Edegharịrị edemede a site na mbipụta 94 nke akwụkwọ akụkọ GANODERMA na 2022. Ikike nwebisiinka nke akụkọ ahụ bụ nke onye dere ya.

Zhi-Bin Lin, prọfesọ nke Ngalaba Pharmacology, Ụlọ Akwụkwọ Mahadum Peking nke Basic Medical Sciences

N'isiokwu a, Prọfesọ Lin webatara okwu abụọ a kọrọ n'akwụkwọ akụkọ sayensị.Otu n'ime ha bụ nke ahụGanoderma lucidumspore ntụ ntụ gwọrọ gastric mgbasa nnukwu B cell lymphoma, nke ọzọ bụ nke ahụGanoderma lucidumntụ ntụ kpatara ịba ọcha n'anya.Nke mbụ gosipụtara na nlọghachi azụ tumor metụtaraGanoderma lucidumspore ntụ ntụ mgbe nke ikpeazụ kpughere nchegbu zoro ezo nke ngwaahịa Ganoderma na-adịghị mma kpatara.Ya mere, otu ọṅụ na otu ujo chetaara ndị na-azụ ahịa ka ha kpachara anya mgbe ha na-azụta ngwaahịa Ganoderma ka ha ghara imefusị ego na imerụ ahụ ha!

Ọtụtụ akwụkwọ akụkọ ahụike nwere kọlụm "Akụkọ ikpe" nke na-akọ nchoputa bara uru site na nyocha na ọgwụgwọ nke ndị ọrịa n'otu n'otu, yana ịchọpụta mmetụta ma ọ bụ mmetụta dị njọ nke ọgwụ.Na akụkọ ihe mere eme nke nkà mmụta ọgwụ, mgbe ụfọdụ nchọpụta onye ọ bụla na-akwalite mmepe nke sayensị.

Dị ka ihe atụ, onye Britain bụ́ ọkà n’ihe banyere nje bacteria bụ́ Alexander Fleming bu ụzọ chọpụta ma kọọ na nzuzo nke penicillin nwere mmetụta na-egbochi staphylococcal na 1928, ma kpọọ ya penicillin.Edobere nchọpụta a ruo ọtụtụ afọ ruo 1941 mgbe ọkà mmụta ọgwụ na Britain bụ Howard Walter Florey na onye German biochemist Ernest Chain kpaliri akwụkwọ Fleming iji mechaa sachaa penicillin na nyocha ọgwụ mgbochi streptococci ya wee gosi na nje bacteria na-arụ ọrụ na onye ọrịa na-anwụ anwụ, penicillin malitere. inweta nlebara anya.

Mgbe nyocha na mmepe nke abụọ ha gasịrị, a na-emepụta penicillin n'ogo ụlọ ọrụ dị ka ọgwụ nje mbụ ejiri mee ihe n'akụkọ ihe mere eme mmadụ, na-azọpụta ọtụtụ ndụ ma ghọọ nnukwu nchọpụta na narị afọ nke 20.Ya mere, Fleming, Florey na Chain, bụ ndị gbagara na nyocha na ịzụlite penicillin, nyere 1945 Nobel Prize in Physiology and Medicine.

Ndị na-esonụ abụọ na-adakarị ikpe akụkọ nkeGanoderma lucidum, ọ bụ ezie na achọpụtara ya na mberede, onye nta akụkọ ejirila nlezianya mụọ ma nyochaa ya.Nke mbụ na-enye ihe akaebe makaojiji nkeGanoderma lucidumna ọgwụgwọ nke nnukwu B cell lymphoma (DBCL) na-agbasa na afọmgbe nke ikpeazụ Ọ na-agwa anyị naọjọọGanoderma lucidumngwaahịa nwere ike ịkpataịba ọcha n'anya.

Ganoderma lucidumspore ntụ ntụ gwọrọ ọrịa nke nnukwu eriri afọ B-cell lymphoma. 

Enwere ọtụtụ ikpe na ndị mmadụGanoderma lucidumnwere mmetụta nke ịgwọ ọrịa kansa, mana ọ dị ụkọ ka akwụkwọ ndị ọkachamara n'ịgwọ ahụike na-akọ.

