Iyi ngingo yakuwe mu nomero ya 94 yikinyamakuru GANODERMA mu 2022. Uburenganzira bwiyi ngingo ni ubw'umwanditsi.

Zhi-Bin Lin, umwarimu w’ishami rya farumasi, ishuri rya kaminuza ya Peking yubumenyi bwibanze bwubuvuzi

Muri iki kiganiro, Prof. Lin yerekanye imanza ebyiri zavuzwe mu binyamakuru bya siyansi.Umwe muri bo yari iyo gufataGanoderma lucidumifu ya spore yakize gastric ikwirakwiza lymphoma nini ya B, naho iyindi yari iyo gufataGanoderma lucidumifu yateje hepatite yuburozi.Abambere bagaragaje ko gusubira inyuma kubyimba bifitanye isanoGanoderma lucidumifu ya spore mugihe aba nyuma bagaragaje impungenge zihishe ziterwa nibicuruzwa byiza bya Ganoderma.Kubwibyo, umunezero umwe no guhungabana byibukije abaguzi kwitonda mugihe baguze ibicuruzwa bya Ganoderma kugirango badasesagura amafaranga kandi bababaza umubiri wabo!

Ibinyamakuru byinshi byubuvuzi bifite inkingi ya "Case Report" itanga ibisubizo bifatika bivuye mu gusuzuma no kuvura abarwayi ku giti cyabo, ndetse no kuvumbura ingaruka cyangwa ingaruka mbi zibiyobyabwenge.Mu mateka yubuvuzi, rimwe na rimwe kuvumbura kugiti cye biteza imbere siyanse.

Kurugero, umuhanga mubya bacteriologue wubwongereza Alexander Fleming yavumbuye bwa mbere atangaza ko ururenda rwa penisiline rufite ingaruka zo kurwanya staphylococcal mu 1928, maze arwita penisiline.Ubu buvumbuzi bwahagaritswe imyaka myinshi kugeza mu 1941 igihe umuhanga mu bya farumasi w’Ubwongereza Howard Walter Florey hamwe n’umudage w’ibinyabuzima witwa Ernest Chain bahumekewe n’impapuro za Fleming kugira ngo barangize isuku rya penisiline hamwe n’ubushakashatsi bwakozwe na farumasi anti-streptococci kandi bagaragaza ko ari antibacterial mu murwayi uri hafi gupfa, penisiline yatangiye. kwitabwaho.

Nyuma y’ubushakashatsi bwabo bwa kabiri n’iterambere, penisiline yakozwe ku ruganda nka antibiyotike ya mbere yakoreshejwe mu mateka y’umuntu, ikiza ubuzima butabarika kandi ihinduka ikintu gikomeye mu kinyejana cya 20.Kubera iyo mpamvu, Fleming, Florey na Chain, bifashishije ubushakashatsi no guteza imbere penisiline, bahawe igihembo cyitiriwe Nobel mu 1945 muri Physiology na Medicine.

Raporo ebyiri zikurikira zamavuriro yaGanoderma lucidum, nubwo byavumbuwe kubwamahirwe, byizwe neza kandi birasesengurwa numunyamakuru.Iyambere itanga ibimenyetso kuriikoreshwa ryaGanoderma lucidummu kuvura diffuse nini B selile lymphoma (DLBCL) mu gifumugihe cya nyuma Iratubwira kobibiGanoderma lucidumibicuruzwa birashobora guterahepatite y'ubumara.

Ganoderma lucidumifu ya spore yakijije ikibazo cya gastric diffuse nini ya B-selile lymphoma. 

Hariho imanza nyinshi mubantu koGanoderma lucidumifite ingaruka zo kuvura kanseri, ariko ntibisanzwe gutangazwa nibitabo byubuvuzi byubuvuzi.

Muri 2007, Wah Cheuk n'abandi.y'ibitaro by'umwamikazi Elizabeth muri Hong Kong byatangajwe muriIkinyamakuru mpuzamahanga cyo kubaga indwaraikibazo cyumurwayi wumugabo wimyaka 47 udafite amateka yubuvuzi aje mu bitaro muri Mutarama 2003 kubera ububabare bwo munda bwo hejuru.

Helicobacter pylorikwandura byagaragaye ko ari byiza mu gupima umwuka wa urea, kandi igice kinini cy’ibisebe byo mu gifu cyabonetse mu gace ka pyloric yo mu gifu na gastroscopi.Ubushakashatsi bwakozwe na Biopsy bwerekanye umubare munini wa lymphocytes ziciriritse nini nini zinjira mu rukuta rwa gastric, hamwe na nuclei zifite imiterere idasanzwe, chromatine ya vacuolated iherereye muri nucleus, na nucleoli ikomeye.

Ikirangantego cya Immunohistochemic cyerekanye ko utugingo ngengabuzima twagize CD20, antigen ya B-selile itandukanye, yerekanaga hejuru ya 95% ya lymphoma B-selile, mu gihe umufasha T selile (Th), selile cytotoxic T (CTL) na selile T (Treg) ) byari bibi kuri CD3, kandi indangagaciro yo gukwirakwiza Ki67, igaragaza ibikorwa byo gukwirakwiza ingirabuzimafatizo y'ibibyimba, yari hejuru ya 85%.Umurwayi bamusanganye indwara ya gastric diffuse nini ya lymphoma B-selile.

