NgoMeyi ka-2021, iqela elikhokelwa ngu-Mohammad Azizur Rahman, uNjingalwazi oDityanisiweyo weSebe le-Biochemistry kunye ne-Molecular Biology, iYunivesithi yaseJahangirnagar, e-Bangladesh, kunye neZiko loPhuhliso lwe-Mushroom, iSebe loLwandiso lwezoLimo, uMphathiswa wezoLimo, e-Bangladesh ngokudibeneyo bapapashe iphepha elibuyela emva. Ijenali yeZizwe ngezizwe yamaMushrooms amayeza ukukhokela abantu abaphantsi kobhubhani we-COVID-19 ukuba basebenzise kakuhle “ulwazi olwaziwayo” kunye “nezixhobo ezikhoyo” ukufuna ukuzikhusela kwithuba elide lokulinda ukusindiswa ngamachiza amatsha.

Ngokusekwe kwiziphumo eziqinisekisiweyo zenzululwazi, ngovavanyo lwengqwalasela esebenzayo efana nokhuseleko olutyiwayo kunye nokufikeleleka kwamakhowa anokutyiwa kunye namayeza kunye nohlalutyo lwendima yawo kwi-antivirus, ukulawulwa kwamajoni omzimba, ukunciphisa ukudumba okubangelwa kukungalingani kwe-ACE / ACE2 kunye nokuphuculwa kwesiqhelo esingapheliyo. izifo ezifana nesifo sentliziyo, isifo seswekile, i-hyperlipidemia, kunye noxinzelelo lwegazi kwizigulana ezinesifo se-coronavirus ka-2019 (COVID-19), eli phepha lichaza izizathu zokuba kutheni abantu kufuneka "batye amakhowa ukunqanda ubhubhane".

Iphepha labonisa izihlandlo ezininzi kwinqaku ukubaI-Ganoderma lucidumngokungathandabuzekiyo lolona khetho lufanelekileyo kuthintelo kunye nonyango lwenoveli coronavirus inyumoniya phakathi kwezinto ezininzi ezityiwayo kunye nezifo zokungunda ngenxa yezithako zayo ezityebileyo nezahlukeneyo ezisebenzayo.

OkoI-Ganoderma luciduminqanda ukuphindaphinda kwentsholongwane, ilawula ukuphendula okugqithisileyo kunye nokungonelanga kwe-immune (i-anti-inflammation kunye nokuphucula ukuxhathisa) ayiqhelekanga kumntu wonke kwaye ixutyushwe kumanqaku amaninzi:

Kulula ukuyiqonda loo ntoI-Ganoderma lucidum, esele ilungile ekukhuseleni intliziyo nesibindi, ukukhusela imiphunga kunye nokuqinisa izintso, ukulawula ukuphakama okuthathu, kunye nokuchasana nokuguga, kunokuphucula amathuba okuba izigulane ezinezifo ezingapheliyo kunye nabantu abaneminyaka ephakathi kunye nabantu abadala ekulweni ukukrala kwemiphunga kwentsholongwane ye-corona entsha.

Kodwa yintoni ukungalingani kwe-ACE/ACE2?Yintoni enxulumene nokudumba?Ingaba kwenzeka njaniI-Ganoderma lucidumungenelele kulungelelaniso?

Ukungalingani kwe-ACE/ACE2 kunokunyusa ukudumba.

I-ACE2 (i-angiotensin eguqula i-enzyme 2) ayisiyiyo kuphela i-receptor ye-SARS-CoV-2 ukuba ihlasele iiseli kodwa inomsebenzi we-catalytic we-enzymes.Indima yayo ephambili kukuphikisana nenye i-ACE (i-angiotensin yokuguqula i-enzyme) ebonakala ifana kakhulu kodwa inemisebenzi eyahlukileyo ngokupheleleyo.

Xa intso ibona ukuhla komthamo wegazi okanye uxinzelelo lwegazi (njengokopha okanye ukuphelelwa ngamanzi emzimbeni), ikhupha i-renin egazini.I-enzyme ekhutshwe sisibindi iguqulwa ibe yi "angiotensin I" engasebenziyo.Xa i-angiotensin I ihamba negazi kwimiphunga ukuze itshintshisene ngegesi, i-ACE ekwi-alveolar capillaries iyiguqulela ekubeni yi-“angiotensin II” esebenzayo ngokwenene esebenza kuwo wonke umzimba.

