Eli nqaku liphinda liveliswe kwi-94 yemagazini ye-GANODERMA ngo-2022. I-copyright yenqaku lombhali.

Zhi-Bin Lin, unjingalwazi weSebe le-Pharmacology, iYunivesithi yasePeking yeSiseko seNzululwazi yezoNyango

Kweli nqaku, uProf. Lin wazisa iimeko ezimbini ezichazwe kwiijenali zesayensi.Enye yazo yayikukuthathaI-Ganoderma lucidumUmgubo we-spore unyange i-gastric diffuse enkulu ye-B cell lymphoma, kwaye enye yayikuthathaI-Ganoderma lucidumumgubo wabangela ihepatitis enetyhefu.Owangaphambili wangqina ukuba ukuncipha kwe-tumor kwakunxulumeneI-Ganoderma lucidumumgubo we-spore ngelixa le yokugqibela iveze iinkxalabo ezifihlakeleyo ezibangelwa ziimveliso ezikumgangatho ophantsi weGanoderma.Ke ngoko, uvuyo olunye kunye nomothuko omnye ukhumbuze abathengi ukuba balumke xa bethenga iimveliso zeGanoderma ukuze bangachithi imali kwaye benzakalise imizimba yabo!

Iijenali zonyango ezininzi zinekholamu "yeNgxelo yeNgxelo" enika ingxelo ngeziphumo ezinentsingiselo ezivela kuxilongo kunye nonyango lwesigulane ngasinye, kunye nokufumanisa iziphumo okanye iziphumo ezibi kakhulu zamachiza.Kwimbali yezonyango, ngamanye amaxesha izinto ezifunyenwe ngumntu zikhuthaza uphuhliso lwesayensi.

Ngokomzekelo, isazi sebhaktiriya saseBrithani u-Alexander Fleming waqala wafumanisa waza wachaza ukuba i-penicillin secretion ine-anti-staphylococcal effect ngo-1928, kwaye wayibiza ngokuba yi-penicillin.Oku kufunyaniswayo kwagcinwa iminyaka emininzi de kwangowe-1941 xa usokhemesti waseBritane uHoward Walter Florey kunye nengcali yenzululwazi yezinto eziphilayo yaseJamani u-Ernest Chain baphefumlelwa liphepha likaFleming ukuba bagqibezele ukucocwa kwepenicillin kunye novavanyo lwayo lwe-anti-streptococci pharmacological kwaye yangqina ukusebenza kwayo kwe-antibacterial kwisigulana esifayo, ipenicillin yaqala. ukufumana ingqalelo.

Emva kophando lwabo lwesibini kunye nophuhliso, i-penicillin iye yaveliswa kwinqanaba lemizi-mveliso njengeyeza lokuqala lokubulala iintsholongwane elisetyenziswa kwimbali yoluntu, lisindisa ubomi obungenakubalwa kwaye libe yinto efunyenweyo enkulu kwinkulungwane yama-20.Ke ngoko, uFleming, uFlorey kunye noChain, abanxibelelana nophando kunye nokuphuhlisa ipenicillin, bawongwa ngebhaso leNobel le-1945 kwiPhysiology and Medicine.

Ezi ngxelo zimbini zilandelayo zezehlo zeklinikhi zeI-Ganoderma lucidum, nangona zifunyenwe ngamabona-ndenzile, ziye zahlolisiswa ngenyameko zaza zahlalutywa yintatheli.Eyangaphambili ibonelela ngobungqinaukusetyenziswa kweI-Ganoderma lucidumkunyango lwe-diffuse B cell lymphoma (DLBCL) enkulu esiswiningelixa le yokugqibela Isixelela loo ntoembiI-Ganoderma lucidumiimveliso kunokubangelaihepatitis enetyhefu.

I-Ganoderma lucidumUmgubo we-spore uphilise imeko ye-gastric diffuse enkulu ye-B-cell lymphoma. 

Kukho iimeko ezininzi ebantwini ukubaI-Ganoderma luciduminesiphumo sokunyanga umhlaza, kodwa kunqabile ukuba kuxelwe kwiimpapasho zeengcali zonyango.

