An sake buga wannan labarin ne daga fitowa ta 94 na mujallar GANODERMA a shekarar 2022. Haƙƙin mallaka na labarin na marubucin ne.

Zhi-Bin Lin, farfesa na Sashen Kimiyyar Magunguna, Makarantar Kimiyyar Kiwon Lafiya ta Jami'ar Peking

A cikin wannan labarin, Farfesa Lin ya gabatar da lokuta biyu da aka ruwaito a cikin mujallolin kimiyya.Daya daga cikinsu shi ne cewa shanGanoderma lucidumHaɗin foda warkar da gastic digo man shafawa babban belymymphoma, kuma ɗayan yana ɗaukaGanoderma lucidumfoda ya haifar da hanta mai guba.Tsohon ya tabbatar da cewa ciwon ƙwayar cuta yana da alaƙa daGanoderma lucidumspore foda yayin da na karshen ya fallasa abubuwan da ke ɓoye waɗanda ke haifar da rashin ingancin kayayyakin Ganoderma.Saboda haka, wani farin ciki daya da wani gigice ya tunatar da masu amfani da su yi taka tsantsan yayin siyan kayan Ganoderma don kada su ɓata kuɗi da cutar da jikinsu!

Yawancin mujallolin likitanci suna da ginshiƙi na "Rahoton Harka" wanda ke ba da rahoton sakamako masu ma'ana daga ganewar asali da kuma kula da marasa lafiya ɗaya, da kuma gano illa ko mummunan tasirin magunguna.A cikin tarihin likitanci, wani lokacin binciken mutum yana inganta ci gaban kimiyya.

Misali, masanin kwayoyin cutar dan kasar Burtaniya Alexander Fleming ya fara ganowa kuma ya bayar da rahoton cewa kwayar cutar penicillin tana da tasirin anti-staphylococcal a cikin 1928, kuma ya sanya mata suna penicillin.An adana wannan binciken tsawon shekaru da yawa har zuwa 1941 lokacin da masanin harhada magunguna na Burtaniya Howard Walter Florey da masanin kimiyyar halittu na Jamus Ernest Chain suka sami wahayi daga takarda Fleming don kammala tsarkakewar penicillin da gwaje-gwajen magunguna na anti-streptococci kuma ya tabbatar da ingancinsa na ƙwayoyin cuta a cikin majiyyaci mai mutuwa, penicillin ya fara. don karbar hankali.

Bayan bincike na biyu da haɓakawa, an samar da penicillin akan sikelin masana'antu a matsayin maganin rigakafi na farko da aka yi amfani da shi a tarihin ɗan adam, wanda ya ceci rayuka marasa adadi kuma ya zama babban ganowa a ƙarni na 20.Saboda haka, Fleming, Florey da Chain, waɗanda suka yi hulɗa da bincike da haɓaka penicillin, an ba su lambar yabo ta Nobel ta 1945 a fannin ilimin halittar jiki da magani.

Rahotanni na asibiti guda biyu masu zuwaGanoderma lucidum, ko da yake an gano ta kwatsam, dan jarida ya yi nazari da nazari sosai.Na farko yana ba da shaida gaamfani daGanoderma luciduma cikin lura da yaduwa manyan B cell lymphoma (DLBCL) a cikin cikiyayin da na karshen Ya gaya mana cewamara kyauGanoderma lucidumsamfurori na iya haifar damai guba hepatitis.

Ganoderma lucidumspore foda ya warkar da shari'ar yaduwa na ciki babban lymphoma B-cell. 

Akwai lokuta da yawa a cikin jama'a cewaGanoderma lucidumyana da tasirin maganin ciwon daji, amma ba kasafai ba ne a ba da rahoto ta hanyar wallafe-wallafen kwararrun likitoci.

A cikin 2007, Wah Cheuk et al.Asibitin Sarauniya Elizabeth da ke Hong Kong ya ruwaito a cikinJarida ta Ƙasashen Duniya na Magungunan Magungunawani lamari na wani majinyaci mai shekaru 47 ba tare da wani tarihin likita ba wanda ya zo asibiti a cikin Janairu 2003 saboda ciwon ciki na sama.

Helicobacter pyloriAn gano kamuwa da cuta ta hanyar gwajin numfashi na urea, kuma an sami babban yanki na gyambon ciki a yankin pyloric na ciki ta hanyar gastroscopy.Samfur na biopsy ya bayyana adadi mai yawa na matsakaici zuwa manyan lymphocytes suna kutsawa cikin bangon ciki, tare da sifofi marasa tsari, chromatin da aka cire da ke cikin tsakiya, da fitattun nucleoli.

