Kepakemapa 2018 / Fujian Medical University Union Hospital, etc. / Integrative Cancer Therapies

Text/ Wu Tingyao

E ʻai anaʻO Ganoderma lucidumkōkua e hoʻomaha i nā hōʻailona o nā maʻi maʻi lolo?ʻO kēia paha ka hōʻike mua ma ka puke pai honua e ʻimi i nā hopena oʻO Ganoderma lucidumi ka pale ʻana i ka lolo lolo i loko o ka vivo ma o nā hoʻokolohua holoholona - hiki iā ia ke lawe mai iā mākou i kekahi mau manaʻo.

ʻO Glioma kahi ʻano maʻamau o ka lolo lolo.Hoʻokumu ʻia ia ma muli o ka hoʻonui ʻia ʻana o nā pūnaewele glial e hoʻopuni ana i nā pūnana nerve.He maʻi maʻi maʻi lohi ka ulu ʻana (inā paha e hōʻeha ia i ke poʻo a me nā hōʻailona hōʻoluʻolu ʻē aʻe e pili ana i ka wahi a me ka nui o ka ʻōpū), a i ʻole he maʻi maʻi ʻino e ulu wikiwiki ana.

Ua nalowale ka glioma maligna i ka hana o ka hānai ʻana, ke kākoʻo a me ka pale ʻana i nā cell nerve.ʻAʻole wale ʻo ia e ulu wikiwiki, akā hiki ke laha i ka manawa pōkole.ʻO kēia ʻano glioma malignant, e ulu a pālahalaha wikiwiki, ua kapa ʻia hoʻi ʻo glioblastoma.ʻO ia kekahi o nā maʻi lolo maʻamau a make i nā kānaka.ʻOiai inā loaʻa i nā mea maʻi ka mālama koʻikoʻi ma hope koke o ka hōʻoia ʻana, ʻo ko lākou awelika o ke ola ʻana he 14 mahina wale nō.ʻO 5% wale nō o nā maʻi e ola ana no nā makahiki ʻoi aku ma mua o ʻelima.

No laila, pehea e hoʻoikaika maikaʻi ai i ka hiki ʻana i ka maʻi maʻi o ka mea maʻi ponoʻī i lilo i kumu nui o ka ʻimi ʻana i ka mālama ʻana i ka glioblastoma i ka lāʻau lapaʻau i nā makahiki i hala iho nei.He mea ʻae ʻia kēlāʻO Ganoderma lucidumHiki i nā polysaccharides (GL-PS) ke hoʻoponopono i ka palekana, akā no ka mea hiki i ka pale koko-lolo ma waena o ka lolo a me nā kīʻaha koko ke koho koho i kekahi mau mea i loko o ke koko mai ke komo ʻana i loko o nā pūnaʻi lolo, inā pahaʻO Ganoderma lucidumHiki i nā polysaccharides ke kāohi i ka glioblastoma i loko o ka lolo pono e hōʻoia hou ʻia.

ʻO kahi hōʻike i paʻi pū ʻia e Fujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University i Kepakemapa 2018 ma "Integrative Cancer Therapies" ua hōʻoia ʻia ua hoʻokaʻawale ʻia nā polysaccharides mai ke kino hua oʻO Ganoderma lucidum(GL-PS) hiki ke pale i ka ulu ʻana o ka glioblastoma a hoʻolōʻihi i ka manawa ola o nā ʻiole e lawe ana i ka tumora.ʻO kāna ʻano hana e pili pono ana i ka hoʻomaikaʻi ʻana i ka pale ʻana.

Ka hopena hoʻokolohua 1: ʻano liʻiliʻi ke koko

ʻO ka GL-PS i hoʻohana ʻia i ka hoʻokolohua he macromolecular polysaccharide me kahi paona molekala kokoke i 585,000 a me kahi ʻano protein o 6.49%.Ua hoʻokomo mua nā mea noiʻi i nā cell glioma i loko o ka lolo ʻiole, a laila lawelawe i ka GL-PS i ka ʻiole ma ka intraperitoneal injection i kēlā me kēia lā o 50, 100 a i ʻole 200 mg / kg).

Ma hope o ʻelua pule o ka mālama ʻana, ua nānā ʻia ka nui o ka lolo o nā ʻiole hoʻokolohua e MRI (Figure 1A).Ua hōʻike nā hopena i ka hoʻohālikelike ʻia me nā ʻiole pūʻulu mana i hoʻopaʻa ʻia me nā maʻi maʻi maʻi akā ʻaʻole i hāʻawi ʻia iā GL-PS, ua hoʻemi ʻia ka nui o ka nui o nā ʻiole i hāʻawi ʻia he 50 a me 100 mg / kg GL-PS e kahi hapakolu o ka awelika ( Helu 1B).

Kiʻi 1 ʻO ka hopena pale o GL-PS ma nā lolo lolo (gliomas)

Ka hopena hoʻokolohua 2: hoʻolōʻihi i ke ola

Ma hope o ka hana ʻana o ka MRI, hoʻomau ʻia nā ʻiole hoʻokolohua a pau a hiki i ka make ʻana.ʻO nā hopena i ʻike ʻia ʻo ka lōʻihi loa e ola ana nā ʻiole i hāʻawi ʻia i ka 100 mg/kg GL-PS.ʻO ka awelika o ka manawa ola he 32 mau lā, ʻo ia ka hapakolu o ka lōʻihi ma mua o nā lā 24 o ka hui hoʻomalu.Ua ola kekahi ʻiole no 45 mau lā.ʻO nā pūʻulu ʻelua ʻē aʻe o nā ʻiole GL-PS, ʻo ka awelika o ka manawa ola ma kahi o 27 mau lā, ʻaʻole i ʻokoʻa loa mai ka pūʻulu mana.