Na 2007, Wah Cheuk et al.nke ụlọ ọgwụ Queen Elizabeth na Hong Kong kọrọ naAkwụkwọ akụkọ International of Surgical Pathologyikpe nke nwoke dị afọ 47 na-enweghị akụkọ ahụike dị mkpa nke bịara n'ụlọ ọgwụ na January 2003 n'ihi mgbu nke elu afọ.

Helicobacter pyloriAchọpụtara ọrịa ahụ dị mma site na nyocha ume ume urea, a chọtara nnukwu ebe ọnya afọ na mpaghara pyloric nke afọ site na gastroscopy.Nlere anya biopsy gosipụtara ọnụ ọgụgụ buru ibu nke ọkara na nnukwu lymphocytes na-abanye n'ime mgbidi afọ, nwere nuclei ndị na-eme ka oge na-aga, chromatin na-ekpochapụ nke dị na nucleus, na nucleoli a ma ama.

Immunohistochemical ntụpọ gosipụtara na mkpụrụ ndụ ndị a dị mma maka CD20, antigen dị iche iche B-cell, nke egosipụtara na ihe karịrị 95% nke lymphomas B-cell, ebe sel T na-enyere aka (Th), sel cytotoxic T (CTL) na sel T na-achịkwa (Treg). ) adịghị mma maka CD3, na Ki67 proliferation index, nke na-egosipụta ọrụ mgbasa nke mkpụrụ ndụ tumo, dị ka 85%.Achọpụtara onye ọrịa ahụ n'ụlọ ọgwụ nwere nnukwu lymphoma nke mkpụrụ ndụ B-cell.

Ebe ọ bụ na onye ọrịa nwalere ihe ọmaHelicobacter pyloriọrịa, ụlọ ọgwụ kpebiri imeHecobacter pyloriikpochapụ ọgwụgwọ na onye ọrịa site na February 1 ruo 7, sochiri ịwa ahụ na February 10. N'ụzọ dị ịtụnanya,Nyocha nke pathological nke ihe nlele anụ ahụ nke eriri afọ emeghị ekpughere mgbanwe akụkọ ihe mere eme nke nnukwu lymphoma B-cell na-agbasa ma kama ịchọta ọnụ ọgụgụ dị ukwuu nke obere CD3 + CD8+ cytotoxic T cell na-abanye n'ogo zuru oke nke mgbidi gastric, na Ki67 proliferation index kwụsịrị. na-erughị 1%.

Na mgbakwunye, n'ọnọdụ RT-PCR nchọpụta T cell receptor beta chain (TCRβ) mRNA gene gosipụtara ụkpụrụ polyclonal, na ọ nweghị ọnụ ọgụgụ cell monoclonal T achọpụtara.

Nsonaazụ ule nke onye nta akụkọ nyere gosiri na mkpụrụ ndụ T dị n'ime anụ ahụ afọ onye ọrịa bụ ihe dị mma karịa nke na-adịghị mma.N'ihi na mkpụrụ ndụ tumor na-efunahụ ike dị iche iche na tozuru okè ma nwee naanị otu akara mkpụrụ ndụ ihe nketa, ha bụ monoclonal mgbe mmụba cell nkịtị bụ polyclonal.

A mụtara site na ajụjụ a na onye ọrịa ahụ were 60 capsulesGanoderma lucidumspore powder (ugboro 3 a na-atụ aro dose nke onye na-akwado ya) kwa ụbọchị site na February 1 ruo 5. Mgbe ịwachara ahụ, onye ọrịa ahụ enwetaghị ọgwụgwọ adjuvant ọ bụla, ụbụrụ ahụ emeghịkwa ọzọ n'oge afọ abụọ na ọkara sochirinụ. - elu.

Ndị nchọpụta ahụ kwenyere na nsonaazụ immunohistochemical nke ihe nlele biopsy nke ejiri ịwa ahụ megharịa anaghị akwado ohere nkeHelicobacter pylorimkpochapụ nke nnukwu lymphoma B-cell, n'ihi ya, ha na-eche na ọ nwere ike ịbụ na ndị ọrịa na-ewere nnukwu doses.Ganoderma lucidumspore ntụ ntụ na-akwalite nzaghachi anụ ahụ na-arụ ọrụ nke mkpụrụ ndụ cytotoxic T na nnukwu lymphoma B-cell, nke n'aka nke ya na-eduga na nkwụghachi azụ tumor zuru ezu [1].

