September 2018 / Fujian Medical University Union Hospital, joalo-joalo / Meriana e Kopanetsoeng ea Kankere

Mongolo/ Wu Tingyao

E jaGanoderma lucidumthusa ho imolla matšoao a bakuli ba hlahala bokong?Mohlomong ena ke tlaleho ea pele koranteng ea machaba ea ho hlahloba liphello tsaGanoderma lucidumka ho thibela lihlahala tsa boko ka har'a vivo ka liteko tsa liphoofolo - e ka re tlisetsa mehopolo.

Glioma ke mofuta o tloaelehileng oa hlahala ea boko.E bakoa ke ho ata ho sa tloaelehang ha lisele tsa glial tse pota-potileng lisele tsa methapo.E ka 'na ea e-ba hlahala e kotsi e ntseng e hōla butle (hore na e tla baka hlooho le matšoao a mang a sa phutholohang ho itšetlehile ka sebaka le boholo ba hlahala), kapa e ka' na ea e-ba hlahala e kotsi e hōlang ka potlako.

Malignant glioma e lahlehetsoe ke mosebetsi oa ho fepa, ho tšehetsa le ho sireletsa lisele tsa methapo.Ha e hole ka potlako feela, empa hape e ka nama ka nako e kgutshwane.Mofuta ona oa malignant glioma, o hōlang le ho ata ka potlako, o boetse o bitsoa glioblastoma.Ke e 'ngoe ea lihlahala tsa boko tse atileng haholo le tse bolaeang bathong.Esita le haeba bakuli ba fumana phekolo e mabifi hang ka mor'a ho hlahlojoa, nako ea bophelo ea bona e setseng ke likhoeli tse 14 feela.Ke 5% feela ea bakuli ba phelang lilemo tse fetang tse hlano.

Ka hona, mokhoa oa ho matlafatsa matla a khahlanong le mofetše oa sesole sa 'mele oa mokuli e se e le tšimo e ka sehloohong ea ho hlahloba kalafo ea glioblastoma lefapheng la bongaka lilemong tsa morao tjena.Ke taba e amohelehang horeGanoderma lucidumpolysaccharides (GL-PS) e ka laola ho itšireletsa mafung, empa hobane mokoallo oa mali-boko pakeng tsa boko le methapo ea mali e ka khetha ho thibela lintho tse itseng tse maling ho kena liseleng tsa boko, ebangGanoderma lucidumpolysaccharides e ka thibela glioblastoma bokong e hloka ho netefatsoa ka ho eketsehileng.

Tlaleho e phatlalalitsoeng ka kopanelo ke Sepetlele sa Fujian Medical University Union, Fujian Institute of Neurosurgery, Fujian Agriculture and Forestry University ka Loetse 2018 ho "Integrative Cancer Therapies" e netefalitse hore li-polysaccharides tse arohaneng le 'mele o behang litholoana.Ganoderma lucidum(GL-PS) e ka thibela kholo ea glioblastoma le ho lelefatsa nako ea ho phela ha likhoto tse nang le hlahala.Mokhoa oa eona oa ts'ebetso o amana haufi-ufi le ntlafatso ea ho itšireletsa mafung.

Sephetho sa liteko 1: hlahala e batla e le nyane

GL-PS e sebelisitsoeng tekong ke macromolecular polysaccharide e nang le boima ba molek'hule bo ka bang 585,000 le protheine ea 6.49%.Bafuputsi ba ile ba qala ho kenya lisele tsa glioma bokong ba rat, ebe ba tsamaisa GL-PS ho rat ka ente ea intraperitoneal ka tekanyo ea letsatsi le letsatsi ea 50, 100 kapa 200 mg / kg).

Kamora libeke tse peli tsa kalafo, boholo ba hlahala ea boko ba likhoto tsa liteko bo ile ba hlahlojoa ke MRI (Setšoantšo sa 1A).Liphello li bontšitse hore ha li bapisoa le likhoto tsa sehlopha sa taolo tse neng li entiloe ka lisele tsa mofetše empa li sa fuoe GL-PS, boholo ba hlahala ba likhoto tse fuoeng 50 le 100 mg / kg GL-PS bo fokotsehile ka hoo e ka bang karolo ea boraro ka karolelano. Setšoantšo sa 1B).

Setšoantšo sa 1 Tšusumetso e thibelang ea GL-PS ho lihlahala tsa boko (gliomas)

Sephetho sa liteko 2: ho lelefatsa ho phela

Ka mor'a hore MRI e etsoe, likhoto tsohle tsa liteko li ile tsa tsoela pele ho feptjoa ho fihlela li shoa.Liphello li fumane hore nako e telele ka ho fetisisa e phelang ke likhoto tse fuoeng 100 mg / kg GL-PS.Karolelano ea nako ea ho phela e ne e le matsatsi a 32, e leng nako e telele ho karolo ea boraro ho feta matsatsi a 24 a sehlopha sa taolo.E 'ngoe ea likhoto e bile ea phela matsatsi a 45.Ha e le lihlopha tse ling tse peli tsa likhoto tsa GL-PS, nako e tloaelehileng ea ho phela e ka bang matsatsi a 27, e sa fapaneng haholo le ea sehlopha sa taolo.

