I Mei 2021, he hui i alakaʻi ʻia e Mohammad Azizur Rahman, Associate Professor o ke Keʻena Biochemistry a me Molecular Biology, Jahangirnagar University, Bangladesh, a me ka Mushroom Development Institute, Department of Agricultural Extension, Ministry of Agriculture, Bangladesh i hoʻopuka pū i kahi pepa retrospective ma. ka International Journal of Medicinal Mushrooms e alakaʻi i ka poʻe ma lalo o ka maʻi maʻi COVID-19 e hoʻohana maikaʻi i ka "ʻike i ʻike ʻia" a me nā "waiwai i loaʻa" e ʻimi i ka pale ponoʻī i ka kali lōʻihi no ke ola me nā lāʻau lapaʻau hou.

Ma muli o nā hualoaʻa i hōʻoia ʻia e ka ʻepekema, ma o ka loiloi ʻana i nā noʻonoʻo pono e like me ka palekana edible a me ka hiki ʻana o nā mea ʻai a me nā lāʻau lapaʻau a me ka nānā ʻana i kā lākou kuleana i ka antivirus, ka hoʻoponopono immune, ka hoʻohaʻahaʻa ʻana i ka mumū i hoʻokumu ʻia e ka ACE/ACE2 imbalance a me ka hoʻomaikaʻi ʻana i ka maʻi maʻamau. nā maʻi e like me ka maʻi cardiovascular, diabetes, hyperlipidemia, a me ka hypertension i nā mea maʻi me ka maʻi coronavirus 2019 (COVID-19), ua wehewehe ka pepa i nā kumu e "ʻai ai ka poʻe i nā halo e pale ai i nā maʻi maʻi".

Ua kuhikuhi pinepine ka pepa i ka ʻatikalaʻO Ganoderma lucidumʻO ia ke koho kūpono loa no ka pale ʻana a me ka mālama ʻana i ka maʻi maʻi coronavirus novel ma waena o nā mea ʻai a me nā lāʻau lapaʻau ma muli o kāna mau mea waiwai a me nā ʻano hana like ʻole.

ʻO kēlāʻO Ganoderma lucidumpale i ka hoʻopiʻi hou ʻana o ka maʻi virus, hoʻoponopono i ka nui a me ka lawa ʻole o nā pane kūlohelohe (anti-inflammation and resistance enhancement) ʻaʻole ʻokoʻa i nā mea āpau a ua kūkākūkā ʻia ma nā ʻatikala he nui:

He maʻalahi ke hoʻomaopopo i kēlāʻO Ganoderma lucidum, ka mea i maikaʻi i ka pale ʻana i ka puʻuwai a me ke akepaʻa, pale i nā māmā a me ka hoʻoikaika ʻana i nā puʻupaʻa, hoʻoponopono i nā kiʻekiʻe ʻekolu, a me ka anti-aging, hiki ke hoʻomaikaʻi i nā kūlana o nā maʻi me nā maʻi maʻi a me nā poʻe waena a me nā ʻelemakule i ka hakakā ʻana. ʻo ka pneumonia coronavirus hou.

Akā he aha ka ʻokoʻa ACE/ACE2?He aha ka pili ʻana me ka mumū?PeheaʻO Ganoderma lucidumkomo i ka hui?

Hiki i ke kaulike ʻole ACE/ACE2 ke hoʻonui i ka mumū.

ʻAʻole ʻo ACE2 (angiotensin converting enzyme 2) wale nō ka mea hoʻokipa no SARS-CoV-2 e hoʻouka i nā cell akā loaʻa pū kekahi i ka hana catalytic o nā enzymes.ʻO kāna hana nui ʻo ka hoʻohālikelike ʻana i kekahi ACE (angiotensin converting enzyme) i like loa ke ʻano akā he ʻokoʻa nā hana.

