Sengoliloeng sena se hlahisitsoe khatisong ea bo94 ea makasine ea GANODERMA ka 2022. Tokelo ea sengoloa ke ea mongoli.

Zhi-Bin Lin, moprofesa oa Lefapha la Pharmacology, Peking University School of Basic Medical Sciences

Sehloohong sena, Prof. Lin o hlahisitse linyeoe tse peli tse tlalehiloeng likoranteng tsa saense.E 'ngoe ea tsona e ne e le ho nkaGanoderma lucidumspore powder folisa gastric diffuse e kholo B cell lymphoma, 'me e' ngoe e ne e le ho nkaGanoderma lucidumphofo e bakileng lefu la sebete le chefo.Ea pele e ile ea paka hore ho fokotseha ha hlahala ho amana leGanoderma lucidumspore powder ha ea morao-rao e ile ea pepesa matšoenyeho a ipatileng a bakoang ke lihlahisoa tsa boleng bo tlaase tsa Ganoderma.Ka hona, thabo e le 'ngoe le tšabo e le' ngoe e ile ea hopotsa bareki hore ba be hlokolosi ha ba reka lihlahisoa tsa Ganoderma e le hore ba se ke ba senya chelete le ho senya 'mele ea bona!

Likoranta tse ngata tsa bongaka li na le kholomo ea “Case Report” e tlalehang liphuputso tse utloahalang ho tsoa tlhahlobong le kalafong ea mokuli ka bomong, hammoho le ho sibolla liphello kapa litla-morao tse tebileng tsa lithethefatsi.Historing ea bongaka, ka linako tse ling lintho tse sibolotsoeng ka bomong li khothalletsa tsoelo-pele ea saense.

Ka mohlala, setsebi sa likokoana-hloko sa Brithani, Alexander Fleming, se ile sa qala ho sibolla le ho tlaleha hore tlhahiso ea penicillin e na le phello e khahlanong le staphylococcal ka 1928, 'me ea e bitsa penicillin.Tšibollo ena e ile ea bolokoa ka lilemo tse ngata ho fihlela ka 1941 ha setsebi sa meriana sa Lebrithani Howard Walter Florey le setsebi sa biochemist sa Jeremane Ernest Chain ba ile ba bululeloa ke pampiri ea Fleming ho phethela tlhoekiso ea penicillin le liteko tsa eona tsa anti-streptococci pharmacological le ho paka katleho ea eona ea antibacteria ho mokuli ea shoang, penicillin e ile ea qala. ho amohela tlhokomelo.

Ka mor'a lipatlisiso tsa bona tsa bobeli le tsoelo-pele, penicillin e hlahisitsoe ka tekanyo ea indasteri e le lithibela-mafu tsa pele tse sebelisoang historing ea batho, ho pholosa bophelo ba batho ba bangata le ho fetoha tšibollo e kholo lekholong la bo20 la lilemo.Ka hona, Fleming, Florey le Chain, ba ileng ba boela ba etsa lipatlisiso le ho hlahisa penicillin, ba ile ba fuoa Khau ea Nobel ea 1945 ea Physiology le Medicine.

Litlaleho tse peli tse latelang tsa tleliniki eaGanoderma lucidum, le hoja li fumanoe ka tšohanyetso, li hlahlobisitsoe ka hloko le ho hlahlojoa ke motlalehi.Ea pele e fana ka bopaki batshebediso yaGanoderma lucidumka kalafo ya diffuse e kgolo B cell lymphoma (DLBCL) ka mpengathe ya morao E re bolella seompeGanoderma lucidumlihlahisoa li ka bakalefu la sebete le chefo.

Ganoderma lucidumphofshoana ea spore e phekotse nyeoe ea gastric diffuse e kholo ea B-cell lymphoma. 

Ho na le linyeoe tse ngata ho batho ba joaloGanoderma lucidume na le phello ea ho phekola mofetše, empa ke ka seoelo e ka tlalehoang ke lingoliloeng tsa litsebi tsa bongaka.

