Kab lus no yog luam tawm los ntawm 94th qhov teeb meem ntawm GANODERMA magazine nyob rau hauv 2022. Cov cai ntawm tsab xov xwm belongs rau tus sau.

Zhi-Bin Lin, tus xibfwb ntawm Department of Pharmacology, Peking University School of Basic Medical Sciences

Hauv tsab xov xwm no, Prof. Lin tau qhia txog ob qhov xwm txheej uas tau tshaj tawm hauv cov ntawv xov xwm tshawb fawb.Ib tug ntawm lawv yog hais tias nojGanoderma lucidumspore hmoov kho gastric diffuse loj B cell lymphoma, thiab lwm tus yog tias nojGanoderma lucidumhmoov ua rau mob kab mob siab.Cov yav tas los ua pov thawj tias qog regression muaj feem xyuam rauGanoderma lucidumspore hmoov thaum tom kawg nthuav tawm cov kev txhawj xeeb zais los ntawm cov khoom tsis zoo Ganoderma.Yog li ntawd, ib qho kev xyiv fab thiab ib qho kev poob siab tau ceeb toom rau cov neeg siv khoom kom ceev faj thaum yuav khoom Ganoderma kom tsis txhob nkim nyiaj thiab ua rau lawv lub cev raug mob!

Ntau phau ntawv kho mob muaj "Case Report" kem uas qhia txog qhov tseem ceeb ntawm kev tshawb pom los ntawm kev kuaj mob thiab kev kho mob ntawm ib tus neeg mob, nrog rau kev tshawb pom qhov tshwm sim lossis kev phiv loj ntawm cov tshuaj.Nyob rau hauv keeb kwm ntawm cov tshuaj, tej zaum ib tug neeg discoveries txhawb txoj kev loj hlob ntawm science.

Piv txwv li, British bacteriologist Alexander Fleming thawj zaug tshawb pom thiab tshaj tawm tias penicillin secretion muaj cov nyhuv anti-staphylococcal hauv xyoo 1928, thiab hu ua penicillin.Qhov kev tshawb pom no tau muab tso tseg rau ntau xyoo mus txog rau xyoo 1941 thaum kws tshuaj British Howard Walter Florey thiab German biochemist Ernest Chain tau txais kev tshoov siab los ntawm Fleming daim ntawv los ua kom tiav cov tshuaj tua kab mob penicillin thiab nws cov tshuaj tiv thaiv kab mob streptococci thiab ua pov thawj nws cov tshuaj tua kab mob hauv cov neeg mob tuag, penicillin pib. kom tau txais kev saib xyuas.

Tom qab lawv cov kev tshawb fawb theem nrab thiab kev loj hlob, penicillin tau tsim nyob rau hauv kev lag luam raws li thawj cov tshuaj tua kab mob siv nyob rau hauv tib neeg keeb kwm, txuag suav tsis tau lub neej thiab dhau los ua ib qho kev tshawb pom loj hauv xyoo pua 20th.Yog li ntawd, Fleming, Florey thiab Chain, uas tau xa mus rau kev tshawb fawb thiab tsim penicillin, tau txais 1945 Nobel nqi zog hauv Physiology thiab Tshuaj.

Ob daim ntawv ceeb toom kev kho mob hauv qab no ntawmGanoderma lucidum, txawm tias nrhiav tau los ntawm lub caij nyoog, tau ua tib zoo kawm thiab tshuaj xyuas los ntawm tus neeg sau xov xwm.Tus qub muab pov thawj raukev siv ntawmGanoderma lucidumhauv kev kho mob ntawm diffuse loj B cell lymphoma (DLBCL) hauv plabthaum kawg Nws qhia peb tiasphemGanoderma lucidumcov khoom tuaj yeem ua rautoxic kab mob siab.

Ganoderma lucidumspore hmoov kho ib rooj plaub ntawm gastric diffuse loj B-cell lymphoma. 

Muaj ntau qhov xwm txheej hauv cov neeg ntawdGanoderma lucidummuaj cov nyhuv ntawm kev kho mob qog noj ntshav, tab sis nws tsis tshua muaj tshwm sim los ntawm kev tshaj tawm kws kho mob.