Ke ʻike ke kīkī i ka emi ʻana o ka nui o ke koko a i ʻole ke kahe koko (e like me ke kahe ʻana a me ka dehydration), hūnā ia i ka renin i loko o ke koko.Hoʻololi ʻia ka enzyme huna ʻia e ke ake i kahi "angiotensin I" hana ʻole.I ka wā e kahe ai ka angiotensin I me ke koko ma o nā māmā no ka hoʻololi kinoea, hoʻololi ka ACE i loko o nā capillaries alveolar i "angiotensin II" ikaika maoli e hana ana ma ke kino holoʻokoʻa.

ʻO ia hoʻi, he kuleana koʻikoʻi ka ACE i ka "renin-angiotensin system" e mālama mau ana i ke koko a me ka nui o ke koko (ʻoiai e mālama mau ana i nā wai kino a me nā electrolytes).

ʻAʻole hiki iā ʻoe ke mālama i nā kīʻaha koko i kahi kūlana paʻa, kiʻekiʻe e like me kēia!Hiki iā ia ke hoʻonui i ka hana o ka puʻuwai e pana i ke koko a me nā puʻupaʻa e kānana i ke koko.ʻO ka mea hou aku, ʻaʻole hoʻolaha wale ka angiotensin II i ka vasoconstriction akā hoʻolaha pū kekahi i ka mumū, oxidation a me fibrosis.ʻAʻole e kaupalena ʻia kona pōʻino mau i ke kino i ke koko kiʻekiʻe!

No laila, no ka loaʻa ʻana o ke kaulike, hoʻonohonoho akamai ke kino i ka ACE2 ma luna o ka ʻili o nā cell endothelial vascular, alveolar, naʻau, puʻupaʻa, ʻōpū liʻiliʻi, bile duct, testis a me nā mea kikoʻī ʻē aʻe, i hiki iā ia ke hoʻololi i ka angiotensin II i ang ( 1-7) e hoʻonui i nā kīʻaha koko, e hoʻohaʻahaʻa i ke koko a hiki i ka anti-inflammation, anti-oxidation a me ka anti-fibrosis.

I nā huaʻōlelo ʻē aʻe, ʻo ACE2 kahi lever i hoʻohana ʻia i ke kino e kaulike i ka hana ʻana o ka angiotensin II nui e ACE.Eia nō naʻe, ʻo ACE2 kahi awa sally no ka novel coronavirus e hoʻouka i nā cell.

Ke hui pū ʻia ʻo ACE2 me ka protein spike o ka novel coronavirus, e huki ʻia i loko o ke kelepona a i hoʻokahe ʻia paha i loko o ke koko ma muli o ka pōʻino o ke kino, no laila e hoʻemi nui ʻia ka ACE2 ma ka ʻili o ke kelepona a ʻaʻole hiki ke hoʻohālikelike i ka angiotensin. II ho'ā 'ia e ACE.

ʻO ka hopena, ua hoʻopili ʻia ka pane inflammatory i hoʻokomo ʻia e ka maʻi me ka hopena pro-inflammatory o ka angiotensin II.ʻO ka pane ʻana o ka maʻi ʻeha e pale aku i ka synthesis o ACE2 e nā cell, e ʻoi aku ka koʻikoʻi o ke kaulahao ma muli o ke kaulike ʻole o ACE/ACE2.E hoʻomāinoino ʻia ka pōʻino oxidative a me ka fibrosis o nā ʻiʻo a me nā kino.

Ua ʻike ʻia nā noiʻi maʻi i ka angiotensin Ⅱ o nā mea maʻi me ka maʻi coronavirus 2019 (COVID-19) i hoʻonui nui ʻia, a ua hoʻopili maikaʻi ʻia me ka nui o ka maʻi maʻi, ke ʻano o ka hōʻeha ʻana o ka pūpū, ka hiki ʻana mai o ka maʻi pneumonia a me ka maʻi ʻeha hanu acute. .Ua hōʻike pū ʻia nā haʻawina ʻo ka pane ʻana o ka inflammatory, ka piʻi ʻana o ke koko, a me ka piʻi ʻana o ka nui o ke koko ma muli o ke kaulike ʻole o ACE/ACE2 he kumu nui ia e hoʻonui ai i ke kaumaha o ka puʻuwai a me nā puʻupaʻa o nā mea maʻi me ka maʻi maʻi maʻi coronavirus novel a ke kumu o ka myocardial a me ka puʻupaʻa. maʻi maʻi.