Akụkọ ikpe a nwere usoro nyocha na ọgwụgwọ doro anya.Onye edemede nke akụkọ ahụ egosila na nkwụghachi azụ tumor metụtaraGanoderma lucidumspore ntụ ntụ site na histopathological na cellular na molecular biological research analysis, bụ nke dị ukwuu nke sayensị na kwesịrị ekwesị maka nyocha ọzọ.

Ihe na-esonụ bụ ikpe ịba ọcha n'anya na-akpataGanoderma lucidumntụ ntụ.

Ọtụtụ nchọpụta ọgwụ egosila nke ahụGanoderma lucidumMkpụrụ osisi na-amịpụta mkpụrụ na polysaccharides na triterpenes, yanaGanoderma lucidumspore ntụ ntụ, nwere mmetụta hepatoprotective doro anya.Ha nwere doro anya mma mmetụta na-adakarị ọgwụgwọ nke malitere ịrịa ịba ọcha n'anya.

Agbanyeghị, na 2004, Man-Fung Yuen et al.nke Mahadum Hong Kong School of Medicine kọrọ akụkọ gbasaraGanoderma lucidumịba ọcha n'anya na-egbu ntụ ntụ n'imeAkwụkwọ akụkọ gbasara ịba ọcha n'anya.

Otu nwanyị dị afọ 78 chọrọ ọgwụgwọ n'ụlọọgwụ a n'ihi ahụ adịghị ya n'ozuzu ya, enweghị agụụ, akpụkpọ ahụ na-afụ ụfụ, na mmamịrị na-acha tii ruo izu abụọ.Onye ọrịa ahụ nwere akụkọ ihe mere eme nke ọbara mgbali elu ma na-aṅụ ọgwụ antihypertensive felodipine mgbe niile maka afọ 2.N'ime oge a, ule ọrụ imeju ya bụ ihe kwesịrị ekwesị, ọ na-ewerekwa calcium, multivitamin mbadamba naGanoderma lucidumn'onwe ya.Mgbe ị na-ewere decoctedGanoderma lucidummaka otu afọ, onye ọrịa ahụ tụgharịrị gaa na azụmaahịa ọhụrụ dịGanoderma lucidumngwaahịa ntụ ntụ. Sọ malitere mgbaàmà ndị a dị n'elu mgbe izu anọ gacharangwaahịa dị otú ahụ.

Nnyocha anụ ahụ gosipụtara jaundice nwere akara na onye ọrịa.E gosipụtara nsonaazụ nyocha biochemical nke ọbara ya na tebụl dị n'okpuru.Immunological nnyocha wepụrụ ekwe omume nke onye ọrịa na-ata ahụhụ site viral ịba ọcha n'anya A, B, C, na E. The histopathological results nke imeju biopsy gosiri na onye ọrịa nwere pathological mgbanwe na ọgwụ-egbu egbu ịba ọcha n'anya.

N'ime otu afọ nke ijiGanoderma lucidummmiri decoction, onye ọrịa ahụ egosighi ihe ọ bụla.Ma mgbe ịgbanwee gaa na azụmahịa dịGanoderma lucidumntụ ntụ, ọ malitere ngwa ngwa mgbaàmà nke ịba ọcha n'anya.Mgbe ọ kwụsịrịGanoderma lucidumntụ ntụ, ihe ngosi biochemical ọbara ya a kpọtụrụ aha n'elu ji nwayọọ nwayọọ laghachi na nkịtị.Ya mere, onye ọrịa a chọpụtara na-egbu egbu ịba ọcha n'anya kpataraGanoderma lucidumntụ ntụ.Onye nta akụkọ ahụ kwuru na ebe ọ bụ na ihe mejupụtara nkeGanoderma lucidumEnweghị ike ịchọta ntụ ntụ, ọ bara uru ịtụle ma ọ bụ ihe ndị ọzọ kpatara nsị imeju ma ọ bụ mgbanwe dose mgbe ọ gbanwere iji were.Ganoderma lucidumntụ ntụ [2].

