Ichi chinyorwa chakadhindwa kubva kumagazini ye94 yeGANODERMA muna 2022. Kopirateti yechinyorwa ndeyemunyori.

Zhi-Bin Lin, purofesa weDhipatimendi rePharmacology, Peking University Chikoro cheBasic Medical Sayenzi.

Muchinyorwa chino, Prof. Lin akatanga nyaya mbiri dzakataurwa mumagazini esainzi.Imwe yacho yaive iyo kutoraGanoderma lucidumspore poda yakarapa gastric diffuse hombe B cell lymphoma, uye imwe yacho yaive iyo kutoraGanoderma lucidumupfu hwakakonzera chepfu hepatitis.Yekutanga yakaratidza kuti bundu regression rakabatana neGanoderma lucidumspore poda apo iyo yekupedzisira yakafumura zvakavanzwa zvinonetsa zvinokonzerwa nehurombo hwemhando yeGanoderma zvigadzirwa.Naizvozvo, mufaro mumwe uye kuvhunduka kumwe kwakayeuchidza vatengi kuti vangwarire pavanenge vachitenga zvigadzirwa zveGanoderma kuti varege kutambisa mari uye kukuvadza miviri yavo!

Majenari mazhinji ezvokurapa ane chikamu che“Nyaya Yenyaya” chinoshuma zvakawanikwa zvine musoro kubva mukuongororwa nekurapwa kwemurwere mumwe nemumwe, pamwe nekuona mhedzisiro kana kukanganisa kwakanyanya kwezvinodhaka.Munhoroondo yemishonga, dzimwe nguva kuwanikwa kwemunhu kunosimudzira kusimukira kwesainzi.

Semuyenzaniso, nyanzvi yezvipembenene yokuBritain, Alexander Fleming, akatanga kuwana ndokushuma kuti kubuda kwepenicillin kune anti-staphylococcal effect muna 1928, ndokuitumidza penicillin.Kuwanikwa uku kwakadzivirirwa kwemakore akawanda kusvika 1941 apo nyanzvi yemishonga yekuBritain Howard Walter Florey uye nyanzvi yemakemikari yezvipenyu wekuGermany Ernest Chain vakafemerwa nebepa raFleming kuti vapedze kucheneswa kwepenicillin nekuedza kwayo kwemishonga yeanti-streptococci uye yakaratidza kushanda kwayo kweantibacterial mumurwere ari kufa, penicillin yakatanga. kugamuchira ngwariro.

Mushure mekutsvakurudza kwavo kwechipiri nekuvandudzwa, penicillin yakagadzirwa pamwero weindasitiri semushonga wekutanga wakashandiswa munhoroondo yevanhu, uchiponesa hupenyu husingaverengeki uye kuva kuwanikwa kukuru muzana remakore rechi20.Naizvozvo, Fleming, Florey naChain, avo vakadzokera kutsvagisa nekugadzira penicillin, vakapihwa mubairo weNobel muna 1945 muPhysiology neMishonga.

Mishumo miviri inotevera yekiriniki yeGanoderma lucidum, kunyange zvazvo zvakawanikwa netsaona, zvakanyatsoongororwa uye zvakaongororwa nemutori wenhau.Yekutanga inopa humbowo hwekushandiswa kweGanoderma lucidummukurapa kwekupararira hombe B cell lymphoma (DLBCL) mudumbunepo chekupedzisira Chinotiudza izvozvozvakaipaGanoderma lucidumzvigadzirwa zvinogona kukonzerachepfu hepatitis.

Ganoderma lucidumspore poda yakarapa nyaya yegastric diffuse hombe B-cell lymphoma. 

Kune zviitiko zvakawanda muvanhu izvoGanoderma lucidumine simba rekurapa gomarara, asi kashoma kutaurwa nemabhuku ezvekurapa.

Muna 2007, Wah Cheuk et al.weQueen Elizabeth Hospital muHong Kong yakashuma muInternational Journal yeKuvhiya PathologyMhosva yemurume ane makore makumi mana nemanomwe ekuberekwa asina nhoroondo yezvehutano yakakosha akauya kuchipatara muna Ndira 2003 nekuda kwekurwadziwa kwepamusoro mudumbu.

Helicobacter pylorihutachiona hwakaonekwa hune hutano neurea breath test, uye nzvimbo yakakura yegumbo remudumbu rakawanikwa munharaunda yepyloric yemudumbu ne gastroscopy.Biopsy sampling yakaratidza huwandu hukuru hwepakati kusvika kuhombe lymphocyte inopinda mumadziro egastric, iine nuclei isina kuumbwa, vacuolated chromatin iri munucleus, uye yakakurumbira nucleoli.