Kuva umurwayi yipimishije nezaHelicobacter pylorikwandura, ibitaro byiyemeje gukoraHelicobacter pylorikuvura kurandura umurwayi kuva ku ya 1 kugeza ku ya 7 Gashyantare, hakurikiraho kubagwa ku ya 10 Gashyantare. Igitangaje,isuzumabumenyi rya pologologi yerekana ingirabuzimafatizo za gastrici ntizagaragaje impinduka za histopathologique ya diffuse nini ya B-selile lymphoma ahubwo yasanze umubare munini wa selile nto za CD3 + CD8 + cytotoxic T zinjira mubwinshi bwuzuye bwurukuta rwa gastrica, kandi indangagaciro ya Ki67 yagabanutse kugeza munsi ya 1%.

Byongeye kandi, muburyo bwa RT-PCR gutahura T selile reseptor ya beta selile (TCRβ) mRNA gene yerekanaga imiterere ya polyclone, kandi nta baturage ba selile T monoclonal yagaragaye.

Ibisubizo by'ibizamini byatanzwe n'umunyamakuru byagaragaje ko selile T ziri mu ngingo z'inda z'umurwayi zari zisanzwe aho kuba mbi.Kuberako selile yibibyimba itakaza ubushobozi bwo gutandukanya no gukura kandi ikagira gusa ibimenyetso byihariye bya genetike, ni monoclonal mugihe ikwirakwizwa ryingirabuzimafatizo risanzwe ari polyclone.

Mu iperereza ryagaragaye ko umurwayi yafashe capsules 60 zaGanoderma lucidumifu ya spore (inshuro 3 inshuro zisabwa uwagusabye) kumunsi kuva 1 Gashyantare kugeza 5. Gashyantare Nyuma yo kubagwa, umurwayi ntiyigeze yivuza, kandi ikibyimba nticyongeye kugaruka mugihe cyimyaka ibiri nigice yakurikiranye -up.

Abashakashatsi bemeza ko ibisubizo by’ubudahangarwa bw’ibinyabuzima byatewe na biopsy byatewe no kubaga bidashyigikiye ko bishobokaHelicobacter pylorikurandura lymphoma nini ya B-selile, bityo bakeka ko bishoboka ko abarwayi bafata dosiye nini yaGanoderma lucidumifu ya spore itera imbaraga zo gukingira ingirabuzimafatizo za cytotoxic T kuri lymphoma nini ya B-selile, nayo iganisha ku kubyimba kwuzuye [1].

Iyi raporo y'urubanza ifite uburyo bunoze bwo gusuzuma no kuvura.Umwanditsi wiyi ngingo yerekanye ko gusubira inyuma kubyimba bifitanye isanoGanoderma lucidumifu ya spore binyuze muri histopathologique na selile na molekuline yubushakashatsi bwibinyabuzima, buhanga cyane kandi bukwiye ubundi bushakashatsi.

Ibikurikira nikibazo cya hepatite yuburozi iterwa naGanoderma lucidumifu.

Ubushakashatsi bwinshi bwa farumasi bwerekanye koGanoderma lucidumimbuto zivamo umubiri hamwe na polysaccharide na triterpène, kimweGanoderma lucidumifu ya spore, ifite ingaruka zigaragara za hepatoprotective.Zifite ingaruka zigaragara zo kuvura kwa hepatite ya virusi.

Ariko, mu 2004, Man-Fung Yuen n'abandi.y'Ishuri ry'ubuvuzi rya kaminuza ya Hong Kong yatanze raporo y'urubanza rwaGanoderma lucidumifu iterwa na hepatite yuburozi muriIkinyamakuru cya Hepatology.

Umugore w'imyaka 78 yashakishije kwivuriza muri ibi bitaro kubera ubumuga rusange, kubura ubushake bwo kurya, uruhu ruteye, hamwe n’inkari zifite icyayi mu byumweru bibiri.Umurwayi yagize amateka ya hypertension kandi yari amaze imyaka 2 afata imiti igabanya ubukana bwa felodipine.Muri kiriya gihe, ibizamini byimikorere yumwijima byari bisanzwe, kandi yafashe na calcium, ibinini bya vitamine naGanoderma lucidumwenyine.Nyuma yo gufataGanoderma lucidumkumwaka umwe, umurwayi yahinduye ubucuruzi bushya bubonekaGanoderma lucidumifu. Syagize ibimenyetso byavuzwe haruguru nyuma yibyumweru bine afataibicuruzwa nkibi.