Ka 2007, Wah Cheuk et al.Sepetlele sa Queen Elizabeth se Hong Kong se tlalehiloe hoInternational Journal of Surgical Pathologynyeoe ea mokuli e motona ea lilemo li 47 ea se nang nalane ea bongaka e nepahetseng ea ileng a tla sepetlele ka Pherekhong 2003 ka lebaka la bohloko bo ka mpeng bo kaholimo.

Helicobacter pyloritšoaetso e fumanoe e le ntle ka tlhahlobo ea phefumoloho ea urea, 'me sebaka se seholo sa seso sa ka mpeng se fumanoe sebakeng sa pyloric sa mpa ka gastroscopy.Sampling ea biopsy e senotse palo e kholo ea li-lymphocyte tse mahareng ho isa ho tse kholo tse kenang leboteng la ka mpeng, tse nang le li-nuclei tse sa bopehileng hantle, li-vacuolated chromatin tse khubung, le nucleoli e hlahelletseng.

Ho silafala ha immunohistochemical ho bonts'itse hore lisele tsena li ntle bakeng sa CD20, antigen ea B-cell differentiation, e hlahisitsoeng ho feta 95% ea B-cell lymphomas, athe mothusi oa T cell (Th), cytotoxic T cell (CTL) le lisele tsa T tse laolang (Treg). ) li ne li le mpe bakeng sa CD3, 'me index ea ho ata ha Ki67, e bontšang mosebetsi oa ho ata ha lisele tsa hlahala, e ne e le holimo ho 85%.Mokuli o ile a fumanoa a e-na le gastric diffuse e kholo ea B-cell lymphoma.

Ho tloha ha mokuli a lekoa a le positive bakeng saHelicobacter pyloritšoaetso, sepetlele se ile sa etsa qeto ea ho sebetsaHElicobacter pyloriphekolo ea ho felisa mokuli ho tloha ka February 1 ho ea ho 7, e lateloa ke ho buuoa ka February 10. Ho makatsang ke hore,tlhahlobo ea pathological ea lisampole tsa mesifa ea mpa e tsosolositsoeng ha ea ka ea senola liphetoho tsa histopathological tsa li-lymphoma tse kholo tsa B-cell empa ho e-na le hoo li fumane palo e kholo ea lisele tse nyenyane tsa CD3 + CD8+ cytotoxic T tse kenang botenya bo feletseng ba lerako la gastric, 'me index ea ho ata ha Ki67 e ile ea theoha. ho ea tlase ho 1%.

Ho phaella moo, in situ RT-PCR ho fumanoa ha T cell receptor beta chain (TCRβ) mRNA gene e bontšitse mokhoa oa polyclonal, 'me ha ho monoclonal T cell population e fumanoeng.

Liphetho tsa liteko tse fanoeng ke moqolotsi oa litaba li bontšitse hore lisele tsa T tse liseleng tsa mpa tsa mokuli li ne li tloaelehile ho e-na le ho ba kotsi.Hobane lisele tsa hlahala li lahleheloa ke matla a ho khetholla le ho hōla 'me li na le letšoao le tšoanang la liphatsa tsa lefutso, li na le monoclonal ha lisele tse tloaelehileng tsa ho ata ke polyclonal.

Ho ile ha ithutoa ho tsoa lipatlisisong hore mokuli o ile a nka li-capsules tse 60 tsaGanoderma lucidumphofo ea spore (makhetlo a 3 ho feta tekanyo e khothalletsoang ea khothaletso) ka letsatsi ho tloha ka February 1 ho ea ho 5. Ka mor'a ho buuoa, mokuli ha aa ka a fumana phekolo leha e le efe ea adjuvant, 'me hlahala ha ea ka ea khutla nakong ea lilemo tse peli le halofo tse latelang. - holimo.

