Nkhaniyi idapangidwanso kuchokera ku magazini ya 94 ya GANODERMA mu 2022. Ufulu wa nkhaniyi ndi wa wolemba.

Zhi-Bin Lin, pulofesa wa Dipatimenti ya Pharmacology, Peking University School of Basic Medical Sciences

M'nkhaniyi, Prof. Lin adayambitsa milandu iwiri yolembedwa m'magazini asayansi.Chimodzi mwa izo chinali kutengaGanoderma lucidumspore ufa anachiritsa chapamimba kufalitsa lalikulu B cell lymphoma, ndipo winayo anali kutengaGanoderma lucidumufa unayambitsa poizoni wa chiwindi.Woyambayo adatsimikizira kuti kuchepa kwa chotupa kunali kogwirizana ndiGanoderma lucidumspore ufa pomwe womalizayo adawulula nkhawa zobisika zomwe zimayambitsidwa ndi zinthu zopanda pake za Ganoderma.Chifukwa chake, chisangalalo chimodzi komanso kugwedezeka kumodzi kudakumbutsa ogula kuti akhale osamala pogula zinthu za Ganoderma kuti asawononge ndalama ndikuvulaza matupi awo!

Mabuku ambiri azachipatala ali ndi gawo la "Case Report" lomwe limafotokoza zotsatira zomveka kuchokera ku matenda ndi chithandizo cha wodwala aliyense payekha, komanso kupeza zotsatirapo kapena zotsatira zoyipa za mankhwala.M'mbiri ya zamankhwala, nthawi zina zomwe munthu amapeza zimalimbikitsa chitukuko cha sayansi.

Mwachitsanzo, katswiri wa mabakiteriya wa ku Britain dzina lake Alexander Fleming anapeza koyamba ndipo ananena kuti mu 1928 katulutsidwe ka penicillin kamakhala ndi anti-staphylococcal effect, ndipo anaitcha penicillin.Kutulukira kumeneku kunasungidwa kwa zaka zambiri mpaka 1941 pamene katswiri wa zamankhwala wa ku Britain Howard Walter Florey ndi katswiri wa sayansi ya zakuthambo wa ku Germany Ernest Chain anauziridwa ndi pepala la Fleming kuti amalize kuyeretsa penicillin ndi kuyesa kwake kwa mankhwala odana ndi streptococci ndipo anatsimikizira mphamvu yake ya antibacterial kwa wodwala wakufa, penicillin inayamba. kulandira chisamaliro.

Pambuyo pa kafukufuku wawo wachiwiri ndi chitukuko, penicillin yapangidwa pamafakitale monga mankhwala oyamba omwe amagwiritsidwa ntchito m'mbiri ya anthu, kupulumutsa miyoyo yambiri ndikukhala chodziwika kwambiri m'zaka za zana la 20.Chifukwa chake, Fleming, Florey ndi Chain, omwe adachitanso kafukufuku ndi kupanga penicillin, adalandira Mphotho ya Nobel mu 1945 mu Physiology and Medicine.

Malipoti awiri otsatirawa azachipatala aGanoderma lucidum, ngakhale kuti zinapezeka mwangozi, zafufuzidwa mosamala ndi kufufuzidwa ndi mtolankhani.Yoyamba imapereka umboni wakugwiritsa ntchitoGanoderma lucidumpochiza kufalikira kwa B cell lymphoma (DLBCL) m'mimbapamene chakumapeto Icho chimatiuza ife zimenezozoipaGanoderma lucidummankhwala angayambitsehepatitis yapoizoni.

Ganoderma lucidumspore ufa anachiritsa vuto chapamimba diffuse lalikulu B-cell lymphoma. 

Pali milandu yambiri mwa anthuGanoderma lucidumali ndi zotsatira za kuchiza khansa, koma si kawirikawiri kuti lipoti ndi zofalitsa zachipatala.

Mu 2007, Wah Cheuk et al.a Queen Elizabeth Hospital ku Hong Kong adanenansoInternational Journal of Surgical Pathologymlandu wa wodwala wamwamuna wazaka 47 wopanda mbiri yakale yachipatala yemwe adabwera kuchipatala mu Januwale 2003 chifukwa cha ululu wam'mimba.

Helicobacter pyloriMatendawa adapezeka kuti ali abwino ndi kuyesa kwa mpweya wa urea, ndipo gawo lalikulu la zilonda zam'mimba linapezeka m'chigawo cha pyloric cha m'mimba mwa gastroscopy.Kuyesa kwa biopsy kunavumbulutsa kuchuluka kwa ma lymphocyte apakati mpaka akulu omwe amalowa m'matumbo am'mimba, okhala ndi ma nuclei osawoneka bwino, ma vacuolated chromatin omwe ali pakatikati, ndi nucleoli yodziwika bwino.

