Lesi sihloko sikhiqizwe kabusha kusukela kumagazini we-GANODERMA wama-94 ngo-2022. I-copyright ye-athikili ingeyombhali.

Zhi-Bin Lin, uprofesa woMnyango Wezakhemisi, ePeking University School of Basic Medical Sciences

Kulesi sihloko, uProf Lin wethula amacala amabili abikwe kumajenali esayensi.Omunye wabo kwaba lokho ukuthathaI-Ganoderma lucidumI-spore powder yelaphe i-gastric diffuse B cell lymphoma enkulu, kanti enye yayiyilokho ukuthathaI-Ganoderma lucidumpowder okubangelwa i-hepatitis enobuthi.Owokuqala wafakazela ukuthi ukwehla kwesimila kwakuhlobeneI-Ganoderma lucidumi-spore powder ngenkathi lena yakamuva idalula ukukhathazeka okufihliwe okubangelwa imikhiqizo ye-Ganoderma esezingeni eliphansi.Ngakho-ke, injabulo eyodwa kanye nokushaqeka okukodwa kukhumbuze abathengi ukuthi baqaphele lapho bethenga imikhiqizo ye-Ganoderma ukuze bangamoshi imali futhi balimaze imizimba yabo!

Amajenali amaningi ezokwelapha anekholomu "Yombiko Wecala" ebika ukutholwa okunengqondo okuvela ekuxilongweni nasekwelapheni kwesiguli ngasinye, kanye nokuthola imiphumela noma imiphumela emibi kakhulu yezidakamizwa.Emlandweni wezokwelapha, ngezinye izikhathi ukutholwa komuntu ngamunye kukhuthaza ukuthuthukiswa kwesayensi.

Ngokwesibonelo, isazi samagciwane saseBrithani u-Alexander Fleming saqala sathola futhi sabika ukuthi ukukhishwa kwe-penicillin kunomphumela we-anti-staphylococcal ngo-1928, futhi wawuqamba ngokuthi i-penicillin.Lokhu kutholakala kwagcinwa iminyaka eminingi kwaze kwaba ngu-1941 lapho usokhemisi waseBrithani uHoward Walter Florey kanye nesazi samakhemikhali ezinto eziphilayo saseJalimane u-Ernest Chain begqugquzelwa yiphepha likaFleming ukuba baqedele ukuhlanzwa kwe-penicillin kanye nokuhlolwa kwayo kwe-anti-streptococci kwezemithi futhi kwafakazela ukusebenza kwayo kwe-antibacterial esigulini esifayo, i-penicillin yaqala. ukuthola ukunakwa.

Ngemva kocwaningo lwabo lwesibili kanye nokuthuthuka, i-penicillin iye yakhiqizwa ngezinga lezimboni njengemithi elwa namagciwane yokuqala esetshenziswa emlandweni wesintu, isindisa izimpilo ezingenakubalwa futhi yaba ukutholwa okukhulu ekhulwini lama-20.Ngakho-ke, uFleming, uFlorey kanye noChain, abadlulisela ucwaningo nokuthuthukisa i-penicillin, baklonyeliswa ngomklomelo kaNobel we-1945 wePhysiology and Medicine.

Imibiko emibili elandelayo yezimo zomtholampilo zeI-Ganoderma lucidum, nakuba zitholwe ngengozi, ziye zacutshungulwa ngokucophelela futhi zahlaziywa yintatheli.Owokuqala unikeza ubufakaziukusetshenziswa kweI-Ganoderma lucidumekwelapheni ukusabalalisa i-B cell lymphoma (DLBCL) enkulu esiswinikuyilapho okwakamuva Kusitshela lokhokubiI-Ganoderma lucidumimikhiqizo kungabangelai-hepatitis enobuthi.

I-Ganoderma lucidumI-spore powder yelapha i-gastric diffuse B-cell lymphoma enkulu. 

Maningi amacala kubantu lokhoI-Ganoderma luciduminomphumela wokwelapha umdlavuza, kodwa akuvamile ukuba kubikwe izincwadi zochwepheshe bezokwelapha.

