Bishii Maajo 2021, koox uu hoggaaminayo Mohammad Azizur Rahman, Associate Professor of Department of Biochemistry and Molecular Biology, Jahangirnagar University, Bangladesh, iyo Machadka Horumarinta Mushroom, Waaxda Fidinta Beeraha, Wasaaradda Beeraha, Bangladesh waxay si wada jir ah u daabacday warqad dib-u-eegis ah Joornaalka Caalamiga ah ee Mushrooms Daawooyinka si uu u hago dadka ku hoos jira masiibada COVID-19 si ay si wanaagsan uga faa'iidaystaan ​​"aqoon la yaqaan" iyo "khayraadka jira" si ay u raadiyaan is-ilaalinta muddada dheer ee sugitaanka badbaadada daawooyinka cusub.

Iyada oo ku saleysan natiijooyinka cilmi ahaan la xaqiijiyay, iyada oo loo marayo qiimeynta tixgalinta la taaban karo sida badbaadada la cuni karo iyo helitaanka boqoshaada la cuni karo iyo daawada iyo falanqaynta doorkooda antivirus, nidaaminta difaaca jirka, yaraynta bararka ee ay keento isu dheelitir la'aanta ACE / ACE2 iyo hagaajinta joogtada ah ee caadiga ah. cudurada sida cudurada wadnaha, sonkorowga, hyperlipidemia, iyo hypertension ee bukaanka qaba cudurka coronavirus 2019 (COVID-19), warqaddu waxay sharraxday sababaha ay dadku u tahay inay "cunaan boqoshaada si ay uga hortagaan cudurrada faafa".

Wargeysku wuxuu dhowr jeer ku tilmaamay maqaalka inGanoderma lucidumShaki la'aan waa doorashada ugu habboon ee ka hortagga iyo daawaynta novel coronavirus pneumonia oo ka mid ah fangaska badan ee la cuni karo iyo kuwa dawooyinka ah sababtoo ah maaddooyinka firfircoon ee hodanka ah iyo kuwa kala duwan.

TaasiGanoderma lucidumwaxay joojisaa ku-noqoshada fayraska, waxay nidaamisaa jawaab-celinta difaaca jirka ee xad-dhaafka ah iyo kuwa aan ku filnayn (ka-hortagga caabuqa iyo xoojinta iska caabbinta) maaha mid la yaab leh qof walba waxaana lagaga hadlay maqaallo badan:

Way fududahay in la fahmoGanoderma lucidum, oo awalba ku wanaagsan ilaalinta wadnaha iyo beerka, ilaalinta sambabada iyo xoojinta kelyaha, nidaaminta saddexda sare, iyo ka hortagga gabowga, waxay hagaajin kartaa nasiibka bukaanka qaba cudurrada daba-dheeraada iyo dadka da'da dhexe iyo waayeelka ah ee dagaalka ka dhanka ah. buuga fayruuska burunkiitada corona.

Laakin waa maxay dheelitir la'aanta ACE/ACE2?Maxay ka qabtaa caabuqa?Sidee u sameeyaaGanoderma lucidumsoo dhexgala isku duwidda?

Isku dheelitir la'aanta ACE/ACE2 waxay ka sii dari kartaa bararka.

ACE2 (angiotensin converting enzyme 2) kaliya maahan soo-dhoweeyaha SARS-CoV-2 si uu u weeraro unugyada laakiin sidoo kale wuxuu leeyahay firfircoonida firfircoonida enzymes.Doorkeeda ugu weyn waa in ay ka hortagto ACE kale (angiotensin converting enzyme) kaas oo aad ugu eg laakiin leh hawlo kala duwan.

Marka kelyuhu ay ogaadaan hoos u dhaca mugga dhiigga ama cadaadiska dhiigga (sida dhiig-baxa ama fuuq-baxa), waxay ku siidaayaan renin dhiigga.Insaymiska uu soo daayay beerka ayaa loo beddelaa mid aan firfircoonayn “angiotensin I”.Marka angiotensin I uu la socdo dhiigga sambabada si ay u beddelaan gaaska, ACE ee xididada alveolar waxay u beddeshaa "angiotensin II" dhab ah oo firfircoon oo ka shaqeeya jidhka oo dhan.

Si kale haddii loo dhigo, ACE waxay door muhiim ah ka ciyaartaa "nidaamka renin-angiotensin" kaas oo ilaaliya cadaadiska dhiigga ee joogtada ah iyo mugga dhiigga (iyadoo la ilaalinayo dareeraha jirka ee joogtada ah iyo electrolytes).

