Disamba 13, 2019 / Jami'ar Yeungnam, da sauransu / Rahotanni na Kimiyya

Rubutu / Wu Tingyao

Kamar yadda rayuwar yau da kullun na dukkan bil'adama ke jin haushin sabon coronavirus na 2019, har yanzu akwai ƙwayoyin cuta da yawa waɗanda ba za su iya warkewa ba.Cutar zazzabin Dengue da ke kamuwa da mutane ta hanyar cizon sauro na daya daga cikinsu.

Kamar kowane ƙwayoyin cuta, ƙwayar dengue da ke cutar da mutane ta hanyar cizon sauro kuma yana amfani da ƙwayoyin cuta don haifuwa na gaba.Saboda haka, yadda za a tsoma baki tare da aiwatar da kwayar cutar a cikin kwayoyin halitta ya zama babban abin da ake amfani da shi don bunkasa magunguna masu dangantaka.

A halin yanzu, yawancin karatu sun yi niyya game da kwayar cutar dengue NS2B-NS3 protease, saboda abu ne mai mahimmanci ga cutar dengue don kammala aikin kwafi.Idan ba tare da aikinta ba, kwayar cutar ba za ta iya haifuwa da kanta don harba wasu kwayoyin halitta ba.

A cewar wani binciken da aka buga a cikin "Rahotanni na Kimiyya" a cikin Disamba 2019, Cibiyar Kimiyyar Halittu ta Jami'ar Yeungnam a Koriya ta Kudu da ƙungiyoyi daga Indiya da Turkiyya sun bincika nau'ikan triterpenoid iri 22 daga cikin 'ya'yan itace.Ganoderma Lucidumkuma sun gano cewa hudu daga cikinsu sun nuna yiwuwar hana NS2B-NS3 ayyukan protease.

Ta hanyar yin amfani da gwaje-gwajen in vitro don kwaikwayi yadda kwayar cutar ke cutar da kwayoyin halitta a cikin jiki, masu binciken sun kara tantance nau'ikan nau'ikan guda biyu.Ganoderma lucidumtriterpenoids:

Masu binciken sun fara al'ada nau'in kwayar cutar dengue 2 (DENV-2, nau'in da zai iya haifar da rashin lafiya mai tsanani) tare da kwayoyin jikin mutum na tsawon awa 1, sa'an nan kuma kula da su da nau'i daban-daban (25 ko 50 μM) naGanoderma lucidumtriterpenoids na 1 hour.Bayan sa'o'i 24, sun yi nazarin rabon sel masu kamuwa da kwayar cutar.

Sakamakon ya nuna cewa ganodermanontriol na iya rage yawan kamuwa da kwayar cutar ta hanyar kusan 25% (25μM) ko 45% (50μM) yayin da dangin ganoderic acid C2 ba shi da tasiri mai hanawa.

Sakamakon wannan bincike ya ba mu wani yiwuwar antiviralGanoderma lucidumda kuma samar da sabuwar dama don maganin zazzabin dengue, wanda babu takamaiman magani da ake samu.

Abin da ke sama shine zane-zane na matakan tantance magungunan ɗan takara don hana ƙwayar dengue dagaGanoderma lucidumtriterpenoids tare da NS2B-NS3 protease azaman manufa.Taswirar ƙididdiga a ƙasan dama tana nuna ƙimar hana ganodermanontriol akan ƙwayoyin cuta masu kamuwa da cutar zazzabin dengue 2.

[Madogararsa] Bharadwaj S, et al.Gano Ganoderma lucidum triterpenoids a matsayin masu hana masu hana cutar Dengue NS2B-NS3 protease.Sci Rep. 2019 Dec 13; 9 (1): 19059.doi: 10.1038/s41598-019-55723-5.

KARSHE
Game da marubucin / Ms. Wu Tingyao
Wu Tingyao tana ba da rahoto kan bayanan Ganoderma lucidum na farko tun daga 1999. Ita ce marubucin Healing tare da Ganoderma (an buga shi a cikin Gidan Buga Likitan Jama'a a cikin Afrilu 2017).

★ An buga wannan labarin ne a ƙarƙashin izini na musamman na marubuci ★ Wadannan ayyukan da ke sama ba za a iya sake su ba, cirewa ko amfani da su ta wasu hanyoyi ba tare da izini daga marubucin ba. Wu Tingyao ne ya rubuta wannan labarin da Sinanci kuma Alfred Liu ya fassara shi zuwa Turanci.Idan akwai wani sabani tsakanin fassarar (Turanci) da na asali (China), asalin Sinanci zai yi nasara.Idan masu karatu suna da wasu tambayoyi, tuntuɓi marubuciyar asali, Ms. Wu Tingyao.