September 2018 / Fujian Medical University Union Hospital, etc. / Integrative Cancer Therapies

Zolemba / Wu Tingyao

AmadyaGanoderma lucidumkuthandiza kuchepetsa zizindikiro za odwala chotupa muubongo?Ili mwina ndi lipoti loyamba m'magazini yapadziko lonse lapansi kufufuza zotsatira zaGanoderma lucidumpoletsa zotupa za muubongo mu vivo kudzera mu kuyesa kwa nyama - kungatibweretsere malingaliro.

Glioma ndi mtundu wamba wa chotupa muubongo.Zimayamba chifukwa cha kuchuluka kwachilendo kwa ma cell a glial omwe amazungulira ma cell a mitsempha.Ikhoza kukhala chotupa choopsa chomwe chimakula pang'onopang'ono (kaya chidzayambitsa mutu ndi zizindikiro zina zosasangalatsa zimadalira malo ndi kukula kwa chotupacho), kapena chikhoza kukhala chotupa choopsa chomwe chikukula mofulumira.

Malignant glioma yasiya kugwira ntchito yopatsa thanzi, kuthandizira ndi kuteteza maselo amitsempha.Sikuti zimangokulirakulira, komanso zimatha kufalikira pakanthawi kochepa.Mitundu yowopsa ya glioma, yomwe imakula ndikufalikira mwachangu, imatchedwanso glioblastoma.Ndi chimodzi mwa zotupa zaubongo zomwe zimafala kwambiri komanso zakupha mwa anthu.Ngakhale odwala atalandira chithandizo chaukali atangotulukira, moyo wawo wotsalira ndi miyezi 14 yokha.Ndi 5% yokha ya odwala omwe amakhala ndi moyo kwa zaka zoposa zisanu.

Chifukwa chake, momwe mungalimbikitsire bwino mphamvu yolimbana ndi khansa ya chitetezo chamthupi cha wodwalayo chakhala gawo lalikulu la kufufuza pochiza glioblastoma m'chipatala m'zaka zaposachedwa.Ndi chowonadi chovomerezeka kutiGanoderma lucidumma polysaccharides (GL-PS) amatha kuwongolera chitetezo chamthupi, koma chifukwa chotchinga chamagazi pakati pa ubongo ndi mitsempha yamagazi chimatha kuteteza mwapadera kuti zinthu zina m'magazi zisalowe m'maselo aubongo, kaya.Ganoderma lucidumma polysaccharides amatha kuletsa glioblastoma muubongo ayenera kutsimikiziridwa.

Lipoti lofalitsidwa ndi Fujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University mu Seputembara 2018 mu "Integrative Cancer Therapies" idatsimikizira kuti ma polysaccharides olekanitsidwa ndi thupi la zipatso.Ganoderma lucidum(GL-PS) imatha kuletsa kukula kwa glioblastoma ndikutalikitsa nthawi yamoyo ya makoswe okhala ndi chotupa.Njira yake yochitira zinthu imagwirizana kwambiri ndi kusintha kwa chitetezo chamthupi.

Chotsatira choyesera 1: chotupacho ndi chaching'ono

GL-PS yogwiritsidwa ntchito poyesera ndi macromolecular polysaccharide yokhala ndi molekyulu yolemera pafupifupi 585,000 ndi mapuloteni okwana 6.49%.Ofufuzawo adayambitsa ma cell a glioma mu ubongo wa makoswe, kenako adapereka GL-PS kwa makoswe ndi jekeseni wa intraperitoneal pa mlingo wa tsiku ndi tsiku wa 50, 100 kapena 200 mg / kg).

Pambuyo pa milungu iwiri ya chithandizo, kukula kwa chotupa cha muubongo cha makoswe oyesera adawunikidwa ndi MRI (Chithunzi 1A).Zotsatira zake zidawonetsa kuti poyerekeza ndi makoswe a gulu lowongolera omwe adalowetsedwa ndi maselo a khansa koma osapatsidwa GL-PS, kukula kwa chotupa cha makoswe omwe adapatsidwa 50 ndi 100 mg / kg GL-PS adachepetsedwa pafupifupi gawo limodzi mwa magawo atatu (pafupifupi). Chithunzi 1B).

Chithunzi 1 Mphamvu yoletsa ya GL-PS pa zotupa muubongo (gliomas)

Chotsatira choyesera 2: kutalikitsa moyo

MRI itatha, makoswe onse oyesera adapitilira kudyetsedwa mpaka atamwalira.Zotsatira zinapeza kuti aatali kwambiri amoyo anali makoswe omwe anapatsidwa 100 mg / kg GL-PS.Nthawi yapakati yopulumuka inali masiku a 32, omwe anali gawo limodzi mwa magawo atatu kuposa masiku a 24 a gulu lolamulira.Mmodzi wa makoswewo anakhala ndi moyo kwa masiku 45.Ponena za magulu ena awiri a makoswe a GL-PS, nthawi yopulumuka pafupifupi masiku a 27, omwe sali osiyana kwambiri ndi gulu lolamulira.