Kwi-2007, u-Wah Cheuk et al.kwisibhedlele iQueen Elizabeth eHong Kong ingxelo kwiIjenali yeHlabathi yePathology yoTyandoityala lesigulane esineminyaka engama-47 ubudala esingenambali yonyango efanelekileyo eya esibhedlele ngoJanuwari 2003 ngenxa yentlungu yesisu esiphezulu.

Helicobacter pyloriusulelo lufunyenwe luhle ngovavanyo lokuphefumula kwe-urea, kwaye indawo enkulu yesilonda esiswini yafunyanwa kwingingqi ye-pyloric yesisu nge-gastroscopy.Isampulu ye-Biopsy ibonise inani elikhulu le-lymphocyte ephakathi ukuya kumakhulu amakhulu angena kudonga lwesisu, kunye ne-nuclei emile ngokungaqhelekanga, i-chromatin evaliweyo ebekwe kwi-nucleus, kunye ne-nucleoli evelele.

I-Immunohistochemical staining ibonise ukuba ezi seli zilungile kwi-CD20, i-antigen ye-B-cell differentiation, echazwe ngaphezu kwe-95% ye-B-cell lymphomas, ngelixa iiseli ezincedisayo ze-T (Th), iiseli ze-cytotoxic T (CTL) kunye neeseli ze-T ezilawulayo (Treg). ) zazingalunganga kwi-CD3, kunye ne-Ki67 index proliferation index, ebonisa umsebenzi okhulayo weeseli ze-tumor, yayiphezulu njenge-85%.Isigulana safunyaniswa ukuba sine-gastric diffuse enkulu ye-B-cell lymphoma.

Ukusukela oko isigulane sivavanywe ukuba sinaloHelicobacter pyloriusulelo, isibhedlele sagqiba ekubeni senzeHelicobacter pyloriUkuphelisa unyango kwisigulane ukususela ngoFebruwari 1 ukuya kwi-7, kulandelwa ukuhlinzwa ngokuhlinzwa ngoFebruwari 10. Okumangalisayo kukuba,Uvavanyo lwe-pathological lwesampulu zezicubu zesisu ezisetyenzisiweyo alukhange luveze utshintsho lwe-histopathological ye-diffuse B-cell lymphoma enkulu kodwa endaweni yoko lufumene inani elikhulu leeseli ezincinci ze-CD3+CD8+ ze-cytotoxic T ezingena kubunzima obugcweleyo bodonga lwesisu, kunye ne-Ki67 proliferation index yehla. ukuya ngaphantsi kwe-1%.

Ukongezelela, kwi-situ i-RT-PCR ukufumanisa i-T cell receptor beta chain (TCRβ) i-mRNA gene ibonise iphethini ye-polyclonal, kwaye akukho nombolo ye-cell ye-T monoclonal yafunyanwa.

Iziphumo zovavanyo ezinikezelwe yintatheli zibonise ukuba iiseli ze-T kwizicubu zesisu zesigulane zaziqhelekile kunokuba zibi.Ngenxa yokuba iiseli ze-tumor zilahlekelwa ukukwazi ukwahlula kunye nokuvuthwa kwaye zinempawu ezifanayo zofuzo kuphela, ziyi-monoclonal ngelixa ukwanda kweeseli eziqhelekileyo kuyi-polyclonal.

Kuye kwafundwa kuphando ukuba isigulane sathatha i-60 capsulesI-Ganoderma lucidumI-powder spore (i-3 amaxesha e-dose ephakanyisiweyo ye-recommender) ngosuku ukususela ngoFebruwari 1 ukuya ku-5. Emva kokuhlinzwa, isigulane asizange sifumane naluphi na unyango lwe-adjuvant, kwaye i-tumor ayizange iphinde iphinde iphinde iphinde iphinde ilandele iminyaka emibini enesiqingatha. -phezulu.

Abaphandi bakholelwa ukuba iziphumo ze-immunohistochemical zeesampulu ze-biopsy ezenziwe ngotyando azikuxhasi ukuba kunokwenzekaHelicobacter pyloriUkupheliswa kwe-B-cell lymphoma enkulu, ngoko bacinga ukuba kunokwenzeka ukuba izigulane zithatha iidosi ezinkuluI-Ganoderma lucidumI-spore powder ikhuthaza ukusabela okusebenzayo komzimba kwiiseli ze-cytotoxic T kwi-B-cell lymphoma enkulu, nto leyo ekhokelela ekuphelisweni kwethumba [1].

