Hoʻopuka hou ʻia kēia ʻatikala mai ka pukana 94th o GANODERMA magazine ma 2022. No ka mea kākau ke kuleana kope o ka ʻatikala.

ʻO Zhi-Bin Lin, ke kaukaʻi o ka 'Oihana o Pharmacology, Ke Kula Nui o Peking University of Basic Medical Sciences

Ma kēia ʻatikala, ua hoʻopuka ʻo Prof. Lin i ʻelua mau hihia i hōʻike ʻia i loko o nā nūpepa ʻepekema.ʻO kekahi o lākou ka lawe ʻanaʻO Ganoderma lucidumʻO ka pauka spore i ho'ōla i ka ʻōpū e hoʻopuehu ana i ka lymphoma cell B nui, a ʻo ka mea ʻē aʻe ʻo ia ka lawe ʻanaʻO Ganoderma lucidumʻo ka pauka i kumu i ka maʻi hepatitis.Ua hōʻoia ka mea mua e pili ana ka regression tumor iʻO Ganoderma lucidumʻO ka pauka spore a ʻo ka mea hope i hōʻike i nā hopohopo huna i hoʻokumu ʻia e nā huahana Ganoderma maikaʻi ʻole.No laila, hoʻokahi hauʻoli a hoʻokahi haʻalulu i hoʻomanaʻo i nā mea kūʻai aku e makaʻala i ke kūʻai ʻana i nā huahana Ganoderma i ʻole e pau ke kālā a hōʻeha i ko lākou kino!

He kolamu "Case Report" ka nui o nā puke pai lāʻau lapaʻau e hōʻike ana i nā ʻike koʻikoʻi mai ka ʻike a me ka mālama ʻana i nā maʻi pākahi, a me ka ʻike ʻana i nā hopena a i ʻole nā ​​hopena koʻikoʻi o nā lāʻau lapaʻau.Ma ka moʻolelo o ka lāʻau lapaʻau, i kekahi manawa, hoʻoikaika ka ʻike kanaka i ka ulu ʻana o ka ʻepekema.

No ka laʻana, ua ʻike mua ʻo Alexander Fleming, ʻo ka lāʻau lapaʻau Pelekania, a hōʻike ʻia he hopena anti-staphylococcal ka penicillin i ka makahiki 1928, a kapa ʻia ʻo ia he penicillin.Ua mālama ʻia kēia ʻike no nā makahiki he nui a hiki i ka makahiki 1941 i ka wā i hoʻoikaika ʻia ai ka lāʻau lapaʻau Pelekane ʻo Howard Walter Florey a me ka mea biochemist Kelemania ʻo Ernest Chain e ka pepa a Fleming e hoʻopau i ka hoʻomaʻemaʻe ʻana i ka penicillin a me kāna mau hoʻokolohua lāʻau anti-streptococci a hōʻoia i kona pono antibacterial i kahi maʻi e make ana, ua hoʻomaka ka penicillin. e loaa ka noonoo.

Ma hope o kā lākou noiʻi ʻana a me ka hoʻomohala ʻana, ua hana ʻia ka penicillin ma kahi ʻano ʻenehana e like me ka lāʻau antibiotic mua i hoʻohana ʻia i ka mōʻaukala kanaka, e mālama ana i nā ola he nui a lilo i mea ʻike nui i ke kenekulia 20.No laila, ua loaʻa iā Fleming, Florey a me Chain, ka mea nāna i noiʻi a hoʻomohala i ka penicillin, i loaʻa i ka 1945 Nobel Prize in Physiology and Medicine.

ʻO nā hōʻike maʻi maʻi ʻelua ma hope oʻO Ganoderma lucidum, ʻoiai ua ʻike ʻia ma ka manawa wale nō, ua aʻo maikaʻi ʻia a nānā ʻia e ka mea kākau.Hāʻawi ka mua i nā hōʻike noka hoohana anaʻO Ganoderma lucidumi ka mālama ʻana i ka diffuse large B cell lymphoma (DLBCL) i loko o ka ʻōpūʻoiai ʻo ka mea hope e haʻi iā mākou i kēlāinoʻO Ganoderma lucidumhiki i nā huahana ke kumuka maʻi hepatitis.

ʻO Ganoderma lucidumUa ho'ōla ka pauka spore i kahi hihia o ka maʻi lymphoma B-cell nui. 