Ngamanye amazwi, i-ACE idlala indima ephambili "kwinkqubo ye-renin-angiotensin" egcina uxinzelelo lwegazi rhoqo kunye nomthamo wegazi (ngelixa igcina i-fluid yomzimba kunye ne-electrolytes rhoqo).

Kuphela nje ukuba awukwazi ukugcina imithambo yegazi ikwimeko eqinileyo, enoxinzelelo oluphezulu ngolu hlobo!Oko kunokwandisa umsebenzi wentliziyo ukutyhala igazi kunye nezintso ukuba zihluze igazi.Ngaphezu koko, i-angiotensin II ayikhuthazi nje i-vasoconstriction kodwa ikhuthaza ukuvutha, i-oxidation kunye ne-fibrosis.Umonakalo wayo oqhubekayo emzimbeni awuyi kuphela kuxinzelelo lwegazi oluphezulu!

Ke, ukuze ube nokulingana, umzimba ulungiselela ngobuchule i-ACE2 kumphezulu weeseli ze-vascular endothelial, i-alveolar, intliziyo, izintso, amathumbu amancinci, i-bile duct, i-testis kunye nezinye iiseli zezicubu, ukuze ikwazi ukuguqula i-angiotensin II ibe yi-ang. 1-7) eyandisa imithambo yegazi, yehlisa uxinzelelo lwegazi kwaye ikwazi ukulwa nokudumba, i-anti-oxidation kunye ne-anti-fibrosis.

Ngamanye amagama, i-ACE2 sisitshixo esisetyenziswa emzimbeni ukulungelelanisa ukuveliswa kwe-angiotensin II egqithisileyo yi-ACE.Nangona kunjalo, i-ACE2 yenzeka ukuba ibe lizibuko le-sally le-coronavirus entsha ukuba ihlasele iiseli.

Xa i-ACE2 idityanisiwe kunye neprotein ye-spike yenoveli coronavirus, iya kutsalelwa kwiseli okanye ichithwe egazini ngenxa yomonakalo wesakhiwo, ukuze i-ACE2 engaphezulu kumphezulu weseli incitshiswe kakhulu kwaye ingakwazi ukumelana ne-angiotensin. II yenziwe yi-ACE.

Ngenxa yoko, impendulo yokuvuvukala eyenziwa yintsholongwane idibene nefuthe le-pro-inflammatory ye-angiotensin II.Ukusabela okukhulayo kokudumba kuya kuthintela udibaniso lwe-ACE2 ngeeseli, zenze umonakalo wetyathanga obangelwe kukungalingani kwe-ACE/ACE2 kubi ngakumbi.Kwakhona kuya kwenza umonakalo we-oxidative kunye nomonakalo we-fibrosis wezicubu kunye namalungu anzima kakhulu.

Izifundo zeklinikhi ziye zaqaphela ukuba i-angiotensin Ⅱ yezigulana ezinesifo se-coronavirus ka-2019 (COVID-19) yonyuka kakhulu, kwaye inxulunyaniswe ngokuqinisekileyo nobungakanani bentsholongwane, inqanaba lokwenzakala kwemiphunga, ukwenzeka kwenyumoniya eqatha kunye nesifo esiqatha sokuphefumla. .Uphononongo lukwaveze ukuba impendulo eyongeziweyo yokudumba, ukonyuka koxinzelelo lwegazi, kunye nokwanda komthamo wegazi okubangelwa kukungalingani kwe-ACE/ACE2 zizizathu ezibalulekileyo ezonyusa umthwalo entliziyweni nasezintso zezigulana ezinenoveli yenyumoniya ye-coronavirus kwaye zibangele i-myocardial kunye nezintso. isifo.

Ukuvinjelwa kwe-ACE kunokuphucula ukungalingani kwe-ACE/ACE2

Izithako ezininzi eziqulethwe kuyoI-Ganoderma luciduminokuthintela i-ACE

Kuba ii-ACE inhibitors eziqhele ukusetyenziswa kunyango loxinzelelo lwegazi zinokuthintela umsebenzi we-ACE, ukunciphisa ukuveliswa kwe-angiotensin II kunye nokunciphisa umonakalo wetyathanga obangelwe kukungalingani kwe-ACE / ACE2, zithathwa njengoncedo kunyango lwenoveli coronavirus pneumonia. .

Abaphengululi base-Bangladeshi basebenzise le ngxoxo njengenye yezizathu zokuba kutheni umngundo otyiwayo kunye namayeza ufanelekile kuthintelo kunye nonyango lwe-COVID-19.