Ebe ọ bụ na onye nta akụkọ akọwaghị isi iyi na ihe onwunwe nkeGanoderma lucidumntụ ntụ, amabeghị ma ntụ ntụ a ọ bụGanoderma lucidumntụ ntụ na-amị mkpụrụ,Ganoderma lucidumspore ntụ ntụ ma ọ bụGanoderma lucidummycelium ntụ ntụ.Na-ede akwụkwọ na-ekwere na ndị kasị akpata nsi ịba ọcha n'anya kpataraGanoderma lucidumntụ ntụ na nke a bụ nsogbu àgwà nke ngwaahịa ọjọọ, ya bụ, mmetọ nke ebu, pesticides na arọ ọla.

Ya mere, mgbe ịzụrụ ngwaahịa Ganoderma,ndị na-azụ ahịa ga-eji nọmba nnabata nke ikike zụrụ ngwaahịa.Naanị ụdị ngwaahịa a nwalere site n'aka ndị ọzọ yana ndị ikike tozuru etozu kwadoro nwere ike inye ndị na-azụ ahịa nkwa ntụkwasị obi, nchekwa yana dị irè.

【Ntụaka】

1. Wah Cheuk, et al.Nlaghachi nke Gastric Large B-Cell Lymphoma Na-eso ya na Florid Lymphoma-dị ka T-cell Reaction: Immunomodulatory Mmetụta nkeGanoderma lucidum(Lingzhi).Akwụkwọ akụkọ International of Surgical Pathology.2007;15 (2): 180-86 .

2. Man-Fung Yuen, et al.Hepatotoxicity n'ihi mmepụta nkeGanoderma lucidum(lingzhi).Akwụkwọ akụkọ gbasara ịba ọcha n'anya.2004;41 (4): 686-7 .

Banyere Prof. Zhi-Bin Lin 

Dị ka onye ọsụ ụzọ na nyocha nke Ganoderma na China, o tinyela onwe ya na nyocha Ganoderma ihe fọrọ nke nta ka ọ bụrụ ọkara narị afọ.Dị ka onye bụbu osote onye isi oche nke Beijing Medical University (BMU), onye bụbu osote onye isi nke BMU School of Basic Medical Sciences na onye bụbu director nke BMU Institute of Basic Medicine na onye bụbu director nke Department of Pharmacology nke BMU, ọ bụ ugbu a a. prọfesọ nke Ngalaba Na-ahụ Maka Ọgwụ na Mahadum Peking School of Basic Medicine.A họpụtara ya ka ọ bụ ọkà mmụta nleta nke World Health Organisation Collaborating Center for Traditional Medicine na Mahadum Illinois dị na Chicago site na 1983 ruo 1984 na prọfesọ nleta na Mahadum Hong Kong site na 2000 ruo 2002. A họpụtara ya prọfesọ nsọpụrụ nke Perm State. Pharmaceutical Academy kemgbe 2006.

Kemgbe 1970, o jirila usoro sci-tech ọgbara ọhụrụ mụọ mmetụta ọgwụ na usoro nke Ganoderma lucidum na ihe ndị na-arụ ọrụ ya.O bipụtala akwụkwọ nyocha karịa 100 na Ganoderma.Site na 2014 ruo 2019, ahọpụtara ya n'ime ndepụta nke ndị nyocha China akpọrọ nke ukwuu nke Elsevier wepụtara maka afọ isii n'usoro.

Ọ bụ ya dereNnyocha ọgbara ọhụrụ na Ganoderma(site na mbipụta nke mbụ ruo mbipụta nke anọ),Lingzhi Site na Ihe omimi rue Sayensị(site na mbipụta nke mbụ ruo mbipụta nke atọ),Ganoderma LucidumNa-enyere aka n'ọgwụgwọ ọrịa kansa site n'ime ka nguzogide anụ ahụ dị ike na iwepụ ihe ndị na-akpata ọrịa., Kwuo okwu na Ganoderma, Ganoderma na ahụikena ọtụtụ ọrụ ndị ọzọ na Ganoderma.