NgoDisemba 13, 2019 / IYunivesithi yaseYeungnam, njl. / IiNgxelo zeNzululwazi

Umbhalo / Wu Tingyao

Kanye njengokuba ubomi bemihla ngemihla babo bonke abantu bucatshukiswa yinoveli coronavirus ka-2019, kusekho iintsholongwane ezininzi ezinganyangekiyo.Intsholongwane yeDengue fever esulela abantu ngokulunywa ziingcongconi yenye yazo.

Njengazo zonke iintsholongwane, intsholongwane yedengue esulela abantu ngokulunywa yingcongconi ikwasebenzisa iiseli ukuvelisa isizukulwana esilandelayo.Ngoko ke, indlela yokuphazamisa inkqubo yokuphindaphinda kwentsholongwane kwiiseli iye yaba yinto ephambili yokuthintela ukuphuhliswa kwamachiza anxulumeneyo.

Okwangoku, uphando oluninzi lujolise kwintsholongwane yedengue NS2B-NS3 protease, kuba yinto eyimfuneko kwintsholongwane yedengue ukugqibezela inkqubo yophindaphindo.Ngaphandle kwendima yayo, intsholongwane ayinako ukuzivelisa kwakhona ukuze yosulele ezinye iiseli.

Ngokophononongo olupapashwe "kwiNgxelo zeNzululwazi" ngoDisemba ka-2019, iBiotechnology Institute yeYunivesithi yaseYeungnam eMzantsi Korea kunye namaqela avela eIndiya naseTurkey avavanya iindidi ezingama-22 ze-triterpenoids kumzimba ovelisa iziqhamo.Ganoderma Lucidumkwaye yafumanisa ukuba ezine kuzo zibonise inhibition enokubakho ye-NS2B-NS3 umsebenzi weprotease.

Ngokusebenzisa iimvavanyo ze-in vitro ukulinganisa indlela intsholongwane eyosulela ngayo iiseli emzimbeni, abaphandi baphinda bavavanya iindidi ezimbini zentsholongwane.I-Ganoderma lucidumtriterpenoids:

Abaphandi baqala bavelisa uhlobo lwe-2 ye-dengue virus (i-DENV-2, olona hlobo lunokubangela ukugula kakhulu) ngeeseli zomntu kwiyure eli-1, kwaye emva koko banyange ngoxinzelelo olwahlukileyo (25 okanye 50 μM)I-Ganoderma lucidumi-triterpenoids yeyure enye.Emva kweeyure ezingama-24, bahlalutya umlinganiselo weeseli ezosulelwe yile ntsholongwane.

Iziphumo zibonise ukuba i-ganodermanontriol inokunciphisa izinga losulelo lweseli malunga ne-25% (25μM) okanye i-45% (50μM) ngelixa i-ganoderic acid C2 ehambelanayo ayinayo impembelelo enkulu yokuthintela.

Iziphumo zolu phando zisinika enye indlela yokulwa neentsholongwaneI-Ganoderma lucidumkwaye ikwabonelela nethuba elitsha lokunyanga i-dengue fever, ekungekho ichiza likhethekileyo elifumanekayo.

Oku kungasentla ngumzobo ocwangcisiweyo wamanyathelo okuhlola amachiza agqatswa ukunqanda intsholongwane yedengueI-Ganoderma lucidumi-triterpenoids ene-NS2B-NS3 protease njengento ekujoliswe kuyo.Itshathi yezibalo esezantsi ngasekunene ibonisa izinga lokuthintela i-ganodermanontriol kwiiseli ezosulelwe luhlobo lwesi-2 lwentsholongwane yedengue.

[Umthombo] Bharadwaj S, et al.Ukufunyaniswa kweGanoderma lucidum triterpenoids njengezithinteli ezinokubakho ngokuchasene nentsholongwane yeDengue NS2B-NS3 protease.Sci Rep. 2019 Dec 13;9(1):19059.doi: 10.1038/s41598-019-55723-5.

ISIPHELO
Malunga nombhali/ Nksz. Wu Tingyao
U-Wu Tingyao uye wabika malunga nolwazi lokuqala lwe-Ganoderma lucidum ukususela ngo-1999. Ungumbhali we-Healing with Ganoderma (epapashwe kwi-People's Medical Publishing House ngo-Ephreli 2017).

★ Eli nqaku lipapashwa phantsi kogunyaziso olukhethekileyo lombhali ★ Le misebenzi ingentla ayinakuphinda kuveliswe, icatshulwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa ngumbhali ★ Ukwaphulwa kwale nkcazo ingasentla, umbhali uya kuqhuba uxanduva lwakhe lomthetho olunxulumeneyo ★ Eyokuqala umbhalo weli nqaku ubhalwe ngesiTshayina nguWu Tingyao kwaye waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.