Kuba ngokophando oludlulileyo, iifungi ezininzi ezidliwayo kunye nezamayeza zinezithako ezisebenzayo ezithintela i-ACE, phakathi kwazoI-Ganoderma luciduminezona zithako zininzi ezisebenzayo.

Zombini iipolypeptides eziqulethwe kwisicatshulwa samanzi seI-Ganoderma lucidumimizimba yeziqhamo kunye ne-triterpenoids (efana ne-ganoderic acids, i-ganoderenic acids kunye ne-ganederols) ekhoyo kwi-methanol okanye isicatshulwa se-ethanolI-Ganoderma lucidumimizimba eneziqhamo inokuthintela umsebenzi we-ACE (Itheyibhile 1) kwaye isiphumo sayo sokuthintela sibalasele kakhulu phakathi kwezinto ezininzi zokungunda ezityiwayo kunye nezamayeza (Itheyibhile 2).

Okona kubaluleke kakhulu, kwangeminyaka yoo-1970, izifundo zeklinikhi eTshayina naseJapan zikuqinisekisile okoI-Ganoderma luciduminokwehlisa ngokufanelekileyo uxinzelelo lwegazi oluphezulu, ebonisa ukubaI-Ganoderma lucidum's inhibition of ACE ayingo "msebenzi onokwenzeka" kuphela kodwa unokusebenza ngomjelo wesisu.

Ukusetyenziswa kweklinikhi ye-ACE inhibitors

Iingqwalasela zokuphucula ukungalingani kwe-ACE/ACE2

Nokuba ngaba kusetyenziswe ii-ACE inhibitors ukunyanga inyumoniya entsha ye-coronavirus kuye kwenza ukuba abezonyango bathandabuze.

Ngenxa yokuba ukuthintela i-ACE kuya kwandisa ngokungathanga ngqo ukubonakaliswa kwe-ACE2.Nangona kuyinto elungileyo ukulwa nokudumba, i-oxidation kunye ne-fibrosis, i-ACE2 yi-receptor yenoveli coronavirus.Ke ukuba ukuthintelwa kwe-ACE kuyakhusela izicubu okanye kuyalwandisa usulelo kwakusaxhalabisa.

Kule mihla, kukho izifundo ezininzi zeklinikhi (jonga iiReferensi 6-9 malunga neenkcukacha) ukuba i-ACE inhibitors ayenzi mandundu ngakumbi imeko yezigulana ezine-coronavirus pneumonia.Ke ngoko, imibutho emininzi yentliziyo okanye yoxinzelelo lwegazi eYurophu naseMelika iye yacebisa izigulane ukuba ziqhubeke nokusetyenziswa kwe-ACE inhibitor ukuba akukho zimo zeklinikhi ezimbi ezenzekayo.

Ngokumalunga nezigulana ze-COVID-19 ezingazange zisebenzise i-ACE inhibitors, ngakumbi ezo zingenaxinzelelo lwegazi, isifo sentliziyo okanye iimpawu zeswekile, nokuba ii-ACE inhibitors ezongeziweyo kufuneka zinikwe okwangoku akuqinisekwanga ikakhulu kuba nangona izifundo zeklinikhi ziye zaqaphela izibonelelo zokusebenzisa i-ACE inhibitors (ezifana ne izinga eliphezulu lokusinda), isiphumo asibonakali sicace ngokwaneleyo ukuba sibe sisindululo sesikhokelo sonyango.

Indima yeI-Ganoderma lucidumingaphezulu kokuthintela i-ACE

Akumangalisi ukuba i-ACE inhibitors ayinakukwazi ukwenza imiphumo ebalulekileyo ngexesha lokuqwalaselwa kweklinikhi (ngokuqhelekileyo i-1 usuku ukuya kwi-1 inyanga).Ukudumba okungalawulekiyo okubangelwa ngumlo phakathi kwentsholongwane kunye nokhuselo lomzimba ngunobangela wokuwohloka kwenoveli coronavirus pneumonia.Ekubeni umtyholi akakapheliswa, ngokuqinisekileyo kunzima ukuguqula izinto ngexesha lokuqala ngokucinezela i-ACE ukujongana nezinto ezihambisana nazo.

Ingxaki yeyokuba ukungalingani kwe-ACE/ACE2 kusenokwenzeka ukuba ibe sisququ sokugqibela sokutyumza inkamela, kwaye kunokwenzeka ukuba ibe sisikhubekiso sokubuyisela kwixesha elizayo.Ke, ukuba ucinga ngokwembono yokulandela ithamsanqa kunye nokuphepha intlekele, ukusetyenziswa kakuhle kwe-ACE inhibitors kuya kunceda ukuchacha kwezigulana ezinenoveli coronavirus pneumonia.