Le ngxelo yecala inokuxilongwa okucacileyo kunye nenkqubo yonyango.Umbhali wenqaku uye wabonisa ukuba ukuguqulwa kwe-tumor kuhambelanaI-Ganoderma lucidumumgubo we-spore ngokusebenzisa uhlalutyo lwe-histopathological kunye neselula kunye ne-molekyuli yebhayoloji, enobunzululwazi kakhulu kwaye ifanele uphando oluthe kratya.

Oku kulandelayo yimeko ye-hepatitis eyityhefu eyenziwa nguI-Ganoderma lucidumumgubo.

Izifundo ezininzi ze-pharmacological ziye zabonisa ukubaI-Ganoderma lucidumisicatshulwa somzimba weziqhamo kunye neepolysaccharides zayo kunye ne-triterpenes, ngokunjaloI-Ganoderma lucidumumgubo we-spore, uneziphumo ezicacileyo ze-hepatoprotective.Banesiphumo esicacileyo sokuphucula kunyango lweklinikhi ye-hepatitis yentsholongwane.

Nangona kunjalo, kwi-2004, uMan-Fung Yuen et al.yeYunivesithi yaseHong Kong School of Medicine yabika ingxelo yetyalaI-Ganoderma lucidumihepatitis eyityhefu eyenziwe ngumgubo kwiIjenali yeHepatology.

Ixhegwazana elineminyaka engama-78 ubudala liye lafuna unyango kwesi sibhedlele ngenxa yokungabi namdla wokutya, ukurhawuzelelwa kwesikhumba, nomchamo omdaka kangangeeveki ezimbini.Isigulana sasinembali yoxinzelelo lwegazi kwaye besithatha ichiza le-antihypertensive i-felodipine ngokwesiqhelo iminyaka emi-2.Ngeli xesha, iimvavanyo zesibindi sakhe zaziqhelekileyo, kwaye wathatha i-calcium, iipilisi ze-multivitamin kunyeI-Ganoderma lucidumyedwa.Emva kokuthatha i-decoctedI-Ganoderma lucidumunyaka omnye, isigulane satshintshela kwintengiso entsha ekhoyoI-Ganoderma lucidumimveliso yomgubo. Swavelisa ezi zimpawu zingasentla emva kweeveki ezine zokuthathaimveliso enjalo.

Uvavanyo lomzimba lubonakalise i-jaundice ephawulweyo kwisigulane.Iziphumo zovavanyo lwe-biochemical yegazi lakhe ziboniswe kwitheyibhile engezantsi.Uvavanyo lwe-immunological luthintele ukuba kunokwenzeka ukuba umguli ophethwe yintsholongwane ye-hepatitis A, B, C, kunye no-E. Iziphumo ze-histopathological ze-biopsy yesibindi zibonise ukuba isigulane sinotshintsho lwe-pathological kwi-hepatitis enetyhefu yeziyobisi.

Ngexesha lonyaka wokuthathaI-Ganoderma lucidumi-decoction yamanzi, isigulane asizange sibonise ukungaqhelekanga.Kodwa emva kokutshintshela kwintengiso ekhoyoI-Ganoderma lucidumpowder, ngokukhawuleza waba neempawu ze-hepatitis enetyhefu.Emva kokuyeka iI-Ganoderma lucidumpowder, izalathi zakhe zegazi ze-biochemical ezikhankanywe ngasentla ngokuthe ngcembe zabuyela kwimeko yesiqhelo.Ngoko ke, isigulane safunyaniswa ukuba sinetyhefu ye-hepatitis ebangelwa yiI-Ganoderma lucidumumgubo.Intatheli iveze ukuba ukusukela ekuqulunqweni kweI-Ganoderma lucidumUmgubo awukwazanga ukufunyanwa, kuyafaneleka ukuqwalasela ukuba i-toxicity yesibindi ibangelwa ezinye izithako okanye utshintsho lwedosi emva kokutshintsha ukuthathaI-Ganoderma lucidumumgubo [2].