Hiki i ka pale ʻana i ka ACE ke hoʻomaikaʻi i ka kaulike ʻole ACE/ACE2

Nui nā meaʻai i lokoʻO Ganoderma lucidumhiki ke kaohi i ka ACE

No ka mea hiki i ka ACE inhibitors i hoʻohana maʻamau i ka mālama ʻana i ke kiʻekiʻe kiʻekiʻe ke kāohi i ka hana o ka ACE, hoʻemi i ka hana ʻana o ka angiotensin II a hoʻohaʻahaʻa i ka pōʻino kaulahao ma muli o ke kaulike ʻole o ACE/ACE2, manaʻo ʻia lākou he mea kōkua no ka mālama ʻana i ka maʻi maʻi coronavirus novel. .

Ua hoʻohana nā loea Bangladeshi i kēia hoʻopaʻapaʻa ʻo ia kekahi o nā kumu e kūpono ai nā haʻuki edible a me nā lāʻau lapaʻau no ka pale ʻana a me ka mālama ʻana o COVID-19.

No ka mea, e like me ka noiʻi i hala aku nei, he nui nā haʻiki hiki ke ʻai a me nā lāʻau lapaʻau i loaʻa nā mea ikaika e kāohi ai i ka ACE, ma waena o lākou.ʻO Ganoderma lucidumloaʻa nā mea hoʻoikaika nui loa.

ʻO nā polypeptides ʻelua i loko o ka wai wai oʻO Ganoderma lucidumnā kino hua a me nā triterpenoids (e like me ganoderic acids, ganoderenic acids a me ganederols) i loko o ka methanol a i ʻole ka ethanol extract oʻO Ganoderma lucidumHiki i nā kino hua ke keʻakeʻa i ka hana ACE (Paukū 1) a ʻoi aku ka maikaʻi o kā lākou hopena pale i waena o nā haʻiki hiki ke ʻai a me nā lāʻau lapaʻau (Papa 2).

ʻO ka mea nui aʻe, i ka hoʻomaka ʻana o ka makahiki 1970, ua hōʻoia nā noiʻi lapaʻau ma Kina a me IapanaʻO Ganoderma lucidumhiki ke hoʻohaʻahaʻa i ke koko kiʻekiʻe, e hōʻike ana i kēlāʻO Ganoderma lucidumʻAʻole ʻo ka hoʻopaʻa ʻana i ka ACE he "hana hiki" wale nō akā hiki ke hana ma ka ʻāpana ʻōpū.

ʻO ka hoʻohana ʻana i ka lāʻau lapaʻau o ACE inhibitors

Nā noʻonoʻo no ka hoʻomaikaʻi ʻana i ke kaulike ACE/ACE2

Inā paha e hoʻohana i ka ACE inhibitors no ka mālama ʻana i ka maʻi maʻi maʻi coronavirus hou i hoʻokaʻulua i ke kaiāulu olakino.

No ka mea, ʻo ke kāohi ʻana i ka ACE e hoʻonui i ka hōʻike o ACE2.ʻOiai he mea maikaʻi ia e hakakā ai i ka mumū, ka oxidation a me ka fibrosis, ʻo ACE2 ka mea loaʻa i ka novel coronavirus.No laila, ʻo ka pale ʻana i ka ACE e pale i nā ʻiʻo a i ʻole e hoʻonui i ka maʻi i hopohopo.

I kēia mau lā, ua nui nā noiʻi lapaʻau (e ʻike i nā References 6-9 no nā kikoʻī) ʻaʻole e hōʻeha nā mea hoʻopaneʻe ACE i ke kūlana o nā maʻi me ka maʻi maʻi maʻi coronavirus.No laila, nui nā hui puʻuwai a i ʻole hypertension ma ʻEulopa a me ʻAmelika Hui Pū ʻIa i ʻōlelo maopopo i ka poʻe maʻi e hoʻomau i ka hoʻohana ʻana i ka ACE inhibitor inā ʻaʻohe pilikia maʻi maʻi.