Kudetsa kwa Immunohistochemical kunawonetsa kuti ma cellwa anali abwino kwa CD20, antigen ya B-cell differentiation, yowonetsedwa kuposa 95% ya B-cell lymphomas, pomwe othandizira T cell (Th), cytotoxic T cell (CTL) ndi ma T cell owongolera (Treg). ) zinali zoipa kwa CD3, ndipo chiwerengero cha kukula kwa Ki67, chomwe chimasonyeza kuchuluka kwa maselo a chotupa, chinali chokwera mpaka 85%.Wodwalayo adapezeka kuti ali ndi chapamimba chachikulu B-cell lymphoma.

Popeza wodwalayo anayesedwa positiveHelicobacter pylorimatenda, chipatala anaganiza kuchitaHElicobacter pyloriKuchotsa chithandizo chamankhwala kwa wodwala kuyambira February 1 mpaka 7, ndikutsatiridwa ndi opaleshoni ya opaleshoni pa February 10. Chodabwitsa,Kufufuza kwapathological kwa zitsanzo zam'mimba zam'mimba sikunawonetse kusintha kwa histopathological kwa B-cell lymphoma yayikulu koma m'malo mwake adapeza maselo ang'onoang'ono a CD3 + CD8 + cytotoxic T omwe amalowa mkati mwa khoma la m'mimba, ndipo kuchuluka kwa Ki67 kutsika. mpaka 1%.

Kuonjezera apo, mu situ RT-PCR kuzindikira kwa T cell receptor beta chain (TCRβ) mRNA gene inasonyeza chitsanzo cha polyclonal, ndipo palibe chiwerengero cha T cell monoclonal chomwe chinapezeka.

Zotsatira zoyesa zomwe mtolankhaniyo adapereka zidawonetsa kuti ma cell a T omwe ali m'matumbo am'mimba mwa wodwalayo anali abwinobwino osati owopsa.Chifukwa ma cell chotupa amatha kusiyanitsa ndi kukhwima ndipo amakhala ndi cholembera chamtundu womwewo, amakhala monoclonal pomwe kuchuluka kwa cell ndi polyclonal.

Zinadziwika kuchokera ku kafukufukuyu kuti wodwalayo adatenga makapisozi 60 aGanoderma lucidumspore powder (kawiri kawiri mlingo wovomerezeka wa recommender) patsiku kuyambira February 1 mpaka 5. Pambuyo pa opaleshoni, wodwalayo sanalandire chithandizo chamankhwala, ndipo chotupacho sichinabwerenso pazaka ziwiri ndi theka. -pamwamba.

Ofufuzawo amakhulupirira kuti zotsatira za immunohistochemical za zitsanzo za biopsy zomwe zachitidwa opaleshoni sizigwirizana ndi kuthekera kwaHelicobacter pylorikuthetsedwa kwa lalikulu B-cell lymphoma, kotero iwo amaganiza kuti mwina odwala kutenga lalikulu Mlingo waGanoderma lucidumspore ufa umalimbikitsa kuyankha kwa chitetezo chamthupi kwa ma cell a cytotoxic T kupita ku B-cell lymphoma yayikulu, zomwe zimapangitsa kuti chotupa chisasunthike [1].

Nkhaniyi ili ndi chidziwitso chomveka bwino komanso njira yochizira.Wolemba nkhaniyi watsimikizira kuti chotupa chotupa chikugwirizana ndiGanoderma lucidumspore ufa kudzera mu histopathological and cellular and molecular biological research analysis, yomwe ndi yasayansi kwambiri komanso yoyenera kufufuza kwina.

Zotsatirazi ndi nkhani ya poizoni wa chiwindi woyambitsidwa ndiGanoderma lucidumufa.

Maphunziro ambiri azachipatala atsimikizira iziGanoderma lucidumfruiting thupi Tingafinye ndi ma polysaccharides ake ndi triterpenes, komansoGanoderma lucidumspore ufa, amakhala ndi zotsatira zoonekeratu za hepatoprotective.Iwo n'zoonekeratu kusintha kwenikweni matenda mankhwala a tizilombo chiwindi.

Komabe, mu 2004, Man-Fung Yuen et al.ya University of Hong Kong School of Medicine inanena za nkhani yaGanoderma lucidumhepatitis yowopsa yopangidwa ndi ufa muJournal of Hepatology.

Mayi wina wazaka 78 anakalandira chithandizo pachipatalachi chifukwa cha kudwaladwala, kusafuna kudya, kuyabwa pakhungu, ndi mkodzo wa tiyi kwa milungu iwiri.Wodwalayo anali ndi mbiri ya matenda oopsa ndipo wakhala akumwa mankhwala a antihypertensive felodipine mwachizolowezi kwa zaka ziwiri.Panthawi imeneyi, kuyezetsa kwake kwa chiwindi kunali koyenera, ndipo adatenganso calcium, mapiritsi a multivitamin ndi mapiritsiGanoderma lucidumyekha.Pambuyo kutenga decoctedGanoderma lucidumkwa chaka chimodzi, wodwalayo anasinthira ku malonda atsopanoGanoderma lucidumufa mankhwala. Sadakhala ndi zizindikiro zomwe zili pamwambazi pambuyo pa masabata anayi akumwamankhwala wotere.