Waa uun inaadan ku hayn karin xididdada dhiigga meel cidhiidhi ah, xaalad cadaadis sare leh oo sidan oo kale ah!Taasi waxay kordhin kartaa culeyska shaqada ee wadnaha si uu u riixo dhiigga iyo kelyaha si loo shaandheeyo dhiigga.Intaa waxaa dheer, angiotensin II ma aha oo kaliya kor u qaadida vasoconstriction laakiin sidoo kale wuxuu kor u qaadaa bararka, oksaydhka iyo fibrosis.Dhaawaca joogtada ah ee uu u geysto jirka kuma koobnaan doono dhiig karka!

Sidaa darteed, si loo helo dheellitirnaan, jidhku wuxuu si xariif ah u habeeyaa ACE2 dusha unugyada xuubka xididada xididada, alveolar, wadnaha, kelyaha, xiidmaha yar, xuubka xuubka, xiniinyaha iyo unugyada kale ee unugyada, si ay u beddesho angiotensin II galay ang ( 1-7) taasoo balaadhisa xididdada dhiigga, hoos u dhigta cadaadiska dhiigga, awoodna u leh inay ka hortagto caabuqa, ka hortagga oksaydhka iyo ka hortagga fibrosis.

Si kale haddii loo dhigo, ACE2 waa kabaal loo isticmaalo jidhka si loogu dheellitiro wax soo saarka angiotensin II ee xad-dhaafka ah ee ACE.Si kastaba ha noqotee, ACE2 waxay u dhacdaa inay u noqoto deked sally ah ee coronavirus-ka cusub si uu u galo unugyada.

Marka ACE2 lagu daro borotiinka sare ee coronavirus-ka cusub, waxaa lagu jiidi doonaa unugga ama waxaa lagu daadin doonaa dhiigga sababtoo ah burburka qaab dhismeedka, si ACE2 ee korka unugga uu aad u yaraado oo uu awoodi waayo inuu ka hortago angiotensin II waxaa kiciyay ACE.

Natiijo ahaan, jawaabta bararka ee uu keeno fayrasku waxay ku xidhan tahay saamaynta pro-bararka ee angiotensin II.Jawaabta bararka ee sii kordheysa waxay joojin doontaa isku-darka unugyada ACE2, taasoo ka dhigaysa dhaawaca silsiladda ee ay sababto isku dheelitir la'aanta ACE/ACE2 mid aad u daran.Waxa kale oo ay ka dhigi doontaa dhaawaca ogsaydhiyaha iyo dhaawaca fibrosis ee unugyada iyo xubnaha mid aad u daran.

Daraasadaha caafimaadku waxay ogaadeen in angiotensin Ⅱ ee bukaannada qaba cudurka coronavirus 2019 (COVID-19) ay si weyn u korodhay, waxayna si togan ula xiriirtaa tirada fayraska, heerka dhaawaca sambabada, dhacdooyinka oof wareenka degdega ah iyo xanuunka neef-mareenka ee daran .Daraasaduhu waxay sidoo kale tilmaameen in falcelinta bararka ee la xoojiyey, cadaadiska dhiigga oo kordha, iyo korodhka mugga dhiigga ee ay keento isu-dheellitir la'aanta ACE/ACE2 ay yihiin sababo muhiim ah oo kordhiya culeyska wadnaha iyo kelyaha bukaannada qaba cudurka sambabada ee coronavirus-ka cusub waxayna sababaan myocardial iyo kelyaha. cudur.

Joojinta ACE waxay wanaajin kartaa isku dheelitir la'aanta ACE/ACE2

Waxyaabo badan oo ku jiraGanoderma lucidumwaxay joojin kartaa ACE

Maadaama ACE inhibitors-ka sida caadiga ah loo isticmaalo daawaynta hypertension ay joojin karaan dhaqdhaqaaqa ACE, waxay yareeyaan wax soo saarka angiotensin II waxayna yareeyaan dhaawaca silsiladda ee ay keento dheelitir la'aanta ACE/ACE2, waxaa loo arkaa inay waxtar u leeyihiin daaweynta novel coronavirus pneumonia. .

Culimada Bangladesh waxay dooddan u isticmaaleen mid ka mid ah sababaha fangaska la cuni karo iyo dawooyinka ay ugu habboon yihiin ka hortagga iyo daaweynta COVID-19.

