Septemba 2018 / Fujian Medical University Union Hospital, njl. / Integrative Cancer Therapy

Umbhalo/ Wu Tingyao

UyatyaI-Ganoderma lucidumukunceda ukuthomalalisa iimpawu zezigulane zobuchopho?Oku mhlawumbi yingxelo yokuqala kwijenali yamazwe ngamazwe ukuphonononga iziphumo zeI-Ganoderma lucidumekuthinteleni amathumba ebuchotsheni kwi-vivo ngokusebenzisa imifuniselo yezilwanyana - inokusizisela iingcinga ezithile.

IGlioma luhlobo oluqhelekileyo lwethumba lobuchopho.Kubangelwa ukwanda okungaqhelekanga kweeseli zeglial ezijikeleza iiseli zemithambo-luvo.Isenokuba ithumba elibuhlungu elikhula ngokucothayo (nokuba liya kubangela intloko ebuhlungu kunye nezinye iimpawu ezingonwabanga kuxhomekeke kwindawo kunye nobukhulu bethumba), okanye isenokuba sisilonda esiyingozi esikhula ngokukhawuleza.

I-glioma enobungozi ilahlekelwe ngumsebenzi wokondla, ukuxhasa kunye nokukhusela iiseli ze-nerve.Ayigcini nje ngokukhula ngokukhawuleza, kodwa inokusasazeka nangexesha elifutshane.Olu hlobo lwe-glioma eyingozi, ekhula kwaye isasazeka ngokukhawuleza, ikwabizwa ngokuba yi-glioblastoma.Lelinye lawona mathumba engqondo axhaphakileyo kwaye abulalayo ebantwini.Nokuba izigulane zifumana unyango olundlongo-ndlongo ngoko nangoko emva kokuxilongwa, umndilili wobomi bazo obushiyekileyo ziinyanga ezili-14 kuphela.Kuphela yi-5% yezigulane eziphila ngaphezu kweminyaka emihlanu.

Ke ngoko, indlela yokuqinisa ngokufanelekileyo amandla okulwa nomhlaza we-immune system yesigulana ibe yeyona ndawo iphambili yokuhlola kunyango lwe-glioblastoma kwicandelo lezonyango kwiminyaka yakutshanje.Yinyaniso eyamkelekileyo ukubaI-Ganoderma lucidumI-polysaccharides (i-GL-PS) inokulawula ukhuselo lomzimba, kodwa ngenxa yokuba umqobo wegazi-ingqondo phakathi kwengqondo kunye nemithambo yegazi inokuthintela ngokukhethiweyo izinto ezithile egazini ukuba zingangeni kwiiseli zengqondo, nokubaI-Ganoderma lucidumi-polysaccharides inokuthintela i-glioblastoma kwingqondo kufuneka iqinisekiswe ngakumbi.

Ingxelo epapashwe ngokudibeneyo yiFujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University ngoSeptemba 2018 kwi "Integrative Cancer Therapies" iqinisekisile ukuba i-polysaccharides yodwa kumzimba weziqhamo.I-Ganoderma lucidum(I-GL-PS) inokuthintela ukukhula kwe-glioblastoma kunye nokwandisa ixesha lokusinda kweegundane ezithwala i-tumor.Indlela yokusebenza kwayo ihambelana ngokusondeleyo nokuphuculwa kokugonywa.

Iziphumo zovavanyo 1: ithumba lincinci

I-GL-PS esetyenziswe kuvavanyo yi-polysaccharide ye-macromolecular enesisindo se-molecular malunga ne-585,000 kunye nomxholo weprotheni we-6.49%.Abaphandi baqala ukufaka iiseli ze-glioma kwingqondo yegundane, kwaye emva koko balawula i-GL-PS kwi-rat nge-injection ye-intraperitoneal kwi-dose yemihla ngemihla ye-50, i-100 okanye i-200 mg / kg).

Emva kweeveki ezimbini zonyango, ubukhulu be-tumor yengqondo yeegundane zokulinga zavavanywa yi-MRI (Figure 1A).Iziphumo zibonise ukuba xa kuthelekiswa neqela lokulawula iigundane ezifakwe kwiiseli zomhlaza kodwa zinganikwa i-GL-PS, ubukhulu be-tumor yeegundane ezinikwe i-50 kunye ne-100 mg / kg i-GL-PS yancitshiswa malunga nesithathu kwi-avareji. Umzobo 1B).

Umzobo 1 Impembelelo yokuthintela ye-GL-PS kwiithumba zengqondo (gliomas)

Iziphumo zovavanyo 2: ukolula ukusinda

Emva kokuba kwenziwe iMRI, zonke iimpuku zokulinga zaqhubeka zityiswa de zafa.Iziphumo zafumanisa ukuba ixesha elide liphila ziigundane ezinikwe i-100 mg / kg GL-PS.Umyinge wexesha lokusinda laliyientsuku ze-32, eyayiyeyesithathu ixesha elide kuneentsuku ze-24 zeqela lokulawula.Enye yeempuku yaphila iintsuku ezingama-45.Ngokubhekiselele kwamanye amaqela amabini eegundane ze-GL-PS, ixesha eliqhelekileyo lokusinda malunga neentsuku ze-27, ezingahluke kakhulu kwiqela lolawulo.

