NgoMeyi 2021, ithimba eliholwa ngu-Mohammad Azizur Rahman, UProfesa Ohlangene woMnyango Wezesayensi Yezinto Eziphilayo kanye Nezimo Zemvelo, Inyuvesi yaseJahangirnagar, e-Bangladesh, kanye ne-Mushroom Development Institute, uMnyango Wokunwetshwa KwezoLimo, uMnyango Wezolimo, e-Bangladesh ngokuhlanganyela bashicilela iphepha lokubheka emuva. I-International Journal of Medicinal Mushrooms ukuze iqondise abantu ngaphansi kobhadane lwe-COVID-19 ukuthi basebenzise kahle “ulwazi olwaziwayo” kanye “nezinsiza ezikhona” ukuze bazivikele ekulindeni isikhathi eside insindiso ngemithi emisha.

Ngokusekelwe emiphumeleni eqinisekiswe ngokwesayensi, ngokuhlolwa kokucatshangelwa okusebenzayo okunjengokuphepha okudliwayo kanye nokufinyeleleka kwamakhowe adliwayo nawezokwelapha kanye nokuhlaziywa kwendima yawo ku-antivirus, ukulawulwa kwamasosha omzimba, ukuncipha kokuvuvukala okubangelwa ukungalingani kwe-ACE/ACE2 kanye nokuthuthukiswa kwezifo ezivamile ezingamahlalakhona. izifo ezifana nesifo senhliziyo, isifo sikashukela, i-hyperlipidemia, kanye nomfutho wegazi ophakeme ezigulini ezinesifo i-coronavirus 2019 (COVID-19), leli phepha lichaze izizathu zokuthi kungani abantu kufanele "badle amakhowe ukuvimbela ubhubhane".

Iphepha laveza izikhathi eziningana esihlokweni ukuthiI-Ganoderma lucidumakungabazeki ukuthi iyisinqumo esifanele kunazo zonke sokuvinjelwa nokwelashwa kwenoveli i-coronavirus pneumonia phakathi kwesikhunta esidliwayo nesezokwelapha ngenxa yezithako zayo ezicebile nezihlukahlukene ezisebenzayo.

LokhoI-Ganoderma lucidumivimbela ukuphindaphinda kwegciwane, ilawula ukusabela komzimba okweqile futhi okunganele (ukulwa nokuvuvukala nokuthuthukisa ukumelana) akuyona into engavamile kuwo wonke umuntu futhi kuxoxwe ngayo ezihlokweni eziningi:

Kulula ukukuqonda lokhoI-Ganoderma lucidum, osekuvele kuhle ekuvikeleni inhliziyo nesibindi, ukuvikela amaphaphu nokuqinisa izinso, ukulawula ukuphakama okuthathu, nokulwa nokuguga, kungathuthukisa amathuba eziguli ezinezifo ezingamahlalakhona kanye nabantu abaneminyaka ephakathi kanye nabantu asebekhulile ekulweni nokuguga. inyumoniya ye-novel coronavirus.

Kodwa yini ukungalingani kwe-ACE/ACE2?Kuhlobene ngani nokuvuvukala?Kwenza kanjaniI-Ganoderma lucidumngenelela ekusebenzisaneni?

Ukungalingani kwe-ACE/ACE2 kungabhebhethekisa ukuvuvukala.

I-ACE2 (i-angiotensin eguqula i-enzyme 2) ayigcini nje ngokuba isamukeli se-SARS-CoV-2 ukuze ihlasele amaseli kodwa futhi inomsebenzi okhuthazayo wama-enzyme.Indima yayo eyinhloko ukulinganisa enye i-ACE (i-angiotensin converting enzyme) ebukeka ifana kakhulu kodwa enemisebenzi ehluke ngokuphelele.

Lapho izinso ithola ukwehla komthamo wegazi noma umfutho wegazi (njengokopha noma ukuphelelwa amanzi emzimbeni), ikhiphela i-renin egazini.I-enzyme ekhiqizwa isibindi iguqulwa ibe "i-angiotensin I" engasebenzi.Lapho i-angiotensin I igeleza negazi emaphashini ukuze ishintshisane ngegesi, i-ACE kuma-alveolar capillaries iyiguqula ibe “i-angiotensin II” esebenza ngempela esebenza kuwo wonke umzimba.