Immunohistochemical staining yakaratidza kuti masero aya aive akanaka kuCD20, B-cell differentiation antigen, inoratidzwa mune inodarika 95% yeB-cell lymphomas, nepo mubatsiri T masero (Th), cytotoxic T masero (CTL) uye anodzora T masero (Treg. ) dzaive dzisina kunaka kuCD3, uye Ki67 proliferation index, iyo inoratidza kuwedzera kwekuita kwebundu maseru, yakakwira kusvika 85%.Murwere akaonekwa aine gastric diffuse hombe B-cell lymphoma.

Sezvo murwere akaongororwa kuti ane positiveHelicobacter pyloriutachiona, chipatara chakasarudza kuitaHelicobacter pylorikurapa kwekubvisa pamurwere kubva munaFebruary 1 kusvika 7, kuteverwa nekuvhiya resection musi waFebruary 10. Zvinoshamisa,kuongororwa kwepathological kweakabviswa gastric tissue samples hakuna kuburitsa histopathological shanduko yekupararira hombe B-cell lymphoma asi panzvimbo pacho yakawana nhamba huru yediki CD3+CD8+ cytotoxic T masero achipinda mukukora kwakazara kwegastric wall, uye Ki67 proliferation index yakadonha. kusvika pasi pe1%.

Mukuwedzera, mu situ RT-PCR kuonekwa kweT cell receptor beta chain (TCRβ) mRNA gene yakaratidza polyclonal pattern, uye hapana monoclonal T cell population yakaonekwa.

Mhedzisiro yebvunzo yakapihwa nemutori wenhau yakaratidza kuti masero eT ari mudumbu remurwere aive akajairwa kwete akashata.Nekuti bundu masero anorasikirwa nekugona kusiyanisa uye kukura uye angove neamwechete chaiwo genetic marker, iwo ari monoclonal nepo zvakajairika sero kuwanda kuri polyclonal.

Zvakadzidzwa kubva mukubvunza kuti murwere akatora 60 capsules yeGanoderma lucidumspore powder (3 nguva inokurudzirwa yeanokurudzira) pazuva kubva munaFebruary 1 kusvika ku5. Mushure mekuvhiyiwa, murwere haana kugamuchira chero adjuvant therapy, uye bundu racho harina kudzoka munguva yekutevera kwemakore maviri nehafu. -kumusoro.

Vatsvagiri vanotenda kuti iyo immunohistochemical mhedzisiro yekuvhiyiwa yakadzokororwa biopsy samples haitsigire mukana wekuita.Helicobacter pylorikubviswa kweB-cell lymphoma yakakura, saka vanofungidzira kuti zvingave kuti varwere vanotora madosi makuru eGanoderma lucidumspore poda inokurudzira kushingaira kwekudzivirira zvirwere zve cytotoxic T masero kusvika kuB-cell lymphoma yakakura, iyo inozotungamirira kukuzadza bundu regression [1].

Iyi nyaya yenyaya ine chirwere chakajeka uye nzira yekurapa.Munyori wechinyorwa aratidza kuti bundu regression rine hukama neGanoderma lucidumspore poda kuburikidza nehistopathological uye cellular uye molecular biological research ongororo, inova yesainzi zvakanyanya uye yakakodzera kuenderera mberi nekutsvaga.

Inotevera inyaya ye toxic hepatitis inokonzerwa neGanoderma lucidumupfu.

Zvidzidzo zvakawanda zvemishonga zvakaratidza izvozvoGanoderma lucidumfruiting body extract uye ayo polysaccharides uye triterpenes, uyewoGanoderma lucidumspore poda, vane pachena hepatoprotective migumisiro.Vane zviri pachena kuvandudza maitiro mukurapa kwehutachiona hwehutachiwana.

Zvisinei, muna 2004, Man-Fung Yuen et al.yeYunivhesiti yeHong Kong Chikoro cheMishonga yakashuma nyaya yenyayaGanoderma lucidumupfu-induced chepfu hepatitis muNyaya yeHepatology.

Mumwe mukadzi ane makore 78 okuberekwa akatsvaga kurapwa pachipatara ichi nekuda kwekusanzwa zvakanaka, kusanzwa kuda kudya, ganda rakafunuka, uye weti ine ruvara rwetii kwemavhiki maviri.Murwere aive nenhoroondo yehypertension uye anga achitora antihypertensive drug felodipine nguva nenguva kwemakore maviri.Munguva iyi, zviedzo zvechiropa chake zvaive zvakajairika, uye akatorawo calcium, mahwendefa e-multivitamin uyeGanoderma lucidumari oga.Mushure mekutora decoctedGanoderma lucidumkwegore rimwe chete, murwere akachinja kune imwe itsva inotengeswaGanoderma lucidumupfu chigadzirwa. Sakatanga zviratidzo zviri pamusoro mushure memavhiki mana ekutorachigadzirwa chakadaro.