Ekubeni intatheli ayizange ichaze umthombo kunye neempawu zeI-Ganoderma lucidumumgubo, akucacanga ukuba lo mgubo ngumguboI-Ganoderma lucidumumgubo womzimba oneziqhamo,I-Ganoderma lucidumumgubo we spore okanyeI-Ganoderma lucidummycelium powder.Umbhali ukholelwa ukuba eyona nto inokwenzeka ye-hepatitis enetyhefu ebangelwaI-Ganoderma lucidumipowder kule meko yingxaki yekhwalithi yemveliso embi, oko kukuthi, ukungcola okubangelwa ngumbumba, i-pesticides kunye nezinyithi ezinzima.

Ke ngoko, xa uthenga iimveliso zeGanoderma,abathengi kufuneka bathenge iimveliso ngenombolo yemvume yogunyaziwe ofanelekileyo.Iimveliso ezinjalo kuphela eziye zavavanywa ngumntu wesithathu kwaye zamkelwa ngugunyaziwe onobuchule zinokubonelela abathengi ngeziqinisekiso ezithembekileyo, ezikhuselekileyo nezisebenzayo.

【Iimbekiselo】

1. Wah Cheuk, et al.Ukuhlehla kweGastric Enkulu ye-B-Cell Lymphoma ekhatshwa yiFlorid Lymphoma-efana ne-T-Cell Reaction: I-Immunomodulatory Effect ofI-Ganoderma lucidum(Lingzhi).Ijenali yeHlabathi yePathology yoTyando.2007;15(2):180-86.

2. Man-Fung Yuen, et al.I-Hepatotoxicity ngenxa yokuqulunqwa kweI-Ganoderma lucidum(ingzhi).Ijenali yeHepatology.2004;41(4):686-7.

Malunga noProf Zhi-Bin Lin 

Njengovulindlela kuphando lweGanoderma eChina, uye wazinikela kuphando lweGanoderma malunga nesiqingatha senkulungwane.Njengowayesakuba ngusekela mongameli weYunivesithi yezoNyango yaseBeijing (BMU), owayesakuba ngusekela mphathi weBMU School of Basic Medical Sciences kunye nowayesakuba ngumlawuli weBMU Institute of Basic Medicine kunye nowayesakuba ngumlawuli weSebe lePharmacology leBMU, ngoku unjingalwazi weSebe le-Pharmacology ye-Peking University School of Basic Medicine.Waye waqeshwa njengomfundi otyeleleyo weWorld Health Organization Collaborating Centre for Traditional Medicine kwiYunivesithi yaseIllinois eChicago ukusuka ngo-1983 ukuya ku-1984 kunye nonjingalwazi otyeleleyo kwiYunivesithi yaseHong Kong ukususela ngo-2000 ukuya ku-2002. Uqeshwe njengonjingalwazi ohloniphekileyo wePerm State. Pharmaceutical Academy ukususela ngo-2006.

Ukususela ngo-1970, uye wasebenzisa iindlela zanamhlanje ze-sci-tech ukufunda iziphumo ze-pharmacological kunye neendlela ze-Ganoderma lucidum kunye nezithako zayo ezisebenzayo.Upapashe ngaphezu kwe-100 amaphepha ophando kwiGanoderma.Ukusukela ngo-2014 ukuya kowama-2019, wakhethwa kuluhlu lwabaphandi baseTshayina abaCatshulwe kakhulu abakhutshwe ngu-Elsevier iminyaka emithandathu ilandelelana.

Ungumbhali weUphando lwangoku kwiGanoderma(ukusuka kuhlelo loku-1 ukuya kuhlelo lwesi-4),Lingzhi Ukusuka kwiMfihlakalo ukuya kwiNzululwazi(ukusuka kuhlelo loku-1 ukuya kuhlelo lwesi-3),Ganoderma LucidumUncedisa kuNyango loMhlaza ngokuQinisa ukuxhathisa koMzimba kunye nokuphelisa izinto zePathogenic., Thetha ngeGanoderma, I-Ganoderma kunye neMpilokunye neminye imisebenzi emininzi kwiGanoderma.