No nā poʻe maʻi COVID-19 ʻaʻole i hoʻohana i ka ACE inhibitors, ʻoi aku ka poʻe me ka hypertension ʻole, nā maʻi puʻuwai a i ʻole nā ​​​​hōʻailona maʻi diabetes, inā paha e hāʻawi ʻia nā mea paʻa ACE hou i kēia manawa ʻaʻole maopopo loa no ka mea ʻoiai ua ʻike nā haʻawina lapaʻau i nā pono o ka hoʻohana ʻana i ka ACE inhibitors (e like me kiʻekiʻe ke ola ola), ʻaʻole ʻike maopopo ʻia ka hopena e lilo i ʻōlelo kuhikuhi alakaʻi olakino.

ʻO ke kuleana oʻO Ganoderma lucidumʻoi aku ma mua o ke kāohi ʻana i ka ACE

ʻAʻole ia he mea kupanaha ʻaʻole hiki i ka ACE inhibitors ke hoʻokō i nā hopena koʻikoʻi i ka wā o ka nānā ʻana i ka maʻi (maʻamau 1 lā a 1 mahina).ʻO ka maʻi ʻaʻole i hoʻopaʻa ʻia e ka hakakā ma waena o ka maʻi a me ka ʻōnaehana pale ke kumu o ka hōʻino ʻana o ka novel coronavirus pneumonia.No ka mea ʻaʻole i hoʻopau ʻia ka mea hewa, he mea paʻakikī ke hoʻohuli i nā mea i ka manawa mua ma ke kāohi ʻana iā ACE e hana me nā accomplices.

ʻO ka pilikia, ʻo ka ACE/ACE2 imbalance ʻo ia ka mauʻu hope loa e ʻoki ai i ke kāmelo, a ʻoi aku ka lilo i mea hina no ka hoʻihoʻi hou ʻana.No laila, inā ʻoe e noʻonoʻo mai ke ʻano o ka ʻimi ʻana i ka pōmaikaʻi a me ka pale ʻana i ka pōʻino, ʻo ka hoʻohana maikaʻi ʻana o ka ACE inhibitors e kōkua i ka hoʻihoʻi ʻana o nā mea maʻi me ka maʻi pneumonia novel coronavirus.

Eia nō naʻe, ke hoʻohālikelike ʻia me nā hopena ʻaoʻao e hiki mai ana e nā mea hoʻopiʻi ACE synthetic, e like me ka maloʻo maloʻo, allotriogeusti a me ke kiʻekiʻe o ka potassium koko, ua manaʻo ka mea aʻoaʻo Bangladeshi nāna i kākau i kēia pepa, ʻo nā ʻāpana ACE-inhibiting i loko o nā ʻano meaʻai a me nā lāʻau lapaʻau. ʻaʻole e hoʻokaumaha i ke kino.I ke ʻano wae,ʻO Ganoderma lucidum, nona nā ʻāpana ACE-inhibiting he nui a me kahi hopena hoʻoweliweli maikaʻi loa, ʻoi aku ka maikaʻi o ka nānā ʻana.

He aha hou aku, he nuiʻO Ganoderma lucidumnā unuhi a i ʻoleʻO Ganoderma lucidumʻO nā mea hana e pale ai i ka ACE hiki ke hoʻopaʻa i ka hoʻopiʻi hou ʻana o ka maʻi virus, hoʻoponopono i ka mumū (ʻalo i ka cytokine storm), hoʻonui i ka pale ʻana, pale i nā ʻōnaehana cardiovascular, hoʻoponopono i ke kō koko, hoʻoponopono i ke koko, hoʻoponopono i nā lipids koko, hoʻemi i ka ʻeha o ke ake, hōʻemi i ka hōʻeha kīkī, hoʻemi i ka ʻeha ʻeha, pale. ka ʻōpū hanu, pale i ka ʻōpū.ʻAʻole hiki ke hoʻohālikelike ʻia nā mea hoʻohui ACE inhibitory synthetic a i ʻole nā ​​​​mea ʻē aʻe ACE inhibitory i loaʻa mai i nā haʻi ʻai a me nā lāʻau lapaʻau.ʻO Ganoderma lucidumma keia mea.