Xyoo 2007, Wah Cheuk et al.ntawm poj huab tais Elizabeth Tsev Kho Mob hauv Hong Kong tau tshaj tawm hauvInternational Journal of Surgical Pathologyib rooj plaub ntawm tus txiv neej hnub nyoog 47 xyoo uas tsis muaj keeb kwm kho mob uas tau tuaj rau hauv tsev kho mob thaum Lub Ib Hlis 2003 vim mob plab sab sauv.

Helicobacter pyloriCov kab mob tau pom tias muaj txiaj ntsig zoo los ntawm kev kuaj urea ua pa, thiab thaj tsam loj ntawm plab hnyuv tau pom nyob rau hauv thaj tsam pyloric ntawm lub plab los ntawm gastroscopy.Kev kuaj ntshav biopsy tau nthuav tawm ntau qhov nruab nrab mus rau qhov loj lymphocytes nkag mus rau hauv lub plab phab ntsa, nrog cov nuclei tsis tu ncua, vacuolated chromatin nyob hauv lub nucleus, thiab tseem ceeb nucleoli.

Immunohistochemical staining pom tias cov hlwb no zoo rau CD20, B-cell sib txawv antigen, qhia ntau tshaj 95% ntawm B-cell lymphomas, whereas pab T hlwb (Th), cytotoxic T hlwb (CTL) thiab tswj T hlwb (Treg. ) yog qhov tsis zoo rau CD3, thiab Ki67 proliferation Performance index, uas qhia txog kev loj hlob ntawm cov qog hlwb, siab li 85%.Tus neeg mob tau kuaj pom tias mob plab hnyuv loj B-cell lymphoma.

Txij li tus neeg mob tau kuaj pom zoo rauHelicobacter pylorikis mob, tsev kho mob txiav txim siab uaHelicobacter pylori cov kab moberadication kho rau tus neeg mob los ntawm Lub ob hlis ntuj 1 mus rau 7, ua raws li kev phais resection rau lub ob hlis ntuj 10. Xav tsis thoob,Kev kuaj kab mob ntawm cov qog nqaij hlav hauv plab tsis tau qhia txog cov kev hloov pauv ntawm cov kab mob loj B-cell lymphoma tab sis pom ntau tus me me CD3 + CD8 + cytotoxic T cells infiltrating tag nrho cov tuab ntawm lub plab phab ntsa, thiab Ki67 proliferation Performance index poob. kom tsawg dua 1%.

Tsis tas li ntawd, nyob rau hauv situ RT-PCR nrhiav pom ntawm T cell receptor beta saw (TCRβ) mRNA gene pom ib tug qauv polyclonal, thiab tsis muaj monoclonal T cell tau kuaj pom.

Cov txiaj ntsig tau muab los ntawm tus neeg sau xov xwm tau qhia tias T hlwb hauv tus neeg mob lub plab cov ntaub so ntswg zoo li qub tsis yog malignant.Vim hais tias cov qog hlwb poob lub peev xwm los sib txawv thiab paub tab thiab tsuas muaj tib yam kab mob tshwj xeeb, lawv yog monoclonal thaum lub cell proliferation yog polyclonal.

Nws tau kawm los ntawm kev nug tias tus neeg mob noj 60 capsules ntawmGanoderma lucidumspore hmoov (3 zaug ntawm qhov pom zoo koob tshuaj ntawm tus neeg pom zoo) nyob rau ib hnub txij Lub Ob Hlis 1 txog rau 5. Tom qab kev phais, tus neeg mob tsis tau txais kev kho mob ntxiv, thiab cov qog tsis rov zoo dua thaum lub sijhawm ob xyoos thiab ib nrab xyoo ua raws. -up.

Cov kws tshawb fawb ntseeg tias cov txiaj ntsig ntawm immunohistochemical ntawm kev kuaj ntshav kuaj ntshav biopsy tsis txhawb qhov ua tau.Helicobacter pyloriKev tshem tawm ntawm B-cell lymphoma loj, yog li lawv xav tias nws yuav yog cov neeg mob noj tshuaj ntauGanoderma lucidumspore hmoov txhawb nqa lub zog tiv thaiv kab mob cov lus teb ntawm cytotoxic T hlwb mus rau B-cell lymphoma loj, uas nyob rau hauv lem ua rau kom tiav qog regression [1].