Nui nā hihia i ka poʻeʻO Ganoderma lucidumloaʻa ka hopena o ka mālama ʻana i ka maʻi kanesa, akā kakaikahi ka hōʻike ʻia e nā paʻi ʻoihana lapaʻau.

Ma 2007, Wah Cheuk et al.o ka Halemai Moiwahine Elizabeth ma Hong Kong i hoikeia ma kaKa Nupepa International of Surgical Pathologyhe hihia o kahi maʻi kāne 47 makahiki me ka moʻolelo olakino pili ʻole i hele mai i ka haukapila i Ianuali 2003 no ka ʻeha o ka ʻōpū o luna.

Helicobacter pyloriUa ʻike ʻia ka maikaʻi o ka maʻi ma o ka hoʻāʻo ʻana i ka hanu urea, a ua ʻike ʻia kahi ʻāpana nui o ka ʻōpū ma ka ʻāpana pyloric o ka ʻōpū ma o ka gastroscopy.Ua hōʻike ʻia kahi laʻana biopsy i ka nui o nā lymphocytes waena a hiki i ka nui e komo ana i ka paia o ka ʻōpū, me ka ʻano nuclei irregularly, vacuolated chromatin aia i loko o ka nucleus, a me ka nucleoli kaulana.

Ua hōʻike ʻia ka pale ʻana i ka immunohistochemical i ka maikaʻi o kēia mau cell no CD20, he antigen hoʻokaʻawale B-cell, i hōʻike ʻia ma mua o 95% o nā lymphomas B-cell, ʻoiai nā mea kōkua T (Th), cytotoxic T cell (CTL) a me nā pūnaewele T regulatory (Treg). ) ʻaʻole maikaʻi no CD3, a ʻo ka Ki67 proliferation index, ka mea e hōʻike ana i ka hana proliferative o nā cell tumor, he kiʻekiʻe e like me 85%.Ua ʻike ʻia ka mea maʻi me ka lymphoma B-cell diffuse nui.

Mai ka mea mai i ho'āʻo maikaʻi noHelicobacter pylorimaʻi, ua hoʻoholo ka haukapila e hanaHelicobacter pylorika hoʻopau ʻana i ka mālama ʻana i ka mea maʻi mai Pepeluali 1 a 7, ukali ʻia e ka ʻoki ʻoki ʻana i ka lā 10 Pepeluali.ʻAʻole i hōʻike ʻia nā hoʻololi histopathological o ka lymphoma B-cell diffuse nui akā ua ʻike ʻia he helu nui o nā CD3 + CD8 + cytotoxic T cell liʻiliʻi e komo ana i ka mānoanoa piha o ka paia ʻōpū, a hāʻule ka Ki67 proliferation index. i lalo o 1%.

Eia kekahi, ma kahi RT-PCR ka ʻike ʻana o ka T cell receptor beta chain (TCRβ) mRNA gene i hōʻike i kahi ʻano polyclonal, a ʻaʻohe kanaka monoclonal T cell i ʻike ʻia.

Ua hōʻike ʻia nā hopena hoʻāʻo i hāʻawi ʻia e ka mea kākau moʻolelo he mea maʻamau nā pūnae T i loko o ka ʻōpū o ka mea maʻi ma mua o ka maʻi.Ma muli o ka nalowale ʻana o ka hiki ke hoʻokaʻawale ʻana a me ke oʻo ʻana a loaʻa wale i ka hōʻailona genetic kikoʻī like ʻole, monoclonal lākou a ʻo ka hoʻonui ʻana o ka cell maʻamau he polyclonal.

Ua aʻo ʻia mai ka nīnau ʻana ua lawe ka mea maʻi i 60 capsules oʻO Ganoderma lucidumʻO ka pauka spore (3 mau manawa i ʻōlelo ʻia e ka mea hoʻolaha) i kēlā me kēia lā mai Pepeluali 1 a 5. Ma hope o ka ʻoki ʻana, ʻaʻole i loaʻa i ka mea maʻi kekahi adjuvant therapy, a ʻaʻole i hoʻi hou ka maʻi maʻi i ka wā o ʻelua a me ka hapa-makahiki ma hope. -luna.

