Tsib Hlis 22, 2015 / Tianjin University of Science thiab Technology / Lipids hauv Kev Noj Qab Haus Huv thiab Kab Mob

Text/Wu Tingyao

Muaj ntau ntau yam kev sib tham txog yuav ua li casGanoderma lucidumfruiting lub cev tuaj yeem txhim kho ntshav qab zib, tab sis muaj qee qhov kev tshawb fawb txog lub luag haujlwm ntawmGanoderma lucidumspores ntawm no hais txog.Daim ntawv tshaj tawm no, luam tawm hauv "Lipids hauv Kev Noj Qab Haus Huv thiab Kab Mob" los ntawm Tianjin University of Science thiab Technology, Tuam Tshoj, tshawb nrhiav cov txiaj ntsig ntawm lub plhaub tawg.Ganoderma lucidumspore hmoov (GLSP) nrog lub plhaub-tawg tus nqi> 99.9% ntawm cov ntshav qabzib, ntshav lipids thiab oxidative kev nyuaj siab hauv hom 2 mob ntshav qab zib nas.

Peb pawg txiv neej nas koom nrog qhov kev sim yog tag nrho cov neeg laus, nrog rau 8 nas nyob rau hauv txhua pab pawg.Pawg 1: Kev tswj ib txwm, cov nas ib txwm nrog cov khoom noj zoo tib yam;Pawg 2: Kev tswj tus qauv, cov nas mob ntshav qab zib nrog cov khoom noj zoo tib yam tsis muaj kev cuam tshuam;Pab Pawg 3: GLSP, cov nas mob ntshav qab zib nrog cov khoom noj zoo tib yam, pab pawg cuam tshuam siv GLSP ntawm 1 g ib hnub twg los ntawm qhov ncauj gavages rau 4 lub lis piam sib law liag.Hauv nas, hom 2 mob ntshav qab zib tau tshwm sim los ntawm kev puas tsuaj ntawm cov islet hlwb los ntawm kev txhaj tshuaj Streptozocin.

Nws tau pom tias cov ntshav qabzib ntawm cov nas ntshav qab zib uas tau noj cov plhaub tawgGanoderma lucidumspore hmoov pib poob los ntawm lub lim tiam thib ob thiab yog 21% qis dua li cov nas ntshav qab zib uas tsis noj Ganoderma lucidum thaum kawg ntawm lub lim tiam thib plaub, tab sis nws tseem yog plaub npaug ntawm cov ntshav qabzib ntawm cov nas ib txwm.

Nyob rau hauv cov nqe lus ntawm cov ntshav lipid muaj pes tsawg leeg, piv nrog cov kab mob ntshav qab zib nas uas tsis noj lub plhaub tawgGanoderma lucidumspore hmoov, tag nrho cov roj cholesterol ntawm cov nas ntshav qab zib hauv covGanoderma lucidumpab pawg raug txo los ntawm 49%, thiab lawv cov triglycerides raug txo los ntawm 17.8%.Txawm li cas los xij, cov kev ntsuas no ntawm ob leeg tau nyob deb ntawm cov nas ib txwm muaj (lawv cov roj cholesterol tag nrho yog li tsib npaug ntawm cov nas ib txwm, thiab lawv cov triglycerides yog ib thiab ib nrab npaug ntau npaum li ntau.) Tsuas yog HDL-C, feem ntau hu ua. "cov roj cholesterol zoo," nce mus rau qib ze li ntawm cov nas ib txwm.