Daim ntawv ceeb toom rooj plaub no muaj kev kuaj pom tseeb thiab kev kho mob.Tus sau ntawm tsab xov xwm tau ua pov thawj tias qog regression muaj feem xyuam rauGanoderma lucidumspore hmoov los ntawm histopathological thiab cellular thiab molecular biological tshawb fawb soj ntsuam, uas yog heev scientific thiab tsim nyog ntawm kev tshawb fawb ntxiv.

Hauv qab no yog ib rooj plaub ntawm tus kab mob siab mob siab ua los ntawmGanoderma lucidumhmoov.

Ntau cov kev tshawb fawb pharmacological tau ua pov thawj tiasGanoderma lucidumfruiting lub cev extract thiab nws cov polysaccharides thiab triterpenes, thiabGanoderma lucidumspore hmoov, muaj qhov pom tseeb hepatoprotective teebmeem.Lawv muaj kev txhim kho pom tseeb hauv kev kho mob ntawm tus kab mob siab viral.

Txawm li cas los xij, xyoo 2004, Man-Fung Yuen et al.ntawm University of Hong Kong Tsev Kawm Ntawv Tshuaj Kho Mob tau tshaj tawm cov ntaub ntawv qhia txogGanoderma lucidumhmoov-induced toxic kab mob siab nyob rau hauv lubPhau ntawv Journal of Hepatology.

Ib tug poj niam muaj hnub nyoog 78 xyoo tau nrhiav kev kho mob ntawm lub tsev kho mob no vim muaj kev tsis haum xeeb, tsis qab los noj mov, khaus tawv nqaij, thiab tso zis xim tshuaj yej rau ob lub lis piam.Tus neeg mob muaj keeb kwm mob ntshav siab thiab tau noj tshuaj felodipine ib txwm muaj rau 2 xyoos.Thaum lub sijhawm no, nws lub siab ua haujlwm tau zoo li qub, thiab nws kuj tau noj calcium, multivitamin ntsiav tshuaj thiabGanoderma lucidumntawm nws tus kheej.Tom qab noj decoctionGanoderma lucidumrau ib xyoos, tus neeg mob tau hloov mus rau qhov kev lag luam tshiabGanoderma lucidumhmoov khoom. Snws tsim cov tsos mob saum toj no tom qab plaub lub lis piam nojxws li cov khoom.

Kev kuaj lub cev qhia tau tias muaj mob daj ntseg hauv tus neeg mob.Cov txiaj ntsig ntawm nws cov ntshav biochemical kuaj tau pom hauv cov lus hauv qab no.Kev kuaj kab mob tiv thaiv kab mob tau txiav txim siab qhov muaj peev xwm ntawm tus neeg mob uas muaj kab mob siab A, B, C, thiab E. Cov txiaj ntsig histopathological ntawm daim siab biopsy pom tias tus neeg mob muaj cov kab mob hloov pauv hauv cov tshuaj lom kab mob siab.

Thaum ib xyoos ntawm kev nojGanoderma lucidumdej decoction, tus neeg mob tsis pom qhov txawv txav.Tab sis tom qab hloov mus rau kev muag khoom muajGanoderma lucidumhmoov, nws sai sai tsim cov tsos mob ntawm toxic hepatitis.Tom qab discontinuing lubGanoderma lucidumhmoov, nws cov ntshav biochemical uas tau hais los saum toj no maj mam rov qab mus rau qhov qub.Yog li ntawd, tus neeg mob tau kuaj pom muaj kab mob siab mob siab los ntawmGanoderma lucidumhmoov.Tus kws sau xov xwm tau taw qhia tias txij li qhov muaj pes tsawg leeg ntawm covGanoderma lucidumhmoov tsis tuaj yeem kuaj pom, nws tsim nyog txiav txim siab seb lub siab toxicity yog tshwm sim los ntawm lwm cov khoom xyaw lossis hloov koob tshuaj tom qab hloov mus rau kev noj cov tshuaj.Ganoderma lucidumhmoov [2].