Kiʻi 2 Ka hopena o GL-PS i ke ola o nā ʻiole me ka lolo lolo (gliomas)

ʻO ka hopena hoʻokolohua 3: Hoʻomaikaʻi i ka hiki ke anti-tumor o ka ʻōnaehana pale

Ua ʻimi hou ka poʻe noiʻi i nā hopena oʻO Ganoderma lucidumpolysaccharides i ka hana pale o nā ʻiole me ka lolo o ka lolo a ua ʻike ʻia ʻo ka cytotoxic T cell (Figure 3) i loko o ka lolo lolo a me nā lymphocytes (me nā T Cells a me B cell) i loko o ka spleen o nā ʻiole i hoʻopaʻa ʻia me.ʻO Ganoderma lucidumUa hoʻonui nui ʻia ka polysaccharides i ke koko.ʻO ka nui o nā cytokine anti-tumor, e like me IL-2 (interleukin-2), TNF-α (tumor necrosis factor α) a me INF-γ (interferon gamma), i hūnā ʻia e nā cell immune i ʻoi aku ka kiʻekiʻe ma mua o ka pūʻulu mana. .

Eia kekahi, ua hōʻoia ʻia nā mea noiʻi ma o nā hoʻokolohua in vitroʻO Ganoderma lucidumʻAʻole hiki i nā polysaccharides ke hoʻonui wale i ka lethality o nā pūnae pepehi kūlohelohe e kū'ē i nā pūnaewele glioma akā hoʻolaha pū kekahi i nā cell dendritic (ʻo nā cell ke kuleana no ka ʻike ʻana i nā ʻenemi haole a hoʻomaka i ka pane ʻana i ka pale ʻana i ka ʻōnaehana immune) , a kōkua pū nō hoʻi i ka hana ʻana o nā pūnaewele T cytotoxic (hiki ke pepehi i nā maʻi maʻi ʻaʻai hoʻokahi).

Kiʻi 3 ʻO ka hopena o GL-PS i ka helu o nā cytotoxic T-cell i loko o ka lolo lolo (gliomas) 

[Description] He ʻāpana ʻiʻo kēia o ka lolo lolo ʻiole, a ʻo ka ʻāpana ʻeleʻele he mau pūnaeau T cytotoxic.E pili ana ka mana i ka pūʻulu mana, a ʻo nā hui ʻekolu ʻē aʻe he pūʻulu GL-PS.ʻO ka ʻikepili i hōʻike ʻia ʻo ia ka dose oʻO Ganoderma lucidumʻO nā polysaccharides i hoʻokomo ʻia i loko o ka lua intraperitoneal o nā ʻiole hāpai i ka maʻi tumora.

ʻIke i ka manawa kūpono oʻO Ganoderma lucidumpolysaccharides e kaua i ka lolo lolo

Hōʻike nā hopena noiʻi ma luna i ka nui kūpono oʻO Ganoderma lucidumHiki i nā polysaccharides ke kōkua i ke kaua ʻana i ka lolo lolo.No ka mea, ʻo nā polysaccharides i hoʻokomo ʻia i loko o ka ʻōpū o ka ʻōpū e komo i loko o ka vein portal o ke ake a hoʻoheheʻe ʻia e ke ake a laila komo i ke kahe koko no ka launa pū ʻana me nā cell immune i loko o ke koko.No laila, ʻo ke kumu e hiki ai ke hoʻomalu ʻia ka ulu ʻana o ka lolo lolo ʻiole a hiki ke hoʻolōʻihi ʻia ka manawa ola e pili ana i ka hoʻoulu ʻana i ka pane ʻana a me ka hoʻomaikaʻi ʻana i ka hana immune.ʻO Ganoderma lucidumpolysaccharides.

ʻIke loa, ʻaʻole e pale ka pale koko-lolo i ka hana physiological i ka hopena inhibitory oʻO Ganoderma lucidumpolysaccharides ma ka lolo lolo.Hōʻike pū nā hopena hoʻokolohua iā mākou i ka dosage oʻO Ganoderma lucidumʻAʻole ʻoi aku ka maikaʻi o ka polysaccharides, akā liʻiliʻi loa ka hopena.ʻEhia ka "nui kūpono".He ʻokoʻa pahaʻO Ganoderma lucidumLoaʻa i nā polysaccharides ko lākou mau wehewehe ponoʻī, a inā paha e like ka hopena o ka hoʻokele waha me ka hoʻokele intraperitoneal pono e hōʻoia ʻia e ka noiʻi hou aku.

Eia naʻe, ua hōʻike ʻia kēia mau hopena i ka hiki ke loaʻa nā polysaccharides maiGanoderma lucidumkaohi ʻana i ka ulu ʻana o ka lolo a me ka hoʻolōʻihi ʻana i ke ola ʻana, pono paha e hoʻāʻo i ke kūlana o kēia manawa o ka mālama ʻana.

[Puna] Wang C, et al.Nā Hana Antitumor a me Immunomodulatory o Ganoderma lucidum Polysaccharides i nā ʻiole lawe Glioma.Hui Pū ʻIa maʻi maʻi maʻi maʻi Ther.2018 Sep;17(3):674-683.

[References] Tony D'Ambrosio.ʻO Glioma vs. Glioblastoma: Hoʻomaopopo i nā ʻokoʻa Lapaʻau.Nā Neurosurgeons o New Jersey.2017 ʻAukake 4.

HOPE

No ka mea kākau/ Ms. Wu Tingyao

Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau.★ ʻAʻole hiki ke paʻi hou ʻia nā hana i luna, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e ka mea kākau.★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ka mea kākau i nā kuleana pili kānāwai.★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.