Bafuputsi ba lumela hore liphetho tsa immunohistochemical tsa lisampole tsa biopsy tse entsoeng ka opereishene ha li tšehetse monyetla oa hoHelicobacter pyloriho felisa B-cell lymphoma e kholo, kahoo ba nahana hore e ka 'na eaba bakuli ba nkang litekanyetso tse kholo tsaGanoderma lucidumspore powder e khothalletsa karabelo e sebetsang ea 'mele ea ho itšireletsa mafung ea lisele tsa cytotoxic T ho B-cell lymphoma e kholo, e leng eona e lebisang ho fokotseha ho feletseng ha hlahala [1].

Tlaleho ena ea nyeoe e na le ts'ebetso e hlakileng ea tlhahlobo le kalafo.Mongoli oa sengoloa o pakile hore ho fokotseha ha hlahala ho amana leGanoderma lucidumspore powder ka tlhahlobo ea histopathological le cellular le molecular biological research, e leng saense e phahameng haholo mme e lokeloa ke lipatlisiso tse ling.

E latelang ke taba ea lefu la sebete le chefo le bakoang keGanoderma lucidumphofo.

Liphuputso tse ngata tsa meriana li pakile seoGanoderma lucidumfruiting body extract le polysaccharides ea eona le triterpenes, hammoho leGanoderma lucidumphofo ea spore, e na le litlamorao tse hlakileng tsa hepatoprotective.Ba na le phello e hlakileng ea ntlafatso ea kalafo ea kokoana-hloko ea lefu la sebete.

Leha ho le joalo, ka 2004, Man-Fung Yuen et al.ea Univesithi ea Hong Kong School of Medicine e tlalehile tlaleho ea nyeoe eaGanoderma lucidumhepatitis e chefo e bakoang ke phofo ka har'aJournal of Hepatology.

Mosali e mong ea lilemo li 78 o ile a batla phekolo sepetleleng sena ka lebaka la ho fokola ka kakaretso, ho lahleheloa ke takatso ea lijo, letlalo le hlohlonang le moroto o nang le tee ka libeke tse peli.Mokuli o ne a e-na le nalane ea khatello ea mali mme o ne a qetile lilemo tse 2 a ntse a sebelisa lithethefatsi tsa antihypertensive felodipine.Nakong ena, liteko tsa sebete sa hae li ne li tloaelehile, hape o ile a nka calcium, matlapa a multivitamin leGanoderma luciduma le mong.Ka mor'a ho noa decoctedGanoderma lucidumbakeng sa selemo se le seng, mokuli o fetohela ho e ncha e fumanehang khoebongGanoderma lucidumsehlahisoa sa phofo. So ile a hlahisa matšoao a boletsoeng ka holimo ka mor'a libeke tse 'nè tsa ho noasehlahisoa se joalo.

Tlhahlobo ea 'mele e ile ea senola jaundice e tšoailoeng ho mokuli.Liphetho tsa liteko tsa mali a hae tsa biochemical li bonts'itsoe lethathamong le ka tlase.Tlhahlobo ea Immunological e ile ea tlosa monyetla oa hore mokuli a tšoeroe ke kokoana-hloko ea lefu la sebete la A, B, C, le E. Liphetho tsa histopathological tsa biopsy ea sebete li bontšitse hore mokuli o na le liphetoho tsa pathological hepatitis e chefo ea lithethefatsi.

Nakong ea selemo se le seng sa ho nkaGanoderma lucidumdecoction ea metsi, mokuli o ne a sa bontše ho sa tloaelehang.Empa ka mor'a ho fetohela ho tse fumanehang khoebongGanoderma lucidumphofo, kapele o ile a ba le matšoao a lefu la sebete le chefo.Ka mor'a ho khaotsa hoGanoderma lucidumphofo, lipontšo tsa hae tse boletsoeng ka holimo tsa mali a biochemical li ile tsa khutlela setloaeling butle-butle.Ka hona, mokuli o ile a fumanoa a e-na le lefu la sebete le chefo le bakoang keGanoderma lucidumphofo.Moqolotsi oa litaba o supile hore ho tloha ha ho qaptjoa theGanoderma lucidumphofo e ne e ke ke ea fumanoa, ho bohlokoa ho nahana hore na chefo ea sebete e bakiloe ke lisebelisoa tse ling kapa phetoho ea lethal dose ka mor'a ho fetola ho nka.Ganoderma lucidumphofo [2].