Setšoantšo sa 2 Phello ea GL-PS nakong ea bophelo ba likhoto tse nang le lihlahala tsa boko (gliomas)

Sephetho sa liteko 3: Ho ntlafatsa bokhoni ba ho thibela hlahala ba sesole sa 'mele

Bafuputsi ba ile ba tsoela pele ho hlahloba liphello tsaGanoderma lucidumli-polysaccharides tse mabapi le ts'ebetso ea 'mele ea ho itšireletsa mafung ea likhoto tse nang le lihlahala tsa boko mme li fumane hore lisele tsa cytotoxic T (setšoantšo sa 3) lihlahala tsa boko le li-lymphocyte (ho kenyeletsoa lisele tsa T le lisele tsa B) spleen ea likhoto tse kentsoeng ka tsona.Ganoderma lucidumli-polysaccharides li ile tsa eketseha haholo maling.Motsoako oa anti-tumor cytokines, joalo ka IL-2 (interleukin-2), TNF-α (tumour necrosis factor α) le INF-γ (interferon gamma), e patiloeng ke lisele tsa 'mele ea ho itšireletsa mafung le eona e ne e phahame ho feta ea sehlopha sa taolo. .

Ntle le moo, bafuputsi le bona ba netefalitse ka liteko tsa in vitro horeGanoderma lucidumli-polysaccharides ha li khone ho ntlafatsa feela kotsi ea lisele tse bolaeang tsa tlhaho khahlano le lisele tsa glioma empa hape li khothaletsa lisele tsa dendritic (lisele tse ikarabellang bakeng sa ho khetholla lira tsa kantle ho naha le ho qala karabelo ea 'mele ea ho itšireletsa mafung) ho potlakisa ts'ebetso ea sesole sa' mele ho loants'a lisele tsa mofetše. , hape e kenya letsoho ho hlahiseng lisele tsa cytotoxic T (tse ka bolaeang lisele tsa kankere ka bonngoe).

Setšoantšo sa 3 Phello ea GL-PS ho palo ea lisele tsa cytotoxic T ka lihlahala tsa boko (gliomas) 

[Tlhaloso] Ena ke karolo ea lisele tsa boko ba rat, moo karolo e sootho e leng cytotoxic T-cells.Taolo e bolela sehlopha sa taolo, 'me lihlopha tse ling tse tharo ke lihlopha tsa GL-PS.Lintlha tse bontšitsoeng ke tekanyo eaGanoderma lucidumli-polysaccharides tse kenngoa ka har'a sekoti sa intraperitoneal sa likhoto tse nang le hlahala.

Ho bona monyetla oa hoGanoderma lucidumpolysaccharides ho loantša lihlahala bokong

Liphetho tsa lipatlisiso tse ka holimo li bontša hore palo e loketseng eaGanoderma lucidumli-polysaccharides li ka thusa ho loantša lihlahala tsa boko.Hobane li-polysaccharides tse kenngoeng ka mpeng li kenngoa ka har'a mothapo oa sebete 'me li kenngoa ka har'a sebete, ebe li kena mali bakeng sa ho sebelisana le lisele tsa' mele tsa ho itšireletsa mafung.Ka hona, lebaka leo ka lona kholo ea lihlahala tsa boko ba rat e ka laoloang esita le nako ea ho phela e ka lelefatsoa e lokela ho amana le ts'usumetso ea karabelo ea 'mele ea ho itšireletsa mafung le ntlafatso ea ts'ebetso ea' mele ea ho itšireletsa mafung.Ganoderma lucidumli-polysaccharides.

Ho hlakile hore tšitiso ea mali-boko ka sebopeho sa fisioloji e ke ke ea sireletsa phello ea inhibitory eaGanoderma lucidumli-polysaccharides ka lihlahala tsa boko.Liphetho tsa liteko li boetse li re bolella hore tekanyo eaGanoderma lucidumLi-polysaccharides ha li betere ho feta, empa tse nyane haholo li bonahala li na le phello e nyane.Ke bokae "chelete e nepahetseng".Ho ka etsahala hore e fapaneGanoderma lucidumli-polysaccharides li na le litlhaloso tsa tsona, le hore na phello ea tsamaiso ea molomo e ka lekana le ea ente ea intraperitoneal e hloka ho netefatsoa ke lipatlisiso tse ling.

Leha ho le joalo, liphetho tsena bonyane li senotse monyetla oa li-polysaccharides ho tlohaGanoderma lucidumho thibela ho hōla ha hlahala ea boko le ho lelefatsa ho phela, e leng ho ka bang molemo ho leka boemong ba hona joale ba phekolo e fokolang.

[Mohloli] Wang C, et al.Antitumor le Immunomodulatory Activities of Ganoderma lucidum Polysaccharides in Glioma-Bearing Rats.Integr Cancer Ther.2018 Sep; 17(3): 674-683.

[Litšupiso] Tony D'Ambrosio.Glioma vs. Glioblastoma: Ho Utloisisa Phapang ea Kalafo.Lingaka tsa Neurosurgeon tsa New Jersey.2017 Aug 4.

QETA

Mabapi le mongoli/ Mme Wu Tingyao

Wu Tingyao esale a tlaleha ka litaba tsa Ganoderma tsa pele ho tloha 1999. Ke eena mongoli oaHo folisa ka Ganoderma(e hatisitsoe ho The People's Medical Publishing House ka April 2017).

★ Sengoliloeng sena se hatisitsoe tlas'a tumello e khethehileng ea mongoli.★ Libuka tse ka holimo li ke ke tsa hlahisoa, tsa qotsoa kapa tsa sebelisoa ka litsela tse ling ntle le tumello ea mongoli.★ Bakeng sa tlōlo ea polelo e ka holimo, mongoli o tla phehella boikarabelo bo nepahetseng ba molao.★ Sengoloa sa mantlha sa sengoloa sena se ngotsoe ka Sechaena ke Wu Tingyao mme se fetoleloa ho Senyesemane ke Alfred Liu.Haeba ho na le phapang lipakeng tsa phetolelo (Senyesemane) le ea mantlha (Sechaena), Sechaena sa mantlha se tla ba teng.Haeba babali ba na le lipotso, ka kopo ikopanye le sengoli sa mantlha, Mme Wu Tingyao.