Sababtoo ah sida laga soo xigtay cilmi-baaristii hore, fangaska badan oo la cuni karo iyo dawooyinka ayaa leh maaddooyin firfircoon oo xannibaya ACE, kuwaas oo ay ka mid yihiinGanoderma lucidumwaxay leedahay maaddooyinka firfircoon ee ugu badan.

Labada polypeptides ee ku jira soosaarka biyaha eeGanoderma lucidumJidhka miraha iyo triterpenoids (sida ganoderic acids, ganoderenic acids iyo ganederols) ee ku jira methanol ama soosaarka ethanolGanoderma lucidumMiraha miraha waxay joojin karaan dhaqdhaqaaqa ACE (Shaxda 1) saameyntooda xannibaadkuna aad ayey ugu fiican tahay fangaska badan ee la cuni karo iyo kuwa dawada (Shaxda 2).

Tan ka sii muhiimsan, horaantii 1970-meeyadii, daraasadaha kiliinikada ee Shiinaha iyo Japan ayaa xaqiijiyay taasGanoderma lucidumwaxay si wax ku ool ah hoos ugu dhigi kartaa dhiig karka, taas oo muujinaysaGanoderma lucidumJoojinta ACE kaliya maaha "waxqabad suurtagal ah" laakiin sidoo kale waxay ka shaqayn kartaa mareenka caloosha iyo mindhicirka.

Codsiga kiliinikada ee ka hortagga ACE

Tixgelinta hagaajinta dheellitirka ACE/ACE2

Haddii loo isticmaalo ka hortagga ACE si loo daweeyo novel coronavirus pneumonia ayaa mar ka dhigtay bulshada caafimaadka inay ka labalabeeyaan.

Sababtoo ah joojinta ACE waxay si dadban u kordhin doontaa muujinta ACE2.In kasta oo ay tahay wax wanaagsan in lala dagaallamo bararka, oksaydhka iyo fibrosis, ACE2 waa soo-dhoweeyaha coronavirus-ka cusub.Markaa haddii xannibaadda ACE ay ilaaliso unugyada ama ay sii xumayso caabuqa ayaa weli walaac ahaa.

Maalmahan, waxaa jiray daraasado caafimaad oo badan (fiiri tixraacyada 6-9 faahfaahinta) in ACE inhibitors aysan uga sii darin xaalada bukaanada qaba cudurka sambabada ee coronavirus.Sidaa darteed, ururo badan oo wadnaha ama dhiig karka ee Yurub iyo Maraykanka ayaa si cad ugu taliyay bukaanada inay sii wadaan isticmaalka ACE inhibitor haddii aysan dhicin xaalado caafimaad oo xun.

Marka loo eego bukaannada COVID-19 ee aan isticmaalin ACE inhibitors, gaar ahaan kuwa aan lahayn hypertension, cudurada wadnaha ama calaamadaha sonkorowga, haddii ACE inhibitors dheeraad ah la siiyo hadda waa mid aan la soo koobi karin sababtoo ah in kasta oo daraasado caafimaad ay arkeen faa'iidooyinka isticmaalka ACE inhibitors (sida. heerka badbaadada sare), saamayntu uma muuqato mid cad oo ku filan si ay u noqoto talobixin tilmaam caafimaad.

DoorkaGanoderma lucidumway ka badan tahay joojinta ACE

Maaha wax la yaab leh in horjoogayaasha ACE aysan awoodin inay sameeyaan saameyn la taaban karo inta lagu jiro xilliga fiirsashada bukaan-socodka (badanaa 1 maalin ilaa 1 bil).Caabuqa aan la xakameynin ee uu keeno dagaalka u dhexeeya fayraska iyo habka difaaca jirka ayaa ah sababta asaasiga ah ee ka sii darista cudurka sambabada ee coronavirus-ka cusub.Maadaama dembiilaha aan la tirtirin, dabcan way adagtahay in wax laga beddelo marka ugu horeysa iyada oo la xakameynayo ACE si loola tacaalo kuwa ku lug leh.

Dhibaatadu waxay tahay in dheelli-tirnaan la'aanta ACE/ACE2 ay u badan tahay inay noqoto cawska ugu dambeeya ee geela, waxayna u badan tahay inay noqoto turunturooyin soo kabashada mustaqbalka.Sidaa darteed, haddii aad ka fikirto dhinaca raadinta nasiibka wanaagsan iyo ka fogaanshaha musiibada, isticmaalka wanaagsan ee ACE inhibitors waxay caawin doontaa soo kabashada bukaanada qaba cudurka sambabada ee coronavirus.