Ngamanye amazwi, i-ACE idlala indima ebalulekile “kuhlelo lwe-renin-angiotensin” olugcina umfutho wegazi njalo nomthamo wegazi (ngenkathi igcina uketshezi oluhlala njalo lomzimba nama-electrolyte).

Ukuthi nje awukwazi ukugcina imithambo yegazi isesimweni esiqinile, somfutho ophakeme ngale ndlela!Lokho kungandisa umsebenzi wenhliziyo ukusunduza igazi nezinso ukuze zisefe igazi.Ngaphezu kwalokho, i-angiotensin II ayigcini nje ngokukhuthaza i-vasoconstriction kodwa futhi ikhuthaza ukuvuvukala, i-oxidation kanye ne-fibrosis.Ukulimala kwayo okuqhubekayo emzimbeni ngeke kukhawulelwe kumfutho wegazi ophakeme!

Ngakho-ke, ukuze kube nokulingana, umzimba uhlela ngobuhlakani i-ACE2 ebusweni bamaseli e-vascular endothelial, i-alveolar, inhliziyo, izinso, amathumbu amancane, i-bile duct, testis namanye amaseli ezicubu, ukuze akwazi ukuguqula i-angiotensin II ibe i-ang. 1-7) enweba imithambo yegazi, yehlisa umfutho wegazi futhi ikwazi ukulwa nokuvuvukala, i-anti-oxidation kanye ne-anti-fibrosis.

Ngamanye amazwi, i-ACE2 iyisivikelo esisetshenziswa emzimbeni ukulinganisa ukukhiqizwa kwe-angiotensin II ngokweqile yi-ACE.Kodwa-ke, i-ACE2 kwenzeka iyichweba elinamandla le-coronavirus yenoveli ukuthi ihlasele amaseli.

Lapho i-ACE2 ihlanganiswa ne-spike protein yenoveli coronavirus, izohudulelwa esitokisini noma ichithelwe egazini ngenxa yokulimala kwesakhiwo, ukuze i-ACE2 engaphezulu kweseli inciphe kakhulu futhi ingakwazi ukumelana ne-angiotensin. II yenziwe i-ACE.

Ngenxa yalokho, ukusabela kokuvuvukala okubangelwa igciwane kuhlanganiswe nomphumela okhuthaza ukuvuvukala we-angiotensin II.Ukusabela okushubile okukhulayo kuzovimbela ukuhlanganiswa kwe-ACE2 ngamaseli, okwenza umonakalo odalwe ukungalingani kwe-ACE/ACE2 kubi kakhulu.Kuzokwenza futhi ukulimala kwe-oxidative kanye nokulimala kwe-fibrosis kwezicubu nezitho zibe nzima kakhulu.

Ucwaningo lwezokwelapha lubone ukuthi i-angiotensin Ⅱ yeziguli ezinesifo se-coronavirus 2019 (COVID-19) inyuke kakhulu, futhi ihlotshaniswa kahle nenani legciwane, izinga lokulimala kwamaphaphu, ukuvela kwenyumoniya eyingozi kanye nesifo sokuphefumula esinamandla sokuphefumula. .Ucwaningo luphinde lwaveza ukuthi ukusabela okuqinile kokuvuvukala, ukukhuphuka komfutho wegazi, kanye nokwanda kwevolumu yegazi okubangelwa ukungalingani kwe-ACE/ACE2 yizizathu ezibalulekile ezikhulisa umthwalo enhliziyweni nasezinso zeziguli ezine-pneumonia ye-coronavirus futhi zibangele i-myocardial kanye nezinso. isifo.

Ukuvinjelwa kwe-ACE kungathuthukisa ukungalingani kwe-ACE/ACE2

Izithako eziningi eziqukethwe kuyoI-Ganoderma lucidumingavimbela i-ACE

Njengoba i-ACE inhibitors evame ukusetshenziswa ekwelapheni umfutho wegazi ophakeme inganqanda umsebenzi we-ACE, inciphise ukukhiqizwa kwe-angiotensin II futhi inciphise umonakalo wamaketanga odalwe ukungalingani kwe-ACE/ACE2, abhekwa njengosizo ekwelapheni inoveli coronavirus pneumonia. .

