September 2018 / Fujian Medical University Union Hospital, njll. / Integrative Cancer Therapies

Umbhalo/ Wu Tingyao

IyadlaI-Ganoderma lucidumukusiza ukukhulula izimpawu zeziguli zesimila ebuchosheni?Lona cishe umbiko wokuqala kujenali yamazwe ngamazwe ukuhlola imiphumelaI-Ganoderma lucidumekuvimbeleni izimila zobuchopho ku-vivo ngokusebenzisa ukuhlolwa kwezilwane - kungasilethela imicabango ethile.

I-Glioma wuhlobo oluvamile lwesimila ebuchosheni.Kubangelwa ukwanda okungavamile kwamaseli e-glial azungeze amangqamuzana ezinzwa.Kungase kube isimila esiyingozi esikhula kancane (ukuthi sizobangela ubuhlungu bekhanda nezinye izimpawu ezingaphatheki kahle kuncike endaweni nobukhulu besimila), noma kungaba isimila esiyingozi esikhula ngokushesha.

I-Malignant glioma ilahlekelwe umsebenzi wokondla, ukusekela nokuvikela amangqamuzana ezinzwa.Akugcini nje ngokukhula ngokushesha, kodwa futhi kungase kusakazeke ngesikhathi esifushane.Lolu hlobo lwe-malignant glioma, olukhula futhi lusakazeke ngokushesha, lubizwa nangokuthi i-glioblastoma.Ingesinye sezimila zobuchopho ezivame kakhulu futhi ezibulalayo kubantu.Ngisho noma iziguli zithola ukwelashwa okunamandla ngokushesha ngemva kokuxilongwa, isilinganiso sesikhathi sazo sokuphila esisele siyizinyanga eziyi-14 kuphela.Ziyi-5% kuphela iziguli eziphila iminyaka engaphezu kwemihlanu.

Ngakho-ke, indlela yokuqinisa ngempumelelo ikhono lokulwa nomdlavuza wezivikeli mzimba zesiguli isibe insimu eyinhloko yokuhlola ekwelapheni i-glioblastoma emkhakheni wezokwelapha eminyakeni yamuva.Kuyiqiniso elamukelekile lokhoI-Ganoderma lucidumama-polysaccharides (GL-PS) angalawula ukungatheleleki, kodwa ngenxa yokuthi umgoqo wegazi nobuchopho phakathi kobuchopho nemithambo yegazi ungavimbela ngokukhetha izinto ezithile ezisegazini ukuthi zingangeni emangqamuzaneni obuchopho, noma ngabeI-Ganoderma lucidumama-polysaccharides angavimbela i-glioblastoma ebuchosheni idinga ukuqinisekiswa okwengeziwe.

Umbiko oshicilelwe ngokuhlanganyela yiFujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University ngoSepthemba 2018 ku-“Integrative Cancer Therapies” ukuqinisekisile ukuthi ama-polysaccharides ahlukaniswe neqembu elithela izithelo.I-Ganoderma lucidum(I-GL-PS) ingavimbela ukukhula kwe-glioblastoma futhi yandise isikhathi sokusinda samagundane athwala isimila.Indlela yayo yokusebenza ihlobene eduze nokuthuthukiswa kokugoma.

Umphumela wokuhlola 1: isimila sincane uma kuqhathaniswa

I-GL-PS esetshenziswe ekuhloleni i-polysaccharide ye-macromolecular enesisindo se-molecular esicishe sibe ngu-585,000 kanye ne-protein engu-6.49%.Abacwaningi baqale bajova amangqamuzana e-glioma ebuchosheni begundane, base besebenzisa i-GL-PS egundaneni ngomjovo we-intraperitoneal ngomthamo wansuku zonke we-50, 100 noma 200 mg/kg).

Ngemuva kwamasonto amabili okwelashwa, ubukhulu besimila sobuchopho samagundane okuhlola buhlolwe yi-MRI (Umfanekiso 1A).Imiphumela yabonisa ukuthi uma kuqhathaniswa namagundane eqembu lokulawula ayefakwe amangqamuzana omdlavuza kodwa anganikezwa i-GL-PS, ubukhulu be-tumor yamagundane anikezwe i-50 kanye ne-100 mg / kg GL-PS yehliswa cishe ingxenye eyodwa kwezintathu ngokwesilinganiso ( Umfanekiso 1B).

Umfanekiso 1 Umphumela ovimbelayo we-GL-PS kumathumba obuchopho (gliomas)

Umphumela wokuhlola 2: ukwandisa ukusinda

Ngemva kokwenziwa kwe-MRI, wonke amagundane okuhlola aqhubeka ephakelwa aze afe.Imiphumela yathola ukuthi amagundane ayephila isikhathi eside kunawo wonke anikezwa i-100 mg/kg GL-PS.Isikhathi sokuphila esimaphakathi sasiyizinsuku ezingama-32, okwakuyingxenye eyodwa kwezintathu kunezinsuku ezingama-24 zeqembu elilawulayo.Elinye lamagundane laphila ngisho nezinsuku ezingu-45.Ngokuqondene namanye amaqembu amabili amagundane e-GL-PS, isikhathi sokusinda esivamile cishe izinsuku ezingu-27, ezingahluke kakhulu kuleso seqembu lokulawula.