Kupenda thupi kunavumbulutsa chizindikiro cha jaundice mwa wodwalayo.Zotsatira za kuyezetsa magazi ake am'magazi zikuwonetsedwa mu tebulo ili m'munsimu.Immunological kufufuza analetsa n`zotheka wodwala kudwala matenda a chiwindi A, B, C, ndi E. The histopathological zotsatira za chiwindi biopsy anasonyeza kuti wodwalayo anali pathological kusintha mankhwala poizoni chiwindi.

Pa chaka chimodzi kutengaGanoderma lucidummadzi decoction, wodwala sanasonyeze zachilendo.Koma mutasintha kukhala malondaGanoderma lucidumufa, iye mwamsanga anayamba zizindikiro za poizoni chiwindi.Pambuyo posiyaGanoderma lucidumufa, zizindikiro zake zamagazi zomwe tazitchula pamwambapa zinabwerera mwakale.Chifukwa chake, wodwalayo adapezeka kuti ali ndi hepatitis yowopsa chifukwa cha iziGanoderma lucidumufa.Mtolankhaniyu wati kuyambira pomwe adalemba buku laGanoderma lucidumufa sunadziwike, ndi bwino kuganizira ngati chiwopsezo cha chiwindi chinayambitsidwa ndi zinthu zina kapena kusintha kwa mlingo mutatha kusintha kuti mutengeGanoderma lucidumufa [2].

Popeza mtolankhani sanafotokoze gwero ndi katundu waGanoderma lucidumufa, sizikudziwika ngati ufa uwu uliGanoderma lucidumfruiting body powder,Ganoderma lucidumspore ufa kapenaGanoderma lucidummycelium ufa.Wolembayo amakhulupirira kuti chifukwa kwambiri chifukwa cha poizoni chiwindi chifukwaGanoderma lucidumufa mu nkhani iyi ndi vuto khalidwe la zoipa mankhwala, ndiko kuti, kuipitsa chifukwa nkhungu, mankhwala ndi zitsulo zolemera.

Chifukwa chake, pogula zinthu za Ganoderma,ogula ayenera kugula zinthu ndi chivomerezo cha olamulira.Zogulitsa zotere zokha zomwe zayesedwa ndi gulu lachitatu ndikuvomerezedwa ndi olamulira oyenerera zitha kupatsa ogula chitsimikizo chodalirika, chotetezeka komanso chothandiza.

【Zowonjezera】

1. Wah Cheuk, et al.Kusintha kwa Gastric Large B-Cell Lymphoma Kuphatikizidwa ndi Florid Lymphoma-ngati T-Cell Reaction: Immunomodulatory Effect ofGanoderma lucidum(Linga).International Journal of Surgical Pathology.2007;15(2):180-86.

2. Man-Fung Yuen, et al.Hepatotoxicity chifukwa cha kapangidwe kakeGanoderma lucidum(nthawi).Journal of Hepatology.2004;41(4):686-7.

Za Prof. Zhi-Bin Lin 

Monga mpainiya pakufufuza kwa Ganoderma ku China, adadzipereka ku kafukufuku wa Ganoderma kwa pafupifupi theka la zaka.Monga wachiwiri kwa purezidenti wakale wa Beijing Medical University (BMU), wachiwiri kwa dean wa BMU School of Basic Medical Sciences ndi mkulu wakale wa BMU Institute of Basic Medicine ndi mkulu wakale wa dipatimenti ya Pharmacology ya BMU, iye tsopano ndi mlembi. pulofesa wa dipatimenti ya Pharmacology ya Peking University School of Basic Medicine.Anasankhidwa kukhala katswiri woyendera wa World Health Organization Collaborating Center for Traditional Medicine pa yunivesite ya Illinois ku Chicago kuyambira 1983 mpaka 1984 komanso pulofesa woyendera pa yunivesite ya Hong Kong kuyambira 2000 mpaka 2002. Wasankhidwa kukhala pulofesa wolemekezeka wa Perm State. Pharmaceutical Academy kuyambira 2006.

Kuyambira 1970, wagwiritsa ntchito njira zamakono za sayansi kuti aphunzire zotsatira za mankhwala ndi njira za Ganoderma lucidum ndi zosakaniza zake.Wasindikiza mapepala ofufuza oposa 100 pa Ganoderma.Kuyambira 2014 mpaka 2019, adasankhidwa kukhala pamndandanda wa Ofufuza Apamwamba Achi China omwe adatulutsidwa ndi Elsevier kwa zaka zisanu ndi chimodzi zotsatizana.

Iye ndi mlembi waKafukufuku Wamakono pa Ganoderma(kuchokera ku 1st edition mpaka 4th edition),Lingzhi Kuchokera ku Chinsinsi mpaka Sayansi(kuchokera ku 1st edition mpaka 3rd edition),Ganoderma LucidumImathandiza Pochiza Khansa mwa Kulimbitsa Kukana kwa Thupi ndi Kuchotsa Zinthu Zoyambitsa Matenda, Lankhulani pa Ganoderma, Ganoderma ndi Healthndi ntchito zina zambiri pa Ganoderma.