Zvita 13, 2019 / Yeungnam University, nezvimwewo / Scientific Reports

Chinyorwa / Wu Tingyao

Sezvinongoita hupenyu hwemazuva ese hwevanhu vese hunotsamwiswa neiyo 2019 novel coronavirus, kuchine hutachiona hwakawanda husingarapike.Utachiona hweDengue fever hunotapurira vanhu kuburikidza nekurumwa neumhutu ndehumwe hwacho.

Kufanana nemavhairasi ese, hutachiona hwedengue hunobata vanhu kuburikidza nekurumwa neumhutu hunoshandisawo maseru kubereka chizvarwa chinotevera.Nokudaro, nzira yekuvhiringidza nzira yekudzokorora kwehutachiona mumaseru ndiyo yakava nzira huru yekugadzirwa kwemishonga yakabatana.

Parizvino, zvidzidzo zvakawanda zvakanangana nehutachiona hwedengue NS2B-NS3 protease, nekuti chinhu chakakosha kuti hutachiona hwedengue hupedze kudzokorora.Pasina basa rayo, utachiona hahukwanisi kuzvibereka kuti hutapure mamwe masero.

Zvinoenderana neongororo yakaburitswa mu "Scientific Reports" muna Zvita 2019, Biotechnology Institute yeYeungnam University kuSouth Korea nezvikwata zveIndia neTurkey zvakaongorora makumi maviri nemaviri emhando dze triterpenoids kubva mucheroGanoderma Lucidumuye akawana kuti ina yacho yakaratidza inogona kuvharidzira yeNS2B-NS3 protease chiitiko.

Nekushandisa in vitro kuyedza kutevedzera nzira iyo hutachiona hunokanganisa maseru mumuviri, vaongorori vakaongororazve marudzi maviri eGanoderma lucidumtriterpenoids:

Vatsvagiri vakatanga kugadzira hutachiona hwedengue 2 (DENV-2, rudzi rwunonyanya kukonzeresa chirwere chakakomba) nemasero emunhu kweawa imwe, vobva vaabata zvakasiyana siyana (25 kana 50 μM)Ganoderma lucidumtriterpenoids kweawa imwe.Mushure memaawa makumi maviri nemana, vakaongorora reshiyo yemasero ane utachiona.

Mhedzisiro yacho yakaratidza kuti ganodermanontriol inogona kuderedza huwandu hwehutachiona hwesero neanenge 25% (25μM) kana 45% (50μM) nepo ganoderic acid C2 isina zvakawanda inhibitory effect.

Mibairo yetsvagiridzo iyi inotipa imwe antiviral mukana weGanoderma lucidumuye kupawo mukana mutsva wekurapa dengue fever, iyo isina mushonga chaiwo unowanikwa.

Zviri pamusoro apa dhayagiramu yematanho ekuongorora zvinodhaka zvekuvharisa utachiona hwedengue kubvaGanoderma lucidumtriterpenoids ine NS2B-NS3 protease sechinangwa.Iyo nhamba yechati pazasi kurudyi inoratidza inhibitory mwero weganodermanontriol pamaseru ane hutachiona hwedengue fever virus type 2.

[Kwakabva] Bharadwaj S, et al.Kuwanikwa kweGanoderma lucidum triterpenoids sezvinogona inhibitors kurwisa Dengue virus NS2B-NS3 protease.Sci Rep. 2019 Zvita 13;9(1):19059.doi: 10.1038/s41598-019-55723-5.

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Nezve munyori/ Ms. Wu Tingyao
Wu Tingyao anga achishuma nezvekutanga-ruoko Ganoderma lucidum ruzivo kubvira 1999. Ndiye munyori weHealing with Ganoderma (yakabudiswa muThe People's Medical Publishing House muna Kubvumbi 2017).

★Chinyorwa ichi chakatsikiswa pasi pemvumo yemunyori chete ★ Mabasa ari pamusoro haagone kutsikiswa, kudonhedzwa kana kushandiswa nedzimwe nzira pasina mvumo yemunyori ★ Kutyora chirevo chiri pamusoro, munyori achaita mabasa anoenderana nemutemo ★ Iwo ekutanga. chinyorwa chechinyorwa ichi chakanyorwa neChinese naWu Tingyao uye chakashandurirwa muchiRungu naAlfred Liu.Kana paine mutsauko pakati peshanduro (yeChirungu) neyekutanga (Chinese), iyo yekutanga Chinese ichakunda.Kana vaverengi vaine mibvunzo, tapota taura nemunyori wemabviro, Ms. Wu Tingyao.