Nangona kunjalo, xa kuthelekiswa neziphumo ebezingalindelekanga ezinokubangelwa ziinhibitors zokwenziwa ze-ACE, ezinjengokhohlokhohlo olomileyo, i-allotriogeusti kunye ne-potassium yegazi ephezulu, umphengululi wase-Bangladeshi owabhala eli phepha wayekholelwa ukuba amacandelo athintela i-ACE kwizinto ezityiwayo nezamayeza ezenzeka ngokwendalo ziya kuthi. ayibangeli umthwalo womzimba.Ukuthi ngqo,I-Ganoderma lucidum, enamacandelo amaninzi e-ACE-inhibiting kunye nesiphumo esihle kakhulu sokuthintela, kubaluleke kakhulu ukujonga phambili.

Ngaphezu koko, abaninziI-Ganoderma lucidumizicatshulwa okanyeI-Ganoderma lucidumizithako ezithintela i-ACE zinokuthintela ukuphindaphinda kwentsholongwane, ukulawula ukuvutha (ukuphepha isaqhwithi se-cytokine), ukwandisa ukhuseleko, ukukhusela iinkqubo zentliziyo, ukulawula iswekile yegazi, ukulawula uxinzelelo lwegazi, ukulawula i-lipids yegazi, ukunciphisa ukulimala kwesibindi, ukunciphisa ukulimala kwezintso, ukunciphisa ukulimala kwemiphunga, ukukhusela. indlela yokuphefumla, khusela umgudu wamathumbu.Izithako zokuthintela i-ACE okanye ezinye izithako ezithintela i-ACE ezivela kwizinto ezityiwayo kunye nefungi yeyeza ayinakuthelekiswa nayo.I-Ganoderma lucidumngale ndlela.

Ukunciphisa umngcipheko wokugula kakhulu kunye nokufa kukunciphisa nje ingxaki.

Ukusukela oko i-coronavirus yenoveli ikhetha i-ACE2 njenge-receptor yohlaselo, imiselwe ukuba yahluke kwezinye iintsholongwane ngokubulala kunye nobunzima.

Kuba iiseli zethishu ezininzi kakhulu emzimbeni womntu zine-ACE2.Inoveli coronavirus inokonakalisa i-alveoli kwaye ibangele i-hypoxia kuwo wonke umzimba, ilandele igazi ukuze ifumane isiseko esifanelekileyo emzimbeni, itsale iiseli zokhuselo lomzimba kuyo yonke indawo ukuba zihlasele, itshabalalise ibhalansi ye-ACE/ACE2 kuyo yonke indawo, iqinise ukudumba, i-oxidation kunye ne-fibrosis, ukonyusa igazi. uxinzelelo kunye nomthamo wegazi, ukwandisa umthwalo entliziyweni kunye nezintso, ukwenza ulwelo lomzimba kunye nokungalingani kwe-electrolytes okuchaphazela ukusebenza kweeseli, kwaye kubangele iziphumo ezininzi ze-domino.

Ke ngoko, ukosuleleka ngenyumoniya entsha ye-coronavirus “akukokufumana ukubanda okukhulu ngakumbi” “okuchaphazela imiphunga kuphela”.Iya kuba nesequelae yexesha elide kwizicubu zomzimba, amalungu kunye nemisebenzi yomzimba.

Nangona iindaba ezimnandi malunga nophuhliso lwamachiza amatsha othintelo kunye nonyango lwe-COVID-19 zivuyisa kakhulu, ezinye iinyani ezingafezekanga zikufuphi:

Ukugonywa (i-inducing antibodies) akuqinisekisi ukuba akuyi kubakho usulelo;

Amachiza okulwa neentsholongwane (ukuthintela ukuphindaphinda kwentsholongwane) akanakuqinisekisa ukunyangwa kwesi sifo;

I-Steroid anti-inflammation (ukunciphisa amajoni omzimba) likrele elintlangothi-mbini;

Iingxaki azinakuphetshwa nokuba akukho sigulo siqatha;

Ukutshintsha kovavanyo lwentsholongwane ukusuka ekubeni une-HIV ukuya kwe-negative akuthethi ukuba umlo onempumelelo ngokuchasene nobhubhane;

Ukuphuma esibhedlele uphila akuthethi ukuba uya kukwazi ukuchacha ngokupheleleyo kwixesha elizayo.