Kaha moqolotsi ha a ka a hlalosa mohloli le thepa eaGanoderma lucidumphofo, ha ho hlake hore na phofo ena keGanoderma lucidumphofo ea 'mele e behang litholoana,Ganoderma lucidumphofshoana kapaGanoderma lucidumphofo ea mycelium.Mongoli oa lumela hore ka ho fetisisa ka etsahala hore ebe sesosa sa hepatitis chefo bakoang keGanoderma lucidumphofo tabeng ena ke bothata ba boleng ba sehlahisoa se sebe, ke hore, tšilafalo e bakoang ke hlobo, chefo e bolaeang likokoanyana le litšepe tse boima.

Ka hona, ha u reka lihlahisoa tsa Ganoderma,bareki ba tlameha ho reka lihlahisoa ka nomoro ea tumello ea bolaoli bo nang le bokhoni.Ke lihlahisoa tse joalo feela tse lekiloeng ke motho e mong le ho amoheloa ke ba boholong ba nang le bokhoni tse ka fang bareki tiisetso e tšepahalang, e sireletsehileng le e sebetsang.

【Litšupiso】

1. Wah Cheuk, le ba bang.Ho fokotseha ha Gastric Large B-Cell Lymphoma Ho Tsamaea le Florid Lymphoma-joaloka T-Cell Reaction: Immunomodulatory Effect ofGanoderma lucidum(Lingzhi).International Journal of Surgical Pathology.2007;15(2):180-86.

2. Man-Fung Yuen, le ba bang.Hepatotoxicity ka lebaka la sebopeho saGanoderma lucidum(ho bua).Journal of Hepatology.2004;41(4):686-7.

Mabapi le Moprofesa Zhi-Bin Lin 

E le pula-maliboho lipatlisisong tsa Ganoderma Chaena, o inehetse ho etsa lipatlisiso tsa Ganoderma hoo e ka bang halofo ea lekholo la lilemo.E le motlatsi oa mehleng oa Beijing Medical University (BMU), motlatsi oa mehleng oa BMU School of Basic Medical Sciences le mookameli oa pele oa BMU Institute of Basic Medicine le mookameli oa mehleng oa Lefapha la Pharmacology ea BMU, hona joale ke moprofesa oa Lefapha la Pharmacology ea Peking University School of Basic Medicine.O ne a khethiloe e le setsebi se etileng sa Setsi sa Tšebelisano sa Lefatše sa Bophelo bo Botle sa Meriana ea Setso Univesithing ea Illinois e Chicago ho tloha 1983 ho isa 1984 le moprofesa ea etileng Univesithing ea Hong Kong ho tloha 2000 ho isa 2002. O khethiloe e le moprofesa ea hlomphehang oa Perm State. Pharmaceutical Academy ho tloha 2006.

Ho tloha 1970, o sebelisitse mekhoa ea sejoale-joale ea mahlale ho ithuta litlamorao tsa pharmacological le mekhoa ea Ganoderma lucidum le metsoako ea eona e sebetsang.O phatlalalitse lipampiri tsa lipatlisiso tse fetang 100 ka Ganoderma.Ho tloha 2014 ho isa 2019, o khethiloe lenaneng la Bafuputsi ba Machaena ba Boletsoeng Haholo ba lokollotsoeng ke Elsevier ka lilemo tse tšeletseng tse latellanang.

Ke eena mongoli oaLipatlisiso tsa morao-rao ka Ganoderma(ho tloha khatisong ea 1 ho isa ho ea 4),Lingzhi Ho Tloha Sephiring ho ea ho Saense(ho tloha khatisong ea 1 ho ea ho ea 3rd),Mofuta oa "Ganoderma Lucidum".E Thusa Phekolong ea Mofets'e ka ho Matlafatsa Khanyetso ea 'Mele le ho Felisa Lintho tse Pathogenic., Bua ka Ganoderma, Ganoderma le Bophelo bo Botlele mesebetsi e meng e mengata ea Ganoderma.