Ngo-2007, u-Wah Cheuk et al.wesibhedlela iQueen Elizabeth eHong Kong kubikwe kuIjenali Yomhlaba Wonke Yezifo Zokuhlinzaicala lesiguli esineminyaka engu-47 ubudala esingenamlando wezokwelapha ofanele owafika esibhedlela ngoJanuwari 2003 ngenxa yobuhlungu obungaphezulu besisu.

I-Helicobacter pyloriukutheleleka kwatholakala ukuthi kuhle ngokuhlolwa kokuphefumula kwe-urea, futhi indawo enkulu yesilonda esiswini yatholakala endaweni ye-pyloric yesisu nge-gastroscopy.Ukusampula kwe-Biopsy kwembule inqwaba yama-lymphocyte aphakathi nendawo ukuya amakhulu angena odongeni lwesisu, ane-nuclei emise ngendlela engavamile, i-vacuolated chromatin etholakala kuyi-nucleus, kanye ne-nucleoli evelele.

I-Immunohistochemical staining ibonise ukuthi lawa maseli ayenayo i-CD20, i-B-cell differentiation antigen, evezwe ngaphezu kwama-95% we-B-cell lymphomas, kuyilapho ama-T cell asizayo (Th), ama-cytotoxic T cells (CTL) nama-T cell alawulayo (Treg). ) zazingezinhle ku-CD3, kanti inkomba yokwanda kwe-Ki67, ebonisa umsebenzi okhulayo wamangqamuzana esimila, yayifinyelela ku-85%.Isiguli satholwa ngokomtholampilo sine-gastric diffuse B-cell lymphoma enkulu.

Njengoba isiguli sihlolelweI-Helicobacter pyloriukutheleleka, isibhedlela sanquma ukwenzaHi-elicobacter pyloriukwelashwa kokuqeda isiguli kusukela ngo-February 1 kuya ku-7, okulandelwa ukuhlinzwa ngokuhlinzwa ngo-February 10. Ngokumangalisayo,ukuhlolwa kwe-pathological kwamasampula ezicubu zesisu azange kuveze izinguquko ze-histopathological ze-B-cell lymphoma enkulu esabalele kodwa esikhundleni salokho kwathola inani elikhulu lamaseli amancane e-CD3+CD8+ cytotoxic T angena ugqinsi olugcwele lodonga lwesisu, futhi inkomba yokwanda kwe-Ki67 yehla. ngaphansi kuka-1%.

Ukwengeza, ukutholwa kwe-RT-PCR ye-T cell receptor beta chain (TCRβ) mRNA gene kubonise iphethini ye-polyclonal, futhi akukho inani le-T cell monoclonal elitholiwe.

Imiphumela yokuhlolwa enikezwe yintatheli ibonise ukuthi ama-T cell esicutshini sesisu sesiguli ayejwayelekile kunokuba abe yingozi.Ngenxa yokuthi amaseli wesimila alahlekelwa amandla okuhlukanisa nokuvuthwa futhi anomaka wofuzo ofanayo kuphela, angama-monoclonal kuyilapho ukwanda kwamaseli okuvamile kuyi-polyclonal.

Kutholwe ophenyweni ukuthi isiguli sathatha amaphilisi angama-60I-Ganoderma lucidumi-spore powder (izikhathi ezingu-3 umthamo onconywayo we-recommender) ngosuku kusukela ngo-February 1 kuya ku-5. Ngemva kokuhlinzwa, isiguli asizange sithole noma yikuphi ukwelashwa kwe-adjuvant, futhi isimila asizange siphinde sibuyele phakathi nokulandela kweminyaka emibili nengxenye. -phezulu.