ʻO ka hōʻemi ʻana i ka pilikia o ka maʻi koʻikoʻi a me ka make ke hoʻopau wale nei i ka pilikia.

Mai ka manawa i koho ai ka novel coronavirus i ka ACE2 ma ke ʻano he invasion receptor, ua manaʻo ʻia e ʻokoʻa mai nā maʻi ʻē aʻe i ka lethality a me ka paʻakikī.

No ka nui loa o nā ʻiʻo i loko o ke kino o ke kanaka he ACE2.Hiki i ka novel coronavirus ke hōʻino i ka alveoli a hoʻoulu i ka hypoxia ma ke kino holoʻokoʻa, e hahai i ke koko e ʻike i kahi kumu kūpono i ke kino, e huki i nā cell immune ma nā wahi āpau e hoʻouka ai, e luku i ke koena ACE / ACE2 ma nā wahi āpau, e hoʻoikaika i ka mumū, oxidation a me fibrosis, hoʻonui i ke koko. ʻO ke kaomi a me ka nui o ke koko, hoʻonui i ke kaumaha o ka puʻuwai a me nā puʻupaʻa, hana i nā wai kino a me nā electrolytes imbalance e pili ana i nā hana cell, a hoʻoulu i nā hopena domino hou aʻe.

No laila, ʻo ka maʻi me ka maʻi maʻi coronavirus novel ʻaʻole loa ia e "loaʻa i ke anuanu koʻikoʻi" e "pili wale i nā māmā".E loaʻa iā ia nā hopena lōʻihi i nā ʻiʻo o ke kino, nā ʻāpana a me nā hana physiological.

ʻOiai ʻo ka nūhou maikaʻi e pili ana i ka hoʻomohala ʻana o nā lāʻau lapaʻau hou no ka pale ʻana a me ka mālama ʻana i ka COVID-19 he mea hoihoi loa, ua kokoke mai kekahi mau mea kūpono ʻole.

ʻAʻole e hōʻoiaʻiʻo ʻia ka loaʻa ʻole o ka maʻi;

ʻAʻole hiki i nā lāʻau lapaʻau Antiviral (ka hoʻopaʻa ʻana i ka hoʻopiʻi ʻana i nā maʻi) ke hōʻoiaʻiʻo i ka hoʻōla ʻana o ka maʻi;

ʻO ka steroid anti-inflammation (immune suppression) he pahi kaua ʻelua;

ʻAʻole hiki ke pale ʻia nā pilikia inā ʻaʻohe maʻi koʻikoʻi;

ʻO ka hoʻololi ʻana o ka nānā ʻana i ka maʻi mai ka maikaʻi a i ka maikaʻi ʻole ʻaʻole ia he manaʻo i ka hakakā kūleʻa i ke ahulau;

ʻO ka hele ʻana i waho o ka haukapila ola ʻaʻole ia he manaʻo e hiki iā ʻoe ke hoʻōla piha i ka wā e hiki mai ana.

I ka wā i kōkua ai nā lāʻau coronavirus a me nā lāʻau lapaʻau iā mākou e hoʻomaopopo i ka "alakaʻi ākea" o ka hōʻemi ʻana i ka hopena o ka maʻi koʻikoʻi, e hōʻemi ana i ka hiki ke make a me ka pōkole o ka lōʻihi o ka hale maʻi, mai poina i ka nui o nā "mea kikoʻī" e pono ai mākou. hilinaʻi iā mākou iho e lawelawe me.

Ke hilinaʻi ke kanaka i ka naʻauao a me ka ʻike e hoʻohui i nā lāʻau lapaʻau kahiko a me nā lāʻau hou i loaʻa nā hopena kikoʻī e loaʻa ai ka hopena maikaʻi loa, pono mākou e aʻo i ka hoʻohana ʻana i kahi lāʻau lapaʻau holoʻokoʻa e pili ana i kēia maʻi paʻakikī.

