Malignant glioma yakarasa basa rekupa chikafu, kutsigira nekudzivirira masero etsinga.Haisi kungokura nekukurumidza, asi inogonawo kupararira munguva pfupi.Mhando iyi yemalignant glioma, inokura nekupararira nekukurumidza, inonziwo glioblastoma.Ndiyo imwe yeakajairika uye anouraya mamota ehuropi muvanhu.Kunyangwe kana varwere vakagamuchira kurapwa kwehasha mushure mekuongororwa, avhareji yehupenyu hwasara imwedzi gumi nemina chete.Chete 5% yevarwere vanorarama kwemakore anopfuura mashanu.

Naizvozvo, maitiro ekusimbisa zvinobudirira kurwisa kenza kugona kwemurwere wega immune system yave iyo nzvimbo huru yekuongorora mukurapa glioblastoma munharaunda yekurapa mumakore achangopfuura.Ichokwadi chinogamuchirwa kutiGanoderma lucidumpolysaccharides (GL-PS) inogona kudzora kusadzivirirwa kwemuviri, asi nekuti iyo yeropa-brain chipingamupinyi pakati pehuropi nemidziyo yeropa inogona kusarudza kudzivirira zvimwe zvinhu zviri muropa kuti zvipinde mumasero europi, kungave.Ganoderma lucidumpolysaccharides inogona kurambidza glioblastoma muuropi inoda kusimbiswa zvakare.

Chirevo chakaburitswa pamwe chete neFujian Medical University Union Hospital, Fujian Institute of Neurosurgery, Fujian Agriculture uye Forestry University munaGunyana 2018 mu "Integrative Cancer Therapies" yakasimbisa kuti ma polysaccharides akaparadzaniswa nemuviri wemuchero we.Ganoderma lucidum(GL-PS) inogona kudzivisa kukura kweglioblastoma uye kuwedzera nguva yekurarama kwemakonzo anotakura bundu.Iyo nzira yekuita kwayo yakabatana zvakanyanya nekuvandudzwa kwekudzivirira.

Kuedza mhedzisiro 1: bundu racho idiki

Iyo GL-PS inoshandiswa mukuedza ndeye macromolecular polysaccharide ine molecular uremu hunosvika 585,000 uye mapuroteni ane 6.49%.Vatsvakurudzi vakatanga kuisa masero eglioma muuropi hwegonzo, ndokuzopa GL-PS kugonzo nejekiseni remukati memushonga wezuva nezuva we50, 100 kana 200 mg/kg.

Mushure memavhiki maviri ekurapwa, hukuru hwebundu rehuropi hwemakonzo ekuyedza akaongororwa neMRI (Mufananidzo 1A).Mhedzisiro yacho yakaratidza kuti kana ichienzaniswa neboka rekudzora makonzo akaiswa inoculated nekenza maseru asi asina kupihwa GL-PS, bundu remakonzo akapihwa 50 uye 100 mg / kg GL-PS yakaderedzwa neinenge chikamu chimwe muzvitatu paavhareji. Mufananidzo 1B).

Mufananidzo 1 Iyo inhibitory mhedzisiro yeGL-PS pamamota europi (gliomas)

Chiyedzo mhedzisiro yechipiri: kurebesa kurarama

Mushure mokunge MRI yaitwa, makonzo ose ekuedza akaramba achipiwa zvokudya kusvikira afa.Mhedzisiro yakawana kuti akareba kwazvo aive makonzo akapihwa 100 mg/kg GL-PS.Avhareji yenguva yekupona yaive mazuva makumi matatu nemaviri, iyo yaive yakareba chikamu chimwe muzvitatu kupfuura mazuva makumi maviri nemana eboka rinodzora.Rimwe remakonzo rakanga richirarama kwemazuva makumi mana nemashanu.Kana ari mamwe mapoka maviri e-GL-PS rats, nguva yenguva yekupona inenge mazuva 27, iyo isina kunyanya kusiyana neboka rekutonga.

Mufananidzo 2 Mhedzisiro yeGL-PS pahupenyu hwemakonzo ane mamota ehuropi (gliomas)

Kuedza mhedzisiro 3: Kuvandudza iyo anti-tumor kugona kweiyo immune system

Vatsvakurudzi vakawedzera kuongorora migumisiro yeGanoderma lucidumpolysaccharides pane immune function yemakonzo ane mabundu ehuropi uye akawana kuti cytotoxic T masero (Mufananidzo 3) muuropi tumors uye lymphocytes (kusanganisira T Cells uye B masero) muspleen yemakonzo akabaiwaGanoderma lucidumpolysaccharides yakawedzera zvakanyanya muropa.Kuwanda kweanti-tumor cytokines, zvakadai seIL-2 (interleukin-2), TNF-α (tumor necrosis factor α) uye INF-γ (interferon gamma), yakavanzwa nemasero ekudzivirira zvirwere yakanga yakakwirirawo kupfuura yeboka rinodzora. .

