu la tsoekere la mofuta oa 2 nakong ea khoeli, ho kenyelletsa le ho theola tsoekere ea mali le lipids tsa mali.Ho latela pono ea liphatsa tsa lefutso, mokhoa oa eona oa ts'ebetso o ka amahanngoa le ho nts'etsapele motsoako oa glycogen, ho thibela gluconeogenesis (ho thibela phetoho ea li-non-carbohydrate hore e be tsoekere), le ho laola karolo ea HDL ho cholesterol.Ha e le hore na ke lisebelisoa life tse sebetsang tse etsang hore khetla e robeheGanoderma lucidumspore powder e sebetsa hantle, pampiri ena ha e hlalose ka ho hlaka.

[Mohloli] Wang F, et al.Phello eaGanoderma lucidumho kenella ha li-spores ho glucose le lipid metabolism liphatsa tsa lefutso tsa mofuta oa mofuta oa 2 oa lefu la tsoekere.Lipids Health Dis.2015 May 22;14:49.doi: 10.1186/s12944-015-0045-y.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.