Txij li thaum tus neeg sau xov xwm tsis piav qhia qhov chaw thiab cov khoom ntawmGanoderma lucidumhmoov, nws tsis paub meej tias cov hmoov no puas yogGanoderma lucidumtxiv hmab txiv ntoo lub cev hmoov,Ganoderma lucidumspore hmoov los yogGanoderma lucidummycelium hmoov.Tus kws sau ntawv ntseeg tias feem ntau yuav ua rau muaj kab mob siab mob siab los ntawmGanoderma lucidumhmoov nyob rau hauv rooj plaub no yog qhov teeb meem zoo ntawm cov khoom tsis zoo, uas yog, cov pa phem tshwm sim los ntawm pwm, tshuaj tua kab thiab cov hlau hnyav.

Yog li ntawd, thaum yuav khoom Ganoderma,cov neeg siv khoom yuav tsum tau yuav cov khoom nrog rau tus lej pom zoo ntawm lub peev xwm muaj peev xwm.Tsuas yog cov khoom lag luam uas tau raug sim los ntawm lwm tus neeg sab nrauv thiab pom zoo los ntawm lub tuam txhab muaj peev xwm tuaj yeem muab cov neeg siv khoom muaj kev ntseeg siab, nyab xeeb thiab muaj txiaj ntsig zoo.

【References】

1. Wah Cheuk, et al.Regression ntawm Gastric Loj B-Cell Lymphoma Nrog Florid Lymphoma zoo li T-Cell Reaction: Immunomodulatory Effect ofGanoderma lucidum(Lingzhi).International Journal of Surgical Pathology.2007;15(2):180-86.

2. Man-Fung Yuen, et al.Hepatotoxicity vim yog formulation ntawmGanoderma lucidum(lingzhi).Phau ntawv Journal of Hepatology.2004;41(4):686-7.

Hais txog Prof. Zhi-Bin Lin 

Raws li tus pioneer hauv kev tshawb fawb ntawm Ganoderma hauv Suav teb, nws tau mob siab rau nws tus kheej rau kev tshawb fawb Ganoderma rau ze li ib nrab xyoo pua.Raws li yav dhau los tus lwm thawj coj ntawm Beijing Medical University (BMU), yav tas los tus lwm thawj saib xyuas ntawm BMU Tsev Kawm Ntawv ntawm Basic Medical Sciences thiab yav tas los tus thawj coj ntawm BMU Institute of Basic Medicine thiab yav tas los tus thawj coj ntawm Department of Pharmacology ntawm BMU, tam sim no nws yog ib tug xib fwb ntawm Department of Pharmacology ntawm Peking University School of Basic Medicine.Nws tau raug xaiv los mus saib xyuas tus kws tshawb fawb ntawm World Health Organization Collaborating Center for Traditional Medicine ntawm University of Illinois ntawm Chicago los ntawm 1983 txog 1984 thiab tuaj xyuas xibfwb hauv University of Hong Kong los ntawm 2000 txog 2002. Nws tau raug xaiv tsa tus kws tshaj lij ntawm Perm State. Pharmaceutical Academy txij thaum 2006.

Txij li thaum xyoo 1970, nws tau siv txoj kev tshawb fawb niaj hnub no los kawm txog cov tshuaj pharmacological thiab cov txheej txheem ntawm Ganoderma lucidum thiab nws cov khoom xyaw nquag.Nws tau luam tawm ntau dua 100 cov ntaub ntawv tshawb fawb ntawm Ganoderma.Los ntawm 2014 txog 2019, nws tau raug xaiv rau hauv cov npe ntawm Cov Kws Tshawb Fawb Suav Siab Tshaj Lij Tshaj Tawm los ntawm Elsevier rau rau xyoo sib law liag.

Nws yog tus sauKev tshawb fawb niaj hnub ntawm Ganoderma(los ntawm 1st edition mus rau 4th edition),Lingzhi Los Ntawm Tsis Paub Txog Kev Tshawb Fawb(los ntawm 1st edition mus rau 3rd edition),Ganoderma LucidumPab hauv kev kho mob qog noj ntshav los ntawm kev ntxiv dag zog lub cev tiv thaiv thiab tshem tawm cov kab mob pathogenic, Tham txog Ganoderma, Ganoderma thiab Healththiab ntau lwm yam haujlwm ntawm Ganoderma.