Nzeri 2018 / Ibitaro by’ubuvuzi bya kaminuza ya Fujian, nibindi / Ubuvuzi bwa Kanseri

Inyandiko / Wu Tingyao

KuryaGanoderma lucidumfasha kugabanya ibimenyetso byabarwayi bo mubwonko?Iyi ishobora kuba ari raporo yambere mu kinyamakuru mpuzamahanga cyo gusuzuma ingaruka zaGanoderma lucidummuguhagarika ibibyimba byubwonko muri vivo binyuze mubushakashatsi bwinyamaswa - birashobora kutuzanira ibitekerezo bimwe.

Glioma ni ubwoko busanzwe bw'ikibyimba mu bwonko.Iterwa no gukwirakwira bidasanzwe kwingirangingo zifata ingirabuzimafatizo.Irashobora kuba ikibyimba gikura buhoro buhoro (cyaba gitera umutwe nibindi bimenyetso bitameze neza biterwa nubunini nubunini bwikibyimba), cyangwa gishobora kuba ikibyimba kibi gikura vuba.

Indwara ya glioma yatakaje imikorere yo kugaburira, gushyigikira no kurinda ingirabuzimafatizo.Ntabwo ikura vuba gusa, ariko irashobora no gukwirakwira mugihe gito.Ubu bwoko bwa glioma mbi, ikura kandi ikwirakwira vuba, nanone yitwa glioblastoma.Ni kimwe mu bibyimba bikunze kubaho kandi byica abantu mu bwonko.Nubwo abarwayi bahabwa imiti ikaze nyuma yo kwisuzumisha, impuzandengo yabo yo kubaho ni amezi 14 gusa.5% gusa by'abarwayi barokoka imyaka irenga itanu.

Kubwibyo, uburyo bwo gushimangira neza ubushobozi bwo kurwanya kanseri sisitemu yumubiri yumurwayi byabaye umurima wingenzi mubushakashatsi mukuvura glioblastoma mubuvuzi mumyaka yashize.Ni ibintu byemewe koGanoderma lucidumpolysaccharide (GL-PS) irashobora kugenga ubudahangarwa, ariko kubera ko inzitizi yubwonko bwamaraso hagati yubwonko nimiyoboro yamaraso irashobora guhitamo kubuza ibintu bimwe na bimwe mumaraso kwinjira mubwonko bwubwonko, bwabaGanoderma lucidumpolysaccharide irashobora kubuza glioblastoma mubwonko igomba kwemezwa neza.

Raporo yasohowe hamwe n’ibitaro by’ubumwe by’ubuvuzi bya kaminuza ya Fujian, Ikigo cya Fujian cy’ubuvuzi bwa Neurosurgie, kaminuza y’ubuhinzi n’amashyamba ya Fujian muri Nzeri 2018 muri “Integrated Cancer Therapies” yemeje ko polysaccharide yitaruye umubiri wera imbuto.Ganoderma lucidum(GL-PS) irashobora kubuza gukura kwa glioblastoma no kongera igihe cyo kubaho kwimbeba zifite ibibyimba.Uburyo bwibikorwa bifitanye isano rya bugufi no kunoza ubudahangarwa.

Ibisubizo byubushakashatsi 1: ikibyimba ni gito

GL-PS ikoreshwa mubushakashatsi ni macromolecular polysaccharide ifite uburemere bwa molekile hafi 585.000 hamwe na proteyine ya 6.49%.Abashakashatsi babanje gutera ingirabuzimafatizo za glioma mu bwonko bw'imbeba, hanyuma batanga GL-PS ku mbeba bakoresheje inshinge za intraperitoneal ku gipimo cya buri munsi cya 50, 100 cyangwa 200 mg / kg).

Nyuma yibyumweru bibiri bivurwa, ubunini bwikibyimba cyubwonko bwimbeba zageragejwe na MRI (Ishusho 1A).Ibisubizo byerekanye ko ugereranije nimbeba zo kugenzura zatewe kanseri ya kanseri ariko zidahabwa GL-PS, ubunini bwibibyimba byimbeba zahawe 50 na 100 mg / kg GL-PS byagabanutseho kimwe cya gatatu ugereranije ( Igicapo 1B).

Igishushanyo 1 Ingaruka zo kubuza GL-PS kubyimba ubwonko (glioma)

Ibisubizo byubushakashatsi 2: kuramba

MRI imaze gukorwa, imbeba zose zigerageza zakomeje kugaburirwa kugeza zipfuye.Ibisubizo byagaragaye ko igihe kirekire ari imbeba zahawe mg / kg 100 GL-PS.Ugereranyije igihe cyo kubaho cyari iminsi 32, kikaba cyari kimwe cya gatatu kurenza iminsi 24 yitsinda rishinzwe kugenzura.Imwe mu mbeba yari muzima iminsi 45.Naho andi matsinda abiri yimbeba za GL-PS, impuzandengo yo kubaho ni iminsi 27, ntabwo itandukanye cyane niyitsinda rishinzwe kugenzura.