Mob ntshav qab zib mellitus tuaj yeem ua rau muaj kev ntxhov siab oxidative hauv lub cev, tab sis noj cov plhaub tawgGanoderma lucidumspores rau plaub lub lis piam tuaj yeem txo qhov concentration ntawm MDA (malondialdehyde) thiab ROS (cov pa oxygen reactive) hauv cov ntshav ntawm cov nas.Ob qhov tseem ceeb no tseem siab dua cov nas ib txwm, tab sis ob qho tseem ceeb antioxidant enzymes, GSH-Px (glutathione peroxidase) thiab SOD (superoxide dismutase) kuj siab dua cov nas ib txwm, qhia tias lub plhaub tawg.Ganoderma lucidumspores tuaj yeem txhim kho lub peev xwm antioxidant ntawm cov nas mob ntshav qab zib, yog li txo cov kev ntxhov siab oxidative ntau dhau.

Kev soj ntsuam ntxiv tau qhia tias ntau cov noob muaj feem xyuam rau cov lipid metabolism (Acox1, ACC, Insig-1 thiab Insig-2), nrog rau cov noob muaj feem xyuam rau glycogen synthesis (GS2 thiab GYG1), muaj ntau theem qhia ntau dua li cov nas ntshav qab zib uas tsis noj. plhaub tawgGanoderma lucidumspores.Txawm li cas los xij, qee cov noob tsis pom qhov sib txawv tseem ceeb, suav nrog SREBP-1, Acly, Fas, Fads1, Gpam thiab Dgat1 koom nrog hauv lipid metabolism, thiab PEPCK thiab G6PC1 koom nrog hauv carbohydrate metabolism.

Tag nrho hauv tag nrho, txawm tias tseem muaj qee qhov kev ncua deb ntawm "rov qab mus rau qhov qub", lub plhaub tawgGanoderma lucidumspore hmoov tau qhia nws cov txiaj ntsig rau hom 2 mob ntshav qab zib hauv ib hlis, suav nrog txo cov ntshav qabzib thiab cov ntshav lipids.Los ntawm qhov kev xav ntawm cov noob qhia, nws cov txheej txheem ntawm kev ua haujlwm yuav cuam tshuam rau kev txhawb nqa glycogen synthesis, inhibiting gluconeogenesis (inhibiting hloov pauv ntawm cov tsis-carbohydrates rau hauv qabzib), thiab tswj qhov feem ntawm HDL hauv cov roj cholesterol.Raws li cov khoom xyaw nquag ua rau lub plhaub tawgGanoderma lucidumspore hmoov zoo, daim ntawv no tsis qhia tshwj xeeb..

[Source] Wang F, et al.Cov nyhuv ntawmGanoderma lucidumKev cuam tshuam spores ntawm cov piam thaj thiab lipid metabolism hauv cov noob qhia profiles hauv hom 2 mob ntshav qab zib nas.Lipids Health Dis.Tsib Hlis 22, 2015, 14:49 teev tsaus ntuj.doi: 10.1186/s12944-015-0045-y.

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Hais txog tus sau/ Ms. Wu Tingyao

Wu Tingyao tau tshaj tawm cov ntaub ntawv Ganoderma thawj zaug txij li xyoo 1999. Nws yog tus sau ntawmKho nrog Ganoderma(tshaj tawm hauv Lub Tsev Kho Mob Tib Neeg Lub Plaub Hlis 2017).

★ Kab lus no tau luam tawm raws li kev tso cai tshwj xeeb ntawm tus sau.★ Cov haujlwm saum toj no tsis tuaj yeem muab luam tawm, txiav tawm lossis siv lwm txoj hauv kev yam tsis muaj kev tso cai los ntawm tus sau.★ Rau kev ua txhaum ntawm cov lus hais saum toj no, tus sau yuav ua raws li cov luag haujlwm raug cai.★ Cov ntawv qub ntawm kab lus no tau sau ua lus Suav los ntawm Wu Tingyao thiab txhais ua lus Askiv los ntawm Alfred Liu.Yog tias muaj qhov tsis sib xws ntawm kev txhais lus (English) thiab tus thawj (Suav), tus thawj Suav yuav yeej.Yog tias cov nyeem muaj lus nug, thov hu rau tus thawj kws sau ntawv, Ms. Wu Tingyao.