Pamusoro pezvo, vaongorori vakasimbisawo kuburikidza ne in vitro kuyedza izvoGanoderma lucidumpolysaccharides haingogone kuwedzera kuuraya kwemasero anouraya echisikigo achipokana nemasero eglioma asiwo kukurudzira dendritic masero (masero ane basa rekuona vavengi vekune dzimwe nyika uye kutanga maitiro ezvirwere zvemuviri wedziviriro) kukurumidza kuita activation ye immune system kurwisa cancer maseru. , uye zvakare inobatsira mukugadzirwa kwecytotoxic T masero (anogona kuuraya cancer maseru one-to-one).

Mufananidzo 3 Mhedzisiro yeGL-PS pahuwandu hwecytotoxic T-masero muuropi tumors (gliomas) 

[Tsanangudzo] Ichi chikamu chematishu chegonzo reuropi bundu, umo chikamu chebrown chiri cytotoxic T-masero.Kudzora kunoreva boka rekutonga, uye mamwe mapoka matatu mapoka eGL-PS.Iyo data yakaratidzwa ndiyo dose yeGanoderma lucidumpolysaccharides jekiseni mu intraperitoneal mhango yemakonzo anotakura bundu.

Kuona mukana weGanoderma lucidumpolysaccharides kurwisa mamota europi

Migumisiro yekutsvakurudza iri pamusoro inoratidza kuti chiyero chakakodzera cheGanoderma lucidumpolysaccharides inogona kubatsira kurwisa mamota europi.Nekuti mapolysaccharides akabaiwa mugomba remudumbu anotorwa nepakati pechiropa tsinga uye anogadzikiswa nechiropa uye obva apinda mukutenderera kweropa kwekudyidzana nemasero ekudzivirira muropa.Naizvozvo, chikonzero nei kukura kwemakonzo brain tumors kuchigona kudzorwa uye kunyangwe nguva yekurarama inogona kurebedzwa inofanirwa kuve ine chekuita nekukurudzira kwekudzivirira kwemuviri uye kuvandudzwa kwesimba rekudzivirira muviri.Ganoderma lucidumpolysaccharides.

Zviripachena, iyo yeropa-brain chipingamupinyi mune ye physiological chimiro hachizo dzivirira inhibitory mhedzisiro yeGanoderma lucidumpolysaccharides pamamota europi.Zviyedzo zvabuda zvinotiudzawo kuti dosige yeGanoderma lucidumpolysaccharides haisi iyo yakanyanya kunaka, asi yakawandisa inoita seisina mhedzisiro.Imarii iyo "mari yakakodzera".Zvinogoneka kuti zvakasiyanaGanoderma lucidumpolysaccharides ine tsananguro dzadzo, uye kana mhedzisiro yekutonga nemuromo inogona kuenzana neiyo intraperitoneal jekiseni inoda kusimbiswa nekumwe tsvagiridzo.

Nekudaro, izvi zvawanikwa zvakaratidza mukana wepolysaccharides kubvaGanoderma luciduminhibiting brain tumor growth uye kurebesa kurarama, izvo zvingave zvakakodzera kuedza mumamiriro ezvinhu epanguva ino yekurapa kushoma.

[Kwakabva] Wang C, et al.Antitumor uye Immunomodulatory Mabasa eGanoderma lucidum Polysaccharides muGlioma-Bearing Rats.Integr Cancer Ther.2018 Sep;17(3):674-683.

[Mashoko] Tony D'Ambrosio.Glioma vs. Glioblastoma: Kunzwisisa Kusiyanisa Kurapa.Neurosurgeons yeNew Jersey.2017 Aug 4.

END

Nezve munyori/ Ms. Wu Tingyao

Wu Tingyao anga achizivisa nezvekutanga-ruoko ruzivo rweGanoderma kubvira 1999. Ndiye munyori weKuporesa neGanoderma(yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★ Chinyorwa ichi chakatsikiswa pasi pemvumo yakasarudzika yemunyori.★ Mabhuku ari pamusoro haagone kutsikiswa, kutorwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori.★ Nekutyorwa kwechirevo chiri pamusoro, munyori achatevera mabasa akakodzera emutemo.★ Manyoro ekutanga echinyorwa ichi akanyorwa neChinese naWu Tingyao uye akashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.