Si kastaba ha ahaatee, marka la barbar dhigo dhibaatooyinka ay keeni karaan inhibitors ACE synthetic, sida qufac qallalan, allotriogeusti iyo potassium dhiigga oo sarreeya, aqoonyahanka Bangladeshi oo qoray warqaddan ayaa aaminsan in qaybaha ACE-ka-hortagga ee fangaska la cuni karo iyo daawada dabiiciga ah ay dhici doonto. ma keeno culeys jireed.Khaas ahaan,Ganoderma lucidum, kaas oo leh qaybo badan oo ka hortag ah ACE iyo saameyn xad dhaaf ah oo aad u fiican, ayaa mudan in la sugo.

Intaa waxaa dheer, badanGanoderma lucidumsoosaar amaGanoderma lucidummaaddooyinka joojiya ACE waxay sidoo kale joojin karaan taranka fayraska, hagaajinta caabuqa (iska ilaali duufaanka cytokine), kor u qaadida difaaca, ilaalinta hababka wadnaha, nidaaminta sonkorta dhiigga, nidaaminta cadaadiska dhiigga, nidaaminta dufanka dhiigga, yaraynta dhaawaca beerka, yaraynta dhaawaca kelyaha, yaraynta dhaawaca sambabada, ilaalinta mareenka neefsiga, ilaalinta marinka mindhicirka.Maaddooyinka ACE-ka-hortagga ah ama maaddooyinka kale ee ka-hortagga ACE ee laga helo fangaska la cuni karo iyo kuwa dawada ah lama barbar dhigi karoGanoderma lucidumarrintan la xiriira.

Yaraynta khatarta cudurrada daran iyo dhimashada waxay yaraynaysaa dhibaatada.

Laga bilaabo wakhtiga uu novel coronavirus u doortay ACE2 inuu yahay soo-dhoweeyaha duulaanka, waxaa loo qoondeeyay inuu ka duwanaado fayrasyada kale ee dilaaga iyo kakanaanta.

Sababtoo ah unugyo tiro badan oo jidhka bini'aadamka ah ayaa leh ACE2.Novel coronavirus wuxuu dhaawici karaa alveoli wuxuuna sababi karaa hypoxia jirka oo dhan, raac dhiigga si aad u hesho saldhig ku habboon jirka, soo jiidata unugyada difaaca meel kasta si ay u weeraraan, baabi'iyaan dheellitirka ACE / ACE2 meel kasta, xoojiya caabuqa, oksaydhka iyo fibrosis, kordhiyaan dhiigga cadaadiska iyo mugga dhiigga, waxay kordhiyaan culayska wadnaha iyo kelyaha, waxay sameeyaan dareeraha jidhka iyo electrolytes dheelitir la'aanta taas oo saamaysa hawlaha unugyada, oo kicisa saameyno domino badan.

Sidaa darteed, infekshanka novel coronavirus pneumonia macnaheedu maaha "qabow hargab ka daran" kaas oo "kaliya saameeya sambabada".Waxay yeelan doontaa daba-galka muddada-dheer ee unugyada jidhka, xubnaha iyo hawlaha jireed.

In kasta oo warka wanaagsan ee ku saabsan horumarinta dawooyinka cusub ee kala duwan ee ka-hortagga iyo daawaynta COVID-19 uu yahay mid aad u xiiso badan, xaqiiqooyin aan dhammaystirnayn ayaa gacanta ku dhow:

Tallaalku (soo-saare unugyada difaaca jirka) ma dammaanad qaadayo in aanu jirin caabuq;

Daawooyinka ka hortagga fayraska (ka-hortagga taranka fayraska) ma dammaanad qaadi karaan daaweynta cudurka;

Steroid anti-bararka (xakamaynta difaaca) waa seef laba af leh;

Dhibaatooyinka laga yaabo inaan la iska ilaalin xitaa haddii aysan jirin cudur daran;

Isbeddelka baadhista fayraska ee togan iyo taban macnaheedu maaha in si guul leh loola dagaallamo cudurka faafa;

Ka bixida cisbitaalka adoo nool macnaheedu maaha inaad awood u yeelan doonto inaad si buuxda u bogsato mustaqbalka.