Immunohistochemical tabo ya nuna cewa wadannan kwayoyin sun kasance tabbatacce ga CD20, wani B-cell bambance-bambancen antigen, wanda aka bayyana a cikin fiye da 95% na B-cell lymphomas, alhãli kuwa mataimaki T Kwayoyin (Th), cytotoxic T Kwayoyin (CTL) da kuma regulatory T Kwayoyin (Treg). ) sun kasance marasa kyau ga CD3, kuma Ki67 proliferation index, wanda ke nuna aikin haɓakar ƙwayar ƙwayar cuta, ya kai 85%.An gano majiyyaci a asibiti tare da yaduwar ƙwayar cuta mai girma B-cell lymphoma.

Tunda majiyyaci ya gwada inganciHelicobacter pylorikamuwa da cuta, asibiti ya yanke shawarar yinHelicobacter pylorimaganin kawar da majiyyaci daga ranar 1 zuwa 7 ga Fabrairu, sannan a yi masa tiyata a ranar 10 ga Fabrairu. Abin mamaki.Binciken ilimin cututtuka na samfurori na nama na ciki da aka sake gyara bai bayyana sauye-sauye na tarihi na lymphoma mai girma B-cell ba amma a maimakon haka ya sami adadi mai yawa na ƙananan CD3 + CD8+ cytotoxic T da ke shiga cikin cikakken kauri na bangon ciki, kuma ƙididdiga na Ki67 ya ragu. zuwa kasa da 1%.

Bugu da ƙari, a cikin wurin gano RT-PCR na T cell receptor beta chain (TCRβ) mRNA gene ya nuna nau'in polyclonal, kuma ba a gano yawan adadin kwayoyin T monoclonal ba.

Sakamakon gwajin da mai ba da rahoto ya bayar ya nuna cewa ƙwayoyin T a cikin ƙwayar ciki na marasa lafiya sun kasance na al'ada maimakon m.Saboda ƙwayoyin tumor sun rasa ikon bambancewa da girma kuma kawai suna da alamar ƙayyadaddun kwayoyin halitta, suna monoclonal yayin da yaduwar kwayar halitta ta al'ada ita ce polyclonal.

An koyi daga binciken cewa majiyyacin ya ɗauki capsules 60 naGanoderma lucidumspore foda (sau 3 da aka ba da shawarar shawarar mai ba da shawara) a kowace rana daga Fabrairu 1 zuwa 5. Bayan tiyata, mai haƙuri bai sami wani magani na adjuvant ba, kuma ciwon daji bai sake dawowa ba a cikin shekaru biyu da rabi. - sama.

Masu binciken sun yi imanin cewa sakamakon immunohistochemical na samfurori na biopsy da aka yi wa tiyata ba su goyi bayan yiwuwar kamuwa da cutar ba.Helicobacter pylorikawar da babban lymphoma na B-cell, don haka suna tunanin cewa yana iya zama marasa lafiya suna shan manyan allurai.Ganoderma lucidumspore foda yana haɓaka amsawar rigakafi mai aiki na ƙwayoyin cytotoxic T zuwa manyan ƙwayoyin lymphoma B-cell, wanda hakan ke haifar da cikakkiyar koma baya na ƙari [1].

Wannan rahoton rahoton yana da bayyananniyar ganewar asali da tsarin jiyya.Marubucin labarin ya tabbatar da cewa ciwon kumburi yana da alaƙa daGanoderma lucidumspore foda ta hanyar bincike-bincike na tarihi da kuma salon salula da kwayoyin halitta, wanda yake da kimiyya sosai kuma ya cancanci ƙarin bincike.

Abin da ke biyo baya shine yanayin cutar hanta mai guba wanda aka jawo taGanoderma lucidumfoda.

Yawancin binciken harhada magunguna sun tabbatar da hakanGanoderma lucidum'Ya'yan itãcen marmari da kuma polysaccharides da triterpenes, kazalikaGanoderma lucidumspore foda, suna da tasirin hanta a fili.Suna da sakamako mai kyau na ingantawa a cikin maganin cutar hanta na asibiti.

Koyaya, a cikin 2004, Man-Fung Yuen et al.na Jami'ar Hong Kong School of Medicine ya ba da rahoton rahoton shari'arGanoderma lucidumfoda mai guba mai guba hepatitis a cikinJaridar Hepatology.

Wata tsohuwa ‘yar shekara 78 ta nemi magani a wannan asibiti sakamakon rashin lafiya da take fama da ita, da rashin sha’awa, fata mai kauri, da fitsari mai launin shayi na tsawon sati biyu.Mai haƙuri yana da tarihin hauhawar jini kuma ya kasance yana shan felodipine na antihypertensive akai-akai tsawon shekaru 2.A wannan lokacin, gwajin aikin hanta ya kasance na al'ada, kuma ta dauki calcium, multivitamin tablets daGanoderma lucidumda kanta.Bayan shan decoctedGanoderma lucidumna shekara guda, mai haƙuri ya canza zuwa wani sabon kasuwanciGanoderma lucidumfoda samfurin. Sya ci gaba da bayyanar cututtuka na sama bayan makonni hudu na shanirin wannan samfurin.

