Disemba 13, 2019 / Yeungnam University, njll. / Imibiko Yesayensi

Umbhalo / Wu Tingyao

Njengoba nje izimpilo zansuku zonke zabo bonke abantu zicasulwa yi-coronavirus yenoveli ka-2019, kusenamagciwane amaningi angelapheki.Igciwane le-dengue fever elithelela abantu ngokulunywa omiyane lingelinye lazo.

Njengawo wonke amagciwane, igciwane lodenga elithelela abantu ngokulunywa omiyane nalo lisebenzisa amangqamuzana ukuze likhiqize isizukulwane esilandelayo.Ngakho-ke, indlela yokuphazamisa inqubo yokuphindaphinda kwegciwane emangqamuzaneni isibe yisinyathelo esiyinhloko sokuthuthukiswa kwezidakamizwa ezihlobene.

Njengamanje, ucwaningo oluningi luqondise igciwane lodenga i-NS2B-NS3 protease, ngoba liyisici esibalulekile ukuze igciwane lodenga liqedele inqubo yokuphindaphinda.Ngaphandle kwendima yalo, leli gciwane alikwazi ukuzikhiqiza ukuze lithelele amanye amangqamuzana.

Ngokocwaningo olwanyatheliswa ku- “Scientific Reports” ngoDisemba 2019, i-Biotechnology Institute yaseYeungnam University eSouth Korea kanye namaqembu avela e-India naseTurkey ahlole izinhlobo ezingama-22 zama-triterpenoids emzimbeni othela izithelo.I-Ganoderma Lucidumfuthi yathola ukuthi ezine zazo zibonise ukuvinjelwa okungenzeka komsebenzi we-NS2B-NS3 protease.

Ngokusebenzisa izivivinyo ze-in vitro ukulingisa indlela leli gciwane elithelela ngayo amangqamuzana emzimbeni, abacwaningi baphinde bahlola izinhlobo ezimbili zamaseli.I-Ganoderma lucidumama-triterpenoids:

Abacwaningi baqale bakhulisa uhlobo 2 lwegciwane lodenga (DENV-2, uhlobo olungadala ukugula kakhulu) ngamaseli omuntu ihora eli-1, base bewaphatha ngokugxila okuhlukile (25 noma 50 μM)I-Ganoderma lucidumtriterpenoids ihora eli-1.Ngemva kwamahora angu-24, bahlaziya isilinganiso samangqamuzana angenwe yileli gciwane.

Imiphumela yabonisa ukuthi i-ganodermanontriol inganciphisa izinga lokutheleleka kweseli cishe ngo-25% (25μM) noma 45% (50μM) kuyilapho i-ganoderic acid C2 ehlobene ingenawo umthelela omningi wokuvinjelwa.

Imiphumela yalolu cwaningo isinikeza elinye ithuba lokulwa namagciwaneI-Ganoderma lucidumfuthi inikeze nethuba elisha lokwelashwa komkhuhlane wodenga, ongekho umuthi othize otholakalayo.

Okungenhla kuwumdwebo wohlelo lwezinyathelo zokuhlola izidakamizwa zokuvimbela igciwane lodengaI-Ganoderma lucidumama-triterpenoids ane-NS2B-NS3 protease njengokuhlosiwe.Ishadi lezibalo elingezansi kwesokudla libonisa izinga lokuvimbela i-ganodermanontriol kumaseli angenwe uhlobo 2 lwegciwane lodenga.

[Umthombo] Bharadwaj S, et al.Ukutholwa kwe-Ganoderma lucidum triterpenoids njengama-inhibitors angaba khona ngokumelene ne-Dengue virus NS2B-NS3 protease.I-Sci Rep. 2019 Disemba 13;9(1):19059.doi: 10.1038/s41598-019-55723-5.

PHELA
Mayelana nombhali/ Nks. Wu Tingyao
U-Wu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali wencwadi ethi Healing with Ganoderma (eshicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).

★ Lesi sihloko sishicilelwe ngaphansi kwegunya elikhethekile lombhali ★ Le misebenzi engenhla ayikwazi ukuphinda ikhiqizwe, icashunwe noma isetshenziswe ngezinye izindlela ngaphandle kwemvume yombhali ★ Ukwephulwa kwesitatimende esingenhla, umbhali uzoqhuba izibopho zayo zomthetho ezihlobene ★ Eyokuqala umbhalo walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.