Gicurasi 22, 2015 / Tianjin University of Science and Technology / Lipide mubuzima nuburwayi

Inyandiko / Wu Tingyao

Habayeho ibiganiro byinshi bya siyansi kuburyoGanoderma lucidumimibiri yera irashobora kunoza diyabete, ariko hariho ubushakashatsi buke bujyanye nuruhare rwaGanoderma lucidumspores muri iyi ngingo.Iyi raporo yasohowe muri “Lipide mu buzima n’indwara” na kaminuza y’ubumenyi n’ikoranabuhanga ya Tianjin, mu Bushinwa, iragaragaza ingaruka zo kumena ibishishwaGanoderma lucidumifu ya spore (GLSP) ifite igipimo cyacitse> 99,9% kuri glucose yamaraso, lipide yamaraso hamwe na stress ya okiside mumbeba ya diyabete yo mu bwoko bwa 2.

Amatsinda atatu yimbeba zabagabo bitabiriye igeragezwa bose ni bakuru, hamwe nimbeba 8 muri buri tsinda.Itsinda rya 1: Igenzura risanzwe, imbeba zisanzwe hamwe nibiryo bisanzwe;Itsinda rya 2: Kugenzura icyitegererezo, imbeba za diyabete hamwe nibiryo bisanzwe bitabaye ngombwa;Itsinda rya 3: GLSP, imbeba za diyabete hamwe nibiryo bisanzwe, itsinda ryabatabazi rikoresha GLSP ya 1 g kumunsi na gavage yo munwa ibyumweru 4 bikurikiranye.Imbeba, diyabete yo mu bwoko bwa 2 ituruka ku gusenya ingirabuzimafatizo zatewe no gutera inshinge Streptozocin.

Byagaragaye ko maraso glucose yimbeba za diyabete yariye igikonjoGanoderma lucidumifu ya spore yatangiye kugabanuka kuva mucyumweru cya kabiri kandi yari munsi ya 21% ugereranije niy'imbeba za diyabete zidafashe Ganoderma lucidum mu mpera z'icyumweru cya kane, ariko yari ikubye inshuro enye glucose yamaraso yimbeba zisanzwe.

Kubijyanye na lipide yamaraso, ugereranije nimbeba za diyabete zitariye igikonjoGanoderma lucidumifu ya spore, cholesterol yuzuye yimbeba za diyabete muriGanoderma lucidumitsinda ryagabanutseho 49%, naho triglyceride yagabanutseho 17.8%.Nyamara, ibi bipimo byombi byari kure cyane yimbeba zisanzwe (cholesterol zose hamwe zikubye inshuro eshanu izo mbeba zisanzwe, kandi triglyceride zabo zikubye inshuro imwe nigice.) Gusa HDL-C, izwi cyane nka “Cholesterol nziza,” irazamuka igera ku nzego zegereye imbeba zisanzwe.

Diyabete irashobora kongera imbaraga za okiside mu mubiri, ariko kurya igiceriGanoderma lucidumspores mu byumweru bine irashobora kugabanya cyane kwibumbira hamwe kwa MDA (malondialdehyde) na ROS (ubwoko bwa ogisijeni ikora) mumaraso yimbeba za diyabete.Indangagaciro zombi ziracyari hejuru kurenza iz'imbeba zisanzwe, ariko enzymes ebyiri zingenzi za antioxydeant, GSH-Px (glutathione peroxidase) na SOD (superoxide dismutase) nazo zirarenze iz'imbeba zisanzwe, byerekana ko igikonjo cyacitseGanoderma lucidumspore irashobora kongera imbaraga za antioxydeant yimbeba za diyabete, bityo bikagabanya imbaraga nyinshi za okiside.

Isesengura ryakozwe ryagaragaje ko ingirabuzima fatizo nyinshi zijyanye na metabolisme ya lipide (Acox1, ACC, Insig-1 na Insig-2), ndetse na gen zijyanye na synthesis ya glycogene (GS2 na GYG1), zifite imvugo nyinshi kurusha izo mbeba za diyabete zitariye IgikonoshwaGanoderma lucidumspores.Nyamara, genes zimwe na zimwe zagaragaje itandukaniro rinini, harimo SREBP-1, Acly, Fas, Fads1, Gpam na Dgat1 bagize uruhare muri metabolisme ya lipide, na PEPCK na G6PC1 bagize uruhare muri metabolism ya karubone.

Byose muri byose, nubwo haracyari intera yo "gusubira mubisanzwe", igikonoshwa-cyacitseGanoderma lucidumifu ya spore yerekanye inyungu zayo kuri diyabete yo mu bwoko bwa 2 mugihe cyukwezi, harimo kugabanya glucose yamaraso na lipide yamaraso.Dufatiye ku mvugo ya gene, uburyo bwayo bwo gukora bushobora kuba bujyanye no guteza imbere synthesis ya glycogene, ikabuza gluconeogenezesi (kubuza ihinduka rya karubone-hydrata muri glucose), no kugenzura igipimo cya HDL muri cholesterol.Kubijyanye nibintu bikora bituma igiceri kimenekaGanoderma lucidumifu ya spore ikora neza, iyi mpapuro ntabwo isobanura neza ..

[Inkomoko] Wang F, n'abandi.Ingaruka yaGanoderma lucidumspores intervention on glucose na lipid metabolism gene imvugo yerekana imiterere ya 2 ya mbeba ya diyabete.Lipide Ubuzima Dis.2015 Gicurasi 22; 14: 49.doi: 10.1186 / s12944-015-0045-y.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.