Satumba 2018 / Fujian Medical University Union Hospital, da dai sauransu / Haɗin Ciwon Ciwon Kankara

Rubutu/ Wu Tingyao

Yana cin abinciGanoderma lucidumTaimakawa wajen sauƙaƙa alamun masu ciwon ƙwayar ƙwayar cuta?Watakila wannan shi ne rahoto na farko a wata jarida ta duniya don gano illolinGanoderma luciduma cikin hana ciwace-ciwacen kwakwalwa a cikin vivo ta hanyar gwaje-gwajen dabba - yana iya kawo mana wasu tunani.

Glioma nau'in ciwon kwakwalwa ne na kowa.Ana haifar da shi ta rashin haɓakar ƙwayoyin glial waɗanda ke nannade kewaye da ƙwayoyin jijiya.Yana iya zama ƙwayar cuta mai saurin girma (ko zai haifar da ciwon kai da sauran alamun rashin jin daɗi ya dogara da wuri da girman ƙwayar cutar), ko kuma yana iya zama ƙwayar cuta mai girma da sauri.

Mummunan glioma ya rasa aikin gina jiki, tallafawa da kare ƙwayoyin jijiya.Ba wai kawai yana girma da sauri ba, har ma yana iya yaduwa cikin ɗan gajeren lokaci.Irin wannan mummunan glioma, wanda ke girma kuma yana yaduwa da sauri, ana kiransa glioblastoma.Yana daya daga cikin ciwace-ciwacen kwakwalwa da suka fi yawa a cikin mutane.Ko da majiyyata sun sami magani mai tsanani nan da nan bayan ganewar asali, matsakaicin ragowar rayuwarsu shine watanni 14 kawai.5% kawai na marasa lafiya suna rayuwa fiye da shekaru biyar.

Sabili da haka, yadda za a karfafa ƙarfin maganin ciwon daji na tsarin rigakafi na majiyyaci ya zama babban filin bincike a cikin maganin glioblastoma a fannin likitanci a cikin 'yan shekarun nan.Abu ne mai yarda cewaGanoderma lucidumpolysaccharides (GL-PS) na iya daidaita rigakafi, amma saboda shingen kwakwalwar jini tsakanin kwakwalwa da tasoshin jini na iya zaɓar hana wasu abubuwa da ke cikin jini shiga cikin ƙwayoyin kwakwalwa, koGanoderma lucidumpolysaccharides na iya hana glioblastoma a cikin kwakwalwa yana buƙatar ƙarin tabbaci.

Wani rahoto da aka buga tare da Fujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture da Jami'ar gandun daji a cikin Satumba 2018 a cikin "Integrative Cancer Therapies" ya tabbatar da cewa polysaccharides sun ware daga jikin 'ya'yan itace.Ganoderma lucidum(GL-PS) na iya hana haɓakar glioblastoma kuma ya tsawaita lokacin rayuwa na berayen da ke ɗauke da ƙari.Tsarin aikinsa yana da alaƙa da haɓakar rigakafi.

Sakamakon gwaji na 1: ƙwayar cuta ta ɗan ƙaranci

GL-PS da aka yi amfani da shi a cikin gwajin shine polysaccharide macromolecular tare da nauyin kwayoyin kusan 585,000 da abun ciki na furotin na 6.49%.Masu binciken sun fara allurar ƙwayoyin glioma a cikin kwakwalwar bera, sannan suka ba da GL-PS ga bera ta hanyar allurar intraperitoneal a adadin yau da kullun na 50, 100 ko 200 mg/kg).

Bayan makonni biyu na jiyya, yawan kwakwalwar kwakwalwa girman berayen da Mri) ya bincika ta Mri (Hoto 1A).Sakamakon ya nuna cewa idan aka kwatanta da berayen ƙungiyar kulawa waɗanda aka yi musu allura da ƙwayoyin cutar kansa amma ba a ba su GL-PS ba, an rage girman ƙwayar berayen da aka ba 50 da 100 mg/kg GL-PS da kusan kashi ɗaya bisa uku akan matsakaita. Hoto na 1B).

Hoto 1 Tasirin hana GL-PS akan ciwan kwakwalwa (gliomas)

Sakamakon gwaji na 2: tsawaita rayuwa

Bayan da aka yi MRI, duk berayen gwaji sun ci gaba da ciyar da su har sai sun mutu.Sakamakon ya gano cewa mafi dadewa da rai shine berayen da aka ba su 100 mg/kg GL-PS.Matsakaicin lokacin rayuwa shine kwanaki 32, wanda ya kasance kashi ɗaya bisa uku fiye da kwanakin 24 na ƙungiyar kulawa.Daya daga cikin berayen ma ya rayu tsawon kwanaki 45.Dangane da sauran rukunoni biyu na berayen GL-PS, matsakaicin lokacin rayuwa shine kusan kwanaki 27, wanda bai bambanta da na ƙungiyar kulawa ba.

