Disembala 13, 2019 / Yeungnam University, etc. / Malipoti a Sayansi

Zolemba / Wu Tingyao

Monga momwe moyo watsiku ndi tsiku wa anthu onse umakhumudwitsidwa ndi buku la 2019 coronavirus, pali ma virus ambiri omwe sachiritsika.Kachilombo ka dengue fever kamene kamakhudza anthu polumidwa ndi udzudzu ndi chimodzi mwa izo.

Mofanana ndi mavairasi onse, kachilombo ka dengue kamene kamakhudza anthu mwa kulumidwa ndi udzudzu kumagwiritsanso ntchito maselo kuberekana m’badwo wotsatira.Choncho, mmene kusokoneza ndi kugawanika ndondomeko ya HIV mu maselo wakhala waukulu countermeasure kwa chitukuko cha zokhudzana mankhwala.

Pakalipano, kafukufuku wambiri wakhudza kachilombo ka dengue NS2B-NS3 protease, chifukwa ndi chinthu chofunika kwambiri kuti kachilombo ka dengue kumalize kubwerezabwereza.Popanda ntchito yake, kachilomboka sikangathe kudzibalanso kuti ipatsire maselo ena.

Malinga ndi kafukufuku yemwe adasindikizidwa mu "Scientific Reports" mu Disembala 2019, Biotechnology Institute ya Yeungnam University ku South Korea ndi magulu aku India ndi Turkey adawunika mitundu 22 ya ma triterpenoids kuchokera kumagulu opatsa zipatso.Ganoderma Lucidumndipo adapeza kuti anayi aiwo adawonetsa kulepheretsa kwa NS2B-NS3 protease ntchito.

Pogwiritsa ntchito kuyesa kwa in vitro kutengera momwe kachilomboka kamafalikira mthupi, ofufuzawo adawunikanso mitundu iwiri ya ma virus.Ganoderma lucidumtriterpenoids:

Ofufuzawo adakulitsa mtundu wa virus wa dengue 2 (DENV-2, mtundu womwe umayambitsa matenda oopsa) ndi maselo amunthu kwa ola limodzi, kenako adawachiritsa mosiyanasiyana (25 kapena 50 μM)Ganoderma lucidumtriterpenoids kwa ola limodzi.Pambuyo pa maola 24, adasanthula kuchuluka kwa maselo omwe ali ndi kachilomboka.

Zotsatira zinawonetsa kuti ganodermanontriol imatha kuchepetsa kuchuluka kwa matenda a cell ndi pafupifupi 25% (25μM) kapena 45% (50μM) pomwe wachibale wa ganoderic acid C2 alibe zoletsa zambiri.

Zotsatira za kafukufukuyu zimatipatsa mwayi wina wa antivayirasiGanoderma lucidumkomanso kupereka mwayi watsopano wochiza matenda a dengue fever, omwe palibe mankhwala enieni omwe alipo.

Zomwe zili pamwambazi ndi chithunzi cha masitepe owunika mankhwala oletsa kufalitsa kachilombo ka dengueGanoderma lucidumtriterpenoids ndi NS2B-NS3 protease monga chandamale.Tchati chowerengera pansi kumanja chikuwonetsa kuchuluka kwa ganodermanontriol pama cell omwe ali ndi kachilombo ka dengue fever mtundu 2.

[Source] Bharadwaj S, et al.Kupezeka kwa Ganoderma lucidum triterpenoids ngati zoletsa motsutsana ndi Dengue virus NS2B-NS3 protease.Sci Rep. 2019 Dec 13;9(1):19059.doi: 10.1038/s41598-019-55723-5.

TSIRIZA
Za wolemba/ Mayi Wu Tingyao
Wu Tingyao wakhala akufotokoza za chidziwitso cha Ganoderma lucidum kuyambira 1999. Iye ndi mlembi wa Healing with Ganoderma (yofalitsidwa mu The People's Medical Publishing House mu April 2017).

★ Nkhaniyi yasindikizidwa ndi chilolezo cha mlembi ★ Ntchito zomwe zili pamwambazi sizingabwerezedwe, kutsanulidwa kapena kugwiritsidwa ntchito mwanjira ina popanda chilolezo cha wolemba ★ Kuphwanya mawu omwe ali pamwambawa, wolemba adzakwaniritsa udindo wake wazamalamulo ★ Zoyambirira Nkhaniyi idalembedwa m'Chitchaina ndi Wu Tingyao ndikumasuliridwa m'Chingerezi ndi Alfred Liu.Ngati pali kusiyana kulikonse pakati pa kumasulira (Chingerezi) ndi choyambirira (Chitchaina), Chitchaina choyambirira chidzapambana.Ngati owerenga ali ndi mafunso, lemberani wolemba woyamba, Mayi Wu Tingyao.