Kuongororwa kwepanyama kwakaratidza jaundice yakaratidza mumurwere.Mhedzisiro yeropa rake biochemical test inoratidzwa mutafura iri pazasi.Immunological kuongorora yakabvisa mukana wemurwere anotambura nehutachiona hwehepatitis A, B, C, uye E. The histopathological migumisiro yechiropa biopsy yakaratidza kuti murwere aiva pathological kuchinja zvinodhaka-chepfu hepatitis.

Mukati megore rimwe rekutoraGanoderma lucidummvura decoction, murwere haana kuratidza abnormality.Asi mushure mekuchinja kune zvekutengesa zviripoGanoderma lucidumupfu, akakurumidza kuva nezviratidzo zvehuputi hwehuputi.Mushure mekurega basaGanoderma lucidumhupfu, ropa rake rataurwa pamusoro apa biochemical zviratidzo zvishoma nezvishoma zvakadzokera kune zvakajairika.Saka, murwere akaonekwa kuti ane chepfu hepatitis yakakonzerwaGanoderma lucidumupfu.Mutori wenhau anoti kubva pakuumbwa kweGanoderma lucidumpoda yaisagona kuonekwa, zvakakosha kufunga kuti huturu hwechiropa hwakakonzerwa nezvimwe zvinongedzo kana shanduko yedosi mushure mekuchinja kutoraGanoderma lucidumupfu [2].

Sezvo mutori wenhau asina kutsanangura kwakabva uye zvinhu zveGanoderma lucidumhupfu, hazvizivikanwe kuti hupfu uhwuGanoderma lucidumfruiting body powder,Ganoderma lucidumSpore powder kanaGanoderma lucidummycelium powder.Munyori anotenda kuti chinonyanya kukonzera chepfu hepatitis inokonzerwaGanoderma lucidumpoda munyaya iyi idambudziko rehutano hwechigadzirwa chakaipa, ndiko kuti, kusvibiswa kunokonzerwa ne mold, pesticides uye heavy metals.

Naizvozvo, kana uchitenga zvigadzirwa zveGanoderma,vatengi vanofanira kutenga zvigadzirwa nenhamba yemvumo yevanokwanisa.Zvigadzirwa zvakadaro chete zvakaedzwa nemunhu wechitatu uye zvakatenderwa neane masimba anokwanisa kupa vatengi vimbiso dzakavimbika, dzakachengeteka uye dzinoshanda.

【Mareferensi】

1. Wah Cheuk, nevamwe.Regression of Gastric Large B-Cell Lymphoma Inoperekedzwa neFlorid Lymphoma-yakafanana neT-Cell Reaction: Immunomodulatory Effect ofGanoderma lucidum(Lingzhi).International Journal yeKuvhiya Pathology.2007;15(2):180-86.

2. Man-Fung Yuen, nevamwe.Hepatotoxicity nekuda kwekugadzirwa kweGanoderma lucidum(lingzhi).Nyaya yeHepatology.2004;41(4):686-7.

Nezve Prof. Zhi-Bin Lin 

Sezvo ari piyona mukutsvakurudza kweGanoderma muChina, akazvipira kuGanoderma tsvakurudzo kweanoda kusvika hafu yezana remakore.Seaimbove mutevedzeri wemutungamiri weBeijing Medical University (BMU), aimbova mutevedzeri weDean weBMU Chikoro cheBasic Medical Sayenzi uye aimbova mutungamiriri weBMU Institute of Basic Medicine uye aimbova director weDhipatimendi rePharmacology yeBMU, iye zvino purofesa weDhipatimendi rePharmacology yePeking University Chikoro cheBasic Medicine.Akanga agadzwa kuva nyanzvi inoshanyira yeWorld Health Organisation Collaborating Center for Traditional Medicine paUniversity of Illinois kuChicago kubva muna 1983 kusvika 1984 uye purofesa anoshanyira paUniversity yeHong Kong kubva muna 2000 kusvika 2002. Akagadzwa kuva purofesa anoremekedzwa wePerm State. Pharmaceutical Academy kubvira 2006.

Kubva 1970, akashandisa nzira dzemazuva ano dzesainzi kuti adzidze maitiro emishonga uye maitirwo eGanoderma lucidum uye ayo anoshanda zvinosanganisa.Akaburitsa anopfuura zana ekutsvagisa mapepa paGanoderma.Kubva 2014 kusvika 2019, akasarudzwa mune rondedzero yeYakanyanya Cited Chinese Vatsvagiri yakaburitswa naElsevier kwemakore matanhatu akateedzana.

Ndiye munyori weKutsvakurudza kwemazuva ano pamusoro peGanoderma(kubva ku1st edition kusvika ku4th edition),Lingzhi Kubva Chakavanzika kuenda kuSainzi(kubva ku1st edition kusvika ku3rd edition),Ganoderma LucidumInobatsira muKurapwa kweCancer nekusimbisa Muviri Resistance uye Kubvisa Pathogenic Factors., Taura nezveGanoderma, Ganoderma uye Utanouye mamwe akawanda mabasa paGanoderma.