Izazi zase-Bangladeshi zisebenzise le mpikiswano njengesinye sezizathu zokuthi kungani isikhunta esidliwayo nesezokwelapha sifanele ukuvinjelwa nokwelashwa kwe-COVID-19.

Ngoba ngokocwaningo lwangaphambilini, isikhunta esiningi esidliwayo nesomuthi sinezithako ezisebenzayo ezivimbela i-ACE, phakathi kwazo.I-Ganoderma luciduminezithako ezisebenzayo eziningi kakhulu.

Womabili ama-polypeptides aqukethwe ku-extract yamanziI-Ganoderma lucidumimizimba ethela izithelo kanye nama-triterpenoids (njengama-ganoderic acid, ama-ganoderenic acid nama-ganederol) akhona ku-methanol noma ku-ethanol extractI-Ganoderma lucidumimizimba ethela izithelo ingavimbela umsebenzi we-ACE (Ithebula 1) futhi umphumela wayo ovimbelayo muhle kakhulu phakathi kwesikhunta esidliwayo nesomuthi (Ithebula 2).

Okubaluleke nakakhulu, ekuqaleni kwawo-1970, izifundo zomtholampilo e-China nase-Japan zikuqinisekisile lokhoI-Ganoderma lucidumkunganciphisa ngempumelelo umfutho wegazi ophakeme, okubonisa lokhoI-Ganoderma lucidumUkuvinjelwa kwe-ACE akuwona "umsebenzi ongenzeka" kuphela kodwa futhi kungasebenza ngomgudu wamathumbu.

Ukusetshenziswa komtholampilo kwe-ACE inhibitors

Imicabango yokuthuthukisa ukungalingani kwe-ACE/ACE2

Ukuthi kusetshenziswe ama-ACE inhibitors ukwelapha inyumoniya entsha ye-coronavirus kuye kwenza umphakathi wezokwelapha wangabaza.

Ngoba ukuvimbela i-ACE kuzokhuphula ngokungaqondile ukuvezwa kwe-ACE2.Yize kuyinto enhle ukulwa nokuvuvukala, i-oxidation kanye ne-fibrosis, i-ACE2 iyisamukeli se-coronavirus yenoveli.Ngakho-ke ukuthi ukuvinjelwa kwe-ACE kuvikela izicubu noma kubhebhethekisa ukutheleleka kwakusakhathaza.

Kulezi zinsuku, kube nocwaningo lwemitholampilo oluningi (bona Izithenjwa 6-9 ukuze uthole imininingwane) ukuthi ama-ACE inhibitors awasenzi sibe sibi kakhulu isimo seziguli ezinenyumoniya ye-coronavirus.Ngakho-ke, izinhlangano eziningi zenhliziyo noma zomfutho wegazi ophakeme eYurophu nase-United States ziye zancoma ngokucacile iziguli ukuthi ziqhubeke nokusebenzisa i-ACE inhibitor uma zingekho izimo ezimbi zomtholampilo ezenzekayo.

Ngokuqondene neziguli ze-COVID-19 ezingazange zisebenzise i-ACE inhibitors, ikakhulukazi lezo ezingenawo umfutho wegazi ophakeme, isifo senhliziyo noma izinkomba zesifo sikashukela, ukuthi kufanele kunikezwe ama-ACE inhibitors engeziwe okwamanje akusho lutho ikakhulukazi ngoba nakuba izifundo zomtholampilo zibonile izinzuzo zokusebenzisa i-ACE inhibitors (njenge-ACE inhibitors). izinga eliphezulu lokusinda), umphumela awubonakali usobala ngokwanele ukuba ube izincomo zesiqondiso sezokwelapha.

Indima yeI-Ganoderma lucidumingaphezu kokuvimbela i-ACE

Akumangazi ukuthi ama-ACE inhibitors angase angakwazi ukwenza imiphumela ebalulekile ngesikhathi sokubhekwa komtholampilo (imvamisa usuku olungu-1 kuya enyangeni engu-1).Ukuvuvukala okungalawuleki okubangelwa ukulwa phakathi kwegciwane namasosha omzimba kuyimbangela yokuwohloka kwenoveli i-coronavirus pneumonia.Njengoba isigebengu singakaqedwa, vele kunzima ukuguqula izinto ngesikhathi sokuqala ngokucindezela i-ACE ukuthi ibhekane nabahambisana nayo.