Manaʻo nā mea noiʻi ʻaʻole kākoʻo nā hopena immunohistochemical o nā laʻana biopsy i hoʻokaʻawale ʻia i ka hiki keHelicobacter pylorika hoʻopau ʻana i ka lymphoma B-cell nui, no laila ke manaʻo nei lākou ʻo ia paha ka poʻe maʻi e lawe ana i ka nui oʻO Ganoderma lucidumʻO ka pauka spore e hoʻoikaika i ka pane immune o ka cytotoxic T cell i ka lymphoma B-cell nui, kahi e alakaʻi ai i ka hoʻopau ʻana i ka tumor [1].

Loaʻa i kēia hōʻike hihia kahi hōʻailona maʻamau a me ka hana lapaʻau.Ua hōʻoia ka mea kākau o ka ʻatikala e pili ana ka regression tumorʻO Ganoderma lucidumʻO ka pauka spore ma o ka histopathological a me ka cellular a me ka molecular biological research analysis, he mea ʻepekema loa a kūpono hoʻi e noiʻi hou aku.

ʻO kēia ka hihia o ka maʻi hepatitis ʻona i hoʻokomo ʻia eʻO Ganoderma lucidumpauda.

Nui nā haʻawina pharmacological i hōʻoia i kēlāʻO Ganoderma lucidumhuaʻai kino extract a me kona polysaccharides a me triterpenes, a meʻO Ganoderma lucidumʻO ka pauka spore, loaʻa nā hopena hepatoprotective maopopo.Loaʻa iā lākou ka hopena maikaʻi i ka mālama ʻana i ka maʻi hepatitis viral.

Eia naʻe, ma 2004, Man-Fung Yuen et al.o ke Kulanui o Hong Kong School of Medicine i hōʻike i kahi hōʻike hihia oʻO Ganoderma lucidumʻO ka maʻi hepatitis i hoʻokomo ʻia i ka pauda i loko o kaNūpepa o ka Hepatology.

Ua ʻimi kekahi wahine he 78 makahiki i ka lapaʻau ʻana ma kēia haukapila ma muli o ka maʻi maʻamau, pau ka ʻai ʻana, ʻili ʻili, a me ka mimi kala kī no ʻelua pule.Ua loaʻa i ka mea maʻi ka moʻolelo o ke kiʻekiʻe kiʻekiʻe a ua lawe mau ʻo ia i ka lāʻau antihypertensive felodipine no 2 mau makahiki.I loko o kēia manawa, ua maʻamau nā hoʻokolohua hana o kāna ate, a lawe pū ʻo ia i ka calcium, nā papa multivitamin a meʻO Ganoderma lucidumnona iho.Ma hope o ka lawe ʻana i decoctedʻO Ganoderma lucidumno hoʻokahi makahiki, ua hoʻololi ka mea maʻi i kahi mea kūʻai houʻO Ganoderma lucidumhuahana pauda. Sua hoʻomohala ʻo ia i nā hōʻailona ma luna ma hope o ʻehā pule o ka lawe ʻanaʻo ia huahana.

Ua hōʻike ʻia ka ʻike kino i ka jaundice i loko o ka mea maʻi.Hōʻike ʻia nā hopena o kāna hoʻāʻo biochemical koko ma ka papa ma lalo.Immunological hoʻokolo 'ana i ka hiki o ka mea maʻi e loaʻa i ka viral hepatitis A, B, C, a me E. Ka histopathological hualoaʻa ma ke ake biopsy hōʻike i ka mea maʻi i pathological loli i ka lāʻauʻawaʻawa hepatitis.

I loko o hoʻokahi makahiki o ka lawe ʻanaʻO Ganoderma lucidumwai decoction, ka mea maʻi hōʻike 'aʻole abnormality.Akā ma hope o ka hoʻololi ʻana i nā mea kūʻaiʻO Ganoderma lucidumpauda, ​​ua hoʻomaka koke ʻo ia i nā hōʻailona o ka maʻi hepaʻa ʻona.Ma hope o ka hoʻopau ʻana i kaʻO Ganoderma lucidumpauda, ​​ua hoʻi mālie kona mau hōʻailona biochemical koko i ʻōlelo ʻia i ka maʻamau.No laila, ua ʻike ʻia ka mea maʻi me ka maʻi hepaʻa ʻona i hana ʻia eʻO Ganoderma lucidumpauda.Ua hōʻike ka mea kākau moʻolelo mai ka haku ʻana o kaʻO Ganoderma lucidumʻAʻole hiki ke ʻike ʻia ka pauka, pono e noʻonoʻo inā ʻo ke ʻano o ka ate i kumu ʻia e nā mea ʻē aʻe a i ʻole ka hoʻololi ʻana o ka maʻi ma hope o ka hoʻololi ʻana e lawe i ka lāʻau.ʻO Ganoderma lucidumpauda [2].