Mai ka hoʻonui ʻana i ke kūpaʻa, ka pale ʻana i ka hoʻopiʻi ʻana i ka maʻi virus, ka hoʻomalu ʻana i ka mumū maʻamau, ke kaupaona ʻana i ka ACE / ACE2 i ka pale ʻana i ka ʻōnaehana cardiovascular, ka hoʻoponopono ʻana i nā kiʻekiʻe ʻekolu a me ka hōʻemi ʻana i ke kaumaha o nā maʻi maʻi ma ke kino, hiki ke ʻōlelo ʻia kēia mau mea pono e hōʻemi i ka nui o ka maʻi o ka maʻi. ʻO COVID-19, ka pale ʻana i ka COVID-19 koʻikoʻi a me ka hoʻomaikaʻi ʻana i ka hoʻihoʻi ʻana o COVID-19.

ʻAʻohe mea i ʻike inā he manaʻolana i ka wā e hiki mai ana e hoʻokō i kēia mau pono kumu i ka manawa like.Malia paha ʻo ka "mea huna huna" i mamao loa i ka lani aia maoli i mua ou.Ua hoʻomākaukau lōʻihi ke Akua lokomaikaʻi i ka meaʻai meaʻai maʻamau, hoʻohana pālua no ka meaʻai a me ka lāʻau lapaʻau, hiki ke loaʻa, a kūpono i nā kāne, nā wahine a me nā keiki.Pili wale ia inā ʻike mākou pehea e hoʻohana ai.

[Kumu]

1. Mohammad Azizur Rahman, et al.Int J Med Halo.2021;23(5):1-11.

2. Aiko Morigiwa, et al.ʻO Chem Pharm Bull (Tokyo).1986;34(7): 3025-3028.

3. Noorlidah Abdullah, et al.Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, et al.Nā Molekula.2014;19(9):13473-13485.

5. Tran Hai-Bang, et al.Phytochem Lett.2015;12: 243-247.

6. ʻO Chirag Bavishi, et al.JAMA Cardiol.2020;5(7):745-747.

7. Abhinav Grover, et al.2020 Iune 15: pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. Renato D. Lopes, et al.Am Heart J. 2020 Aug;226: 49–59.

9. Renato D. Lopes, et al.JAMA.2021 Ian 19;325(3):254–264.

HOPE

No ka mea kākau/ Ms. Wu Tingyao
Ua hōʻike ʻo Wu Tingyao i ka ʻike Ganoderma lucidum lima mua mai 1999. ʻO ia ka mea kākau oHoola me Ganoderma(i paʻi ʻia ma The People's Medical Publishing House ma ʻApelila 2017).
 
★ Ua paʻi ʻia kēia ʻatikala ma lalo o ka mana kūʻokoʻa o ka mea kākau, a no GANOHERB ka mea nona.

★ ʻAʻole hiki ke hana hou ʻia nā hana ma luna aʻe, ʻokiʻoki a hoʻohana ʻia ma nā ʻano ʻē aʻe me ka ʻole o ka ʻae ʻia e GanoHerb.

★ Inā ua ʻae ʻia nā hana e hoʻohana ʻia, pono e hoʻohana ʻia i loko o ke ʻano o ka mana a hōʻike i ke kumu: GanoHerb.

★ No ka uhaki ʻana i ka ʻōlelo ma luna, e ʻimi ʻo GanoHerb i nā kuleana pili kānāwai.

★ Ua kākau ʻia ka kikokikona kumu o kēia ʻatikala ma ka ʻōlelo Pākē e Wu Tingyao a unuhi ʻia i ka ʻōlelo Pelekania e Alfred Liu.Inā loaʻa kekahi ʻokoʻa ma waena o ka unuhi (English) a me ka unuhi mua (Pake), e lanakila ka Pākē mua.Inā he nīnau ka poʻe heluhelu, e ʻoluʻolu e kelepona i ka mea kākau kumu, ʻo Ms. Wu Tingyao.
 

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