Abacwaningi bakholelwa ukuthi imiphumela ye-immunohistochemical yamasampula e-biopsy ahlinzekwe ngokuhlinzwa ayisekeli ukuthi kungenzekaI-Helicobacter pyloriukuqedwa kwe-B-cell lymphoma enkulu, ngakho bacabanga ukuthi kungenzeka ukuthi iziguli ezithatha imithamo emikhulu yeI-Ganoderma lucidumI-spore powder ikhuthaza ukusabela kokuzivikela komzimba okusebenzayo kwamaseli e-cytotoxic T kuya ku-B-cell lymphoma enkulu, okuholela ekuqedeni ukuhlehla kwesimila [1].

Lo mbiko wecala unokuxilongwa okucacile kanye nenqubo yokwelashwa.Umbhali wendatshana ufakazele ukuthi ukwehla kwesimila kuhlobeneI-Ganoderma lucidumi-spore powder ngokusebenzisa ukuhlaziywa kocwaningo lwe-histopathological kanye neselula kanye ne-molecular biological biological, okungokwesayensi kakhulu futhi okufanele kwenziwe ucwaningo olwengeziwe.

Okulandelayo yindaba ye-hepatitis enobuthi ebangelwaI-Ganoderma lucidumimpushana.

Izifundo eziningi zemithi ziye zakufakazela lokhoI-Ganoderma lucidumi-fruiting body extract kanye nama-polysaccharides ayo nama-triterpenes, kanyeI-Ganoderma lucidumi-spore powder, ibe nemiphumela esobala ye-hepatoprotective.Banomphumela osobala wokuthuthuka ekwelashweni komtholampilo kwe-viral hepatitis.

Nokho, ngo-2004, Man-Fung Yuen et al.weNyuvesi yaseHong Kong School of Medicine wabika umbiko wecalaI-Ganoderma lucidumi-powder-induced toxic hepatitis ku-Ijenali ye-Hepatology.

Isalukazi esineminyaka engu-78 ubudala safuna ukwelashwa kulesi sibhedlela ngenxa yokungathandi ukudla, isikhumba esilumayo, nomchamo onemibala yetiye amasonto amabili.Isiguli sasinomlando womfutho wegazi ophakeme futhi besikade sithatha isidakamizwa se-antihypertensive i-felodipine ngokujwayelekile iminyaka emi-2.Ngalesi sikhathi, ukuhlolwa kwesibindi sakhe kwakujwayelekile, futhi wathatha i-calcium, amaphilisi e-multivitamin kanyeI-Ganoderma lucidumyedwa.Ngemva kokuthatha decoctedI-Ganoderma lucidumunyaka owodwa, isiguli sashintshela endaweni entsha etholakala ngokwentengisoI-Ganoderma lucidumumkhiqizo powder. Swaba nezimpawu ezingenhla ngemva kwamasonto amane ezithathileumkhiqizo onjalo.

Ukuhlolwa ngokomzimba kwembula i-jaundice ephawulekayo esigulini.Imiphumela yokuhlolwa kwamakhemikhali egazi lakhe ikhonjisiwe kulelithebula elingezansi.Ukuhlolwa kokugonywa kwamasosha omzimba kwakhipha ukuthi kungenzeka isiguli esiphethwe isifo sokusha kwesibindi kohlobo A, B, C, no-E.

Ngonyaka owodwa wokuthathaI-Ganoderma lucidumi-decoction yamanzi, isiguli asizange sibonise ukungavamile.Kodwa ngemva kokushintshela ekutholakaleni kwezohweboI-Ganoderma lucidumpowder, ngokushesha waba nezimpawu ze-hepatitis enobuthi.Ngemva kokuyeka i-I-Ganoderma lucidumpowder, izinkomba zegazi lakhe elishiwo ngenhla kwamakhemikhali egazi kancane kancane zabuyela kwesijwayelekile.Ngakho-ke, isiguli satholakala sine-hepatitis enobuthi ebangelwaI-Ganoderma lucidumimpushana.Intatheli iveze ukuthi selokhu kwaqanjwa iqembu leI-Ganoderma lucidumI-powder ayizange ibonakale, kufanelekile ukucabangela ukuthi ubuthi besibindi bubangelwa ezinye izithako noma ukushintsha umthamo ngemva kokushintsha ukuthathaI-Ganoderma lucidumimpushana [2].