Isuzuma ry'umubiri ryagaragaje indwara ya jaundice ku murwayi.Ibisubizo by'ibizamini bya maraso biochemiki byerekanwe mumbonerahamwe ikurikira.Isuzuma ry’ikingira ryerekanye ko bishoboka ko umurwayi arwara hepatite ya virusi A, B, C, na E. Ibisubizo bya histopathologique ya biopsy y’umwijima byerekanaga ko umurwayi yagize impinduka z’indwara ziterwa na hepatite y’ibiyobyabwenge.

Mugihe cyumwaka umwe wo gufataGanoderma lucidumamazi meza, umurwayi yerekanye ko bidasanzwe.Ariko nyuma yo guhindukira mubucuruzi burabonekaGanoderma lucidumifu, yahise agira ibimenyetso bya hepatite yuburozi.Nyuma yo guhagarikaGanoderma lucidumifu, ibipimo byerekana amaraso biochemiki yavuzwe haruguru byagarutse mubisanzwe.Kubwibyo, umurwayi bamusanganye indwara ya hepatite yuburozi yatewe naGanoderma lucidumifu.Umunyamakuru yerekanye ko kuva ibice bigizeGanoderma lucidumifu ntishobora kuboneka, birakwiye ko harebwa niba uburozi bwumwijima bwatewe nibindi bikoresho cyangwa ihinduka ryimiti nyuma yo guhindura gufataGanoderma lucidumifu [2].

Kuva umunyamakuru atasobanuye inkomoko numutungo waGanoderma lucidumifu, ntibisobanutse niba iyi fu ariGanoderma lucidumimbuto zifu yumubiri,Ganoderma lucidumifu ya spore cyangwaGanoderma lucidumifu ya mycelium.Umwanditsi yemera ko impamvu zishobora gutera indwara ya hepatite y’ubumara iterwa naGanoderma lucidumifu muriki kibazo nikibazo cyiza cyibicuruzwa bibi, ni ukuvuga umwanda uterwa nimbuto, imiti yica udukoko hamwe nicyuma kiremereye.

Kubwibyo, mugihe uguze ibicuruzwa bya Ganoderma,abaguzi bagomba kugura ibicuruzwa bifite numero yemewe yubuyobozi bubifitiye ububasha.Gusa ibicuruzwa nkibi byageragejwe nundi muntu kandi byemejwe nubuyobozi bubifitiye ububasha birashobora guha abakiriya ingwate zizewe, umutekano kandi nziza.

Reba】

1. Wah Cheuk, n'abandi.Kwisubiraho kwa Gastric nini B-selile Lymphoma Iherekejwe na Lymphoma ya Floride isa na T-Cell reaction: Ingaruka zo gukingira indwara yaGanoderma lucidum(Lingzhi).Ikinyamakuru mpuzamahanga cyo kubaga indwara.2007;15 (2): 180-86.

2. Umuntu-Fung Yuen, n'abandi.Hepatotoxicity kubera formulaire yaGanoderma lucidum(lingzhi).Ikinyamakuru cya Hepatology.2004;41 (4): 686-7.

Ibyerekeye Prof. Zhi-Bin Lin 

Nkumupayiniya mubushakashatsi bwa Ganoderma mubushinwa, yitangiye ubushakashatsi bwa Ganoderma mugihe cyikinyejana.Nk’uwahoze ari visi perezida wa kaminuza y’ubuvuzi ya Beijing (BMU), yahoze ari umuyobozi wungirije w’ishuri ry’ubuvuzi bw’ibanze rya BMU akaba yarahoze ari umuyobozi w’ikigo cy’ubuvuzi bw’ibanze cya BMU akaba yarahoze ari umuyobozi w’ishami ry’imiti ya BMU, ubu ni a umwarimu w'ishami rya farumasi rya Peking University School of Medicine Basic.Yagizwe intiti yasuye ikigo cy’ubuzima ku isi gishinzwe ubufatanye bw’ubuvuzi gakondo muri kaminuza ya Illinois i Chicago kuva 1983 kugeza 1984 ndetse anasura umwarimu muri kaminuza ya Hong Kong kuva mu 2000 kugeza 2002. Yagizwe umwarimu w’icyubahiro wa Leta ya Perm Ishuri rya Farumasi kuva 2006.

Kuva mu 1970, yakoresheje uburyo bugezweho bwa tekinoloji yiga ingaruka za farumasi nuburyo bwa Ganoderma lucidum nibiyigize.Yasohoye inyandiko zirenga 100 zubushakashatsi kuri Ganoderma.Kuva mu 2014 kugeza 2019, yatoranijwe ku rutonde rw'Abashakashatsi Bashinwa Bavuzwe cyane na Elsevier mu myaka itandatu ikurikiranye.

Ni umwanditsi waUbushakashatsi bugezweho kuri Ganoderma(kuva ku nshuro ya 1 kugeza ku ya 4),Lingzhi Kuva Amayobera Kugeza Mubumenyi(kuva ku nshuro ya 1 kugeza ku ya 3),Ganoderma LucidumIfasha mu kuvura Kanseri mu Kongera imbaraga z'umubiri no kurandura ibintu bitera indwara, Vuga kuri Ganoderma, Ganoderma n'ubuzimanibindi bikorwa byinshi kuri Ganoderma.