Umfanekiso wesi-2 Umphumo we-GL-PS kwixesha lokuphila kweempuku ezinamathumba ebuchotsheni (gliomas)

Iziphumo zovavanyo 3: Ukuphucula amandla okulwa nethumba amajoni omzimba

Abaphandi baphonononga ngakumbi imiphumo yeI-Ganoderma lucidumi-polysaccharides ekusebenzeni komzimba kweempuku ezinamathumba engqondo kwaye yafumanisa ukuba iiseli ze-cytotoxic T (umzobo 3) kwi-brain tumors kunye ne-lymphocytes (kubandakanywa neeseli ze-T kunye neeseli ze-B) kwi-spleen yeempuku ezifakweI-Ganoderma lucidumiipolysaccharides zanda kakhulu egazini.Ukuxinwa kwe-anti-tumor cytokines, njenge-IL-2 (interleukin-2), i-TNF-α (i-tumor necrosis factor α) kunye ne-INF-γ (i-interferon gamma), efihliweyo ngamaseli omzimba ayephezulu kuneqela lokulawula. .

Ukongeza, abaphandi baye baqinisekisa ngovavanyo lwe-in vitro ukubaI-Ganoderma lucidumI-polysaccharides ayinako ukukhulisa nje ukubulawa kweeseli zendalo ezibulalayo ngokuchasene neeseli ze-glioma kodwa zikwakhuthaza iiseli ze-dendritic (iiseli ezinoxanduva lokuchonga iintshaba zangaphandle kunye nokuqalisa impendulo yokuzikhusela kwi-immune system) ukukhawulezisa ukusebenza kwamajoni omzimba ukulwa iiseli zomhlaza. , kwaye kwakhona negalelo ekuveliseni iiseli ze-cytotoxic T (ezinokubulala iiseli zomhlaza enye-to-one).

Umzobo 3 Isiphumo se-GL-PS kwinani le-cytotoxic T-cells kwi-brain tumors (gliomas) 

[Inkcazelo] Eli licandelo lethishu yethumba lobuchopho bempuku, apho indawo emdaka ziiseli T-cytotoxic.Ulawulo lubhekisa kwiqela lolawulo, kwaye amanye amaqela amathathu ngamaqela e-GL-PS.Idatha ebonisiweyo yidosi yeI-Ganoderma lucidumi-polysaccharides efakwe kwi-intraperitoneal cavity yeempuku ezithwele ithumba.

Ukubona ithuba lokuI-Ganoderma lucidumiipolysaccharides ukulwa namathumba ebuchotsheni

Iziphumo zophando ezingentla zibonisa ukuba isixa esifanelekileyo seI-Ganoderma lucidumiipolysaccharides zinokunceda ukulwa namathumba ebuchotsheni.Ngenxa yokuba iipolysaccharides ezitofelwe kumgodi wesisu zifunxwa nge-portal vein yesibindi kwaye i-metabolized sisibindi kwaye ingena kumjikelezo wegazi ukuze idibane neeseli zokuzivikela egazini.Ke ngoko, isizathu sokuba ukukhula kwamathumba obuchopho begundane kunokulawulwa kwaye kwanexesha lokusinda linokwandiswa kufuneka linxibelelene nokuvuselela ukuphendula komzimba kunye nokuphuculwa kokusebenza komzimba ngoku.I-Ganoderma lucidumiipolysaccharides.

Ngokucacileyo, isithintelo segazi-ingqondo kwisakhiwo somzimba asiyi kukhusela isiphumo sokuthintelaI-Ganoderma lucidumiipolysaccharides kwiithumba zengqondo.Iziphumo zovavanyo zikwasixelela ukuba ithamo leI-Ganoderma lucidumI-polysaccharides ayiyona nto ingcono, kodwa incinci kakhulu ibonakala inempembelelo encinci.Yimalini "isixa esifanelekileyo".Inokwenzeka ukuba yahlukileI-Ganoderma lucidumI-polysaccharides ineenkcazo zazo, kwaye ingaba isiphumo sokulawulwa komlomo sinokulingana ne-injection ye-intraperitoneal ifuna ukuqinisekiswa ngophando olongezelelweyo.

Nangona kunjalo, ezi ziphumo zibonakalise ubuncinci ubunokwenzeka bepolysaccharides ukusukaGi-anoderma luciduminqanda ukukhula kwethumba ebuchotsheni kunye nokwandisa ixesha lokuphila, elinokuba lixabiso lokuzama kwimeko yangoku yonyango olulinganiselweyo.

[Umthombo] Wang C, et al.I-Antitumor kunye ne-Immunomodulatory Activities ye-Ganoderma lucidum Polysaccharides kwi-Glioma-Bearing Rats.Integr Cancer Ther.2018 Sep; 17 (3): 674-683.

[Iimbekiselo] uTony D'Ambrosio.I-Glioma vs. Glioblastoma: Ukuqonda Umahluko woNyango.IiNeurosurgeons zaseNew Jersey.2017 Agasti 4.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao

UWu Tingyao unike ingxelo ngolwazi lweGanoderma lokuqala ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).

★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali.★ Le misebenzi ingasentla ayinakuphinda iveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali.★ Ukwaphulwa kwengxelo engentla, umbhali uya kulandela uxanduva olusemthethweni olufanelekileyo.★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.