Inkinga ukuthi ukungalingani kwe-ACE/ACE2 kungenzeka kube utshani bokugcina bokuchoboza ikamela, futhi kungenzeka kube yisikhubekiso sokululama esikhathini esizayo.Ngakho-ke, uma ucabanga ngombono wokuphishekela inhlanhla nokugwema inhlekelele, ukusetshenziswa kahle kwama-ACE inhibitors kuzosiza ukululama kweziguli ezine-coronavirus pneumonia entsha.

Kodwa-ke, uma kuqhathaniswa nemiphumela engemihle engase ibangelwe ama-synthetic ACE inhibitors, njengokukhwehlela okomile, i-allotriogeusti kanye ne-potassium yegazi ephakeme, isazi sase-Bangladeshi esabhala leli phepha sikholelwa ukuthi izakhi ezivimbela i-ACE kusikhunta esidliwayo nesezokwelapha ezenzeka ngokwemvelo. akubangeli umthwalo womzimba.Ngokuqondene,I-Ganoderma lucidum, enezingxenye eziningi ze-ACE-inhibiting kanye nomphumela omuhle kakhulu wokuvinjelwa, kufanelekile ukubheka phambili.

Ngaphezu kwalokho, abaningiI-Ganoderma lucidumama-extracts nomaI-Ganoderma lucidumizithako ezivimbela i-ACE zingase futhi zivimbele ukuphindaphinda kwegciwane, zilawule ukuvuvukala (zigweme isivunguvungu se-cytokine), zithuthukise ukuzivikela komzimba, zivikele izinhlelo zenhliziyo, zilawule ushukela wegazi, zilawule umfutho wegazi, zilawule ama-lipids egazi, zinciphise ukulimala kwesibindi, zinciphise ukulimala kwezinso, zinciphise ukulimala kwamaphaphu, zivikele. umgudu wokuphefumula, uvikele umgudu wamathumbu.Izithako ezivimbela i-ACE zokwenziwa noma ezinye izithako ezivimbela i-ACE ezithathwe kusikhunta esidliwayo nesomuthi asinakuqhathaniswaI-Ganoderma lucidumMayelana nalokhu.

Ukunciphisa ingozi yokugula okunzima nokufa nje kunciphisa le nkinga.

Kusukela lapho i-coronavirus yenoveli ikhetha i-ACE2 njengesamukeli sokuhlasela, imiselwe ukuthi yehluke kwamanye amagciwane ngokubulala nokuba yinkimbinkimbi.

Ngoba amaseli amaningi ezicubu emzimbeni womuntu ane-ACE2.I-coronavirus yenoveli ingalimaza i-alveoli futhi ibangele i-hypoxia emzimbeni wonke, ilandele igazi ukuze ithole isisekelo esifanele emzimbeni, ihehe amaseli omzimba yonke indawo ukuthi ihlasele, ibhubhise ibhalansi ye-ACE/ACE2 yonke indawo, iqinise ukuvuvukala, i-oxidation kanye ne-fibrosis, yandise igazi. umfutho wegazi kanye nomthamo wegazi, kwenyusa umthwalo enhliziyweni nezinso, kwenza uketshezi lomzimba nokungalingani kwama-electrolyte okuthinta ukusebenza kwamangqamuzana, futhi kubangele imiphumela eminingi ye-domino.

Ngakho-ke, ukutheleleka ngenyumoniya entsha ye-coronavirus akukhona “ukuthola umkhuhlane oyingozi kakhulu” “othinta amaphaphu kuphela”.Izoba ne-sequelae yesikhathi eside yezicubu zomzimba, izitho kanye nemisebenzi yomzimba.

