Kekemapa 13, 2019 / Ke Kulanui ʻo Yeungnam, etc. / Hōʻike ʻepekema

kikokiko / Wu Tingyao

E like me ka pilikia o ke ola o nā kānaka a pau i ka 2019 novel coronavirus, aia nō ka nui o nā maʻi i hiki ʻole ke hoʻōla.ʻO ka maʻi maʻi maʻi maʻi Dengue e hoʻopilikia i ke kanaka ma o ka nahu ʻana o ka makika kekahi o lākou.

E like me nā maʻi maʻi ʻē aʻe, hoʻohana pū ka maʻi maʻi dengue i ke kanaka ma o ka nahu ʻana o ka makika e hana hou i ka hanauna e hiki mai ana.No laila, pehea e hoʻopilikia ai i ke kaʻina hana replication o ka maʻi i loko o nā cell i lilo i ka countermeasure nui no ka hoʻomohala ʻana i nā lāʻau pili.

I kēia manawa, nui nā haʻawina i hoʻopaʻa ʻia i ka dengue virus NS2B-NS3 protease, no ka mea, he mea nui ia no ka maʻi dengue e hoʻopau i ke kaʻina hana hou.Me ka ʻole o kāna kuleana, ʻaʻole hiki i ka maʻi ke hana hou iā ia iho e hoʻopili i nā cell ʻē aʻe.

Wahi a kahi noiʻi i paʻi ʻia ma "Scientific Reports" i Dekemaba 2019, ua nānā ka Biotechnology Institute o Yeungnam University ma South Korea a me nā hui mai India a me Turkey i 22 mau ʻano triterpenoids mai ke kino hua oGanoderma Luciduma ua ʻike ʻia ʻehā o lākou i hōʻike i ka hiki ke hoʻopaʻa i ka hana protease NS2B-NS3.

Ma ka hoʻohana ʻana i nā hoʻokolohua in vitro e hoʻohālikelike i ke ʻano o ka hoʻopili ʻana o ka maʻi i nā cell i loko o ke kino, ua loiloi hou nā mea noiʻi i ʻelua ʻanoʻO Ganoderma lucidumtriterpenoids :

Ua hoʻomaʻamaʻa mua nā mea noiʻi i ka maʻi maʻi dengue type 2 (DENV-2, ke ʻano e hoʻoulu ai i ka maʻi koʻikoʻi) me nā pūnaewele kanaka no 1 hola, a laila mālama iā lākou me nā ʻano ʻokoʻa (25 a i ʻole 50 μM) oʻO Ganoderma lucidumtriterpenoids no 1 hola.Ma hope o 24 mau hola, nānā lākou i ka ratio o nā cell i loaʻa i ka maʻi.

Ua hōʻike ʻia nā hopena e hiki i ka ganodermanontriol ke hoʻemi i ka helu o ka maʻi cell ma kahi o 25% (25μM) a i ʻole 45% (50μM) ʻoiai ʻaʻole nui ka hopena inhibitory o ka ganoderic acid C2.

ʻO nā hopena o kēia noiʻi e hāʻawi iā mākou i kahi mea antiviral ʻē aʻeʻO Ganoderma luciduma hāʻawi pū i kahi manawa hou no ka mālama ʻana i ka maʻi dengue, ʻaʻohe lāʻau lapaʻau kūikawā.

ʻO ka mea i luna nei he kiʻi kiʻi o nā ʻanuʻu o ka nānā ʻana i nā lāʻau moho e pale ai i ka maʻi dengue maiʻO Ganoderma lucidumtriterpenoids me NS2B-NS3 protease e like me ka pahuhopu.Hōʻike ka pakuhi helu helu ma ka ʻaoʻao ʻākau i ka helu hoʻohiolo o ka ganodermanontriol ma nā sela i loaʻa i ka maʻi maʻi dengue ʻano 2.

[Kumu] Bharadwaj S, et al.ʻO ka ʻike ʻana o Ganoderma lucidum triterpenoids ma ke ʻano he mea hiki ke pale aku i ka maʻi Dengue NS2B-NS3 protease.Sci Rep. 2019 Dec 13;9(1):19059.doi: 10.1038/s41598-019-55723-5.

HOPE
No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao i ka ʻike mua Ganoderma lucidum mai 1999. ʻO ia ka mea kākau o Healing with Ganoderma (i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).

★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau ★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻoki ʻia a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻana o ka mea kākau ★ ʻAʻole i ʻae ʻia ka ʻōlelo ma luna, e hahai ka mea kākau i kāna mau kuleana pili i ke kānāwai ★ ʻO ke kumu kumu. Ua kākau ʻia nā kikokikona o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.