Chithunzi 2 Zotsatira za GL-PS pautali wamoyo wa makoswe okhala ndi zotupa muubongo (gliomas)

Zotsatira zoyeserera 3: Kupititsa patsogolo mphamvu yolimbana ndi chotupa cha chitetezo chamthupi

Ofufuzawo adafufuzanso zotsatira zaGanoderma lucidumma polysaccharides pa chitetezo chamthupi cha makoswe okhala ndi zotupa muubongo ndipo adapeza kuti ma cell a cytotoxic T (Chithunzi 3) mu zotupa zaubongo ndi ma lymphocytes (kuphatikiza ma T Cell ndi B cell) mu ndulu ya makoswe omwe amabayidwa nawo.Ganoderma lucidumma polysaccharides adawonjezeka kwambiri m'magazi.Kuchuluka kwa anti-tumor cytokines, monga IL-2 (interleukin-2), TNF-α (tumour necrosis factor α) ndi INF-γ (interferon gamma), yotulutsidwa ndi maselo a chitetezo cha mthupi inalinso yapamwamba kuposa ya gulu lolamulira. .

Kuphatikiza apo, ofufuzawo atsimikiziranso kudzera mu kuyesa kwa in vitro kutiGanoderma lucidumma polysaccharides samangowonjezera kupha kwa maselo akupha achilengedwe motsutsana ndi ma cell a glioma komanso amalimbikitsa ma cell a dendritic (ma cell omwe ali ndi udindo wozindikiritsa adani akunja ndikuyambitsa kuyankha kwa chitetezo chamthupi) kuti afulumizitse kuyambitsa kwa chitetezo chamthupi kuthana ndi ma cell a khansa. , komanso amathandizira kupanga maselo a cytotoxic T (omwe amatha kupha maselo a khansa imodzi ndi imodzi).

Chithunzi 3 Zotsatira za GL-PS pa kuchuluka kwa ma cell a cytotoxic T mu zotupa za muubongo (gliomas) 

[Kufotokozera] Ichi ndi gawo la chotupa cha muubongo wa makoswe, pomwe mbali ya bulauni ndi ma cytotoxic T-cell.Kuwongolera kumatanthawuza gulu lolamulira, ndipo magulu ena atatu ndi magulu a GL-PS.Zomwe zikuwonetsedwa ndi mlingo waGanoderma lucidumpolysaccharides jekeseni mu intraperitoneal patsekeke wa makoswe chotupa.

Kuwona mwayi waGanoderma lucidumpolysaccharides kulimbana ndi zotupa za muubongo

Zotsatira za kafukufuku zomwe zili pamwambazi zikuwonetsa kuti kuchuluka koyenera kwaGanoderma lucidumma polysaccharides amathandizira kulimbana ndi zotupa muubongo.Chifukwa polysaccharides jekeseni mu m'mimba patsekeke odzipereka kudzera zipata mtsempha wa chiwindi ndi zimapukusidwa ndi chiwindi ndiyeno kulowa magazi kwa mogwirizana ndi chitetezo maselo m'magazi.Chifukwa chake, chifukwa chomwe kukula kwa zotupa muubongo wa makoswe kumatha kuwongoleredwa ndipo ngakhale nthawi yopulumuka imatha kupitilira nthawi yayitali iyenera kukhala yokhudzana ndi kulimbikitsa kuyankha kwa chitetezo chamthupi komanso kukonza magwiridwe antchito a chitetezo chamthupi.Ganoderma lucidumma polysaccharides.

Mwachiwonekere, chotchinga chamagazi-ubongo mu kapangidwe ka thupi sichingateteze kulepheretsa kwaGanoderma lucidumpolysaccharides pa zotupa za ubongo.Zotsatira zoyeserera zimatiuzanso kuti mlingo waGanoderma lucidumma polysaccharides sakhala abwinoko, koma ochepa kwambiri amawoneka kuti alibe mphamvu.Kodi "ndalama zoyenerera" ndi zingati.N'zotheka kuti zosiyanaGanoderma lucidumma polysaccharides ali ndi matanthauzo awo, ndipo ngati zotsatira za kayendetsedwe ka pakamwa zingakhale zofanana ndi za jekeseni wa intraperitoneal zimafunika kutsimikiziridwa ndi kufufuza kwina.

Komabe, zotsatirazi zawonetsa kuthekera kwa ma polysaccharides kuchokeraGanoderma lucidumkuletsa kukula kwa chotupa cha muubongo ndikutalikitsa moyo, zomwe zingakhale zofunikira kuyesa ngati pali chithandizo chochepa.

[Chitsime] Wang C, et al.Antitumor ndi Immunomodulatory Activities of Ganoderma lucidum Polysaccharides mu Glioma-Bearing Rats.Integr Cancer Ther.2018 Sep; 17 (3): 674-683.

[Mawu] Tony D'Ambrosio.Glioma vs. Glioblastoma: Kumvetsetsa Kusiyana kwa Chithandizo.Ma Neurosurgeons aku New Jersey.2017 Aug 4.

TSIRIZA

Za wolemba/ Mayi Wu Tingyao

Wu Tingyao wakhala akufotokoza zambiri za Ganoderma kuyambira 1999. Iye ndi mlembi wa bukuli.Kuchiza ndi Ganoderma(lofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa pansi pa chilolezo cha wolemba.★ Ntchito zomwe zili pamwambazi sizingathe kupangidwanso, kuchotsedwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba.★ Pakuphwanya mawu omwe ali pamwambawa, wolemba adzatsata maudindo oyenera azamalamulo.★ Zolemba zoyambirira za nkhaniyi zidalembedwa m'Chitchaina ndi Wu Tingyao ndikumasulira m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.