Njengoba intatheli ingawuchazanga umthombo nezakhiwo zeI-Ganoderma lucidumimpushana, akucaci ukuthi iyimpushana yiniI-Ganoderma lucidumi-fruiting body powder,I-Ganoderma lucidumspore powder nomaI-Ganoderma lucidumi-mycelium powder.Umbhali ukholelwa ukuthi imbangela engenzeka kakhulu ye-hepatitis enobuthi ebangelwaI-Ganoderma lucidumpowder kuleli cala inkinga yekhwalithi yomkhiqizo omubi, okungukuthi, ukungcola okubangelwa isikhunta, izibulala-zinambuzane nezinsimbi ezinzima.

Ngakho-ke, lapho uthenga imikhiqizo ye-Ganoderma,abathengi kufanele bathenge imikhiqizo ngenombolo yokugunyazwa yesiphathimandla esinekhono.Imikhiqizo enjalo kuphela ehlolwe inkampani yangaphandle futhi yagunyazwa isiphathimandla esinekhono enganikeza abathengi iziqinisekiso ezithembekile, eziphephile nezisebenzayo.

【Izithenjwa】

1. Wah Cheuk, et al.Ukuhlehla Kwe-Gastric Large B-Cell Lymphoma Kuhambisana ne-Florid Lymphoma-like T-Cell Reaction: Immunomodulatory Effect ofI-Ganoderma lucidum(Lingi).Ijenali Yomhlaba Wonke Yezifo Zokuhlinza.2007;15(2):180-86.

2. UMan-Fung Yuen, et al.I-Hepatotoxicity ngenxa yokwakhiwa kweI-Ganoderma lucidum(ingoma).Ijenali ye-Hepatology.2004;41(4):686-7.

Mayelana noProf. Zhi-Bin Lin 

Njengengqalabutho ocwaningweni lweGanoderma eChina, uye wazinikela ocwaningweni lweGanoderma cishe iminyaka eyikhulu.Njengowayeyiphini likamongameli we-Beijing Medical University (BMU), owayeyiphini lika-Dean we-BMU School of Basic Medical Science kanye nomqondisi wangaphambili we-BMU Institute of Basic Medicine kanye nomqondisi wangaphambili woMnyango Wezemithi ye-BMU, manje usengumfundisi. uprofesa woMnyango Wezemithi wePeking University School of Basic Medicine.Wayeqokwe njengesazi esivakashelayo se-World Health Organization Collaborating Center for Traditional Medicine eNyuvesi yase-Illinois eChicago kusukela ngo-1983 kuya ku-1984 kanye noprofesa ovakashele eNyuvesi yaseHong Kong kusukela ngo-2000 kuya ku-2002. Uqokwe njengoprofesa ohloniphekile we-Perm State. I-Pharmaceutical Academy kusukela ngo-2006.

Kusukela ngo-1970, usebenzise izindlela zesimanje ze-sci-tech ukutadisha imiphumela yemithi nezindlela ze-Ganoderma lucidum kanye nezithako zayo ezisebenzayo.Ushicilele amaphepha ocwaningo angaphezu kwe-100 ku-Ganoderma.Kusukela ngo-2014 kuya ku-2019, wakhethwa ohlwini lwabacwaningi baseShayina Abacashunwe Kakhulu abakhishwe ngu-Elsevier iminyaka eyisithupha ilandelana.

Ungumbhali weUcwaningo Lwesimanje Nge-Ganoderma(kusuka kuhlelo lokuqala kuye kolwesine),I-Lingzhi Kusukela Kuyimfihlakalo Kuya Kwesayensi(kusuka kuhlelo lokuqala ukuya kuhlelo lwesi-3),I-Ganoderma LucidumIsiza Ekwelapheni Umdlavuza Ngokuqinisa Ukumelana Nomzimba Nokuqeda Izinto Ezibangela I-Pathogenic, Khuluma nge-Ganoderma, I-Ganoderma kanye Nezempiloneminye imisebenzi eminingi kuGanoderma.