Hoto 2 Tasirin GL-PS akan tsawon rayuwar berayen tare da ciwan kwakwalwa (gliomas)

Sakamakon gwaji na 3: Inganta ƙarfin rigakafin ƙwayar cuta na tsarin rigakafi

Masu binciken sun kara bincikar illolinGanoderma lucidumpolysaccharides akan aikin rigakafi na berayen tare da ciwace-ciwacen ƙwayoyin cuta kuma sun gano cewa ƙwayoyin cytotoxic T (Hoto 3) a cikin ciwace-ciwacen ƙwayoyin cuta da ƙwayoyin lymphocytes (ciki har da ƙwayoyin T da ƙwayoyin B) a cikin ɓarna na berayen da aka yi musu allura.Ganoderma lucidumpolysaccharides sun karu sosai a cikin jini.Matsakaicin cytokines anti-tumor, irin su IL-2 (interleukin-2), TNF-a (tumo necrosis factor α) da INF-γ (interferon gamma), wanda ƙwayoyin rigakafi suka ɓoye su kuma sun fi na ƙungiyar kulawa. .

Bugu da kari, masu binciken sun kuma tabbatar ta hanyar gwaje-gwajen in vitro cewaGanoderma lucidumpolysaccharides ba kawai zai iya haɓaka kisa na ƙwayoyin kisa na halitta ba akan ƙwayoyin glioma amma kuma suna haɓaka ƙwayoyin dendritic (sel ɗin da ke da alhakin gano maƙiyan ƙasashen waje da fara amsawar rigakafi a cikin tsarin rigakafi) don hanzarta kunna tsarin rigakafi don yaƙar ƙwayoyin cutar kansa. , da kuma taimakawa wajen samar da kwayoyin cytotoxic T (wanda zai iya kashe kwayoyin cutar kansa daya-da-daya).

Hoto 3 Tasirin GL-PS akan adadin ƙwayoyin T-cytotoxic a cikin ciwace-ciwacen ƙwaƙwalwa (gliomas) 

[Bayani] Wannan sashe na nama ne na cutar kwakwalwa, wanda launin ruwan kasa shine sel cytotoxic T-sel.Sarrafa yana nufin ƙungiyar kulawa, kuma sauran ƙungiyoyi uku sune ƙungiyoyin GL-PS.Bayanan da aka nuna shine kashi naGanoderma lucidumpolysaccharides allura a cikin kogon intraperitoneal na berayen da ke ɗauke da ƙari.

Ganin damarGanoderma lucidumpolysaccharides don yaki da ciwan kwakwalwa

Sakamakon bincike na sama ya nuna cewa adadin da ya daceGanoderma lucidumpolysaccharides na iya taimakawa wajen yaki da ciwan kwakwalwa.Domin polysaccharides da aka yi wa allurar a cikin rami na ciki suna shiga ta hanyar jijiyar hanta kuma hanta ta daidaita sannan kuma su shiga cikin jini don yin hulɗa da ƙwayoyin rigakafi a cikin jini.Saboda haka, dalilin da ya sa za a iya sarrafa ci gaban ciwan kwakwalwar bera kuma har ma da lokacin rayuwa na iya tsawaita ya kamata ya kasance yana da alaƙa da haɓakar amsawar rigakafi da haɓaka aikin rigakafi ta hanyar.Ganoderma lucidumpolysaccharides.

Babu shakka, shingen jini-kwakwalwa a cikin tsarin ilimin lissafi ba zai kare tasirin hanawa baGanoderma lucidumpolysaccharides akan ciwan kwakwalwa.Sakamakon gwaji ya kuma gaya mana cewa adadinGanoderma lucidumpolysaccharides ba shine mafi kyau ba, amma kadan kadan yana da tasiri kadan.Nawa ne "adadin da ya dace".Yana yiwuwa dabanGanoderma lucidumpolysaccharides suna da nasu ma'anar, kuma ko tasirin gudanarwa na baki zai iya zama daidai da na allurar intraperitoneal yana buƙatar tabbatar da ƙarin bincike.

Koyaya, waɗannan sakamakon sun aƙalla sun bayyana yiwuwar polysaccharides dagaGanoderma lucidumhana haɓakar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta za ta iya zama abin da ya kamata a yi la'akari da shi a halin da ake ciki na jiyya mai iyaka.

[Madogararsa] Wang C, et al.Ayyukan Antitumor da Immunomodulatory na Ganoderma lucidum Polysaccharides a cikin Berayen Glioma.Integr Cancer Ther.2018 Satumba; 17 (3): 674-683.

[References] Tony D'Ambrosio.Glioma vs. Glioblastoma: Fahimtar bambance-bambancen Jiyya.Neurosurgeons na New Jersey.4 ga Agusta 2017.

KARSHE

Game da marubucin / Ms. Wu Tingyao

Wu Tingyao ta kasance tana ba da rahoto game da bayanan Ganoderma na farko tun 1999. Ita ce marubucin labarun Ganoderma.Waraka tare da Ganoderma(an buga a The People's Medical Publishing House a Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubucin.★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cire su ko amfani da su ta wasu hanyoyi ba tare da izinin marubuci ba.★ Don keta bayanin da ke sama, marubucin zai bi alhakin da ya dace na shari'a.★ Asalin rubutun wannan labarin Wu Tingyao ne ya rubuta shi da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.