Marka dawooyinka coronavirus iyo tallaaladu ay naga caawiyeen inaan fahanno "jihada guud" ee yaraynta halista jirro daran, yaraynta ixtimaalka dhimashada iyo soo gaabin dhererka cusbitaalka, ha iloobin inay jiraan "faahfaahin" badan oo ay tahay inaannu nahay. isku haleyno nafteena in aan wax ka qabano.

Marka bini'aadanku ay ku tiirsan yihiin garaadka iyo waayo-aragnimada si ay isugu daraan daawooyin kala duwan oo duug ah iyo kuwo cusub kuwaas oo leh saameyn gaar ah si loo gaaro saameynta ugu wanaagsan, waa inaan baranaa sida loo qaato daaweyn dhamaystiran oo qaabka cocktail ah si loola tacaalo cudurkan adag.

Laga soo bilaabo kor u qaadida iska caabinta, joojinta fayraska taranka, xakamaynta caabuqa aan caadiga ahayn, dheelitirka ACE / ACE2 si loo ilaaliyo nidaamka wadnaha, nidaaminta saddexda sare iyo yaraynta culeyska cudurada dabadheeraad ee jirka, kuwan waxaa la dhihi karaa sida baahiyaha aasaasiga ah ee dhimista heerka caabuqa COVID-19, ka hortagga COVID-19 daran iyo hagaajinta soo kabashada COVID-19.

Qofna ma garanayo inay jirto rajo mustaqbalka ah si loo daboolo baahiyahan aasaasiga ah isku mar.Waxaa laga yaabaa in "cuntada sirta ah" ee cirka ka fog ay dhab ahaantii hortaada ku taal.Ilaaha naxariista leh waxa uu muddo dheer diyaariyey cunto karinta cocktail ah oo dabiici ah, oo loo isticmaalo cuntada iyo daawada, diyaarsan, kuna habboon ragga, haweenka iyo carruurta.Waxay ku xiran tahay oo kaliya haddii aan ognahay sida loo isticmaalo.

[Isha]

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2. Aiko Morigiwa, iyo al.Chem Pharm Bull (Tokyo).1986;34 (7): 3025-3028.

3. Nuurlidah Abdullah, iyo al.Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, iyo al.Unugyada.2014;19 (9): 13473-13485.

5. Tran Hai-Bang, iyo al.Phytochem Lett.2015;12: 243-247.

6. Chirag Bavishi, iyo al.JAMA Cardiol.2020;5 (7):745-747.

7. Abhinav Grover, iyo al.Juun 15, 2020: pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. Renato D. Lopes, iyo al.Am Heart J. 2020 Agoosto; 226: 49–59.

9. Renato D. Lopes, iyo al.JAMA.2021 Jan 19;325(3):254–264.

DHAMAAD

Ku saabsan qoraaga/Ms. Wu Tingyao
Wu Tingyao waxa ay ka warbixinaysay ganoderma lucidum macluumaadka gacanta koowaad tan iyo 1999. Iyadu waa qoraagaKu bogsashada Ganoderma(waxaa lagu daabacay Guriga Daabacaada Caafimaadka Dadweynaha Abriil 2017).
 
★ Maqaalkan waxa lagu daabacay oggolaansho gaar ah oo uu leeyahay qoraaga, lahaanshahana waxaa iska leh GANOHERB.

★ Shaqooyinka kor ku xusan lama soo saari karo, lama soo saari karo ama looma isticmaali karo siyaalo kale iyada oo aan oggolaansho laga helin GanoHerb.

Haddii shaqooyinka loo oggolaaday in la isticmaalo, waa in lagu dhex isticmaalo xadka oggolaanshaha oo ay tilmaamaan isha: GanoHerb.

Jebinta kasta oo bayaankan kor ku xusan, GanoHerb waxay sii wadi doontaa mas'uuliyadaha sharci ee la xidhiidha.

★ Qoraalka asalka ah ee maqaalkan waxaa ku qoray Shiinaha Wu Tingyao, waxaana u turjumay Ingiriisi Alfred Liu.Haddii uu jiro farqi u dhexeeya tarjumaada (Ingiriiska) iyo kan asalka ah (Shiineyska), Shiinaha asalka ah ayaa guulaysan doona.Haddii akhristayaasha ay qabaan wax su'aalo ah, fadlan la xiriir qoraaga asalka ah, Ms. Wu Tingyao.
 

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