May 22, 2015 / Tianjin University of Science and Technology / Lipids in Health and Disease

Mawu/Wu Tingyao

Pakhala pali zokambirana zambiri zasayansi za momweGanoderma lucidummatupi a fruiting amatha kusintha matenda a shuga, koma pali maphunziro ochepa okhudzana ndi ntchito yaGanoderma lucidumspores pankhaniyi.Lipoti ili, lofalitsidwa mu "Lipids in Health and Disease" lolemba Tianjin University of Science and Technology, China, likuwunikira zotsatira za kusweka kwa zipolopolo.Ganoderma lucidumSpore powder (GLSP) yokhala ndi chipolopolo chosweka> 99.9% pa shuga wamagazi, lipids m'magazi ndi kupsinjika kwa okosijeni mumtundu wa 2 makoswe.

Magulu atatu a makoswe amphongo omwe akugwira nawo ntchitoyi ndi akuluakulu, omwe ali ndi makoswe a 8 pagulu lililonse.Gulu 1: Kuwongolera koyenera, makoswe abwinobwino okhala ndi chakudya wamba;Gulu 2: Kuwongolera kwachitsanzo, makoswe a shuga okhala ndi chakudya wamba popanda kulowererapo;Gulu 3: GLSP, makoswe omwe ali ndi matenda ashuga okhala ndi chakudya wamba, gulu lothandizira lomwe limagwiritsa ntchito GLSP ya 1 g patsiku ndikutulutsa pakamwa kwa milungu inayi yotsatizana.Mu makoswe, mtundu wa shuga wa 2 umachokera ku kuwonongeka kwa ma islet cell ndi jekeseni wa Streptozocin.

Zinapezeka kuti glucose m'magazi a makoswe omwe amadya chipolopolo choswekaGanoderma lucidumufa wa spore unayamba kutsika kuyambira sabata yachiwiri ndipo unali 21% wotsika kuposa wa makoswe odwala matenda a shuga omwe sanatenge Ganoderma lucidum kumapeto kwa sabata lachinayi, koma anali akadali kanayi kuchuluka kwa shuga wamagazi a makoswe abwinobwino.

Pankhani ya magazi a lipid nyimbo, poyerekeza ndi makoswe a shuga omwe sanadye chipolopolo choswekaGanoderma lucidumspore powder, cholesterol yonse ya makoswe a shuga m'magaziGanoderma lucidumgulu linachepetsedwa ndi 49%, ndipo triglycerides yawo inachepetsedwa ndi 17.8%.Komabe, zolozera za onse aŵirizi zinali kutali ndi zija za makoswe abwinobwino (cholesterol yawo yonse ndi pafupifupi kuŵirikiza kasanu kuposa ya makoswe wamba, ndipo ma triglycerides awo amachuluka kuŵirikiza kamodzi ndi theka.) HDL-C yokha, yodziŵika mofala kuti Cholesterol "yabwino," imakwera kufika pamlingo woyandikira wa makoswe wamba.

Matenda a shuga amatha kuonjezera kwambiri kupsinjika kwa okosijeni m'thupi, koma kudya wosweka chipolopoloGanoderma lucidumspores kwa milungu inayi imatha kuchepetsa kwambiri kuchuluka kwa MDA (malondialdehyde) ndi ROS (mtundu wa oxygen wokhazikika) m'magazi a makoswe a shuga.Makhalidwe awiriwa akadali apamwamba kuposa makoswe wamba, koma ma enzyme awiri ofunika kwambiri a antioxidant, GSH-Px (glutathione peroxidase) ndi SOD (superoxide dismutase) nawonso ndi apamwamba kuposa makoswe wamba, kusonyeza kuti chipolopolo chosweka.Ganoderma lucidumspores amatha kupititsa patsogolo mphamvu ya antioxidant ya makoswe odwala matenda ashuga, potero kuchepetsa kupsinjika kwakukulu kwa okosijeni.

Kusanthula kwina kunawonetsa kuti majini angapo okhudzana ndi lipid metabolism (Acox1, ACC, Insig-1 ndi Insig-2), komanso majini okhudzana ndi glycogen synthesis (GS2 ndi GYG1), ali ndi mawonekedwe ochulukirapo kuposa makoswe omwe sanadye. chipolopolo choswekaGanoderma lucidumspores.Komabe, majini ena sanawonetse kusiyana kwakukulu, kuphatikizapo SREBP-1, Acly, Fas, Fads1, Gpam ndi Dgat1 yomwe imakhudzidwa ndi kagayidwe ka lipid, ndi PEPCK ndi G6PC1 zomwe zimakhudzidwa ndi metabolism ya carbohydrate.

Zonsezi, ngakhale kuti pali mtunda wina kuchokera "kubwerera ku chikhalidwe", chipolopolo choswekaGanoderma lucidumspore powder wasonyeza ubwino wake kwa mtundu 2 shuga m`kati mwa mwezi umodzi, kuphatikizapo kuchepetsa magazi shuga ndi magazi lipids.Kutengera mawonekedwe a jini, kachitidwe kake kamakhala kogwirizana ndi kulimbikitsa kaphatikizidwe ka glycogen, kuletsa gluconeogenesis (kuletsa kutembenuka kwamafuta osapatsa kukhala shuga), ndikuwongolera kuchuluka kwa HDL mu cholesterol.Zomwe zimagwira ntchito zimapangitsa kuti chipolopolocho chiswekeGanoderma lucidumspore ufa wogwira mtima, pepala ili silimalongosola mwatsatanetsatane.

[Chitsime] Wang F, et al.Zotsatira zaGanoderma lucidumspores kulowererapo kwa glucose ndi lipid metabolism gene expression profiles mu mtundu wa 2 shuga makoswe.Lipids Health Dis.2015 May 22; 14:49.doi: 10.1186/s12944-015-0045-y.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.