Binciken jiki ya nuna jaundice mai alama a cikin majiyyaci.Ana nuna sakamakon gwaje-gwajen biochemical na jininta a cikin jadawalin da ke ƙasa.Binciken na rigakafi ya kawar da yiwuwar majiyyaci da ke fama da ciwon hanta na viral A, B, C, da E. Sakamakon histopathological na hanta biopsy ya nuna cewa mai haƙuri yana da canje-canje na pathological a cikin hanta mai guba mai guba.

A lokacin shekara guda na shanGanoderma lucidumdecoction na ruwa, mai haƙuri bai nuna rashin daidaituwa ba.Amma bayan canzawa zuwa kasuwanci akwaiGanoderma lucidumfoda, da sauri ta ci gaba da bayyanar cututtuka na hepatitis mai guba.Bayan katsewaGanoderma lucidumfoda, alamun sinadarai na jini da aka ambata a sama a hankali sun dawo daidai.Saboda haka, an gano mai haƙuri tare da ciwon hanta mai guba wanda ya haifar da shiGanoderma lucidumfoda.Wakilin ya nuna cewa tun lokacin da aka tsara naGanoderma lucidumfoda ba za a iya ganowa ba, yana da daraja la'akari da ko ciwon hanta ya haifar da wasu sinadaran ko canjin kashi bayan canzawa don ɗaukarGanoderma lucidumfoda [2].

Tun da wakilin bai bayyana madogara da kaddarorin baGanoderma lucidumfoda, ba a sani ba ko wannan foda neGanoderma lucidumfruiting jiki foda,Ganoderma lucidumspore foda koGanoderma lucidummycelium foda.Marubucin ya yi imanin cewa mafi kusantar dalilin cutar hanta mai guba ta haifar daGanoderma lucidumfoda a cikin wannan yanayin shine matsalar ingancin samfurin mara kyau, wato, gurɓataccen gurɓataccen ƙwayar cuta, magungunan kashe qwari da ƙananan ƙarfe.

Don haka, lokacin siyan samfuran Ganoderma.dole ne mabukaci su sayi samfur tare da lambar amincewar hukumar da ta dace.Irin waɗannan samfuran ne kawai waɗanda wani ɓangare na uku suka gwada kuma aka amince da su daga wata hukuma mai ƙarfi za su iya samar wa masu amfani da ingantaccen, aminci da garanti mai inganci.

【Reference】

1. Wah Cheuk, et al.Komawar Gastric Large B-Cell Lymphoma Tare da Taimakon Florid Lymphoma-kamar T-Cell: Tasirin Immunomodulatory naGanoderma lucidum(Lingzhi).Jarida ta Ƙasashen Duniya na Magungunan Magunguna.2007;15 (2): 180-86.

2. Man-Fung Yuen, et al.Hepatotoxicity saboda wani tsariGanoderma lucidum(linghi).Jaridar Hepatology.2004;41 (4): 686-7.

Game da Farfesa Zhi-Bin Lin 

A matsayinsa na majagaba a cikin binciken Ganoderma a kasar Sin, ya sadaukar da kansa ga binciken Ganoderma kusan rabin karni.A matsayinsa na tsohon mataimakin shugaban Jami'ar Kiwon Lafiya ta Beijing (BMU), tsohon mataimakin shugaban makarantar BMU School of Basic Medical Sciences kuma tsohon darektan Cibiyar Nazarin Magunguna ta BMU kuma tsohon darektan Sashen Kula da Magungunan Magunguna na BMU, yanzu ya zama malami. farfesa na Sashen Nazarin Magungunan Magunguna na Makarantar Kiwon Lafiya ta Jami'ar Peking.An nada shi malami mai ziyara na Cibiyar Haɗin gwiwar Hukumar Lafiya ta Duniya a Jami'ar Illinois da ke Chicago daga 1983 zuwa 1984 kuma Farfesa mai ziyara a Jami'ar Hong Kong daga 2000 zuwa 2002. An nada shi Farfesa mai girma a jihar Perm. Kwalejin Pharmaceutical tun 2006.

Tun daga 1970, ya yi amfani da hanyoyin fasaha na zamani don nazarin tasirin magunguna da hanyoyin Ganoderma lucidum da kayan aikin sa.Ya buga fiye da 100 takardun bincike akan Ganoderma.Daga shekarar 2014 zuwa 2019, an zabe shi cikin jerin masu bincike na kasar Sin da aka fi sani da Elsevier ya fitar na tsawon shekaru shida a jere.

Shi ne marubucinBinciken Zamani akan Ganoderma(daga bugu na 1 zuwa bugu na 4)Lingzhi Daga Sirrin zuwa Kimiyya(daga bugu na 1 zuwa bugu na 3),Ganoderma LucidumTaimakawa wajen Maganin Ciwon Sankara ta hanyar Ƙarfafa Juriyar Jiki da Kawar da Abubuwan da ke haifar da Cutar, Yi magana akan Ganoderma, Ganoderma da Lafiyada sauran ayyuka da yawa akan Ganoderma.