Xa amayeza e-coronavirus kunye nogonyo luye lwasinceda ukuba sibambe "umkhombandlela jikelele" wokunciphisa umngcipheko wokugula kakhulu, ukunciphisa amathuba okufa kunye nokunciphisa ubude bokulaliswa esibhedlele, ungalibali ukuba zininzi "iinkcukacha" ekufuneka sizenze. sithembele kuthi ukuba siphathe kunye.

Xa abantu bexhomekeke kubukrelekrele kunye namava ukudibanisa amayeza achanekileyo amadala kunye namatsha aneziphumo ezithile ukufikelela esona siphumo silungileyo, kufuneka sifunde ukwamkela unyango olubanzi lwendlela yokujongana nesi sifo sinzima.

Ukusuka ekomelezeni ukuchasana, ukuthintela ukuphindaphinda kwentsholongwane, ukulawula ukudumba okungaqhelekanga, ukulinganisa i-ACE / i-ACE2 ukukhusela inkqubo yentliziyo, ukulawula iindawo ezithathu eziphakamileyo kunye nokunciphisa umthwalo wezifo ezingapheliyo emzimbeni, ezi zinokuthiwa njengezidingo ezisisiseko zokunciphisa izinga losulelo. I-COVID-19, ukuthintela okumandundu kwe-COVID-19 kunye nokuphucula ukuchacha kwe-COVID-19.

Akukho mntu waziyo enoba likho ithemba kwikamva lokuhlangabezana nezi mfuno zisisiseko ngaxeshanye.Mhlawumbi “iresiphi eyimfihlo” ekude esibhakabhakeni iphambi kwakho.UThixo onenceba kudala elungiselela iresiphi yecocktail eyendalo, esetyenziswa kabini ekutyeni namayeza, efumaneka lula, nefanele amadoda, abafazi nabantwana.Kuxhomekeke ekubeni siyayazi indlela yokuyisebenzisa.

[Umthombo]

1. U-Mohammad Azizur Rahman, et al.Int J Med Mushrooms.2021;23(5):1-11.

2. Aiko Morigiwa, et al.I-Chem Pharm Bull (eTokyo).1986;34(7): 3025-3028.

3. Noorlidah Abdullah, et al.I-Evid Based Complement Alternat Med.2012;2012:464238.

4. Tran Hai-Bang, et al.Iimolekyuli.2014;19 (9): 13473-13485.

5. Tran Hai-Bang, et al.Phytochem Lett.2015;12: 243-247.

6. Chirag Bavishi, kunye nabanye.JAMA Cardiol.2020;5(7):745-747.

7. Abhinav Grover, et al.2020 Jun 15 : pvaa064.doi:10.1093/ehjcvp/pvaa064.

8. URenato D. Lopes, et al.Am Heart J. 2020 Aug;226: 49–59.

9. URenato D. Lopes, et al.JAMA.2021 Jan 19;325(3):254–264.

ISIPHELO

Malunga nombhali/ Nksz. Wu Tingyao
UWu Tingyao unike ingxelo ngolwazi lokuqala lweGanoderma lucidum ukusukela ngo-1999. Ungumbhali wencwadiUkunyanga ngeGanoderma(ipapashwe kwiNdlu yePeople's Medical Publishing House ngo-Epreli 2017).
 
★ Eli nqaku lipapashwe phantsi kogunyaziso olulodwa lombhali, kwaye ubunini bobuka-GANOHERB.

★ Le misebenzi ingentla ayinakuphinda iveliswe, ikhutshwe okanye isetyenziswe ngezinye iindlela ngaphandle kokugunyaziswa kweGanoHerb.

★ Ukuba imisebenzi igunyazisiwe ukuba isetyenziswe, kufuneka isetyenziswe ngaphakathi kwendawo yogunyaziso kwaye ibonise umthombo: GanoHerb.

★ Nakuphi na ukuphulwa kwengxelo engentla, i-GanoHerb iya kulandela uxanduva olusemthethweni olunxulumeneyo.

★ Umbhalo wokuqala weli nqaku ubhalwe ngesiTshayina nguWu Tingyao waza waguqulelwa kwisiNgesi nguAlfred Liu.Ukuba kukho nakuphi na ukungangqinelani phakathi kwenguqulelo (isiNgesi) kunye neyoqobo (isiTshayina), isiTshayina sokuqala siya koyisa.Ukuba abafundi banayo nayiphi na imibuzo, nceda uqhagamshelane nombhali wokuqala, uNks. Wu Tingyao.
 

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