No ka mea, ʻaʻole i wehewehe ka mea kākau moʻolelo i ke kumu a me nā waiwai oʻO Ganoderma lucidumpauda, ​​maopopo ole keia paudaʻO Ganoderma lucidumpauda kino hua,ʻO Ganoderma lucidumpauda spore a i ʻoleʻO Ganoderma lucidumpauka mycelium.Manaʻo ka mea kākau ʻo ke kumu nui loa o ka maʻi hepaʻa ʻona i hana ʻia eʻO Ganoderma lucidumʻO ka pauka i kēia hihia, ʻo ia ka pilikia maikaʻi o ka huahana maikaʻi ʻole, ʻo ia hoʻi, ka haumia i hoʻokumu ʻia e ka mold, pesticides a me nā metala kaumaha.

No laila, i ke kūʻai ʻana i nā huahana Ganoderma,pono nā mea kūʻai aku e kūʻai i nā huahana me ka helu ʻae o ka mana kūpono.ʻO ia mau huahana wale nō i hoʻāʻo ʻia e kahi ʻaoʻao ʻekolu a ʻae ʻia e kahi mana kūpono e hiki ke hāʻawi i nā mea kūʻai aku me nā hōʻoia hilinaʻi, palekana a maikaʻi.

【References】

1. Wah Cheuk, et al.ʻO ka hoʻihoʻi hou ʻana o ka maʻi maʻi maʻi B-Cell Lymphoma i hele pū ʻia me ka Florid Lymphoma-like T-Cell Reaction: Immunomodulatory Effect ofʻO Ganoderma lucidum(Lingzhi).Ka Nupepa International of Surgical Pathology.2007;15(2):180-86.

2. Man-Fung Yuen, et al.Hepatotoxicity ma muli o ka hoʻokumu ʻana oʻO Ganoderma lucidum(lingzhi).Nūpepa o ka Hepatology.2004;41(4):686-7.

No Prof. Zhi-Bin Lin 

Ma ke ʻano he paionia i ka noiʻi ʻana o Ganoderma ma Kina, ua hoʻolaʻa ʻo ia iā ia iho i ka noiʻi Ganoderma no ka hapalua haneli.Ma keʻano he pelekikena mua o Beijing Medical University (BMU), ka hope dean mua o BMU School of Basic Medical Sciences a me ka luna mua o BMU Institute of Basic Medicine a me ka luna mua o ka 'Oihana Pharmacology o BMU, i kēia manawa he polopeka o ka 'Oihana o Pharmacology o Peking University School of Basic Medicine.Ua koho ʻia ʻo ia i mākaʻikaʻi kipa no ka World Health Organization Collaborating Center for Traditional Medicine ma ke Kulanui o Ilinoi ma Chicago mai 1983 a i 1984 a he kaukaʻi kipa ma ke Kulanui o Hong Kong mai 2000 a i 2002. Ua koho ʻia ʻo ia i kumu hoʻohanohano no Perm State Pharmaceutical Academy mai 2006.

Mai ka makahiki 1970, ua hoʻohana ʻo ia i nā ʻano sci-tech hou e aʻo ai i nā hopena pharmacological a me nā hana o Ganoderma lucidum a me kāna mau mea hana.Ua paʻi ʻo ia ma mua o 100 mau pepa noiʻi ma Ganoderma.Mai 2014 a 2019, ua koho ʻia ʻo ia i ka papa inoa o Highly Cited Chinese Researchers i hoʻokuʻu ʻia e Elsevier no ʻeono mau makahiki.

ʻO ia ke kumu oʻImi hou no Ganoderma(mai 1st edition to 4th edition),Lingzhi Mai Pohihihi a ʻEpekema(mai ka paʻi 1 a i ka paʻi 3),Ganoderma LucidumKōkua i ka mālama ʻana i ka maʻi maʻi ma o ka hoʻoikaika ʻana i ke kūpaʻa o ke kino a me ka hoʻopau ʻana i nā kumu pathogenic., Kūkākūkā ma Ganoderma, Ganoderma a me ke Olaa me nā hana ʻē aʻe he nui ma Ganoderma.