Disemba 13, 2019 / Mahadum Yeungnam, wdg / Akụkọ sayensị

Ederede / Wu Tingyao

Dị nnọọ ka ndụ mmadụ niile na-adị kwa ụbọchị na-ewe iwe site na coronavirus novel 2019, a ka nwere ọtụtụ nje na-enweghị ngwọta.Nje Virus Dengue fever nke na-ebute mmadụ site n'ata anwụnta bụ otu n'ime ha.

Dị ka nje virus niile, nje dengue nke na-ebute ụmụ mmadụ site n'ịta anwụnta na-ejikwa mkpụrụ ndụ na-amụba ọgbọ ọzọ.Ya mere, otu esi egbochi usoro mmegharị nke nje na mkpụrụ ndụ aghọwo ihe bụ isi maka ịmepụta ọgwụ ndị metụtara ya.

Ka ọ dị ugbu a, ọtụtụ ọmụmụ echerela nje virus dengue NS2B-NS3 protease, n'ihi na ọ bụ ihe dị mkpa maka nje dengue iji mechaa usoro mmegharị ahụ.Na-enweghị ọrụ ya, nje a enweghị ike ịmụpụta onwe ya ibunye mkpụrụ ndụ ndị ọzọ.

Dị ka otu nnyocha e bipụtara na "Scientific Reports" na December 2019, Biotechnology Institute of Yeungnam University na South Korea na otu si India na Turkey enyochala ụdị triterpenoid iri abụọ na abụọ site na mkpụrụ osisi.Ganoderma Lucidumwee chọpụta na anọ n'ime ha gosipụtara ike igbochi ọrụ NS2B-NS3 protease.

Site n'iji nnwale in vitro mee ka nje virus si emetụta mkpụrụ ndụ n'ime ahụ, ndị nyocha ahụ tụlere n'ihu n'ụdị abụọ.Ganoderma lucidumtriterpenoids:

Ndị ọrụ nyocha ahụ buru ụzọ mepụta ụdị nje dengue 2 (DENV-2, ụdị nke nwere ike ibute ọrịa siri ike) na mkpụrụ ndụ mmadụ maka elekere 1, wee mesoo ha dị iche iche (25 ma ọ bụ 50 μM) nkeGanoderma lucidumtriterpenoids maka 1 hour.Mgbe awa 24 gachara, ha nyochara nha nke sel ndị nje butere.

Nsonaazụ gosiri na ganodermanontriol nwere ike ibelata ọnụọgụ ọrịa mkpụrụ ndụ ihe dịka 25% (25μM) ma ọ bụ 45% (50μM) ebe onye ikwu ganoderic acid C2 enweghị mmetụta mgbochi.

Nsonaazụ nke nyocha a na-enye anyị ohere ọzọ antiviralGanoderma lucidumma nyekwa ohere ọhụrụ maka ọgwụgwọ ọrịa ahụ ọkụ dengue, nke na-enweghị ọgwụ ọ bụla akọwapụtara.

Ihe a dị n'elu bụ schematic eserese nke usoro nyocha nke ọgwụ ndị na-eme nyocha iji gbochie nje dengue site naGanoderma lucidumtriterpenoids nwere NS2B-NS3 protease dị ka ebumnuche.Chaatị ndekọ ọnụ ọgụgụ dị na ala aka nri na-egosi ọnụọgụ mgbochi nke ganodermanontriol na sel ndị nwere nje virus ụdị 2 nke dengue.

[Isi iyi] Bharadwaj S, et al.Nchọpụta Ganoderma lucidum triterpenoids dị ka ndị nwere ike igbochi nje Dengue NS2B-NS3 protease.Sci Rep. 2019 Dec 13; 9 (1): 19059 .doi: 10.1038/s41598-019-55723-5.

N'ikpeazụ
Banyere onye odee/ Oriakụ Wu Tingyao
Wu Tingyao na-akọ banyere ozi Ganoderma lucidum nke mbụ kemgbe 1999. Ọ bụ onye edemede nke Healing with Ganoderma (nke e bipụtara na Ụlọ Nbipụta Ahụike Ndị Mmadụ na April 2017).

★ A na-ebipụta akụkọ a n'okpuru ikike nke onye edemede ★ Ọrụ ndị a dị n'elu enweghị ike imepụtaghachi, wepụ ma ọ bụ jiri ya mee ihe n'ụzọ ndị ọzọ na-enweghị ikike nke onye edemede ★ imebi okwu a dị n'elu, onye edemede ga-agbaso ọrụ iwu metụtara ya ★ The mbụ Wu Tingyao dere ederede akụkọ a n'asụsụ Chinese ma Alfred Liu sụgharịrị ya na Bekee.Ọ bụrụ na enwere nghọtahie n'etiti ntụgharị asụsụ (Bekee) na nke izizi (Chinese), Chinese izizi ga-emeri.Ọ bụrụ na ndị na-agụ akwụkwọ nwere ajụjụ ọ bụla, biko kpọtụrụ onye edemede mbụ bụ Oriakụ Wu Tingyao.