Umfanekiso 2 Umthelela we-GL-PS esikhathini sokuphila samagundane anamathumba ebuchosheni (gliomas)

Umphumela wokuhlola wesi-3: Ukwenza ngcono amandla e-anti-tumor amasosha omzimba

Abacwaningi baphinde bahlola imiphumela yeI-Ganoderma lucidumama-polysaccharides ekusebenzeni kokuzivikela komzimba kwamagundane anezicubu zobuchopho futhi athola ukuthi ama-cytotoxic T cells (Umfanekiso 3) kuzicubu zobuchopho nama-lymphocyte (kuhlanganise nama-T Cells nama-B cell) ku-spleen yamagundane ajovwe.I-Ganoderma lucidumama-polysaccharides akhuphuka kakhulu egazini.Ukuhlushwa kwe-anti-tumor cytokines, njenge-IL-2 (interleukin-2), i-TNF-α (i-tumor necrosis factor α) ne-INF-γ (i-interferon gamma), efihliwe ngamaseli omzimba futhi yayiphakeme kuneqembu lokulawula. .

Ngaphezu kwalokho, abacwaningi baye baqinisekisa ngokuhlolwa kwe-in vitro lokhoI-Ganoderma lucidumama-polysaccharides awakwazi nje ukuthuthukisa ukubulawa kwamangqamuzana abulalayo emvelo ngokumelene namaseli e-glioma kodwa futhi akhuthaze amaseli e-dendritic (amaseli anesibopho sokuhlonza izitha zakwamanye amazwe kanye nokuqala ukuphendula kwamasosha omzimba kumasosha omzimba) ukusheshisa ukusebenza kwamasosha omzimba ukulwa namaseli omdlavuza. , futhi iphinde ibe negalelo ekukhiqizeni amaseli e-cytotoxic T (angabulala amangqamuzana omdlavuza eyodwa-to-one).

Umfanekiso 3 Umthelela we-GL-PS enanini lama-T-cell angama-cytotoxic kumathumba obuchopho (gliomas) 

[Incazelo] Lesi yingxenye yethishu yesimila sobuchopho begundane, lapho ingxenye ensundu ingama-T-cell ayi-cytotoxic.Ukulawula kubhekisela eqenjini elilawulayo, futhi amanye amaqembu amathathu amaqembu e-GL-PS.Idatha ekhonjisiwe umthamo weI-Ganoderma lucidumama-polysaccharides afakwa emgodini we-intraperitoneal wamagundane aphethe isimila.

Ukubona ithuba lokuI-Ganoderma lucidumama-polysaccharides ukulwa nezimila zobuchopho

Imiphumela yocwaningo engenhla ikhombisa ukuthi inani elifanele leI-Ganoderma lucidumama-polysaccharides angasiza ukulwa nezimila zobuchopho.Ngoba ama-polysaccharides ajovwe emgodini wesisu amuncwa ngomthambo we-portal wesibindi futhi agaywe isibindi bese engena egazini ukuze axhumane namangqamuzana omzimba omzimba egazini.Ngakho-ke, isizathu sokuthi kungani ukukhula kwezimila zobuchopho begundane kungalawuleka futhi ngisho nesikhathi sokusinda singanwetshwa kufanele sihlobane nokugqugquzelwa kokusabela kwamasosha omzimba kanye nokwenza ngcono umsebenzi wokuzivikela komzimba.I-Ganoderma lucidumama-polysaccharides.

Ngokusobala, umgoqo wegazi nobuchopho esakhiweni sokuphila ngeke uvikele umphumela wokuvimbelaI-Ganoderma lucidumama-polysaccharides kuma-tumor ebuchosheni.Imiphumela yokuhlolwa futhi isitshela ukuthi umthamo weI-Ganoderma lucidumI-polysaccharides ayiyona engcono kakhulu, kodwa encane kakhulu ibonakala inomphumela omncane.Ingakanani “inani elifanelekile”.Kungenzeka ukuthi ezahlukeneI-Ganoderma lucidumama-polysaccharides anezincazelo zawo, futhi ukuthi umphumela wokuphathwa ngomlomo ungalingana yini nomjovo we-intraperitoneal udinga ukuqinisekiswa ngocwaningo olwengeziwe.

Kodwa-ke, le miphumela iveze okungenani ukuthi kungenzeka ama-polysaccharides kusukaGi-anoderma lucidumukuvimbela ukukhula kwesimila ebuchosheni kanye nokwandisa ukuphila, okungase kudingeke sizame esimweni samanje sokwelashwa okulinganiselwe.

[Umthombo] Wang C, et al.I-Antitumor kanye ne-Immunomodulatory Activities ye-Ganoderma lucidum Polysaccharides kumagundane athwala i-Glioma.Integr Cancer Ther.2018 Sep;17(3):674-683.

[Izikhombo] Tony D'Ambrosio.I-Glioma vs. Glioblastoma: Ukuqonda Umehluko Wokwelashwa.Ama-Neurosurgeons aseNew Jersey.2017 Aug 4.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao

UWu Tingyao ubelokhu ebika ngolwazi lwe-Ganoderma lokuqala kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kokugunyazwa okukhethekile kombhali.★ Le misebenzi engenhla ayinakuphinda ikhiqizwe, ikhishwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali.★ Ngokuphulwa kwesitatimende esingenhla, umbhali uzolandela izibopho ezingokomthetho ezifanele.★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.