Yize izindaba ezinhle mayelana nokwakhiwa kwemithi emisha ehlukahlukene yokuvimbela nokwelashwa kwe-COVID-19 zijabulisa kakhulu, amanye amaqiniso angaphelele aseseduze:

Ukugoma (amasosha omzimba okudala) akuqinisekisi ukuthi ngeke kube khona ukutheleleka;

Imithi elwa namagciwane (ukuvimbela ukuphindaphinda kwegciwane) ayikwazi ukuqinisekisa ukwelashwa kwesifo;

I-steroid anti-inflammation (ukucindezelwa kwamasosha omzimba) inkemba esika nhlangothi zombili;

Izinkinga angeke zigwenywe ngisho noma kungekho ukugula okunzima;

Ukushintsha kokuhlolwa kwegciwane kusuka ku-positive kuya kwebi akusho impi ephumelelayo yokulwa nalolu bhubhane;

Ukuphuma esibhedlela uphila akusho ukuthi uzokwazi ukululama ngokugcwele esikhathini esizayo.

Lapho imishanguzo ye-coronavirus kanye nemithi yokugoma isisisizile ukuthi sibambe “isiqondiso esijwayelekile” sokunciphisa ingozi yokugula kakhulu, ukunciphisa amathuba okufa kanye nokunciphisa ubude bokulaliswa esibhedlela, ungakhohlwa ukuthi miningi “imininingwane” okufanele siyenze. sithembele kithi ukuthi siphathe.

Lapho abantu bethembele ekuhlakanipheni nasekwazini ukuhlanganisa imithi ehlukahlukene emidala nemisha enemiphumela ethize ukuze bathole umphumela ongcono kakhulu, kufanele sifunde ukusebenzisa indlela yokwelapha ebanzi yesitayela se-cocktail ukuze sibhekane nalesi sifo esiyinkimbinkimbi.

Kusukela ekuthuthukiseni ukumelana, ukuvimbela ukuphindaphinda kwegciwane, ukulawula ukuvuvukala okungavamile, ukulinganisa i-ACE/ACE2 ekuvikeleni uhlelo lwenhliziyo, ukulawula ukuphakama okuthathu nokunciphisa umthwalo wezifo ezingamahlalakhona emzimbeni, lokhu kungashiwo njengezidingo eziyisisekelo zokunciphisa izinga lokutheleleka. I-COVID-19, ukuvimbela i-COVID-19 enzima kanye nokwenza ngcono ukululama kwe-COVID-19.

Akekho owaziyo ukuthi likhona yini ithemba esikhathini esizayo lokuhlangabezana nalezi zidingo eziyisisekelo ngesikhathi esisodwa.Mhlawumbe “iresiphi eyimfihlo” ekude esibhakabhakeni empeleni iphambi kwakho.UNkulunkulu onesihe sekuyisikhathi eside elungiselela iresiphi ye-cocktail engokwemvelo, esetshenziswa kabili ukudla nemithi, etholakala kalula, futhi elungele amadoda, abesifazane nezingane.Kuya ngokuthi siyazi ukuthi sisetshenziswa kanjani.

[Umthombo]

1. U-Mohammad Azizur Rahman, et al.I-Int J Med Mushrooms.2021;23(5):1-11.

2. Aiko Morigiwa, et al.I-Chem Pharm Bull (Tokyo).1986;34(7): 3025-3028.

3. Noorlidah Abdullah, et al.I-Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, et al.Amangqamuzana.2014;19(9):13473-13485.

5. Tran Hai-Bang, et al.I-Phytochem Lett.2015;12:243-247.

6. UChirag Bavishi, nabanye.JAMA Cardiol.2020;5(7):745-747.

7. U-Abhinav Grover, et al.2020 Jun 15 : pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. URenato D. Lopes, et al.Am Heart J. 2020 Aug;226: 49–59.

9. URenato D. Lopes, et al.JAMA.2021 Jan 19;325(3):254–264.

PHELA

Mayelana nombhali/ Nks. Wu Tingyao
UWu Tingyao ubelokhu ebika ngolwazi lokuqala lwe-Ganoderma lucidum kusukela ngo-1999. Ungumbhali wencwadiUkwelapha nge-Ganoderma(ishicilelwe ku-People's Medical Publishing House ngo-Ephreli 2017).
 
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★ Umbhalo wokuqala walesi sihloko ubhalwe ngesiShayina nguWu Tingyao futhi wahunyushelwa esiNgisini ngu-Alfred Liu.Uma kukhona ukungqubuzana phakathi kokuhumusha (isiNgisi) kanye nokwangempela (isiShayina), isiShayina sangempela siyonqoba.Uma abafundi benemibuzo, sicela uthinte umbhali wokuqala, uNksz. Wu Tingyao.
 

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