Igishushanyo 2 Ingaruka za GL-PS ku mibereho yimbeba zifite ibibyimba byo mu bwonko (glioma)

Ibisubizo byubushakashatsi 3: Kunoza ubushobozi bwo kurwanya ibibyimba sisitemu yumubiri

Abashakashatsi bakomeje gukora ubushakashatsi ku ngaruka zaGanoderma lucidumpolysaccharide ku mikorere yubudahangarwa bwimbeba zifite ibibyimba byo mu bwonko maze isanga selile cytotoxic T (Ishusho 3) mu bibyimba byo mu bwonko na lymphocytes (harimo na T selile na B selile) mu ruhago rwimbeba zateweGanoderma lucidumpolysaccharide yariyongereye cyane mumaraso.Ubwinshi bwa cytokine irwanya ibibyimba, nka IL-2 (interleukin-2), TNF-α (tumor necrosis factor α) na INF-γ (interferon gamma), yasohowe na selile immunite nayo yari hejuru kurenza iy'itsinda rishinzwe kugenzura .

Byongeye kandi, abashakashatsi bemeje kandi binyuze mu bushakashatsi bwa vitro koGanoderma lucidumpolysaccharide ntishobora kongera gusa kwica ingirabuzimafatizo zica zirwanya selile glioma ahubwo inateza imbere selile dendritic (selile ishinzwe kumenya abanzi b’amahanga no gutangiza ubudahangarwa bw'umubiri muri sisitemu y’umubiri) kugirango byihutishe imikorere y’umubiri urwanya kanseri ya kanseri. , kandi ikanagira uruhare mu kubyara selile ya cytotoxic T (ishobora kwica kanseri imwe kuri imwe).

Igicapo 3 Ingaruka za GL-PS ku mubare wa cytotoxic T-selile yibibyimba byo mu bwonko (glioma) 

Iki ni igice cyumubiri cyikibyimba cyubwonko bwimbeba, aho igice cyumukara ari cytotoxic T-selile.Igenzura bivuga itsinda rishinzwe kugenzura, andi matsinda atatu ni GL-PS.Ibyerekanwe ni igipimo cyaGanoderma lucidumpolysaccharide yatewe mu mwobo wa intraperitoneal yimbeba zifite ibibyimba.

Kubona amahirwe yaGanoderma lucidumpolysaccharide yo kurwanya ibibyimba byo mu bwonko

Ibisubizo byubushakashatsi byavuzwe haruguru byerekana ko umubare ukwiye waGanoderma lucidumpolysaccharide irashobora gufasha kurwanya ibibyimba byo mu bwonko.Kuberako polysaccharide yatewe mumyanya yinda yinjizwa mumitsi yumwijima hanyuma igahindurwa numwijima hanyuma ikinjira mumaraso kugirango imikoranire ningirangingo z'umubiri mumaraso.Kubwibyo, impanvu ituma imikurire yibibyimba byubwonko bwimbeba ishobora kugenzurwa ndetse nigihe cyo kubaho gishobora kumara igihe kirekire bigomba kuba bifitanye isano no gukangura ubudahangarwa bw'umubiri ndetse no kunoza imikorere yubudahangarwa naGanoderma lucidumpolysaccharide.

Ikigaragara ni uko inzitizi yamaraso-ubwonko muburyo bwa physiologique itazarinda ingaruka zo kubuzaGanoderma lucidumpolysaccharide ku bibyimba byo mu bwonko.Ibisubizo byubushakashatsi bitubwira kandi ko dosiye yaGanoderma lucidumpolysaccharide ntabwo aribyiza cyane, ariko bike cyane bisa nkibidafite ingaruka nke.Ni bangahe "umubare ukwiye".Birashoboka ko bitandukanyeGanoderma lucidumpolysaccharide ifite ibisobanuro byayo, kandi niba ingaruka zubuyobozi bwo mu kanwa zishobora kuba zihwanye n’inshinge za intraperitoneal bisaba kwemezwa n’ubushakashatsi bwakozwe.

Ariko, ibisubizo byibuze byagaragaje bishoboka ko polysaccharide iturukaGanoderma lucidumkubuza ikibyimba mu bwonko gukura no kuramba, bishobora kuba byiza kugerageza mubihe byubuvuzi buke.

[Inkomoko] Wang C, n'abandi.Antitumor na Immunomodulatory Ibikorwa bya Ganoderma lucidum Polysaccharide muri Glioma-Yera Imbeba.Indwara ya Kanseri.2018 Nzeri; 17 (3): 674-683.

Tony D'Ambrosio.Glioma na Glioblastoma: Gusobanukirwa Itandukaniro ryo Kuvura.Neurosurgueons wa New Jersey.2017 Kanama 4.

IHEREZO

Ibyerekeye umwanditsi / Madamu Wu Tingyao

Wu Tingyao yagiye atanga amakuru ku makuru ya Ganoderma kuva mu 1999. Ni umwanditsi waGukiza hamwe na Ganoderma(byasohotse mu gitabo cy’ubuvuzi cy’abaturage muri Mata 2017).

★ Iyi ngingo yasohowe uruhushya rwihariye rwumwanditsi.Works Ibikorwa byavuzwe haruguru ntibishobora gusubirwamo, gucibwa cyangwa gukoreshwa mubundi buryo utabiherewe uburenganzira n'umwanditsi.★ Kurenga ku magambo yavuzwe haruguru, umwanditsi azakurikirana inshingano zemewe n'amategeko.Text Umwandiko wumwimerere wiyi ngingo wanditswe mu gishinwa na Wu Tingyao uhindurwa mu cyongereza na Alfred Liu.Niba hari itandukaniro riri hagati yubuhinduzi (icyongereza) numwimerere (igishinwa), igishinwa cyumwimerere kizatsinda.Niba abasomyi bafite ikibazo, nyamuneka hamagara umwanditsi wambere, Madamu Wu Tingyao.